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Remnant neuromuscular junctions in denervated muscles contribute to functional recovery in delayed peripheral nerve repair

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Neural Regeneration Research 2020年第4期15卷 731-738页

作者： Leyang Li Hiroyuki Yokoyama Hidetoshi Kaburagi Takashi Hirai Kunikazu Tsuji Mitsuhiro Enomoto yoshiaki wakabayashi Atsushi Okawa Department of Orthopedic and Spinal Surgery Graduate SchoolTokyo Medical and Dental UniversityTokyoJapan Department of Cartilage Regeneration Tokyo Medical and Dental UniversityTokyoJapan

Schwann cell proliferation in peripheral nerve injury(PNI)enhances axonal regeneration compared to central nerve ***,even in PNI,long-term nerve damage without repair induces degeneration of neuromuscular junctions(NMJs),and muscle atrophy results in irreversible *** peripheral regeneration of motor axons depends on the duration of skeletal muscle *** overcome this difficulty in nerve regeneration,detailed mechanisms should be determined for not only Schwann cells but also NMJ degeneration after PNI and regeneration after nerve ***,we examined motor axon denervation in the tibialis anterior muscle after peroneal nerve transection in thy1-YFP mice and regeneration with nerve reconstruction using *** number of NMJs in the tibialis anterior muscle was maintained up to 4 weeks and then decreased at 6 weeks after *** contrast,the number of Schwann cells showed a stepwise decline and then reached a plateau at 6 weeks after *** regeneration,we reconstructed the degenerated nerve with an allograft at 4 and 6 weeks after injury,and evaluated functional and histological outcomes for 10 to 12 weeks after grafting.A higher number of pretzel-shaped NMJs in the tibialis anterior muscle and better functional recovery were observed in mice with a 4-week delay in surgery than in those with a 6-week *** repair within 4 weeks after PNI is necessary for successful recovery in *** of synaptic acetylcholine receptor degeneration may play a key role in peripheral nerve *** animal experiments were approved by the Institutional Animal Care and Use Committee of Tokyo Medical and Dental University on 5 July 2017,30 March 2018,and 15 May 2019(A2017-311C,A2018-297A,and A2019-248A),respectively.

关键词： axon nerve allograft nerve regeneration neurodegeneration neuromuscular junction peripheral nerve injury Schwann cell skeletal muscle

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Surgical Repair of Dorsal Capsulo-Ligamentous Complex for Dislocation of the Thumb Carpometacarpal Joint

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Open Journal of Orthopedics 2019年第8期9卷 145-151页

作者： Haruhiko Shimura Tetsuya Sato Akimoto Nimura yoshiaki wakabayashi Koji Fujita Department of Orthopedic Surgery Tokyo Bay Urayasu Ichikawa Medical Center Chiba Japan Department of Orthopedic Surgery Doai Memorial Hospital Tokyo Japan Department of Functional Joint Anatomy Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University Tokyo Japan Department of Orthopedic Surgery Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University Tokyo Japan

Background: Acute dislocation of the thumb carpometacarpal (CMC) joint is a rare and challenging injury, and its treatment remains controversial. The purpose of the study was to evaluate the clinical outcome after surgical repair of the dorsal capsulo-ligamentous complex. Materials and methods: Eight patients with a mean age of 39.8 years (range, 23 - 56 years) treated for the thumb CMC joint were treated in our hospital between 2008 and 2018. The ruptured dorsal capsulo-ligamentous complex was repaired using suture anchors in all patients, and the joint was immobilized with a Kirschner wire pinning and splint for 3 weeks. The clinical outcome was assessed by measuring the range of motion of the thumb CMC joint and the Japanese Society for Surgery of the Hand version of the Quick Disability of the Arm, Shoulder, and Hand (Q-DASH-JSSH) score. Results: The mean radial abduction of the thumb CMC joint was 66°, and the volar abduction was 63°. The mean Q-DASH-JSSH score was 4.8 (range, 0 - 15.6). There were no cases of infection, nerve disturbance, or osteoarthritis. Anatomical reduction was observed in seven patients at the final follow-up and in a rugby football player at 6 months of follow-up;however, subluxation of the thumb CMC joint at 12 months of follow-up due to reinjury was observed. Conclusion: Surgical repair of the dorsal capsulo-ligamentous complex with suture anchors is a reliable and simple treatment for acute unstable dislocation of the thumb CMC joint.

