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Food Science and Human Wellness 2012年第1期1卷 65-73页

作者： Min-Hsiung Pan Shiming Li Ching-Shu Lai Yutaka miyauchi Michiko Suzawa Chi-Tang Ho Department of Seafood Science National Kaohsiung Marine UniversityKaohsiung 811TaiwanChina Department of Food Science Rutgers UniversityNew BrunswickNJ 08901USA miyauchi Citrus Research Center 324-10 Shigoka-MachiTakasakiGunma 370-0845Japan

The inhibitory effects of a formulated product from citrus peel extract,Gold Lotion(GL),on 12-O-tetradecanoylphorbol 13-acetate(TPA)-induced expression of inducible nitric oxide synthase(iNOS)and cyclooxygenase-2(COX-2)in mouse skin was reported in this *** is found that in the TPA-induced skin inflammation model,the topical application of GL effectively inhibited the transcriptional activation of iNOS and its mRNA and protein in mouse *** is also discovered that GL significantly inhibited TPA-induced mouse skin inflammation by decreasing inflammatory gene ***,GL dramatically inhibited 7,12-dimethylbenez[a]anthracene(DMBA)/TPA-induced skin tumor formation and reduced tumor incidence,tumor weight and tumor multiplicity of papillomas at 20 *** essence,these in vivo data have revealed that GL is an effective anti-tumor agent that functions by down-regulating the protein levels of COX-2,ornithine decarboxylase(ODC),and vascular endothelial growth factor(VEGF)in mouse skin,suggesting that GL is a novel functional natural product capable of preventing inflammation-associated tumorigenesis.©2012 Production and hosting by Elsevier *** behalf of Beijing Academy of Food Sciences.

关键词： Inhibition Skin cancer Citrus flavonoids Inflammation Tumorigenesis

PID-Type Fuzzy Controller for Grid-Supporting Inverter of Battery in Embedded Small Variable Speed Wind Turbine

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Journal of Power and Energy Engineering 2014年第4期2卷 151-160页

作者： Ferdian Ronilaya Hajime miyauchi Adi Kurniawan Department of Frontier Technology for Energy and Devices Kumamoto University Kumamoto-shi Japan Department of Electrical Power Engineering The State Polytechnic of Malang Malang Indonesia Institut Teknologi Sepuluh Nopember Surabaya Indonesia

Frequency and voltage of embedded variable speed wind turbine (VSWT) driving a permanent magnet synchronous generator (PMSG) is strongly affected by wind speed fluctuations. In practice, power imbalance between supply and demand is also common, especially when VSWT-PMSG is connected to a weak micro grid (MG). If load demand fluctuations become high, isolated MG may be unable to stabilize the frequency and voltage so that battery storage needs to be installed into the MG to adjust energy supply and demand. To allow flexible control of active and reactive power flow from/to battery storage, grid-supporting inverters are used. For a system that contains highly nonlinear components, the use of conventional linear proportional-integral-derivative (PID) controllers may cause system performance deterioration. Additionally, these controllers show slow, oscillating responses, and complex equations are required to obtain optimum responses in other controllers. To cope with these limitations, this paper proposes PID-type fuzzy controller (PIDfc) design to control grid-supporting inverter of battery. To ensure safe battery operating limits, we also propose a new controller scheme called intelligent battery protection (IBP). This IBP is integrated into PIDfc. Several simulation tests are performed to verify the scheme’s effectiveness. The results show that the proposed PIDfc controller exhibits improved performance and acceptable responses, and can be used instead of conventional controllers.

关键词： Battery PID-Type Fuzzy Controller Inverter Permanent Magnet Synchronous Generator (PMSG) Variable Speed Wind Turbine (VSWT)

A New Evolutionary Method for Solving Combined Economic and Emission Dispatch

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Energy and Power Engineering 2013年第4期5卷 774-779页

作者： A. N. Afandi Hajime miyauchi Computer Science and Electrical Engineering GSST Kumamoto University Kumamoto Japan

This paper presents a new evolutionary method called in Harvest Season Artificial Bee Colony (HSABC) algorithm for solving constrained problems of Combined Economic and Emission Dispatch (CEED). The IEEE-30 bus system is adopted as a sample system for determining the best solutions of the CEED problems considering operational constraints. Running outs of designed programs for the HSABC show that applications of various compromised factors have different implications on the CEED’s results, that minimum cost computations are started at different values, and that increasing load demands have affected costs, pollutant emissions and generated powers.

