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Correlation between hepatic blood flow and liver function in alcoholic liver cirrhosis

World Journal of Gastroenterology 2014年第45期20卷 17065-17074页

作者： Hideaki Takahashi Ryuta Shigefuku yoshihito yoshida Hiroki Ikeda Kotaro Matsunaga Nobuyuki Matsumoto Chiaki Okuse Shigeru Sase Fumio Itoh Michihiro Suzuki Division of Gastroenterology and Hepatology Department of Internal Medicine St.Marianna University School of Medicine Division of Gastroenterology Department of Internal Medicine Sapporo Shirakabadai Hospital Department of Molecular Biology Sapporo Medical University School of Medicine Anzai Medical Co. Ltd.

AIM: To elucidate the correlation between hepatic blood flow and liver function in alcoholic liver cirrhosis (AL-LC).

关键词： Alcoholic liver cirrhosis Hepatic tissue blood flow Liver function Indocyanine green Xenon computed tomography

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An updated review of gastric cancer in the next-generation sequencing era:Insights from bench to bedside and vice versa

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World Journal of Gastroenterology 2014年第14期20卷 3927-3937页

作者： Hiroyuki Yamamoto Yoshiyuki Watanabe Tadateru Maehata Ryo Morita yoshihito yoshida Ritsuko Oikawa Shinya Ishigooka Shun-ichiro Ozawa Yasumasa Matsuo Kosuke Hosoya Masaki Yamashita Hiroaki Taniguchi Katsuhiko Nosho Hiromu Suzuki Hiroshi Yasuda Yasuhisa Shinomura Fumio Itoh Division of Gastroenterology and Hepatology Department of Internal MedicineSt. Marianna University School of Medicine Division of Cancer Cell Research Institute of Medical ScienceUniversity of Tokyo Department of Gastroenterology Rheumatology and Clinical ImmunologySapporo Medical University School of Medicine Department of Molecular Biology Sapporo Medical University School of Medicine

Gastric cancer(GC)is one of the most common malignancies and remains the second leading cause of cancer-related death *** is an increasing understanding of the roles that genetic and epigenetic alterations play in *** studies using nextgeneration sequencing(NGS)have revealed a number of potential cancer-driving genes in ***-exome sequencing of GC has identified recurrent somatic mutations in the chromatin remodeling gene ARID1A and alterations in the cell adhesion gene FAT4,a member of the cadherin gene *** in chromatin remodeling genes(ARID1A,MLL3 and MLL)have been found in 47%of ***-genome sequencing and whole-transcriptome sequencing analyses have also discovered novel alterations in *** studies of cancer epigenetics have revealed widespread alterations in genes involved in the epigenetic machinery,such as DNA methylation,histone modifications,nucleosome positioning,noncoding RNAs and *** advances in molecular research on GC have resulted in the introduction of new diagnostic and therapeutic strategies into clinical *** antihuman epidermal growth receptor 2(HER2)antibody trastuzumab has led to an era of personalized therapy in *** addition,ramucirumab,a monoclonal antibody targeting vascular endothelial growth factor receptor(VEGFR)-2,is the first biological treatment that showed survival benefits as a single-agent therapy in patients with advanced GC who progressed after firstline *** NGS to systematically identify gene alterations in GC is a promising approach with remarkable potential for investigating the pathogenesis of GC and identifying novel therapeutic targets,as well as useful *** this review,we will summarize the recent advances in the understanding of the molecular pathogenesis of GC,focusing on the potential use of these genetic and epigenetic alterations as diagnostic biomarkers and novel therapeutic targets.

关键词： Next-generation sequencing Microsatellite instability MicroRNA Epigenetic field defect Gastric washes Insulin-like growth factor 1 receptor

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Advantages of rapid solidification over casting of Mg-0.4Zn-1Y alloy

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Journal of Magnesium and Alloys 2024年第7期12卷 2847-2862页

作者： Drahomír Dvorský Shin-Ichi Inoue Ayami yoshida JiríKubásek Jan Duchon Esther de Prado Andrea Školáková Klára Hosová Petr Svora yoshihito Kawamura Institute of Physics Czech Academy of SciencePragueNa Slovance 1999/218221 Praha 8Czechia Magnesium Research Center Kumamoto UniversityKumamoto2-39-1 Kurokami Chuo-ku Kumamoto860-8555 Japan Department of Metals and Corrosion Engineering Faculty of Chemical TechnologyUniversity of Chemistry and Technology PragueTechnická516628 Praha 6–DejviceCzechia

The Mg-Y-Zn magnesium alloy system is commonly recognized for its remarkable combination of high strength and ductility,achieved even with minimal amounts of alloying *** exceptional performance is attributed to its unique microstructure,which includes Long-Period Stacking Ordered(LPSO)phases or the distinctive microstructure derived from the LPSO phase,referred to as the Mille-Feuille structure(MFS).This study systematically compares the traditional ingot metallurgy method with the rapid solidification technique,coupled with diverse heat treatments and extrusion *** analyses reveal variations in the presence of LPSO phases,Mille-Feuille structure,and grain size,leading to divergent mechanical and corrosion *** rapid solidification approach stands out,ensuring superior mechanical properties alongside a reasonable corrosion rate.

关键词： Rapid solidification LPSO Kink Extrusion Corrosion Ignition temperature

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