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Efficacy and safety of sofosbuvir and ledipasvir in Japanese patients aged 75 years or over with hepatitis C genotype 1

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World Journal of Hepatology 2017年第36期9卷 1340-1345页

作者： Yoshinori Ozono Kenji Nagata Satoru Hasuike Hisayoshi Iwakiri Kenichi Nakamura Mai Tsuchimochi Yuri Yamada Yuka Takaishi Mitsue Sueta Tadashi Miike yoshihiro tahara Shojiro Yamamoto Kotaro Shide Tomonori Hidaka Yoko Kubuki Kazunori Kusumoto Toshimasa Ochiai Junya Kato Naoto Komada Shuichi Hirono Kazuo Kuroki Masafumi Shigehira Kazuya Shimoda Department of Gastoroenterology and Hematology Faculty of Medicine University of Miyazaki Department of Liver Disease University of Miyazaki Hospital Department of Internal Medicine Koga General Hospital Department of Internal Medicine National Hospital Organization Miyakonojo Medical Center Department of Internal Medicine Hirono Naika Clinic Department of Internal Medicine Kushima Municipal Hospital Department of Internal Medicine Shigehira Clinic

AIM To evaluate the efficacy and safety of a regimen containing sofosbuvir(SOF) and ledipasvir(LDV) in Japanese patients aged ≥ 75 years with hepatitis C genotype *** This multicenter, retrospective study consisted of 246 Japanese patients with HCV genotype 1 at nine centers in Miyazaki prefecture in Japan. Demographic, clinical, virological, and adverse effects(AE)-related data obtained during and after SOF/LDV therapy were collected from medical records. These patients were divided into two groups, younger(aged < 75 years) and elderly(aged ≥ 75 years). Virological data and AEs were analyzed by age *** The sustained virological response(SVR) rates at 12 wk after treatment were 99.2%, 99.4%, and 98.7% in the overall population and in patients aged < 75 and ≥ 75 years, respectively. Common AEs during therapy were headache, pruritus, constipation, and insomnia. These occurred in fewer than 10% of patients, and their incidence was not significantly different between the younger and elderly groups. Two patients discontinued treatment, one due to a skin eruption and the other due to cerebral bleeding. CONCLUSION Compared with younger patients, elderly patients had a similar virological response and tolerance to SOF/LDV therapy.

关键词： Chronic hepatitis C Sofosbuvir Ledipasvir Sustained virological response Direct acting antivirals

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Study on analysis of crystal structure in CeO_2 doped with Er_2O_3 or Gd_2O_3

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Journal of Rare Earths 2010年第S1期28卷 164-167页

作者： Yuki tahara Kazufumi Yasunaga Toshiyuki Matsui Fuminobu Hori Akihiro Iwase Department of Materials Science Osaka Prefecture University1-1Gakuen-choNaka-kuSakaiOsaka599-8531Japan Department of Applied Quantum Physics and Nuclear Engineering Kyushu University744MotookaNishikuFukuoka 819-0395Japan

To simulate the effects of burnable poison doping in nuclear fuel UO2,Er2O3(or Gd2O3)-doped CeO2 pellets were prepared. Changes in lattice constant and atomic disordering for CeO2 due to the Er2O3 and Gd2O3 doping were measured by means of XRD and XAFS. By the Er2O3 doping,the lattice constant decreased,and a disordering of lattice structure was induced in the samples. The doping with Er2O3 also induced the disordering of atomic arrangement around Er atoms,which was observed through the change in XAFS spectra. In contrast,the effect of Gd2O3 doping was smaller than that of Er2O3 doping. The result was discussed in terms of ionic size of dopants in CeO2 crystal.

关键词： CeO2 ceramic pellets Er2O3 and Gd2O3 doping Change in lattice structure XRD XAFS rare earths

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Adding dimensions with Lucy-Richardson-Rosen algorithm to incoherent imaging

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Opto-Electronic Advances 2023年第5期6卷 7-9页

作者： Tatsuki tahara National Institute of Information and Communications Technology 4-2-1 NukuikitamachiKoganeiTokyo 184-8795Japan

A novel computational reconstruction method called the Lucy–Richardson–Rosen algorithm(LRRA)for the construction of a single-shot infrared 3D imaging microscope was reported in Opto-Electronic *** that study,a commonly available optical element,the Cassegrain objective lens,was used as a coded aperture for 3D imaging using *** regular coded aperture imaging systems,achieving 3D imaging using commonly available imaging devices leads to the development of hybrid imaging systems where direct and indirect imaging concepts *** development above will make 3D imaging more commonly used in daily life.