关键词： Bees Cost Economic Emission Harvest Minimum

Neoadjuvant chemotherapy for locally advanced cervical cancer

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Chinese Journal of Cancer Research 2016年第2期28卷 235-240页

作者： Takashi Iwata Azumi miyauchi Yukako Suga Hiroshi Nishio Masaru Nakamura Akiko Ohno Nobumaru Hirao Tohru Morisada Kyoko Tanaka Hiroki Ueyama Hidemichi Watari Daisuke Aoki Department of Obstetrics and Gynecology Keio University School of Medicine Department of Obstetrics and Gynecology Hokkaido University Graduate School of Medicine

Neoadjuvant chemotherapy followed by surgery （NCS） has not been fully evaluated clinically. Currently, the main regimen of neoadjuvant chemotherapy （NAC） used in NCS includes cisplatin. The antitumor effects of NAC reduce lymph node metastasis and the tumor diameter in patients prior to surgery, and this can reduce the number of high risk patients who require postoperative radiation therapy. Many randomized controlled trials （RCTs） have examined the long-term prognosis of NCS compared to primary surgery, but the utility of NCS remains uncertain. The advent of concurrent chemoradiotherapy （CCRT） has markedly improved the outcome of radiotherapy （RT）, and CCRT is now used as a standard method in many cases of advanced bulky cervical cancer. NCS gives a better treatment outcome than radiation therapy alone, but it is important to verify that NCS gives a similar or better outcome compared to CCRT.

关键词： Neoadjuvant chemotherapy (NAC) cervical cancer

Therapeutic target for nephrotic syndrome: Identification of novel slit diaphragm associated molecules

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World Journal of Nephrology 2014年第3期3卷 77-84页

作者： Yoshiyasu Fukusumi Naoko miyauchi Taeko Hashimoto Akira Saito Hiroshi Kawachi Department of Cell Biology Institute of Nephrology Niigata University Graduate School of Medical and Dental Sciences Niigata 951-8510 Japan

The slit diaphragm bridging the neighboring foot processes functions as a final barrier of glomerular capillary wall for preventing the leak of plasma proteins into primary *** is now accepted that the dysfunction of the sit diaphragm contributes to the development of proteinuria in several glomerular ***,a gene product of NPHS1,a gene for a congenital nephrotic syndrome of Finnish type,constitutes an extracellular domain of the slit *** was identified as a gene product of NPHS2,a gene for a familial steroid-resistant nephrotic syndrome of *** binds the cytoplasmic domain of *** then,CD2 associated protein,NEPH1 and transient receptor potential-6 were also found as crucial molecules of the slit *** order to explore other novel molecules contributing to the development of proteinuria,we performed a subtraction hybridization assay with a normal rat glomerular RNA and a glomerular RNA of rats with a puromycin aminonucleoside nephropathy,a mimic of a human minimal change type nephrotic *** we have found that synaptic vesicle protein 2B,ephrin-B1 and neurexin were already downregulated at the early stage of puromycin amino-nucleoside nephropathy,and that these molecules were localized close to *** is conceivable that these molecules are the slit diaphragm associated molecules,which participate in the regulation of the barrier *** molecules could be targets to establish a novel therapy for nephrotic syndrome.

关键词：毛细血管壁肾小球治疗方法临床分析

Application of Slantlet Transform Based Support Vector Machine for Power Quality Detection and Classification

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Journal of Power and Energy Engineering 2015年第4期3卷 215-223页

作者： Faridah Hanim M. Noh Hajime miyauchi M. Faizal Yaakub Department of Frontier Technology for Energy & Devices Kumamoto University Kumamoto Japan Department of Electrical Power Engineering Universiti Tun Hussein Onn Malaysia Johor Malaysia Department of Electrical Engineering Technology Universiti Teknikal Malaysia Melaka Melaka Malaysia

Concern towards power quality (PQ) has increased immensely due to the growing usage of high technology devices which are very sensitive towards voltage and current variations and the de-regulation of the electricity market. The impact of these voltage and current variations can lead to devices malfunction and production stoppages which lead to huge financial loss for the production company. The deregulation of electricity markets has made the industry become more competitive and distributed. Thus, a higher demand on reliability and quality of services will be required by the end customers. To ensure the power supply is at the highest quality, an automatic system for detection and localization of PQ activities in power system network is required. This paper proposed to use Slantlet Transform (SLT) with Support Vector Machine (SVM) to detect and localize several PQ disturbance, i.e. voltage sag, voltage swell, oscillatory-transient, odd-harmonics, interruption, voltage sag plus odd-harmonics, voltage swell plus odd-harmonics, voltage sag plus transient and pure sinewave signal were studied. The analysis on PQ disturbances signals was performed in two steps, which are extraction of feature disturbance and classification of the dis- turbance based on its type. To take on the characteristics of PQ signals, feature vector was constructed from the statistical value of the SLT signal coefficient and wavelets entropy at different nodes. The feature vectors of the PQ disturbances are then applied to SVM for the classification process. The result shows that the proposed method can detect and localize different type of single and multiple power quality signals. Finally, sensitivity of the proposed algorithm under noisy condition is investigated in this paper.

