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Knockdown of Dock7 <i>in vivo</i>specifically affects myelination by Schwann cells and increases myelin thickness in sciatic nerves without affecting axon thickness

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American Journal of Molecular Biology 2012年第3期2卷 210-216页

作者： Tomohiro Torii Yuki Miyamoto Motoshi Nagao Naoko Onami Hideki Tsumura Masahiro Maeda Kazuaki Nakamura Akito Tanoue Junji yamauchi Department of Pharmacology National Research Institute for Child Health and Development Tokyo Japan Immuno-Biological Laboratories Co. Ltd. Gunma Japan Laboratory Animal Resource Facility National Research Institute for Child Health and Development Tokyo Japan The Japan Human Health Sciences Foundation Tokyo Japan

During development of the peripheral nervous system (PNS), Schwann cells (SCs) wrap individual axons to form myelin sheaths, which act as surrounding insulators and markedly enhance the propagation of the action potential. In peripheral neuropathies such as Guillain-Barré syndrome (GBS) and inherited demyelinating Charcot-Marie-Tooth (CMT) disease and diabetic neuropathies, chronic demyelination and defective remyelination are repeated, causing more severe neuropathies. It is thus thought that development of a drug that promotes proper myelination with minimal side effects could provide an effective therapy for these diseases. As yet, however, little is known about therapeutic target molecules and genetically-modified mice for testing such approaches. We previously cloned the dock7 gene and characterized Dock7 as the regulator controlling SC myelination;however, an important issue, whether knockdown of Dock7 specifically affects myelination by SCs but not leaves neurons unaffected, has remained unclear. Here, we generate newly-produced transgenic mice harboring short-hairpin RNA (shRNA) targeting Dock7. We also describe that Dock7 shRNA transgenic mice exhibit enhanced myelin thickness without affecting axon thickness in sciatic nerves of the PNS, as reduced thickness of the axon diameter is the primary indicator of denatured neurons. Similarly, purified in vitro SC-neuronal cocultures established from transgenic mice exhibit enhanced formation of myelin segments, suggesting that knockdown of Dock7 promotes myelination by SCs. Collectively, Dock7 knockdown specifically affects SC myelination in sciatic nerves, providing evidence that Dock7 may be a promising drug-target-specific molecules for developing a therapy for peripheral neuropathies that aims to enhance myeliantion.

关键词： Dock7 Transgenic Mouse Schwann Cell Myelination Axon Diameter

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EFFECT OF SINGLE ALIEN CHROMOSOME FROM SHALLOT ON CARBOHYDRATE PRODUCTION IN THE LEAF BLADE OF BUNCHING ONION

EFFECT OF SINGLE ALIEN CHROMOSOME FROM SHALLOT ON CARBOHYDRA...

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4～(th) International Ishs Symposium on Edible Alliaceae(ISEA)

作者： T.T.M.Hang M.Shigyo M.Nakashima N.yamauchi Faculty of Agriculture Yamaguchi UniversityYamaguchi 753-8515 Japan Faculty of Agriculture Yamaguchi UniversityYamaguchi 753-8515 Japan Faculty of Agriculture Yamaguchi UniversityYamaguchi 753-8515 Japan Faculty of Agriculture Yamaguchi UniversityYamaguchi 753-8515 Japan

＜正＞ Eight kinds of A. fistulosuin - shallot monosomic additions （2n=17, FF+1A -FF+8A） display morphological and physiological characteristics that are different from those of the recipient parent. Therefore, it seems that the alien gene on the extra chromosome affects various phenotypic expressions of A. fistulosuin. To apply this complete set of monosomic additions to the breeding of bunching onion with specific chemical compositions, an addition

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Room-temperature growth of carbon nanofibers induced by Ar+-ion bombardment

Room-temperature growth of carbon nanofibers induced by Ar+-...

