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The neck burn scar contracture:a concept of effective treatment

Burns & Trauma 2017年第3期5卷 140-147页

作者： Sadanori Akita Kenji Hayashida Satoshi Takaki yoshihisa kawakami Takuto Oyama Hiroyuki Ohjimi Department of Plastic Surgery Wound Repair and Regeneration School of Medicine Fukuoka University 7-45-1 Nanakuma Jonan ku Fukuoka 8140180 Japan Section of Plastic Surgery School of Medicine Shimane University Shimane Japan Department of Plastic Surgery School of Medicine Fukuoka University Fukuoka Japan

A neck scar contracture can severely and negatively affect the function of mastication, phonic, or breathing and result in neck pain and issues with esthetics. The best way is of course to avoid such contracture by means of non-surgical treatment such as use of a growth factor. The basic fibroblastic growth factor is clinically well proven in decreasing scar formation and improving healing. There are numerous reconstructive methods for neck contracture, especially when the lesions are relatively limited in part of the neck. However, a very severe and full circumferential scar contracture requires extensive reconstruction. The thin groin flap is one of the answers and well matches with the tissue texture and maintains the flexibility. Even with extensive burns and delayed reconstructions due to resuscitation first, the groin area is well preserved and can be safely harvested by dual vasculature systems of the superficial circumflex iliac artery and superficial epigastric artery, which warrant more reliability compared to the perforator flaps in this area. More demanding and stringent forms of the neck burn scar contracture are the sequelae of radiation. A radiation burn or radiation injury can be progressing and hard to heal. Adipose-derived stem cells can reverse the scar contracture as the surrounding tissue is softened and can accelerate wound healing. In this review, different types of neck burn scar contracture and reconstructive methods are summarized, including innovative use of bFGF and ADSCs in the management of difficult wound healing and scar contracture.

关键词： Neck scar contracture Anatomical locations Prophylaxis Severe scar contracture Thin groin flap Radiation injury Adipose-derived stem cell

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Molecular processes in iron and zinc homeostasis and their modulation for biofortification in rice

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Journal of Integrative Plant Biology 2018年第12期60卷 1181-1198页

作者： Yuta kawakami Navreet K.Bhullar Plant Biotechnology Department of Biology ETH Zurich

More than a billion people suffer from iron or zinc deficiencies globally. Rice(Oryza sativa L.) iron and zinc biofortification; i.e., intrinsic iron and zinc enrichment of rice grains, is considered the most effective way to tackle these deficiencies. However, rice iron biofortification, by means of conventional breeding, proves difficult due to lack of sufficient genetic variation. Meanwhile,genetic engineering has led to a significant increase in the iron concentration along with zinc concentration in rice grains. The design of impactful genetic engineering biofortification strategies relies upon vast scientific knowledge of precise functions of different genes involved in iron and zinc uptake, translocation and storage. In this review, we present an overview of molecular processes controlling iron and zinc homeostasis in rice. Further,the genetic engineering approaches adopted so far to increase the iron and zinc concentrations in polished rice grains are discussed in detail, highlighting the limitations and/or success of individual strategies. Recent insight suggests that a few genetic engineering strategies are commonly utilized for elevating iron and zinc concentrations in different genetic backgrounds, and thus, it is of great importance to accumulate scientific evidence for diverse genetic engineering strategies to expand the pool of options for biofortifying farmer-preferred cultivars.

关键词： Molecular processes in iron and zinc homeostasis and their modulation for biofortification in rice Zn

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Do not curse the darkness of the spinal cord,light TDP-43

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Neural Regeneration Research 2021年第5期16卷 986-987页

作者： Kazuhide Asakawa Hiroshi Handa Koichi kawakami Department of Chemical Biology Tokyo Medical UniversityTokyoJapan Division of Molecular and Developmental Biology National Institute of GeneticsDepartment of GeneticsGraduate University for Advanced Studies(SOKENDAI)ShizuokaJapan

Cytoplasmic inc lus ions containing the transactivation response element(TAR)DNAbinding protein-43(TDP-43)aggregates are hallmarks of neurodegenerative disorders,such as amyotrophic lateral sclerosis(ALS)and frontotemporal dementia(Arai et al.,2006;Neumann et al.,2006).Despite the well-recognized correlation between TDP-43 aggregation and neuronal degeneration,whether this relationship is causal has remained unclear.