关键词： Thumb Carpometacarpal Joint Dislocation Dorsal Capsulo-Ligamentous Complex Surgical Repair Suture Anchors

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First quarter century of laparoscopic liver resection

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World Journal of Gastroenterology 2017年第20期23卷 3581-3588页

作者： Zenichi Morise Go wakabayashi Department of Surgery Fujita Health University School of Medicine Department of Surgery Center for Advanced Treatment of HBP DiseasesAgeo Central General Hospital

The beginnings of laparoscopic liver resection(LLR)were at the start of the 1990s,with the initial reports being published in 1991 and *** were followed by reports of left lateral sectionectomy in *** the years following,the procedures of LLR were expanded to hemi-hepatectomy,sectionectomy,segmentectomy and partial resection of posterosuperior segments,as well as the parenchymal preserving limited anatomical resection and modified anatomical(extended and/or combining limited)resection *** expanded range of LLR procedures,mimicking the expansion of open liver resection in the past,was related to advances in both technology(instrumentation)and technical skill with conceptual *** this period of remarkable development,two international consensus conferences were held(2008 in Louisville,KY,United States,and 2014 in Morioka,Japan),providing up-to-date summarizations of the status and perspective of *** advantages of LLR have become clear,and include reduced intraoperative bleeding,shorter hospital stay,and-especially for cirrhotic patients-lower incidence of complications(e.g.,postoperative ascites and liver failure).In this paper,we review and discuss the developments of LLR in operative procedures(extent and style of liver resections)during the first quarter century since its inception,from the aspect of relationships with technological/technical developments with conceptual changes.

关键词： Hepatectomy Laparoscopic surgery Liver cancer History Technology Technique Concept Approach Posture Simulation

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Flat friction stir spot welding of low carbon steel by double side adjustable tools

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Journal of Materials Science & Technology 2021年第7期66卷 1-9页

作者： Xiaopei Wang yoshiaki Morisada Hidetoshi Fujii Joining and Welding Research Institute Osaka University11-1 MihogaokaIbarakiOsaka 567-0047Japan

2 mm low carbon steel plates were successfully welded by the flat friction stir spot welding(FSSW) using double side adjustable tools, by which the keyhole formed in the conventional FSSW was eliminated and a flat surface on both the top and bottom sides of the welded joints was obtained. In addition, the hook shape usually generated in the conventional FSSW was eliminated by this technique, and the unbonded interface was parallel to the surface of the sheets. Owing to the enlarged bonded interface width by eliminating the keyhole and the intermixed interface by the adjustable probe, the plug fracture occurred under all the welding conditions in the present study. Due to the suppression of the thickness thinning and elimination of the hook shape, the joint performance was improved in the plug fracture mode. The shear tensile performance was considered to strongly depend on the microstructure in the tip area of the unbonded interface and the maximum shear fracture load of 23.0 kN was achieved in this study.

