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Systematic review:Eosinophilic esophagitis in Asian countries

World Journal of Gastroenterology 2015年第27期21卷 8433-8440页

作者： yoshikazu kinoshita Norihisa Ishimura Naoki Oshima Shunji Ishihara Department of Gastroenterology and Hepatology Shimane University School of Medicine

AIM: to investigate the prevalence and the clinical characteristics of Asian patients with eosinophilic ***: We conducted a systematic search of the Pub Med and Web of Science databases for original studies, case series, and individual case reports of eosinophilic esophagitis in Asian countries published from January 1980 to January 2015. We found 66 and 80 articles in the Pub Med and Web of Science databases, respectively; 24 duplicate articles were removed. After excluding animal studies, articles not written in English, and meeting abstracts, 25 articles containing 217 patients were selected for ***: Sample size-weighted mean values were determined for all pooled prevalence data and clinical characteristics. The mean age of the adult patients with eosinophilic esophagitis was approximately 50 years, and 73% of these patients were male. They frequently presented with allergic diseases including bronchial asthma, allergic rhinitis, food allergy, and atopic dermatitis. Bronchial asthma was the most frequent comorbid allergic disease, occurring in 24% of patients with eosinophilic esophagitis. Dysphagia was the primary symptom reported; 44% of the patients complained of dysphagia. Although laboratory blood tests are not adequately sensitive for an accurate diagnosis of eosinophilic esophagitis, endoscopic examinations revealed abnormal findings typical of this disease, including longitudinal furrows and concentric rings, in 82% of the cases. One-third of the cases responded to proton pump inhibitor ***: The characteristics of eosinophilicesophagitis in Asian patients were similar to those reported in Western patients, indicating that this disease displays a similar pathogenesis between Western and Asian patients.

关键词： Eosinophilic esophagitis Allergy Prevalence Symptom Endoscopy Asia Treatment

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Unsedated transnasal small-caliber esophagogastroduoden oscopy in elderly and bedridden patients

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World Journal of Gastroenterology 2009年第44期15卷 5586-5591页

作者： Mika Yuki Yuji Amano Yoshinori Komazawa Hiroyuki Fukuhara Toshihiro Shizuku Shun Yamamoto yoshikazu kinoshita Division of Internal Medicine Izumo-City General Medical Center613 Nadabunn-choIzumo-shi Shimane 693-0003Japan Division of Endoscopy Shimane University Hospital89-1 Enya-choIzumo-shiShimane 693-8501Japan Division of Internal Medicine Unnan Municipal General Hospital96-1 Iida-choUnnan-shiShimane 699-1221Japan Second Department of Internal Medicine Shimane UniversitySchool of Medicine89-1 Enya-choIzumo-shiShimane 693-8501Japan

AIM： To evaluate the safety of unsedated transnasal small-caliber esophagogastroduodenoscopy （EGD） for elderly and critically ill bedridden patients. METHODS： One prospective randomized comparative study and one crossover comparative study between transnasal small-caliber EGD and transoral conventional EGD was done （Study 1）. For the comparative study, we enrolled 240 elderly patients aged 〉 65 years old. For the crossover analysis, we enrolled 30 bedridden patients with percutaneous endoscopic gastrostomy （PEG）（Study 2）, We evaluated cardiopulmonary effects by measuring arterial oxygen saturation （SpO2） and calculating the rate-pressure product （RPP）（pulse rate x systolic blood pressure/100） at baseline, 2 and 5 min after endoscopic intubation in Study 1. To assess the risk for endoscopy-related aspiration pneumonia during EGD, we also measured blood leukocyte counts and serum C-reactive protein （CRP） levels before and 3 d after EGD in Study 2. RESULTS： In Study 1, we observed significant decreases in SpO2 during conventional transoral EGD, but not during transnasal small-caliber EGD （0.24% vs -0.24% after 2 min, and 0.18% vs -0.29% after 5 min, P = 0.034, P = 0.044）. Significant differences of the RPP were not found between conventional transoral and transnasal small-caliber EGD. In Study 2, crossover analysis showed statistically significant increases of the RPP at 2 min after intubation and the end of endoscopy （26.8 and 34.6 vs 3.1 and 15.2, P = 0.044, P = 0.046）, and decreases of SpO2 （-0.8% vs -0.1%, P = 0.042） during EGD with transoral conventional in comparison with transnasal small-caliber endoscopy. Thus, for bedridden patients with PEG feeding, who were examined in the supine position, transoral conventional EGD more severely suppressed cardiopulmonary function than transnasal small-caliber EGD. There were also significant increases in the markers of inflammation, blood leukocyte counts and serum CRP values, in bedridden patients after transoral co

