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Single-Walled Carbon Nanotube Growth with Non-Iron- Group “Catalysts” by Chemical Vapor Deposition

Nano Research 2009年第10期2卷 793-799页

作者： yoshikazu homma Huaping Liu Daisuke Takagi Yoshihiro Kobayashi Department of Physics Tokyo University of ScienceShinjukuTokyo 162-8601Japan NTT Basic Research Laboratories Nippon Telegraph and Telephone CorporationAtsugiKanagawa 243-0198Japan National Institute of Advanced Industrial Science and Technology Nanotechnology Research InstituteTsukubaIbaraki305-8561Japan Department of Applied Physics Osaka UniversitySuitaOsaka 565-0871Japan

Various materials have been found to“catalyze”carbon nanotube growth in chemical vapor deposition(CVD)when they become nano-sized *** involve not only metals,such as Pd,Pt,Au,Ag,and Cu,but also semiconductors,such as Si,Ge,and *** and diamond nanoparticles also produce carbon ***“catalysts”,which are better called“seeds”,can be categorized into two types:one type forms a eutectic liquid or highly-mobile alloy with carbon,and carbon atoms precipitate from the eutectic alloy;the other type remains as a solid phase and form a carbon surface layer during CVD *** this paper,we review recent studies of SWCNT growth with these non-iron-group materials and highlight the mechanisms involved.

关键词： Carbon nanotube catalyst seed growth mechanism chemical vapor deposition vapor liquid solid mechanism

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Dendritic cell-based vaccine for pancreatic cancer in Japan

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2016年第1期7卷 133-138页

作者： Masato Okamoto Masanori Kobayashi yoshikazu Yonemitsu Shigeo Koido Sadamu homma Department of Advanced Immunotherapeutics Kitasato University School of Pharmacy Oncology Cencer Kitasato Institute Hospital Seren Clinic Nagoya R and D Laboratory for Innovative Biotherapeutics Graduate School of Pharmaceutical Sciences Kyushu University Division of Gastroenterology and Hepatology Department of Internal Medicine the Jikei University School of Medicine Department of Oncology the Jikei University School of Medicine

“Vaccell” is a dendritic cell (DC)-based cancer vaccine which has been established in Japan. The DCs play central roles in deciding the direction of host immune reactions as well as antigen presentation. We have demonstrated that DCs treated with a streptococcal immune adjuvant OK-432, produce interleukin-12, induce Th1-dominant state, and elicit anti-tumor effects, more powerful than those treated with the known DC-maturating factors. We therefore decided to mature DCs by the OK-432 for making an effective DC vaccine, Vaccell. The 255 patients with inoperable pancreatic cancer who received standard chemotherapy combined with DC vaccines, were analyzed retrospectively. Survival time of the patients with positive delayed type hypersensitivity (DTH) skin reaction was significantly prolonged as compared with that of the patients with negative DTH. The findings strongly suggest that there may be “Responders” for the DC vaccine in advanced pancreatic cancer patients. We next conducted a small-scale prospective clinical study. In this trial, we pulsed HLA class II-restricted WT1 peptide (WT1-II) in addition to HLA class?I-restricted peptide (WT1-I) into the DCs. Survival of the patients received WT1-I?and -II pulsed DC vaccine was significantly extended as compared to that of the patients received DCs pulsed with WT1-I?or WT1-II alone. Furthermore, WT1-specific DTH positive patients showed significantly improved the overall survival as well as progression-free survival as compared to the DTH negative patients. The activation of antigen-specific immune responses by DC vaccine in combination with standard chemotherapy may be associated with a good clinical outcome in advanced pancreatic cancer. We are now planning a pivotal study of the Vaccell in appropriate protocols in Japan.

关键词： Dendritic cell Cancer vaccine Pancreatic cancer Cancer immunotherapy Anti-cancer immunity

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