关键词： Richardson dimensions algorithm

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Feasibility of drug delivery to the eye’s posterior segment by topical instillation of PLGA nanoparticles

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Asian Journal of Pharmaceutical Sciences 2017年第4期12卷 394-399页

作者： Kohei tahara Keiichi Karasawa Risako Onodera Hirofumi Takeuchi Laboratory of Pharmaceutical Engineering Gifu Pharmaceutical University

We investigated the delivery of drugs to the posterior segment of the eye by non-invasive topical instillation using submicron-sized poly(D,L-lactide-co-glycolide)(PLGA) nanoparticles(NPs). Surface-modified PLGA NPs were developed to improve the drug delivery efficiency to the retina and were administered as topical eye drops to mice. Chitosan(CS) and glycol chitosan(GCS), which are mucoadhesive polymers, and polysorbate 80(P80) were used as surface modifiers, and have been reported to increase the association of NPs with ***-6 was used as a model drug and fluorescent marker, and after ocular administration of PLGA NP eye drops, the fluorescence intensity of coumarin-6 was observed in the retina. The fluorescence image analysis indicated that there are several possible routes to the retina and fates of PLGA NPs in ocular tissue, and that these pathways involved the corneal,non-corneal, or uveal routes. Delivery to the mouse retina segments after topical administration was increased by surface modification with CS, GCS, or P80. Surface-modified PLGA NPs are a promising method for retinal drug delivery via topical instillation.

关键词： PLGA Nanoparticles Topical instillation Retina Surface modification

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Efficacy of adhesive strapping on umbilical hernia in children:a systematic review and meta-analysis of cohort studies

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World Journal of Pediatric Surgery 2023年第4期6卷 206-216页

作者： Takuya Sugimoto Kazunori tahara Koshi Uchida Kazuhiko Yoshimoto Department of Pediatric Surgery Japanese Red Cross Kumamoto HospitalKumamotoJapan

Background Although adhesive strapping(AS)for pediatric umbilical hernia(UH),which was once obsolete,has been reconsidered as a common practice in Japan,its efficacy is still *** study aimed to evaluate its efficacy by reviewing related *** A comprehensive literature search of PubMed,Cochrane,Google Scholar,and Igaku Chuo Zasshi via Ichushi-Web was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses *** studies reporting on the UH closure rate after AS compared with observation-only management were *** A total of 10 cohort studies were included,and the overall UH closure rate was not statistically significant(p=0.31,risk ratio(RR)=0.76,95%confidence interval(CI)0.45 to 1.28).However,there were significant differences in the UH closure rate at the age of 6 months(p<0.01,RR=0.55,95%CI 0.41 to 0.75)and the efficacy of preventing protruding umbilici with redundant skin(p=0.049,RR=0.16,95%CI 0.03 to 0.99).Conclusions Although the efficacy of AS on UH compared with observation-only management did not differ in terms of the UH closure rate,the application of AS may be effective for faster UH closure and the prevention of protruding ***,due to the high heterogeneity of the study,further large-scale studies,particularly randomized controlled trials,are warranted to reach a conclusion.

关键词： hernia prevention closure

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Recent advances in particulate drug delivery systems: Oral, pulmonary, and ophthalmic administrations

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Asian Journal of Pharmaceutical Sciences 2016年第1期11卷 3-4页

作者： Hirofumi Takeuchi Kohei tahara Risako Onodera Gifu Pharmaceutical University

Colloidal drug carriers such as liposomes,lipid emulsions,and polymeric nanoparticles have great potential to deliver drugs *** of nano-crystals of API has also received much attention to design dosage forms to complete effective drug delivery.A variety of investigations have been carried out toward the design of an optimal particulate system.

关键词： Drug delivery systems Liposomes Administration routes Absorption

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High Temperature Gas Chromatography with Fiber-Packed Capillary as the Medium

High Temperature Gas Chromatography with Fiber-Packed Capill...