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Ⅻ International Symposium on Small Particles and Inorganic Clusters

作者： Masaki Tanemura T.Okita H.yamauchi S.Tanemura R.Morishima Department of Environmental Technology Graduate School of EngineeringNagoya Institute of TechnologyGokiso-cho Showa-kuNagoya 466-8555Japan Department of Environmental Technology Graduate School of EngineeringNagoya Institute of TechnologyGokiso-cho Showa-kuNagoya 466-8555Japan Department of Environmental Technology Graduate School of EngineeringNagoya Institute of TechnologyGokiso-cho Showa-kuNagoya 466-8555Japan Department of Environmental Technology Graduate School of EngineeringNagoya Institute of TechnologyGokiso-cho Showa-kuNagoya 466-8555Japan Toyota Motor Corporation Higashifuji Technical Center 1200 Mishuku SusonoShizuoka 410-1193Japan

＜正＞ The synthesis of low-dimensional materials, such as carbon nanotubes （CNTs） and carbon nanofibers （CNFs）, is one of the current topics in materials science and microelectronics technology. The ion bombardment of solid surfaces sometimes entails the formation of nano- to micro-sized surface structures, taking such forms as ripples, pyramids, conical protrusions and whiskers, depending on the sputtering parameters. Thus, ion bombardment

关键词： carbon nanofiber sputtering seed cone nano-structure.

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First case of IgG4-related sclerosing cholangitis associated with autoimmune hemolytic anemia

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World Journal of Gastroenterology 2014年第26期20卷 8740-8744页

作者： Hironori Masutani Kosuke Okuwaki Mitsuhiro Kida Hiroshi yamauchi Hiroshi Imaizumi Shiro Miyazawa Tomohisa Iwai Miyoko Takezawa Wasaburo Koizumi Department of Gastroenterology Kitasato University East Hospital

To our knowledge,patients with immunoglobulin G4-related sclerosing cholangitis(IgG4-SC)associated with autoimmune hemolytic anemia(AIHA)have not been reported *** patients with IgG4-SC have autoimmune pancreatitis(AIP)and respond to steroid ***,isolated cases of IgG4-SC are difficult to *** describe our experience with a patient who had IgG4-SC without AIP in whom the presence of AIHA led to *** patient was a73-year-old man who was being treated for *** dysfunction was diagnosed on blood tests at another *** studies suggested the presence of carcinoma of the hepatic hilus and primary sclerosing cholangitis,but a rapidly progressing anemia developed *** the diagnosis of AIHA,steroid treatment was begun,and the biliary stricture ***4-SC without AIP was thus diagnosed.

关键词： IgG4-related sclerosing cholangitis Immunoglobulin

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Passive-bending,short-type single-balloon enteroscope for endoscopic retrograde cholangiopancreatography in Roux-en-Y anastomosis patients

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World Journal of Gastroenterology 2015年第5期21卷 1546-1553页

作者： Hiroshi yamauchi Mitsuhiro Kida Kosuke Okuwaki Shiro Miyazawa Tomohisa Iwai Shuko Tokunaga Miyoko Takezawa Hiroshi Imaizumi Wasaburo Koizumi Department of Gastroenterology Kitasato University East HospitalKana-gawa 252--0380Japan

AIM:To evaluate short-type-single-balloon enteroscope(SBE) with passive-bending,high-force transmission functions for endoscopic retrograde cholangiopancreatography(ERCP) in patients with Roux-en-Y ***:Short-type SBE with this technology(SIF-Y0004-V01; working length,1520 mm; channel diameter,3.2 mm) was used to perform 50 ERCP procedures in 37 patients with Roux-en-Y *** rate of reaching the blind end,time required to reach the blind end,diagnostic and therapeutic success rates,and procedure time and complications were studied retrospectively and compared with the results of 34 sessions of ERCP performed using a short-type SBE without this technology(SIF-Y0004; working length,1520 mm; channel diameter,3.2 mm) in 25 ***:The rate of reaching the blind end was 90% with SIF-Y0004-V01 and 91% with SIF-Y0004(P = 0.59).The median time required to reach the papilla was significantly shorter with SIF-Y0004-V01 than with SIF-Y0004(16 min vs 24 min,P = 0.04).The diagnostic success rate was 93% with SIFY0004-V01 and 84% with SIF-Y0004(P = 0.17).The therapeutic success rate was 95% with SIF-Y0004-V01 and 96% with SIF-Y0004(P = 0.68).The median procedure time was 40 min with SIF-Y0004-V01 and 36 min with SIF-Y0004(P = 0.50).The incidence of hyperamylasemia was 6.0% in the SIF-Y0004-V01 group and 14.7% in the SIF-Y0004 group(P = 0.723).The incidence of pancreatitis was 0% in the SIFY0004-V01 group and 5.9% in the SIF-Y0004 group(P > 0.999).The incidence of gastrointestinal perforation was 2.0%(1/50) in the SIF-Y0004-V01 group and 2.9%(1/34) in the SIF-Y0004 group(P > 0.999).CONCLUSION:SIF-Y0004-V01 is useful for ERCP inpatients with Roux-en-Y anastomosis and may reduce the time required to reach the blind end.

