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Return to sports activity by athletes after treatment of spondylolysis

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World Journal of Orthopedics 2010年第1期1卷 26-30页

作者： Jun Iwamoto yoshihiro Sato Tsuyoshi Takeda Hideo Matsumoto Institute for Integrated Sports Medicine Keio University School of MedicineTokyo 160-8582Japan Department of Neurology Mitate HospitalFukuoka 826-0041Japan

AIM:To clarify the efficacy of conservative and surgical treatment of spondylolysis in ***:PubMed was used to perform a search of the literature for studies published during the period from 1990 to 2009 that reported data on the outcome of conservative or surgical treatment of spondylolysis in *** articles were examined for data on the percentage of athletes who returned to sports activities and the interval between the start of treatment and their ***:Five studies were *** studies were concerned with conservative treatment and the other three with surgical treatment(wire fixation or screw fixation with bone graft).The percentages of athletes who returned to sports activities ranged from 80.0%to 89.3%and from 81.9%to 100%,respectively,and the intervals until their return ranged from 5.4 to 5.5 mo and from 7 to 12 mo,***:The percentages of athletes who returned to sports activities after conservative and surgical treatment appeared to be satisfactory,but the

关键词： Spondylolysis Athletes Conservative treatment Surgical treatment Return to play Literature review

Indian monsoon variability in the Mahanadi Basin over the last two glacial cycles and its implications on the Indonesian throughflow

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Geoscience Frontiers 2023年第1期14卷 215-229页

作者： Jongmin Lee Sunghan Kim Minoru Ikehara Keiji Horikawa yoshihiro Asahara Chan Min Yoo Boo-Keun Khim Department of Oceanography Pusan National UniversityBusan 46241South Korea Deep-sea Mineral Resources Research Center Korea Institute of Ocean Science&TechnologyBusan 49111South Korea Division of Glacial Environment Research Korea Polar Research InstituteIncheon 21990South Korea Center for Advanced Marine Research Kochi UniversityKochi 783-8502Japan Graduate School of Science and Engineering for Research University of ToyamaToyama 930-8555Japan Department of Earth and Planetary Sciences Nagoya UniversityNagoya 464-8601Japan

The orbital-scale variability of the Indian summer monsoon(ISM)has been influenced by multiple factors,such as atmospheric CO_(2)concentration,global ice volume,and *** for weathering activity and paleo-productivity provide potential insights into the driving forces of its *** documented multi-proxy data at IODP Site U1445,located in the Mahanadi Basin of the northwestern Bay of Bengal,to find out ISM variability over the last 200 *** proxy records,such as Nd/Sr isotopes of detrital particles,clay mineral compositions of the fine-grained sediments,biogenic opal and CaCO_(3),organic carbon contents,and carbon isotopes of organic matter,represent sediment sources,weathering patterns,and paleo-productivity related to the ISM *** Nd/Sr isotope data and clay mineral compositions suggest that the sediments at Site U1445 originated mainly from the Ganges,Brahmaputra,and Meghna rivers without dramatic provenance change between the glacial and interglacial *** weathering activity inferred from clay mineral compositions and the paleo-productivity shift reconstructed by biogenic opal and CaCO_(3)contents suggest that the land-sea interactions were closely linked to the ISM precipitation between the glacial and interglacial *** precipitation by the strong ISM resulted in intense chemical weathering and dominant biogenic opal deposition during the interglacial *** contrast,low precipitation by the weak ISM led to reduced chemical weathering and predominant CaCO_(3)deposition during the glacial ***,the ISM variability driving the land-sea interactions in the Mahanadi Basin was modulated by the Indonesian throughflow(ITF).Our study emphasizes the role of low-latitude forcing of climatic changes in the strong relationship between the ISM and ITF over orbital periods,providing a base for future investigations.