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第十五次全国色谱学术报告会

作者： Kiyokatsu Jinno Ai tahara Mitsuhiro Ogawa Motohiro Imaizumi yoshihiro Saito School of Materials Science Toyohashi University of Technology．Toyohashi 441-8580 JAPAN School of Materials Science Toyohashi University of Technology．Toyohashi 441-8580 JAPAN School of Materials Science Toyohashi University of Technology．Toyohashi 441-8580 JAPAN School of Materials Science Toyohashi University of Technology．Toyohashi 441-8580 JAPAN School of Materials Science Toyohashi University of Technology．Toyohashi 441-8580 JAPAN

＜正＞Gas chromatography （GC） is one of the most versatile separation methods for volatile compounds, and a wide variety of polymeric materials as the stationary phases have been developed for various applications. In contrast to the successful applications and subsequent commercialization of these polymer-coated columns, such as wall-coated, support-coated and pellicular-coated, the reports for the fibrous

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Novel approaches for posterior segment ocular drug delivery with folate-modified liposomal formulation

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Asian Journal of Pharmaceutical Sciences 2016年第1期11卷 201-202页

作者： Toshiki Hayashi Risako Onodera Kohei tahara Hirofumi Takeuchi Gifu Pharmaceutical University

The leading causes of vision impairment and blindness are posterior segment-related diseases including age-related macular degeneration,diabetic macular edema and ***,pharmaceutical approaches to these diseases have used steroids and *** drugs are usually administered via invasive injection because noninvasive delivery method such as eye drop administration of drugs is not ***,repeated injections are associated with potential risks of ***,patients may not comply with such regimens.

关键词： Liposome Retina Eyedrop Active targeting

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Formulation design of granules prepared by wet granulation method using a multi-functional single-punch tablet press to avoid tableting failures

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Asian Journal of Pharmaceutical Sciences 2018年第2期13卷 113-119页

作者： Takashi Osamura Yoshiko Takeuchi Risako Onodera Masahiro Kitamura Yoshiteru Takahashi Kohei tahara Hirofumi Takeuchi Laboratory of Pharmaceutical Engineering Gifu Pharmaceutical University Pharmaceutical Technology Department Sawai Pharmaceutical Co.Ltd

We previously determined "Tableting properties" by using a multi-functional single-punch tablet press(GTP-1). We plotted "Compactability" on the x-axis against "Manufacturability"on the y-axis to allow visual evaluation of "Tableting properties". Here, we examined whether this evaluation method can be used in the formulation design of tablets prepared by wet granulation. We used the GTP-1 to measure "Tableting properties" with different amounts of binder, disintegrant, and lubricant, and compared the results with those of tableting on a commercial rotary tableting machine. Tableting failures(capping and binding in particular) occurred when samples that had been evaluated as having poor "Compactability" or"Manufacturability" on the GTP-1 were compressed on the rotary tableting machine. Thus,our evaluation method predicted tableting failure at the commercial scale. The method will prove useful for scaling up production.

关键词： tableting formulation design wet granulation capping binding single-punch tablet press

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Prediction of effects of punch shapes on tableting failure by using a multi-functional single-punch tablet press

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Asian Journal of Pharmaceutical Sciences 2017年第5期12卷 412-417页

作者： Takashi Osamura Yoshiko Takeuchi Risako Onodera Masahiro Kitamura Yoshiteru Takahashi Kohei tahara Hirofumi Takeuchi Laboratory of Pharmaceutical Engineering Gifu Pharmaceutical University1-25-4Daigaku-NishiGifu501-1196Japan Pharmaceutical Technology Department Sawai Pharmaceutical Co.Ltd12-34HiroshibachoSuita-ShiOsaka564-0052Japan

We previously determined 'Tableting properties' by using a multi-functional single-punch tablet press(GTP-1). We proposed plotting 'Compactability' on the x-axis against'Manufacturability' on the y-axis to allow visual evaluation of 'Tableting properties'. Various types of tableting failure occur in commercial drug production and are influenced by the amount of lubricant used and the shape of the punch. We used the GTP-1 to measure'Tableting properties' with different amounts of lubricant and compared the results with those of tableting on a commercial rotary tableting machine. Tablets compressed with a small amount of lubricant showed bad 'Manufacturability', leading to sticking of powder on *** also tested various punch shapes. The GTP-1 correctly predicted the actual tableting results for all punch shapes. With punches that were more likely to cause tableting failure, our system predicted the effects of lubricant quantity in the tablet formulation and the occurrence of sticking in the rotary tableting machine.

关键词： Tableting Formulation design Lubricant Punch shape Single-punch tablet press Losartan potassium

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