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Clinical impact of minimal cancer cell detection in various colorectal cancer specimens

World Journal of Gastroenterology 2014年第35期20卷 12458-12461页

作者： Kazuhiko Yoshimatsu Hajime Yokomizo yoshihiko naritaka Department of Surgery Tokyo Women’s Medical UniversityMedical Center East

Detection of cancer cells using molecular targets is achieved by combining immunochemical reactions with gene amplification *** enables the detection of cancer cells in specimens that are traditionally determined to be *** improvements in detection can lead to prognoses that are different from those derived by conventional pathological *** is worse when cancer cells are detected in regional lymph nodes compared to when the nodes are ***,the circulating tumor cell(CTC) count increases as the cancer ***,there is a correlation between CTC count and ***,large-scale prospective studies are required to confirm *** development of more convenient and cost-effective analysis techniques will facilitate the practical application of these findings.

关键词： Micrometastasis Circulating tumor cell Colorectal cancer Prognosis Molecular marker

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An Absolute Standardized Uptake Value Is More Useful than the Decreased Rate of Uptake of FDG-PET to Predict Responses to Neoadjuvant Chemoradiotherapy for Esophageal Cancer

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Open Journal of Gastroenterology 2016年第11期6卷 373-385页

作者： Masanobu Nakajima Hiroyuki Kato Tatsuya Miyazaki Takanori Inose naritaka Tanaka Shigemasa Suzuki Takehiko Yokobori Makoto Sakai Akihiko Sano Keisuke Ieta Makoto Sohda Minoru Fukuchi Hiroyuki Kuwano Department of Surgery I Dokkyo Medical University Mibu Japan Department of General Surgical Science Gunma University Graduate School of Medicine Maebashi Japan

Background: Neoadjuvant chemoradiotherapy (CRT) is frequently performed for esophageal squamous cell carcinoma. In this study, we retrospectively assessed the standardized uptake value (SUV) of FDG-PET against decreased rates of SUV to assess the response of advanced esophageal squamous cell carcinoma patients to neoadjuvant CRT, and the correlation of this response with histopathological findings. Patients and Methods: Thirty-three patients receiving CRT followed by surgery were analyzed. Results: Using the decreased rate of maximum SUV, the sensitivity and specificity in distinguishing complete responders (CR) from non-CR patients was 63% and 44%. Using the maximum SUV before surgery, the sensitivity and specificity for distinguishing pathological CR from non-CR was 88% and 56%. Conclusions: To identify complete responders of CRT for esophageal cancer, absolute maximum SUV value is a better predictor than decreased rate of the maximum SUV.

关键词： Esophageal Cancer Neoadjuvant Therapy Chemoradiotherapy FDG-PET SUV

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