关键词： Provenance Weathering activity Paleo-productivity Indian summer monsoon Bay of Bengal Indonesian throughflow

Photochemical Reactions of Microcystin-LR Following Irradiation with UV Light

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Open Journal of Physical Chemistry 2016年第4期6卷 79-85页

作者： yoshihiro Mizukami Faculty of Liberal Arts and Education Shiga University Otsu Japan

Photochemical reactions of microcystin-LR, a toxic compound produced by some blue green algae, were investigated. Ultraviolet absorption of microcystin-LR was assessed. Time-dependent density functional theory (TDDFT) calculations indicated that absorption peak at 238 nm was mainly due to excitation of electrons from the linear chain structure Adda of microcystin-LR. Irradiation of microcystin-LR with UV light resulted in the reduction of the 238 nm absorption peak and the appearance of a new peak at 300 nm. Density functional theory (DFT) and TDDFT calculations with a model molecule suggested that this 300 nm peak was due to tricyclo-Adda microcystin-LR, an intermediate in photochemical reactions of microcystin-LR. Analysis of the rate of this photochemical reaction showed that it was a first order reaction.

关键词： Microcystin-LR UV Irradiation UV Spectra DFT Calculations Photochemical Reactions

A case of gallbladder carcinoma associated with pancreatobiliary reflux in the absence of a pancreaticobiliary maljunction:A hint for early diagnosis of gallbladder carcinoma

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World Journal of Gastroenterology 2006年第28期12卷 4593-4595页

作者： Masafumi Suyama yoshihiro Kubokawa Department of Gastroenterology Juntendo UniversityTokyoJapan

A 62-year-old man with progressive thickening of the gallbladder wall visited our outpatient clinic. The biliary amylase level in the common bile duct was 19900 IU/L and that of the gallbladder was 127000 IU/L, although endoscopic retrograde cholangiopancreatography revealed no pancreaticobiliary maljunction. Histology demonstrated a moderately differentiated adenocarcinoma of the gallbladder. Pancreatobiliary reflux and associated gallbladder carcinoma were confirmed in the present case, in the absence of a pancreaticobiliary maljunction. Earlier detection of the pancreatobiliary reflux and progressive thickening of the gallbladder wall might have led to an earlier resection of the gallbladder and improved this patient＇s poor prognosis.

关键词： Amylase Bile Gallbladder carcinoma Pancreatobiliary reflux Pancreaticobiliary maljunction Diagnosis

Glycosylation and an amino acid insertion in the head of hemagglutinin independently affect the antigenic properties of H5N1 avian influenza viruses

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Science China(Life Sciences) 2019年第1期62卷 76-83页

作者： Chunyang Gu Xianying Zeng Yangming Song Yanbing Li Liling Liu yoshihiro Kawaoka Dongming Zhao Hualan Chen State Key Laboratory of Veterinary Biotechnology Harbin Veterinary Research Institute Chinese Academy of Agricultural Sciences Division of Virology Department of Microbiology and Immunology Institute of Medical Science University of Tokyo

Antigenic drift forces us to frequently update influenza vaccines; however, the genetic basis for antigenic variation remains largely unknown. In this study, we used clade 7.2 H5 viruses as models to explore the molecular determinants of influenza virus antigenic variation. We generated eight monoclonal antibodies(MAbs) targeted to the hemagglutinin(HA) protein of the index virus A/chicken/Shanxi/2/2006 and found that two representative antigenically drifted clade 7.2 viruses did not react with six of the eight MAbs. The E131 N mutation and insertion of leucine at position 134 in the HA protein of the antigenically drifted strains eliminated the reactivity of the virus with the MAbs. We also found that the amino acid N131 in the H5 HA protein is glycosylated. Our results provide experimental evidence that glycosylation and an amino acid insertion or deletion in HA influence antigenic variation.