关键词： Aged Aspiration pneumonia Gastrointestina endoscopy Critical illness

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A dose-up of ursodeoxycholic acid decreases transaminases in hepatitis C patients

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World Journal of Gastroenterology 2009年第22期15卷 2782-2786页

作者： Shuichi Sato Tatsuya Miyake Hiroshi Tobita Naoki Oshima Junichi Ishine Takuya Hanaoka Yuji Amano yoshikazu kinoshita Department of Gastroenterology and Hepatology Shimane UniversitySchool of Medicine Division of Gastrointestinal Endoscopy Shimane University Hospital

AIM:To examine whether a dose-up to 900 mg of ursodeoxycholic acid(UDCA) decreases transaminases in hepatitis C ***:From January to December 2007,patients with chronic hepatitis C or compensated liver cirrhosis with hepatitis C virus(HCV)(43-80 years old) showing positive serum HCV-RNA who had already taken 600 mg/d of UDCA were recruited into this *** parameters were examined at 4,8 and 24 wk after increasing the dose of oral UDCA from 600 to 900 mg/***:Serum alanine aminotransferase(ALT),aspartate aminotransferase(AST),and gamma-glutamyl transpeptidase(GGT) levels were signifi cantly decreased following the administration of 900 mg/d as compared to 600 mg/*** decrease in ALT from immediately before the dose-up of UDCA to 8 wk after the dose-up was 14.3 IU/L,while that for AST was 10.5 IU/L and for GGT was 9.8 IU/*** count tended to increase after the dose-up of UDCA,although it did not show a statistically signifi cant level(P=0.05).Minor adverse events were observed in 3 cases,although no drop-outs from the study ***:Oral administration of 900 mg/d of UDCA was more effective than 600 mg/d for reducing ALT,AST,and GGT levels in patients with HCV-related chronic liver disease.

关键词： Chronic hepatitis Hepatitis C virus Liver fibrosis Transaminase Ursodeoxycholic acid

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Randomized study of lafutidine vs lansoprazole in patients with mild gastroesophageal reflux disease

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World Journal of Gastroenterology 2016年第23期22卷 5430-5435页

作者： Ryuta Takenaka Hiroyuki Okada Seiji Kawano Yoshinori Komazawa Fumiya Yoshinaga Shinji Nagata Masafumi Inoue Hirohisa Komatsu Seiji Onogawa Yoshinori Kushiyama Shinichi Mukai Hiroko Todo Hideharu Okanobu Noriaki Manabe Shinji Tanaka Ken Haruma yoshikazu kinoshita Department of Gastroenterology Tsuyama Chuo Hospital Tsuyama 708-0841 Japan Department of Gastroenterology and Hepatology Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama 708-0841 Japan Division of Internal Medicine Izumo City General Medical Center Izumo 691-0003 Japan Department of Gastroenterology Mihara Red Cross Hospital Mihara 723-0011 Japan Department of Endoscopy Hiroshima City Asa Citizens Hospital Hiroshima 731-0293 Japan Department of Gastroenterology Okayama Red Cross Hospital Okayama 700-0941 Japan Department of Gastroenterology Hiroshima General Hospital Hiroshima 734-8551 Japan Department of Gastroenterology Onomichi General Hospital Onomichi 722-8508 Japan Department of Gastroenterology Matsue Red Cross Hospital Matsue 690-8506 Japan Department of Gastroenterology Miyoshi Central Hospital Miyoshi 728-0023 Japan Department of Gastroenterology Hiroshima-Nishi Medical Center Hiroshima 739-0651 Japan Department of Gastroenterology Chugoku Rosai Hospital Kure 737-0134 Japan Department of Gastroenterology Kawasaki Medical School Hospital Kurashiki 701-0192 Japan Department of Endoscopy Hiroshima University Hospital Hiroshima 734-8551 Japan Department of General Internal Medicine 2 Kawasaki Hospital Kawasaki Medical School Okayama 708-0841 Japan Department of Gastroenterology and Hepatology Shimane University Hospital Izumo 693-0021 Japan

