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World Journal of Gastroenterology 2024年第18期30卷 2402-2417页

作者： Daisuke Usuda Yuki Kaneoka Rikuo Ono Masashi Kato Yuto Sugawara Runa Shimizu Tomotari Inami Eri Nakajima Shiho Tsuge Riki Sakurai Kenji Kawai Shun Matsubara Risa Tanaka Makoto Suzuki Shintaro Shimozawa Yuta Hotchi Ippei Osugi Risa Katou Sakurako Ito Kentaro Mishima Akihiko Kondo Keiko Mizuno Hiroki takami Takayuki Komatsu Tomohisa Nomura Manabu Sugita Department of Emergency and Critical Care Medicine Juntendo University Nerima HospitalNerima 177-8521TokyoJapan Department of Sports Medicine Faculty of MedicineJuntendo UniversityBunkyo 113-8421TokyoJapan

Viral hepatitis represents a major danger to public health,and is a globally leading cause of *** five liver-specific viruses:Hepatitis A virus,hepatitis B virus,hepatitis C virus,hepatitis D virus,and hepatitis E virus,each have their own unique epidemiology,structural biology,transmission,endemic patterns,risk of liver complications,and response to antiviral *** remain few options for treatment,in spite of the increasing prevalence of viral-hepatitiscaused liver ***,chronic viral hepatitis is a leading worldwide cause of both liver-related morbidity and mortality,even though effective treatments are available that could reduce or prevent most patients’*** 2016,the World Health Organization released its plan to eliminate viral hepatitis as a public health threat by the year 2030,along with a discussion of current gaps and prospects for both regional and global eradication of viral ***,treatment is sufficiently able to prevent the disease from reaching advanced ***,future therapies must be extremely safe,and should ideally limit the period of treatment necessary.A better understanding of pathogenesis will prove beneficial in the development of potential treatment strategies targeting infections by viral *** review aims to summarize the current state of knowledge on each type of viral hepatitis,together with major innovations.

关键词： Hepatitis A virus Hepatitis B virus Hepatitis C virus Hepatitis D virus Hepatitis E virus Current perspectives

RANKL^(+) senescent cells under mechanical stress: a therapeutic target for orthodontic root resorption using senolytics

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International Journal of Oral Science 2023年第2期15卷 278-290页

作者： Yue Zhou Aki Nishiura Hidetoshi Morikuni Wenqi Deng Toru Tsujibayashi yoshihiro Momota Yuki Azetsu Masamichi takami Yoshitomo Honda Naoyuki Matsumoto Department of Orthodontics Osaka Dental UniversityHirakataOsakaJapan Department of Physics Osaka Dental UniversityHirakataOsakaJapan Department of Anesthesiology Osaka Dental UniversityHirakataOsakaJapan Department of Pharmacology Showa University School of Dentistry1-5-8HatanodaiShinagawakuTokyoJapan Department of Oral Anatomy Osaka Dental University8-1 KuzuhahanazonochoHirakataOsakaJapan

In dentistry,orthodontic root resorption is a long-lasting issue with no effective treatment strategy,and its mechanisms,especially those related to senescent cells,remain largely ***,we used an orthodontic intrusion tooth movement model with an L-loop in rats to demonstrate that mechanical stress-induced senescent cells aggravate apical root resorption,which was prevented by administering senolytics(a dasatinib and quercetin cocktail).

关键词： stress therapeutic ortho

Clinical application and management of temporary mechanical circulatory support:A clinical consensus

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Chinese Medical Journal 2024年第10期137卷 1135-1139页