关键词： al. degeneration TDP

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Design of Electro-Functional Polymeric Systems with Siloxane Components

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复旦学报（自然科学版） 2005年第5期44卷 635-636页

作者： Yusuke kawakami Japan Advanced Institute of Science and Technology (JAIST) Asahidai 1-1 Nomi Ishikawa 923-1292Japan

Siloxane derivatives have many unique static and dynamic properties like low surface free energy, incompatibility with other component, and bond flexibility. Various functional polymeric systems were designed by takin... 详细信息

关键词：聚合体热稳定性全息术硅氧烷浓缩工艺

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A modified normalized input-output minimization (Mod-NIOM) method for seismic wave propagation modeling

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Earthquake Engineering and Engineering Vibration 2010年第4期9卷 481-491页

作者： Santa Man Shrestha Hideji kawakami Eric Augustus Tingatinga Hidenori Mogi Department of Civil and Environmental Engineering Saitama University Geosphere Research Institute Saitama University Institute of Civil Engineering University of the Philippines Diliman

A new method for wave propagation modeling is introduced in this paper. By using the constraint optimization （Lagrange multiplier） method, the sum of weighted squared Fourier amplitudes is minimized when subjected to a constraint. The sum of the maximum amplitudes obtained from all output models is normalized to unity and is taken as a constraint. In this method, all the actual time histories are considered as outputs and dealt with equally. Independently of the combinations of time histories （or the first time history selected） during the analysis, the method captures the relationship of actual time histories by showing clear peaks. This paper describes the formulation of the models and illustrates the advantage of this method over the normalized input-output minimization （NIOM） method. The Mod-NIOM is then used to analyze the time histories of the Hyogoken-nanbu earthquake recorded at the Port Island vertical array site in Kobe, which suffered from liquefaction caused by the strong motions during the main shock. This method showed good correlations between the observed time histories at the site even though the surface time history was greatly modified by the liquefaction.

关键词： wave propagation constraint optimization S-wave velocity liquefaction amplification vertical array Hyogoken-nanbu earthquake

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Improvement of solidification model and analysis of 3D channel blockage with MPS method

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Frontiers in Energy 2021年第4期15卷 946-958页

作者： Reo kawakami Xin LI Guangtao DUAN Akifumi YAMAJI Isamu SATO Tohru SUZUKI Cooperative Major in Nuclear Energy Graduate School and Advanced Science and EngineeringFaculty of Science and EngineeringWaseda University3-4-1 OkuboShinjuku-kuTokyo169-8555Japan Department of Nuclear Engineering and Management The University of Tokyo7-3-1 HongoBunkyo-kuTokyo113-8656Japan Department of Nuclear Safety Engineering Faculty of EngineeringTokyo City University1-28-1 TamazutsumiSetagaya-kuTokyo158-0087Japan

In a severe accident of a nuclear power reactor,coolant channel blockage by solidified molten core debris may significantly influence the core degradations that *** moving particle semi-implicit(MPS)method is one of the Lagrangian-based particle methods for analyzing incompressible *** the study described in this paper,a novel solidification model for analyzing melt flowing channel blockage with the MPS method has been developed,which is suitable to attain a sufficient numerical accuracy with a reasonable calculation *** prompt velocity diffusion by viscosity is prioritized over the prompt velocity correction by the pressure term(for assuring incompressibility)within each time step over the“mushy zone”(between the solidus and liquidus temperature)for accurate modeling of solidification before fixing the coordinates of the completely solidified *** sustain the numerical accuracy and stability,the corrective matrix and particle shifting techniques have been applied to correct the discretization errors from irregular particle arrangements and to recover the regular particle arrangements,*** validate the newly developed algorithm,2-D benchmark analyses are conducted for steady-state freezing of the water in a laminar flow between two parallel ***,3-D channel blockage analyses of a boiling water reactor(BWR)fuel support piece have been *** results show that a partial channel blockage develops from the vicinity of the speed limiter,which does not fully develop into a complete channel blockage,but still diverts the incoming melt flow that follows to the orifice region.

关键词： boiling water reactor(BWR) severe accident channel blockage moving particle semi-implicit(MPS)method solidification*

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MICROSCOPIC ANALYSIS OF POLYCRYSTALLINE MATERIAL AT HIGH TEMPERATURE

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Acta Metallurgica Sinica(English Letters) 2004年第4期17卷 350-354页

作者： S.Imatani R.kawakami Y.Kawano Kyoto University Sakyo-Ku Kyoto 606-8501 JapanKyoto University Sakyo-Ku Kyoto 606-8501 JapanKyoto University Sakyo-Ku Kyoto 606-8501 Japan

The microscopic analyses of polycrystalline material at high temperature were carried out. The crystal plasticity model proposed by Asaro and Needleman was applied to a polycrystal model in the finite element simulation and the crystal slip system was randomly provided for each crystal. The grain boundary sliding, which was characteristic at high temperature, was also taken into account. It was shown that the inhomo-geneous deformation develops over the polycrystal and that the strain concentration appears around the triple point of crystal grain boundary.