AIM: To compare the clinical efficacy of the secondgeneration H2 RA lafutidine with that of lansoprazole in Japanese patients with mild gastroesophageal reflux disease(GERD). METHODS: Patients with symptoms of GERD and a diagnosis of grade A reflux esophagitis(according to the Los Angeles classification) were randomized to receive lafutidine(10 mg, twice daily) or lansoprazole(30 mg, once daily) for an initial 8 wk, followed by maintenance treatment comprising half-doses of the assigned drug for 24 wk. The primary endpoint was the frequency and severity of heartburn during initial and maintenance treatment. The secondary endpoints were the sum score of questions 2 and 3 in the Gastrointestinal Symptom Rating Scale(GSRS), and the satisfaction ***: Between April 2012 and March 2013, a total of 53 patients were enrolled, of whom 24 and 29 received lafutidine and lansoprazole, respectively. After 8 wk, the frequency and severity of heartburn was significantly reduced in both groups. However, lafutidine was significantly inferior to lansoprazole with regard to the severity of heartburn during initial and maintenance treatment(P = 0.016). The sum score of questions 2 and 3 in the GSRS, and satisfaction scores were also significantly worse in the lafutidine group than the lansoprazole group(P = 0.0068 and P = 0.0048, respectively).CONCLUSION: The clinical efficacy of lafutidine was inferior to that of lansoprazole, even in Japanese patients with mild GERD.

关键词： Gastroesophageal reflux disease Proton pump inhibitors Histamine receptor-2 antagonists Los Angeles classification

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Effects of anti-hypertensive drugs on esophageal body contraction

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World Journal of Gastroenterology 2010年第8期16卷 987-991页

作者： Koichi Yoshida Kenji Furuta Kyoichi Adachi Shunji Ohara Terumi Morita Takashi Tanimura Shuji Nakata Masaharu Miki Kenji Koshino yoshikazu kinoshita Second Department of Internal Medicine Shimane University Faculty of Medicine Department of Clinical Nursing Shimane University Faculty of Medicine

AIM:To clarify the effects of anti-hypertensive drugs on esophageal contraction and determine their possi-ble relationship with gastro-esophageal reflux ***:Thirteen healthy male volunteers were enrolled. Esophageal body peristaltic contractions and lower esophageal sphincter (LES) pressure were measured using high resolution manometry. All subjects were randomly examined on four separate occasions following administrations of nifedipine,losartan,and atenolol,as well as without any drug ***:Peristaltic contractions by the esophageal body were separated into three segments by two troughs. The peak peristaltic pressures in the mid and lower segments of the esophageal body under atenolol administration were signifi cantly higher than those without medication in a supine position. On the other hand,peristaltic pressures under nifedipine administration were lower than those observed without drug ad-ministration. Losartan did not change esophageal body peristalsis. Atenolol elevated LES pressure and slowed peristaltic wave transition,while the effects of nifedip-ine were the opposite. CONCLUSION:Among the anti-hypertensive drugs tested,atenolol enhanced esophageal motor activity,which was in contrast to nifedipine.

关键词： Anti-hypertensive drug High-resolution manometry Lower esophageal sphincter Esophageal body contraction Calcium-channel blocker β1 blocker

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Esophageal epithelial surface in patients with gastroesophageal reflux disease:An electron microscopic study

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World Journal of Gastroenterology 2008年第37期14卷 5712-5716页

作者： Takane Azumi Kyoichi Adachi Kenji Furuta Shuji Nakata Shunji Ohara Kenji Koshino Masaharu Miki Terumi Morita Takashi Tanimura Nobuo Ashizawa yoshikazu kinoshita Second Department of Internal Medicine Shimane University School of MedicineShimane 693-8501 Japan

A/M： To investigate the intercellular spaces between the most superficially located esophageal epithelial cells in patients with gastroesophageal reflux disease （GERD）. METHODS： Eighteen patients with erosive esophagitis, 10 patients with non-erosive reflux disease （NERD）, and 18 normal asymptomatic volunteers were enrolled. Biopsy specimens were obtained from the lower esophageal mucosa without ulcer or erosion. Scanning electron microscopy was employed to investigate the tightness of the superficial cellular attachment. RESULTS： The intercellular space between the most superficially located epithelial cells in patients with erosive esophagitis or NERD was not different from that in asymptomatic healthy individuals. CONCLUSION： Widened luminal intercellular spaces of esophageal superficial epithelium are not responsible for the induction of reflux symptoms in patients with GERD.

关键词： Reflux esophagitis Non-erosive gastroesophageal reflux diseases Electron microscopy Questionnaire

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Pro-and anti-epileptic roles of microglia

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Neural Regeneration Research 2021年第7期16卷 1369-1371页

作者： Shinichi kinoshita Ryuta Koyama Laboratory of Chemical Pharmacology Graduate School of Pharmaceutical SciencesThe University of TokyoTokyoJapan

Microglia are brain-resident immune cells that contribute to the maintenance of brain *** the epileptic brain, microglia show various activation phenotypes depending on the stage of ***, it remains unclear whether microglial activation acts in a pro-epileptic or anti-epileptic *** mesial temporal lobe epilepsy, one of the most common form of epilepsies, microglia exhibit at least two distinct morphologies, amoeboid shape and ramified *** microglia are often found in sclerotic area, whereas ramified microglia are mainly found in non-sclerotic area;however, it remains unclear whether these structurally distinct microglia share separate roles in the epileptic ***, we review the roles of the two distinct microglial phenotypes, focusing on their pro-and anti-epileptic roles in terms of inflammatory response, regulation of neurogenesis and microglia-neuron interaction.