作者： Nianguo Dong Liangwan Chen Xin Chen Huishan Wang Yingbin Xiao Xianqiang Wang Jinsong Huang Yang Yan Pramod Bonde Neel Sodha Pavan Atluri Juan Pablo Maureira AndréVincentelli Masanobu Yanase Yixuan Wang Haitao Zhang Xiaotong Hou Yoshijuki takami Pascal Leprince Thierry Folliguet Frank W Sellke Chinese Society for Thoracic and Cardiovascular Surgery Chinese Association of Cardiovascular Surgeons Cardiac Critical Care Professional Committee of Chinese Medical Association Chinese Society of Extracorporeal Life Support European Society of Cardiovascular and Endovascular Surgery French Society of Thoracic and Cardiovascular Surgery Japanese Society for Cardiovascular Surgery Japanese Society of Artificial Organs Department of Cardiovascular Surgery Union Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Department of Cardiovascular Surgery Fujian Medical University Union HospitalFuzhouFujian 350000China Department of Thoracic and Cardiovascular Surgery Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu 210000China Department of Cardiovascular Surgery General Hospital of Northern Theater CommandShenyangLiaoning 110000China Department of Cardiovascular Surgery Xinqiao HospitalThird Military Medical UniversityChongqing 400037 China Department of Cardiovascular Surgery Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100000 China Department of Cardiovascular Surgery Guangdong Provincial Cardiovascular InstituteGuangdong General HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdong 510000 China Department of Cardiovascular Surgery First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi 710061China Department of Cardiac Surgery Yale School of Medicine330 Cedar St204 BoardmanNew HavenCT 06510USA Department of Cardiothoracic Surgery Alpert Medical SchoolBrown University Rhode Island HospitalProvidenceRI 02912USA Department of Cardiovascular Surgery Department of SurgeryUniversity of PennsylvaniaPhiladelphiaPA 19113USA Department of Cardiovascular Surgery and Transplantation University Hospital of NancyUniversity of LorraineVandoeuvre-lès-Nancy 54500France Department of Cardiovascular Surgery University Hospital of LilleUniversity of LilleLille 59037France Department of Cardiology Fujita Health University School of MedicineToyoakeAichi 470-1192Japan Department of Adult Surgical Intensive Care Unit Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100000China Department of Cardiac Intensive Care Beijing Institute of HeartLung and B

Temporary mechanical circulatory support(tMCS)plays a pivotal role in managing severe or refractory cardiogenic shock(CS),furnishing essential hemodynamic support,and sustaining organ perfusion from hours to weeks,or to even *** the past decade,the utilization of tMCS has witnessed a signicant increase in American and European *** in Asia,the newly developed concepts and devices constituting tMCS have also made rapid ***,the absence of a consensus or standardized guidelines,especially for the Asian population considering inherited polymorphism,is *** address this knowledge gap,eight associations/societies and experts in thiseld came up with the present consensus after repeated discussions,more specically for the Asian *** comprehensively elucidates the commonly employed tMCS devices,criteria for patient selection,indications and contraindications,clinical management,and the optimal timing for implantation and *** goal of this statement is to promote the standardized application of tMCS and make reasonable decisions in clinical ***-length version of the consensus can be seen in Supplementary File,http://***/CM9/B883.

关键词： application statement discussions

高糖环境对浅二度烫伤创面VEGF表达及创面血管化的影响

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上海交通大学学报（医学版） 2006年第8期26卷 860-864页

作者：乔亮陆树良高見佳宏董叫云金曙雯花兰女廖镇江史济湘v 上海交通大学医学院瑞金医院灼伤整形科上海市烧伤研究所上海200025 杏林大学医学院整形外科

目的建立糖尿病大鼠浅二度烫伤模型和不同浓度的高葡萄糖体外培养体系,研究高糖环境对促血管化生长因子的表达及创面血管化的影响。方法①90只清洁级SD大鼠分为对照组和STZ诱导的速发型糖尿病组,两组同时形成10%体表总面积(TBSA)的浅二... 详细信息

目的建立糖尿病大鼠浅二度烫伤模型和不同浓度的高葡萄糖体外培养体系,研究高糖环境对促血管化生长因子的表达及创面血管化的影响。方法①90只清洁级SD大鼠分为对照组和STZ诱导的速发型糖尿病组,两组同时形成10%体表总面积(TBSA)的浅二度烫伤模型,分别取烫伤后第1、3、7、10、14天创面皮肤组织样本,测定糖含量、FGF-2、血管内皮生长因子(VEGF)表达,检测微血管密度。②人脐带静脉内皮细胞分别在正常环境及30、50mmol/L葡萄糖中培养7d,ELISA法检测内皮细胞释放VEGF水平。结果糖尿病组大鼠烫伤创面组织局部糖含量及VEGF表达均明显高于对照组,而其微血管密度显著低于对照组;体外培养的血管内皮细胞,高糖组释放VEGF水平显著低于正常环境组。结论在糖尿病浅二度烫伤创面愈合过程中,存在促血管化生长因子高表达与血管内皮细胞低反应性的分离现象。