关键词： crystal plasticity finite element method grain boundary inho-mogeneity

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Fatigue properties of rolled AZ31B magnesium alloy plate

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Transactions of Nonferrous Metals Society of China 2010年第B07期20卷 523-526页

作者： S.MORITA N.OHNO F.TAMAI Y.kawakami Faculty of Science and Engineering Saga University Material and Environment Department Industrial Technology Center of Saga

Fatigue strength,crack initiation and propagation behavior of rolled AZ31B magnesium alloy plate were investigated. Axial tension-compression fatigue tests were carried out with cylindrical smooth *** types of specimens were machined with the loading axis parallel(L-specimen)and perpendicular(T-specimen)to rolling *** compressive 0.2%proof stress,tensile strength and tensile elongation were similar for both *** the other hand,monotonic tensile 0.2%proof stress of the L-specimen was slightly higher than that of the ***,monotonic compressive 0.2%proof stresses were lower than tensile ones for both *** fatigue strengths of 107cycles of the L-and T-specimens were 95 and 85 MPa,respectively. Compared with the monotonic compressive 0.2%proof stresses,the fatigue strengths were higher for both *** other words, the fatigue crack did not initiate and propagate even though deformation twins were formed in compressive stress under the cyclic tension-compression *** fatigue crack initiated at early stage of the fatigue life in low cycle regime regardless of specimen *** crack growth rate of the L-specimen was slightly lower than of the ***,the fatigue lives of the L-specimen were longer than those of the T-specimen in low cycle regime.

关键词： magnesium alloy compressive proof stress fatigue strength crack initiation crack propagation

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LC-MS/MS method for the quantitation of serum tocilizumab in rheumatoid arthritis patients using rapid tryptic digestion without IgG purification

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Journal of Pharmaceutical Analysis 2022年第6期12卷 852-859页

作者： Takashi Mochizuki Kaito Shibata Takafumi Naito Kumiko Shimoyama Noriyoshi Ogawa Masato Maekawa Junichi kawakami Department of Hospital Pharmacy Hamamatsu University School of MedicineHamamatsu431-3192Japan Department of Pharmacy Shinshu University HospitalMatsumotoNagano390-8621Japan Third Division Department of Internal MedicineHamamatsu University School of MedicineHamamatsu431-3192Japan Department of Laboratory Medicine Hamamatsu University School of MedicineHamamatsu431-3192Japan

The quantitation of serum tocilizumab using liquid chromatography tandem-mass spectrometry(LC-MS/MS)method has not been widely applied in clinical settings because of its time-consuming and costly sample *** present study aimed to develop a validated LC-MS/MS method for detecting serum tocilizumab by utilizing immobilized trypsin without an immunoglobulin G purification step and evaluate its applicability in the treatment of rheumatoid arthritis(RA)patients administered intravenously or subcutaneously with *** tocilizumab-derived signature peptide was deciphered using a nano-LC system coupled to a hybrid quadrupole-orbitrap mass *** serum tocilizumab was rapidly digested by immobilized trypsin for 30 *** chromatographic peak of the signature peptide and that of the internal standard were separated from the serum digests for a total run time of 15 *** calibration curve of serum tocilizumab concentration was linear with a range of 2-200 μg/*** intra-and inter-day accuracy and relative standard deviation(RSD)were 90.7%-109.4%and<10%,*** serum tocilizumab concentrations in the RA patients receiving intravenous and subcutaneous injections were 5.8-28.9 and 2.4-63.5 μg/mL,*** serum tocilizumab concentrations using the current method positively correlated with those using the enzyme-linked immunosorbent assay,although a systematic error was observed between these *** conclusion,a validated LC-MS/MS method with minimal sample pretreatments for monitoring serum tocilizumab concentrations in RA patients was developed.

关键词： Tocilizumab LC-MS/MS Immobilized trypsin IgG purification Proteomics Rheumatoid arthritis

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Recent Progress of Thioester Method

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Chemical Research in Chinese Universities 2006年第2期22卷 253-257页

作者： Saburo Aimoto Kenta Teruya Koki Hasegawa Takeshi Sato Kenichi Akaji Toru kawakami Institute for Protein Research Osaka University Suita Osaka 565-0871 Japan

Introduction The availability of site-specifically modified peptides is of vital importance for biochemical and biophysical studies. Biological methods, such as expression using bacteria, are useful. They are, however, not always applicable to the synthesis of peptides with sitespecific modifications. Chemical methods can be viable alternatives to those biological approaches. Peptides obtained by chemical and biological means,

关键词： Thioester method Thiol linker Peptide

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