关键词： Influenza virus H5N1 antigenic variation genetic basis

Morphological and biochemical responses of Oryza sativa L.(cultivar MR219) to ion beam irradiation

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第12期14卷 1132-1143页

作者： Anna Pick Kiong LING Ying Chian UNG Sobri HUSSEIN Abdul Rahim HARUN Atsushi TANAKA Hase yoshihiro Division of Human Biology International Medical University (IMU)57000 Kuala Lumpur Malaysia Department of Science Faculty of Engineering and Science Universiti Tunku Abdul Rahman53300 Setapak Kuala Lumpur Malaysia Agrotechnology and Bioscience Division Malaysian Nuclear Agency Bangi43000 Kajang Selangor Malaysia Radiation-Applied Biology Division Quantum Beam Science Directorate Japan Atomic Energy Agency 1233 Watanuki-machiTakasaki Gunma 370-1292 Japan

Objective: Heavy ion beam, which has emerged as a new mutagen in the mutation breeding of crops and ornamental plants, is expected to result in the induction of novel mutations. This study investigates the morphological and biochemical responses of Oryza sativa toward different doses of carbon ion beam irradiation. Methods: In this study, the dry seeds of O. sativa were irradiated at 0, 20, 40, 60, 80, 100, and 120 Gy, followed by in-vitro germination under controlled conditions. Morphological and biochemical studies were conducted to investigate the morphological and physiological responses of O. sativa towards ion beam irradiation. Results: The study demonstrated that low doses(10 Gy) of ion beam have a stimulating effect on the height, root length, and fresh weight of the plantlets but not on the number of leaves. Meanwhile, doses higher than 10 Gy caused reductions in all the morphological parameters studied as compared to the control samples. The highest total soluble protein content [(2.11±0.47) mg/g FW] was observed in plantlets irradiated at 20 Gy. All irradiated plantlets were found to have 0.85% to 58.32% higher specific activity of peroxidase as compared to the control samples. The present study also revealed that low doses of ion beam(10 and 20 Gy) had negligible effect on the total chlorophyll content of O. sativa plantlets while 40 Gy had a stimulating effect on the chlorophyll content. Plantlets irradiated between 40 to 120 Gy were shown to be 0.38% to 9.98% higher in total soluble nitrogen content which, however, was not significantly different from the control samples. Conclusions: Carbon ion beam irradiation administered at low to moderate doses of 10 to 40 Gy may induce O. sativa mutants with superior characteristics.

关键词： In vitro mutagenesis Ion beam irradiation Total chlorophyll content Total soluble protein content Mutation breeding

Bioprinted Vascularized Mature Adipose Tissue with Collagen Microfibers for Soft Tissue Regeneration

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Cyborg and Bionic Systems 2021年第1期2021卷 1-15页

作者： Fiona Louis Marie Piantino Hao Liu Dong-Hee Kang yoshihiro Sowa Shiro Kitano Michiya Matsusaki Joint Research Laboratory(TOPPAN)for Advanced Cell Regulatory Chemistry Graduate School of EngineeringOsaka UniversityJapan Department of Applied Chemistry Graduate School of EngineeringOsaka UniversityJapan Department of Plastic and Reconstructive Surgery Graduate School of Medical SciencesKyoto Prefectural University of MedicineJapan Toppan Printing Co. Ltd.TokyoJapan

The development of soft tissue regeneration has recently gained importance due to safety concerns about artificial breast *** autologous fat graft implantations can result in up to 90%of volume loss in long-term outcomes due to their limited *** tissue has a highly vascularized structure which enables its proper homeostasis as well as its endocrine *** adipocytes surrounded by a dense vascular network are the specific features required for efficient regeneration of the adipose tissue to perform host anastomosis after its ***,bioprinting has been introduced as a promising solution to recreate in vitro this architecture in large-scale ***,the in vitro induction of both the angiogenesis and adipogenesis differentiations from stem cells yields limited maturation states for these two *** overcome these issues,we report a novel method for obtaining a fully vascularized adipose tissue reconstruction using supporting bath *** the first time,directly isolated mature adipocytes encapsulated in a bioink containing physiological collagen microfibers(CMF)were bioprinted in a gellan gum supporting *** multilayered bioprinted tissues retained high viability even after 7 days of ***,the functionality was also confirmed by the maintenance of fatty acid uptake from mature ***,this method of constructing fully functional adipose tissue regeneration holds promise for future clinical applications.