关键词：糖尿病创面愈合生长因子血管化血管内皮细胞

Varicella-zoster virus-associated meningitis,encephalitis,and myelitis with sporadic skin blisters:A case report

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World Journal of Clinical Cases 2022年第2期10卷 717-724页

作者： Ken takami Tsuneaki Kenzaka Ayako Kumabe Megumi Fukuzawa Yoko Eto Shun Nakata Katsuhiro Shinohara Kazunori Endo Department of Internal Medicine Sainokuni Higashiomiya Medical CenterSaitama 331-8577SaitamaJapan Division of Community Medicine and Career Development Kobe University Graduate School of MedicineKobe 652-0032HyogoJapan Department of Neurology Sainokuni Higashiomiya Medical CenterSaitama 331-8577SaitamaJapan Department of Dermatology Sainokuni Higashiomiya Medical CenterSaitama 331-8577SaitamaJapan Emergency Department Sainokuni Higashiomiya Medical CenterSaitama 331-8577SaitamaJapan

BACKGROUND Varicella-zoster virus(VZV)generally causes chickenpox at first infection in childhood and then establishes latent infection in the dorsal root ganglia of the spinal cord or other *** reactivation owing to an impaired immune system causes inflammation along spinal nerves from the affected spinal segment,leading to skin manifestations(herpes zoster).Viremia and subsequent hematogenous transmission and nerve axonal transport of the virus may lead to meningitis,encephalitis,and *** such case is described in this *** SUMMARY A 64-year-old man presented with dysuria,pyrexia,and progressive disturbance in *** had signs of meningeal irritation,and cerebrospinal fluid(CSF)analysis revealed marked pleocytosis with mononuclear predominance and a CSF/serum glucose ratio of *** magnetic resonance imaging revealed hyperintense areas in the frontal *** had four isolated blisters with papules and halos on his right chest,right lumbar region,and left scapular *** giant cells were detected using the Tzanck *** epidermal cells with intranuclear inclusion bodies and ballooning degeneration were present on skin *** VZV antibody titers suggested previous infection,and the CSF tested positive for *** developed paraplegia,decreased temperature perception in the legs,urinary retention,and fecal *** patient was diagnosed with meningitis,encephalitis,and myelitis and was treated with acyclovir for 23 days and prednisolone for 14 *** gradual improvement,the urinary retention and gait disturbances persisted as *** VZV reactivation should be considered in differential diagnoses of patients with sporadic blisters and unexplained central nervous system symptoms.

关键词： Varicella-zoster virus Encephalitis Meningitis Myelitis Central nervous system Case report

Characteristic of organic aerosol in a remote area of Okinawa Island

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Journal of Environmental Sciences 2009年第10期21卷 1371-1377页

作者： LUN Xiaoxiu takami Akinori MIYOSHI Takao HATAKEYAMA Shiro Beijing Forestry University Beijing 100083 China National Institute for Environmental Studies Tsukuba 305-8506 Japan Tokyo University of Agriculture and Technology Tokyo 183-8538 Japan

A continuous investigation of aerosol pollutants in Cape Hedo, Japan was conducted from October 2005 to August 2006 by Aerodyne aerosol mass spectrometer （AMS）. This article focused on the analysis of long-range transport of organic aerosol from continental origin to the remote island. Based on the transport distance and air mass origin, four main air mass origins were considered, including North China, South China, Japan and Korea. Although the mass concentration and air mass origin were quite different during study period, the mass spectrum and size distribution of organic matter and oxidized organics were similar, which showed uni-modal distribution with modal diameter of around 500 nm. The loss rate of organics was （5.15 ± 0.55） × 10^-6 s^-1 obtained by plotting the concentration against the transport time. Conversion rate of SO2 to sulfate and oxidation rate of organics were （1.07 ± 0.15） × 10^-5 and （1.09 ± 0.52） × 10^-6 s^-1, respectively.