关键词： Features Extraction Power Quality Disturbances Slantlet Transform Support Vector Machine

CuPd催化剂调节中间反应能垒提高电催化CO_(2)生成二碳产物的选择性

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Chinese Journal of Catalysis 2021年第9期42卷 1500-1508页

作者：朱莉林翌阳刘康 Emiliano Cortés 李红梅胡俊华 Akira Yamaguchi 刘小良 Masahiro miyauchi 傅俊伟刘敏中南大学物理与电子学院湖南长沙410083 慕尼黑大学物理学院慕尼黑德国郑州大学材料科学与工程学院河南郑州450052 东京工业大学材料与化工技术学院材料与科学工程系东京日本

过度的碳排放已造成了严重的全球环境问题,电催化CO_(2)还原是一种利用间歇性过剩电能将CO_(2)转化为有价值的化学物质的有效策略.在多种CO_(2)还原产物中,二碳(C2)产物(如乙烯、乙醇)因其比一碳产物(如甲酸、甲烷、甲醇)具有更高的能... 详细信息

过度的碳排放已造成了严重的全球环境问题,电催化CO_(2)还原是一种利用间歇性过剩电能将CO_(2)转化为有价值的化学物质的有效策略.在多种CO_(2)还原产物中,二碳(C2)产物(如乙烯、乙醇)因其比一碳产物(如甲酸、甲烷、甲醇)具有更高的能量密度而备受关注.Cu是唯一能用电化学方法将CO_(2)转化为多碳产物的单金属催化剂.如何提高Cu基催化剂上CO_(2)还原为C2产物的效率已引起了极大关注.电催化还原CO_(2)生成C2产物有两个重要步骤:一是参与碳碳偶联反应的CO*中间体的量(*代表中间体吸附在基底表面),二是碳碳偶联步骤的能垒.对于Cu单金属催化剂,虽然其表面碳碳偶联步骤的能垒相对较低,但是Cu对CO_(2)的吸附能力和CO_(2)*加氢能力并不高,导致在Cu表面不能生成足量的CO*中间体参与碳碳偶联反应,因而对C2产物的选择性和活性并不理想.与Cu单金属催化剂相反,在Pd单金属催化剂表面,CO*中间体的形成具有超快的反应动力学,但是CO*易在Pd表面中毒且后续碳碳偶联步骤的能垒极高,使其表面不能生成C2产物.为了充分发挥Cu(碳碳偶联步骤能垒较低)和Pd(CO*形成具有超快反应动力学)的双重优势,本文构建了一种紧密的CuPd(100)界面,以调节中间反应能垒,从而提高C2产率.密度泛函理论(DFT)计算表明,CuPd(100)界面增强了CO_(2)的吸附,且降低了CO_(2)*加氢步骤的能垒,从而能够催化生成更多的CO*中间体参与碳碳偶联反应.且CuPd(100)界面上CO_(2)还原为C2产物的电位决定步骤能垒为0.61 eV,低于Cu(100)表面的(0.72 eV).本文采用了一种简便的湿化学法制备了CuPd(100)界面催化剂.X射线衍射和X射线光电子能谱测试以及扩展X射线吸收精细结构光谱结果表明,合成的是相分离的CuPd双金属催化剂,而非CuPd合金催化剂.同时高分辨透射电镜可以观察到清晰的CuPd(100)界面.由此可见,本文成功合成了CuPd(100)界面催化剂.程序升温脱附实验结果表明,CuPd(100)界面对CO_(2)和CO*的吸附比Cu强,结果与理论预测一致.气体传感实验结果表明,CuPd(100)界面CO_(2)*加氢能力比Cu强.为评估CuPd(100)界面催化剂的催化活性,进行了CO_(2)电化学还原实验.结果表明,在0.1 mol/L的KHCO3电解液中,CuPd(100)界面催化剂在‒1.4 VRHE下,C2产物的法拉第效率为50.3%±1.2%,是同电位下Cu催化剂的(23.6%±1.5%)的2.1倍,C2产物的选择性是Cu催化剂的2.4倍,且具有更高的电流密度和更大的电化学活性面积.本文通过调控中间反应能垒以合理设计铜基CO_(2)还原电催化剂提供了参考.