关键词： supporting printing fibers

Myocardial metastasis from ZEB1-and TWIST-positive spindle cell carcinoma of the esophagus:A case report

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World Journal of Gastroenterology 2024年第11期30卷 1636-1643页

作者： yoshihiro Shibata Hirofumi Ohmura Kazuki Komatsu Kosuke Sagara Atsuji Matsuyama Ryuji Nakano Eishi Baba Department of Medical Oncology Fukuoka Wajiro HospitalFukuoka 811-0213Japan Department of Oncology and Social Medicine Kyushu University Graduate School of Medical SciencesFukuoka 812-8582Japan Department of Pathology and Oncology University of Occupational and Environmental HealthKitakyushu 807-8555Japan Department of Diagnostic Pathology Fukuoka Wajiro HospitalFukuoka 811-0213Japan

BACKGROUND Metastatic cardiac tumors are known to occur more frequently than primary cardiac tumors,however,they often remain asymptomatic and are commonly dis-covered on *** tumors with a relatively high frequency of cardiac metastasis include mesothelioma,melanoma,lung cancer,and breast cancer,whereas reports of esophageal cancer with cardiac metastasis are *** SUMMARY The case of a 60-year-old man who complained of dysphagia is *** gastrointestinal endoscopy showed a submucosal tumor-like elevated lesion in the esophagus causing ***-enhanced computed tomography showed left atrial compression due to the esophageal tumor,multiple liver and lung metastases,and a left pleural *** examination of a biopsy speci-men from the esophageal tumor showed spindle-shaped cells,raising suspicion of esophageal *** disease progressed rapidly,and systemic chemotherapy was deemed necessary,however,due to his poor general condition,adminis-tration of cytotoxic agents was considered *** his high Combined Positive Score,nivolumab was administered,however,the patient soon died from the *** autopsy confirmed spindle cell carcinoma(SCC)of the esophagus and cardiac metastasis with similar histological *** stem cell markers,ZEB1 and TWIST,were positive in both the primary tumor and the cardiac *** To the best of our knowledge,there have been no prior reports of cardiac metastasis of esophageal *** case highlights our experience with a patient with esophageal SCC who progressed rapidly and died from the disease,with the autopsy examination showing cardiac metastasis.

关键词： Spindle cell carcinoma Esophagus Myocardial metastasis Epithelial-mesenchymal transition Case report

Complete response with sorafenib and transcatheter arterial chemoembolization in unresectable hepatocellular carcinoma

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World Journal of Gastroenterology 2016年第42期22卷 9445-9450页

作者： Michitoshi Takano Takashi Kokudo yoshihiro Miyazaki Yumiko Kageyama Amane Takahashi Katsumi Amikura Hirohiko Sakamoto Division of gastroenterological surgery Saitama Cancer Center

Patients with advanced hepatocellular carcinoma(HCC) showing portal vein tumor thrombosis(PVTT) have an extremely poor prognosis. According to treatment guidelines, the only option for HCC patients with PVTT is sorafenib chemotherapy. However, in Asia, various treatments have been attempted and possible prolongation of overall survival has been repeatedly reported. We herein report the first case of a patient with an initially unresectable advanced HCC with PVTT who underwent curative hepatectomy after sorafenib and transcatheter arterial chemoembolization(TACE) showing complete histological response. Two months after induction with sorafenib, a significant decrease in serum alpha-fetoprotein level was observed and computed tomography imaging showed a significant decrease in tumor size. Because of remaining PVTT, TACE and curative resection were performed. The combination of sorafenib and TACE may be an effective treatment for HCC patients with PVTT.

关键词： Hepatocellular carcinoma Sorafenib Complete response Portal vein tumor thrombosis Transcatheter arterial chemoembolization