关键词： Friction stir spot welding Interface structure Low carbon steel Mechanical properties Microstructure

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Interface strengthening in dissimilar double-sided friction stir spot welding of AZ31/ZK60 magnesium alloys by adjustable probes

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Journal of Materials Science & Technology 2021年第26期85卷 158-168页

作者： Xiaopei Wang yoshiaki Morisada Hidetoshi Fujii Joining and Welding Research Institute Osaka University11-1 MihogaokaIbarakiOsaka 567-0047Japan

Dissimilar welding of AZ31/ZK60 magnesium alloys with a thickness of 2 mm was successfully carried out by the double-sided friction stir spot welding with adjustable probes.A dissimilar joint bearing flat surfaces on both sides without a keyhole was obtained and the shear failure load of 8.7±0.5 kN was *** role of the adjustable probes has been revealed in *** the center of the stir zone,the welding interface structure was heterogeneous around which some distinct oxides still remained,leading to a weak interface *** the contrary,the welding interface structure around the shoulder/probe interface was homogeneous with no oxides giving rise to a strong interface strength,which is attributed to the severe material flow introduced by the adjustable *** addition,the vicinity outside the shoulder/probe interface,where the fracture occurred during the shear tensile tests,was also strengthened owing to the shearing and torsion by the adju stable ***,a stable plug failure can be obtained and the joint properties can be improved.

关键词： Friction stir spot welding Dissimilar welding Interface strengthening Microstructure Magnesium alloys

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Integrating the effect of abutments in estimating the average vertical stress of elastic hard rock pillars by combining numerical modelling and artificial neural networks

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Underground Space 2023年第6期13卷 121-135页

作者： Nevaid Dzimunya yoshiaki Fujii Youhei Kawamura Faculty of Engineering Hokkaido UniversitySapporo N13W8Japan

Estimating average vertical pillar stresses is a critical step in designing room-and-pillar *** analytical methods can be used to estimate the vertical stresses acting on the ***,the present analytical methods fail to adequately account for the influence of abutments on the distribution of vertical stresses,especially when applied to narrow panel widths and pillar layouts comprising evenly spaced *** this study,a multi-layer perceptron neural network(MLPNN)was applied to predict the vertical loads of regular pillars more *** of room-and-pillar mine layouts were modeled using a displacement discontinuity method(DDM),and a database of 2355 sampled pillar cases was *** MLPNN was trained based on this database,and its prediction capabilities were further validated using simulations by a finite difference code(i.e.,FLAC3D).The model predictions and the FLAC3D simulations reasonably agreed with a regression coefficient of *** model was also adapted for mine cases with evenly spaced barrier pillars,and its application to a real case study mine has shown to provide accurate pillar stress estimations;hence,this model is suitable for practical use at *** though the MLPNN model cannot be applied universally to all mine situations,it seems as a significant improvement over existing analytical techniques in terms of accounting for the influence of abutments on pillar stresses.

关键词： Pillar stress Abutments Multi-layer perceptron neural network Numerical simulation Room-and-pillar mine

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A new algorithm based on metaheuristics for data clustering

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第12期11卷 921-926页

作者： Tsutomu SHOHDOHJI Fumihiko YANO yoshiaki TOYODA Department of Computer and Information Engineering Faculty of EngineeringNippon Institute of Technology Division of Integrated Sciences J.F.Oberlin University Aoyama Gakuin University

This paper presents a new algorithm for clustering a large amount of *** improved the ant colony clustering algorithm that uses an ant’s swarm intelligence,and tried to overcome the weakness of the classical cluster analysis *** our proposed algorithm,improvements in the efficiency of an agent operation were achieved,and a new function "cluster condensation" was *** proposed algorithm is a processing method by which a cluster size is reduced by uniting similar objects and incorporating them into the cluster *** with classical cluster analysis methods,the number of steps required to complete the clustering can be suppressed to 1% or less by performing this procedure,and the dispersion of the result can also be ***,our clustering algorithm has the advantage of being possible even in a small-field cluster *** addition,the number of objects that exist in the field decreases because the cluster condenses;therefore,it becomes possible to add an object to a space that has become *** other words,first,the majority of data is put on *** are then clustered,gradually adding parts of the standby data to the clustering *** method can be adopted for a large amount of *** experiments confirmed that our proposed algorithm can theoretically applied to an unrestricted volume of data.