关键词： epilepsy epileptogenesis inflammatory cytokines microglia neurogenesis neuron-microglia interaction seizure

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Accelerated Gas Carburizing (URX Gas Carburizing)

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材料热处理学报 2004年第5期25卷 378-381页

作者： yoshikazu Shimosato Mamoru Kamitani Hiroyuki Nakatsu Chugai Ro Co. Ltd. Osaka JapanChugai Ro Co. Ltd. Osaka JapanChugai Ro Co. Ltd. Osaka Japan

URX gas Carburizing is an accelerated gas Carburizing method with 50% CO + 50% H2 gas which comes from CFLt gas + CO2 gas. By using this gas composition, the Carburizing reaction rate increases to the maximum and the controllability of carbon potential improves. A carbon mass flow rate is the product of the Carburizing reaction rate multiplied by the difference of carbon percent between carbon potential of the gas and the carbon content of the surface of treated steel parts. We have obtained excellent results from the experimental tests at our laboratory as mentioned bellow. 1) Carburizing time can be shortened by 40% for 0.5 - 0.9 mm effective case depth. 2) Uniform Carburizing case depth 3) Less internal oxidation with the same case depth. We have already developed the new roller hearth type continuous Carburizing furnace and the new URX gas generator .

关键词：气体渗碳内部氧化质量流速反应速率系数

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Theoretical study of current-voltage characteristics of carbon nanotube wire functionalized with hydrogen atoms

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Science China Chemistry 2012年第5期55卷 796-801页

作者： FUENO Hiroyuki KOBAYASHI yoshikazu TANAKA Kazuyoshi Department of Molecular Engineering Graduate School of Engineering Kyoto University Nishikyo-ku Kyoto 615-8510 Japan

A functionalized single-walled carbon nanotube (SWCNT) of a finite length with a ring-like hydrogenation around its surface is designed toward fabrication of a molecular field-effect transistor (FET) device. The molecular wire thus designed is equipped with a quantum dot inside, which is confirmed by theoretical analysis for electronic transport. In particular, the current-voltage (I-V) characteristics under influence of the gate voltage are discussed in detail.

关键词： single-walled carbon nanotube molecular field-effect transistor molecular wire electron transport

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Complete resection of recurrent anal canal cancer using endoscopic submucosal dissection and transanal resection: A case report

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World Journal of Gastrointestinal Endoscopy 2025年第1期17卷 54-60页

作者： Mayuko kinoshita Tetsuro Maruyama Shutaro Hike Takuya Hirosuna Shunsuke Kainuma Kazuya kinoshita Akira Nakano Gaku Ohira Masaya Uesato Hisahiro Matsubara Department of Frontier Surgery Graduate School of MedicineChiba UniversityChiba 260-8670Japan Department of Surgery Seirei Sakura Citizen HospitalSakura 285-8765Japan Department of Surgery Kumagaya General HospitalKumagaya 360-8567Japan

BACKGROUND Early anal canal cancer is frequently treated with endoscopic submucosal dis-section(ESD)to preserve anal ***,if the lesion is in the anal canal,then significant difficulties such as bleeding and challenges associated with scope manipulation can *** SUMMARY A 70-year-old woman undergoing follow-up after transverse colon cancer surgery was diagnosed with anal canal cancer extending to the dentate *** patient underwent a combination of ESD and transanal resection(TAR).The specimen was excised in pieces,which resulted in difficulty performing the pathological evaluation of the margins,especially on the anal side where TAR was performed and severe crushing was *** follow-up was performed,and local recurrence was observed 3 years *** the patient had super-ficial cancer without lymph node metastasis,local resection was performed *** second treatment attempt was improved as follows:(1)TAR and ESD were performed appropriately based on the situation by the same physician;(2)A needle scalpel was used during TAR to prevent tissue crushing;and(3)The lesion borders were marked using ESD techniques before *** resection was performed without *** Anal canal lesions can be safely and reliably removed when ESD and TAR are used appropriately.

关键词： Anal canal cancer Recurrence Endoscopic submucosal dissection Transanal resection Case report

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