关键词： Passive bending Roux-en-Y anastomosis Endoscopic r

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Antibody markers in the diagnosis of inflammatory boweldisease

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World Journal of Gastroenterology 2016年第3期22卷 1304-1310页

作者： Keiichi Mitsuyama Mikio Niwa Hidetoshi Takedatsu Hiroshi Yamasaki Kotaro Kuwaki Shinichiro Yoshioka Ryosuke yamauchi Shuhei Fukunaga Takuji Torimura Inflammatory Bowel Disease Center Kurume University School of MedicineKurume 830-0011Japan Division of Gastroenterology Department of MedicineKurume University School of MedicineKurume 830-0011Japan Institute for Advanced Sciences Toagosei Co.Ltd.2 OhkuboTsukubaIbaraki 300-2611Japan

Inflammatory bowel disease(IBD), including Crohn's disease and ulcerative colitis, is a chronic intestinal inflammation of unknown etiology. The diagnosis of IBD is based on endoscopic, radiologic and histopathologic criteria. Recently, the search for a noninvasive marker that could augment or replace part of this diagnostic process has become a focus of IBD research. In this review, antibody markers, including microbial antibodies, autoantibodies and peptide antibodies, will be described, focusing on their common features. At present, no single marker with qualities that are satisfactory for the diagnosis and treatment of IBD has been identified, although panels of some antibodies are being evaluated with keen interest. The discovery of novel IBD-specific and sensitive markers is anticipated. Such markers could minimize the use of endoscopic and radiologic examinations and could enable clinicians to implement individualized treatment plans designed to improve the long-term prognosis of patients with IBD.

关键词： Biomarker Crohn's disease Serologicalantibody Ulcerative colitis

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Early Ligation of the Inferior Pancreaticoduodenal Artery Using Intraoperative Ultrasonography during Pancreaticoduodenectomy

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Surgical Science 2015年第2期6卷 50-54页

作者： Takamitsu Sasaki Daisuke Kato Satoshi Shinya Kanefumi Yamashita Ryo Nakashima Hironari Shiwaku Yasushi yamauchi Tomoaki Noritomi Yuichi Yamashita Department of Gastroenterological Surgery Fukuoka University School of Medicine Fukuoka Japan

Background: While the safety of pancreaticoduodenectomy (PD) has improved, the high level of difficulty associated with this operation means that the procedure carries a high mortality rate compared to other gastrointestinal operations. Various trials have been implemented in efforts to reduce the incidence of complications after PD. In particular, a large amount of intraoperative bleeding and the use of red blood cell transfusions are reportedly risk factors for postoperative complications after PD. Aim: In an attempt to reduce the amount of intraoperative bleeding during PD, consideration was given to the anatomical characteristics of the region of the pancreatic head, and the gastroduodenal artery (GDA) and inferior pancreaticoduodenal artery (IPDA) were ligated in advance of separating the head from the portal vein. We herein report the use of ultrasonography during PD to facilitate the early identification and ligation of the IPDA. Case Presentation: A 72-year-old female was diagnosed with pancreatic cancer and underwent pylorus-preserving pancreatoduodenectomy. We used ultrasonography during the operation to initially identify the IPDA and then ligate it in advance, after which the GDA was ligated before separating the pancreatic head from the superior mesenteric artery and portal vein. Identification of the IPDA was performed with the SMA as a guide using ultrasonography in Doppler mode. The amount of intraoperative bleeding was 235 ml. The patient left the hospital without any postoperative complications and has since demonstrated a good postoperative course, with no evidence of recurrent disease. Conclusions: Early ligation of the IPDA using intraoperative US is non-invasive and makes it simple to identify the IPDA. This method may be a useful technique for reducing intraoperative bleeding during the normal course of PD procedures.