关键词： Metaheuristics Ant colony clustering Data clustering Swarm intelligence

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Dysfunction of axonal transport in normal-tension glaucoma:a biomarker of disease progression and a potential therapeutic target

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Neural Regeneration Research 2021年第3期16卷 506-507页

作者： Kazuyuki Hirooka Tohru Yamamoto yoshiaki Kiuchi Department of Ophthalmology and Visual Science Graduate School of Biomedical SciencesHiroshima UniversityHiroshimaJapan Department of Molecular Neurobiology Kagawa University Faculty of MedicineKagawaJapan

Glaucoma and dysfunction of axonal transport:One of the leading causes of irreversible blindness worldwide is glaucoma,with increased intraocula r pressu re(IOP)being the most common risk ***,in some glaucoma patients it has been shown that the IOP does not differ from that of the normal *** Japan,normal-tension glaucoma(NTG),which accounts for 92%of primary open-angle glaucoma,has been shown to be more frequent in the population.

关键词： glaucoma axonal transport

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Preoperative blood circulation modification prior to pancreaticoduodenectomy in patients with celiac trunk occlusion:Two case reports

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World Journal of Gastrointestinal Surgery 2022年第11期14卷 1310-1319页

作者： Marco Colella Kohei Mishima Taiga wakabayashi Yoshiki Fujiyama Malek A Al-Omari Go wakabayashi Center for Advanced Treatment of HBP Diseases Ageo Central General HospitalAgeo 362-8588SaitamaJapan

BACKGROUND Celiac trunk stenosis or occlusion is a common condition observed in patients undergoing pancreaticoduodenectomy(PD).The risk of upper abdominal organ ischemia or failure increases if the blood circulation in the celiac arterial system is not maintained after the *** SUMMARY We present two cases of elderly patients with distal cholangiocarcinoma and celiac trunk occlusion who underwent *** performed blood circulation modification preoperatively with transcatheter coil embolization of the arterial arcades of the pancreatic head via the superior mesenteric artery to develop collateral communication between the superior mesenteric artery and the common hepatic or splenic arteries to ensure arterial blood flow to the upper abdominal *** postoperative course was marked by delayed gastric emptying,but no major surgical complications,such as biliary or pancreatic fistula,or clinical,biochemical,or radiological evidence of ischemic disease,was *** Preoperative blood circulation modification may be a valid alternative procedure for elderly patients with celiac trunk occlusion who are ineligible for interventional or surgical revascularization.

关键词： Preoperative blood circulation modification Cholangiocarcinoma Pancreaticoduodenectomy Whipple procedure Celiac trunk occlusion Atherosclerosis Transcatheter coil embolization Case report

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Effect of Ca addition on the microstructure and the mechanical properties of asymmetric double-sided friction stir welded AZ61 magnesium alloy

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Journal of Magnesium and Alloys 2020年第1期8卷 91-102页

作者： Mengran Zhou yoshiaki Morisada Hidetoshi Fujii Joining and Welding Research Institute(JWRI) Osaka UniversityJapan

The effects of 2%Ca addition on the microstructure and the mechanical properties of the asymmetric double-sided friction stir welded magnesium alloy AZ61 were *** to the Ca-free AZ61magnesium alloy,the addition of 2%Ca significantly refines the grains in the stir zone after *** to the existence of thermally stable Al2Ca particles,there is no noticeable change in the grain size in the stir zone regardless of the welding heat *** electron backscattered diffraction analysis at the center of the stir zone confirmed the significant deterioration of the(0001)texture strength from the addition of 2%*** tensile test of the joint suggested that the addition of 2%Ca provides stable tensile properties to the joint regardless of the welding *** critical(0001)texture strength that determines the ultimate tensile strength decreased from 20 to 15 by the Ca *** addition of Ca enhanced the deterioration of the plastic elongation when the(0001)texture strength increased.

关键词： Mg alloy Friction stir welding Microstructure Mechanical properties Texture

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