关键词：二氧化碳电催化还原二碳产物铜钯界面催化剂中间反应能垒

A study of the interaction of drugs with liposomes with isothermal titration calorimetry

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Journal of Biophysical Chemistry 2013年第1期4卷 11-21页

作者： Hiroko Osanai Tastuya Ikehara Seiji miyauchi Kazumi Shimono Jun Tamogami Toshifumi Nara Naoki Kamo College of Pharmaceutical Sciences Matsuyama University Matsuyama Japan Faculty of Pharmaceutical Sciences Toho University Funabashi Japan Graduate School of Pharmaceutical Sciences Hokkaido University Sapporo Japan

Isothermal titration calorimetry (ITC) was applied to investigate the interaction of drugs with liposomes. Two types of titration are possible. One type is when the liposome suspension in the cell is titrated by aliquots of drug solution, and the other is when the drug and liposome solutions take the opposite roles. In this paper, we employed the latter type because the disturbance of liposomes may be minimal in this titration type. We derived an equation in which the accumulated heat-flow is expressed as a function of the added lipid concentration. In the derivation, the uniform binding model was used although there may be various binding sites. This equation contains a parameter n, the number of binding sites per lipid molecule. In addition, we derive the relation between the dissociation constant (Kd), partition coefficient (Pm) and n. Binding parameters such as Kd, n, the Gibbs energy change, enthalpy change and entropy change were estimated for ANS (1-anilino-8-naphtarenesulfonate), TPB (tetraphenylborate), amlodipine, nifedipine, amitriptyline, nortriptyline, imipramine, desipramine, propranolol, chlorpromazine, promethazine, miconazole, indomethacin, diclofenac and diflunisal. For some drugs, the enthalpy change was the major binding affinity instead of the classical hydrophobic interaction in which entropy takes the essential role. We proved an approximate rule that for drugs with smaller n (the number of binding sites per lipid molecule), the entropy change contributes more than the enthalpy change.

关键词： TC Drug Binding Liposome Dissociation Constant ΔH and ΔS Change

EFFECT OF HOT DIP GALVANIZING ON STRENGTH OF 590MPa CLASS TENSILE STRENGTH STEEL

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EFFECT OF HOT DIP GALVANIZING ON STRENGTH OF 590MPa CLASS TE...

Challenge to Welding and Joining Technology for Applying Multi-material in Electric Vehicle Production

第一届中日机械零件国际学术研讨会

作者： Gendai ETOH Kunio FUNAMI Hideharu SHIMIZU Haruyuki YASUI Yasutoshi miyauchi CHIBA INSTITUTE OF TECHNOLOGY 2-17-1TSUDANUMANARASHINO275JAPAN NASU OENKI-TEKKO CO. LTD.YOSHIHASHIYACHIYO CITYCHIBA PREFECTURE276JAPAN

＜正＞In this paper,the degree of liquid metal embrittlement in 590MPa class steel（STKT590） and 400MPa class steel（SS400） have been studied by conducting bending test in a molten zinc bath etc. As a result,it was ... 详细信息

关键词： Liquid Metal Embrittlement Hot Dip Galvanizing Precracked Specimen Crack Growth Three Points Bending Test

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材料科学与工程（中英文A版） 2022年第4期12卷 107-114页

作者： Tomoyuki Ueyama Shinichi Hasegawa Takaaki miyauchi Testuo Era Hidetoshi Fujii DAIHEN(OTC)Corporation Kobe 658-0033Japan Joining and Welding Research Institute Osaka University Ibaraki 567-0047Japan

Advanced high strength steel,aluminum alloy and plastic materials are used in the right places for the purpose of reducing the weight of EV(electric vehicle)bodies and in-vehicle parts,and multi-material structures are ***,it is difficult to handle the welding and joining processes of automobile structures by the conventional arc welding and resistance spot welding,which have been applied to steel joining,and various joining processes are being applied depending on the *** above mentioned background,the authors have developed some unique joining processes for multi-materials that are used in the right *** paper introduces the dissimilar metal joining between the galvanized steel and aluminum alloy by laser arc hybrid process,the metal/thermoplastic dissimilar material joining using laser process and the solid-state resistance spot joining process of advanced high strength steel for EV body structural ***,the authors describe the high-speed plasma jet GTA(Gas Tungusten Arc)welding process of copper applied to electrical components such as motors.

关键词： Arc welding laser arc hybrid dissimilar joining spot joining electric vehicle.