关键词： Intraoperative Bleeding Early Ligation Inferior Pancreaticoduodenal Artery Pancreaticoduodenectomy Ultrasonography

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拼元式多色薄膜电致发光器件

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光电子技术 1989年第1期9卷 52-55,51页

作者：田祥

引言自从橙黄色(ZnS:Mn)单色薄膜电致发光(TFEL)显示器件达到商业性应用阶段以来,人们把大量的工作都集中于研究彩色TFEL。近年来,三基色TFEL器件的亮度和效率都有了很大的提高。下一个目标就是通过组合基色电致发光来产生多色EL器件。... 详细信息

引言自从橙黄色(ZnS:Mn)单色薄膜电致发光(TFEL)显示器件达到商业性应用阶段以来,人们把大量的工作都集中于研究彩色TFEL。近年来,三基色TFEL器件的亮度和效率都有了很大的提高。下一个目标就是通过组合基色电致发光来产生多色EL器件。方法有两种:一种是层叠不同颜色的发光薄膜;另一种是拼排不同颜色的发光薄膜单元(拼元式)。

关键词：电致发光拼元式多色 TFEL器件

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结合烷烃硫醇类自组装单层的亚稳原子光刻

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现代科学仪器 2006年第Z1期23卷 16-17页

作者：巨新 KURAHASHI M SUZUKI T yamauchi Y 南京大学中国国立材料科学研究院日本国立材料科学研究院日本

　　A number of demonstrations of nanofabrication with atom optics have been carried out by using both the direct deposition of atoms and atom lithography for vailous molecular surfaces in the past several years[1]. ……

关键词：烷烃醇类自组装单层 direct deposition atom lithography

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以盒维数法分形分析水稻根系形态特征及初探其与锌吸收积累的关系

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作物学报 2008年第9期34卷 1637-1643页

作者：汪洪金继运山内章中国农业科学院农业资源与农业区划研究所/农业部植物营养与养分循环重点开放实验室北京100081 名古屋大学生命农学研究科

利用特定根盒装土,培养4个水稻品种(MADHUKAR、IR8192-200、IR26、IR8192-31)植株,用钉板法结合透明塑料膜固定获得近似原位根系样品,扫描得到根系的二维平面图像,以分形理论为基础,利用盒维数法结合根系图像分形分析程序计算根系构型... 详细信息

利用特定根盒装土,培养4个水稻品种(MADHUKAR、IR8192-200、IR26、IR8192-31)植株,用钉板法结合透明塑料膜固定获得近似原位根系样品,扫描得到根系的二维平面图像,以分形理论为基础,利用盒维数法结合根系图像分形分析程序计算根系构型的分形维数和分形丰度,比较各品种根系的形态特征,并对分形参数、根系长度和植株锌含量间的相关关系做了初步探讨。结果表明,根系分形维数和分形丰度以MADHUKAR最大,IR8192-200最小,说明MADHUKAR根系分支多,在土壤中拓展体积大。分形维数、分形丰度与根系总长度之间均呈明显正相关,而且根系总长度与分形丰度相关系数高于与分形维数的相关系数。分形维数和分形丰度与植株地上部干重、单位Zn浓度所产出的地上部生物量、地上部Zn吸收总量之间均呈显著正相关,与地上部Zn浓度呈负相关。水稻根系形态和构型的变化影响植株生长,影响植株Zn吸收积累及体内Zn的利用效率。盒维数法分形分析模型可用于研究水稻根系形态和构型,为其提供新方法。

关键词：分形根系水稻锌

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