关键词： long-range transport Okinawa organics loss rate

A Twin Unidirectional Impulse Turbine for Wave Energy Conversion

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Journal of Thermal Science 2011年第5期20卷 394-397页

作者： Manabu Takao Akiyasu takami Shinya Okuhara Toshiaki Setoguchi Matsue College of Technology 14-4 NishiikumaMatsueShimane 690-8518Japan Saga University 1 HonjoSagaSaga 840-8502Japan

A twin unidirectional impulse turbine has been proposed in order to enhance the performance of wave energy *** turbine system uses two unidirectional impulse turbines and their flow direction is different from each ***,the turbine characteristics have not been clarified to *** performances of a unidirectional impulse turbine under steady flow conditions were investigated experimentally by using a wind tunnel with large piston/cylinder in this ***,efficiency of the twin impulse turbine have been estimated by a quasi-steady analysis using experimental results.

关键词：冲击式水轮机单向波能转换涡轮机流动方向轮机系统准稳态活塞

加强灌注的枕-颈-胸穿支皮瓣在下面部和颈部重建术中的应用

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中国美容整形外科杂志 2013年第5期24卷 I0018-I0018页

作者： Shimpei Ono Kevin C. Chung yoshihiro takami Takafumi Chin Rei Ogawa Jian-Hua Gao Hiko Hyakusoku 朱利娜(译) 魏峰(译) 高景恒(译) 日本医科大学整形再造和美容外科日本东京密歇根大学卫生系统外科部整形外科美国密歇根州安阿伯市南方医科大学整形再造外科中国广州《中国美容整形外科杂志》编辑部

背景与目的枕一颈．胸皮瓣在枕叶区有局部的皮肤蒂，皮瓣远端在胸肌区。枕．颈一胸皮瓣的一个缺点是皮瓣长度有限。为克服这一不足，可以使用加强灌注穿支的手法来扩大皮瓣的长度。本研究的目的是介绍加强灌注穿支的枕．颈．胸皮瓣在面... 详细信息

背景与目的枕一颈．胸皮瓣在枕叶区有局部的皮肤蒂，皮瓣远端在胸肌区。枕．颈一胸皮瓣的一个缺点是皮瓣长度有限。为克服这一不足，可以使用加强灌注穿支的手法来扩大皮瓣的长度。本研究的目的是介绍加强灌注穿支的枕．颈．胸皮瓣在面颈部重建术中的应用，并讨论加强灌注穿支的手法和穿支解剖学。方法回顾分析所有面颈部重建术中使用的加强灌注穿支的枕．颈一胸皮瓣。结果所有9例患者中，第二乳内动脉穿支与枕一颈．胸皮瓣尾部连接，对对侧面动脉受体血管加强灌注。皮瓣的平均大小为22．6cm×6．2cm，无任何皮瓣损失。利用薄且柔韧的局部皮肤组织覆盖延伸至对侧较大范围的缺损是可行的。所有患者术后6个月对功能和美观均满意。结论内乳动脉加强灌注穿支的枕。颈．胸皮瓣可当做双蒂穿支皮瓣的一种类型，且可提供可靠的皮瓣血供。通过使用加强灌注穿支的手法，我们可以根据缺损的形状调整并扩大皮瓣的长度。（循证医学证据等级：Ⅳ级，疗法）

关键词：穿支皮瓣重建术面颈部灌注胸肌应用面部皮肤组织

Long-range transport of organic aerosol to Cape Hedo,Japan

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Particuology 2014年第2期12卷 35-41页

作者： Xiaoxiu Lun Akinori takami Weifang Ma Akio Shimono Shiro Hatakeyama Beijing Forestry University National Institute for Environmental Studies Onogawa 16-2Tsukuba 305-8506Japan Sanyu Plant Service Co. Ltd.Hashimotodai 1-8-21Kanagawa 229-1132Japan Tokyo University of Agriculture and Technology 3-8-IHarumi-choFuchu-shiTokyo 183-8538Japan

An investigation at Cape Hedo, Japan, from 2005 to 2006, focused on the long-range transport of organic aerosol （OA） from the Asian continent. An Aerodyne aerosol mass spectrometer was used to investigate the OA data collected over the study. OA concentrations were low from July to September and peaked during March and April. Based on air mass origins, four OA source regions were identified： northern China, southern China, Japan, and Korea. OA concentrations measured at Cape Hedo from the four sources did not exhibit large differences. Conversely, the frequencies of the air masses reaching Cape Hedo from the different regions varied considerably. Northern China was identified as the primary source of organic aerosols at Cape Hedo. Examination of variations in the ratio of m/z 44 to OA concentrations with transport time showed that OAs were partially oxidized during transport

关键词： Long-range transportOrganic aerosolSource contributionOkinawa