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International Journal of Communications, Network and System Sciences 2015年第9期8卷 342-357页

作者： Yuya Minami Yuya Kitaura Yuri Tsutsui Eitaro Kohno Shinji Inoue Tomoyuki Ohta yoshiaki kakuda Graduate School of Information Sciences Hiroshima City University Hiroshima Japan

Dual-purpose systems for both normal and disaster situations are necessary for providing continuous services from normal situations to disaster situations. We have been developing the dual-purposed systems based on the assurance network design principle. The assurance network design principle makes the dual-purpose systems work stably in both normal and disaster situations. This paper proposes a connectivity-dependent data propagation scheme, in which each terminal transfers data adaptively by wireless multi-hop data transfer or store-and-forward data transfer depending on whether the terminal has connections to its neighboring terminals. To verify the resilience against disconnection among neighboring terminals, we show field experimental results on data propagation time. Also we propose the dual-purpose system, in which there are two types of graphical user interface (GUI) for both situations. Whenever each terminal receives a special packet in disaster situations, the GUI automatically switches from one type for normal situations to another type for disaster situations. We have unified these two types of GUI so that users can understand how to use them even when GUI is automatically switched. To validate feasibility of the dual-purpose normal and disaster situations system, we show experimental results on dissemination of assessment information and automatical switching of GUIs.

关键词： Android Bluetooth MANET GUI Dual-Purpose System Data Propagation Wireless Multi-Hop Data Transfer Epidemic Routing

Nonlinear Activation Functions in CNN Based on Fluid Dynamics and Its Applications

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Computer Modeling in Engineering & Sciences 2019年第1期118卷 1-14页

作者： Kazuhiko kakuda Tomoyuki Enomoto Shinichiro Miura Department of Mathematical Information Engineering College of Industrial TechnologyNihon UniversityChiba 275-8575Japan Department of Liberal Arts and Basic Sciences College of Industrial TechnologyNihon UniversityChiba

The nonlinear activation functions in the deep CNN(Convolutional Neural Network)based on fluid dynamics are *** propose two types of activation functions by applying the so-called parametric softsign to the negative *** use significantly the well-known TensorFlow as the deep learning *** CNN architecture consists of three convolutional layers with the max-pooling and one fullyconnected softmax *** CNN approaches are applied to three benchmark datasets,namely,MNIST,CIFAR-10,and *** results demonstrate the workability and the validity of the present approach through comparison with other numerical performances.

关键词： Deep learning CNN activation function fluid dynamics MNIST CIFAR-10 CIFAR-100.

Clinicopathological study of primary biliary cirrhosis with interface hepatitis compared to autoimmune hepatitis

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World Journal of Gastroenterology 2014年第13期20卷 3597-3608页

作者： Mio Kobayashi Yuko kakuda Kenichi Harada Yasunori Sato Motoko Sasaki Hiroko Ikeda Mitsuhiro Terada Munenori Mukai Shuichi Kaneko Yasuni Nakanuma Department of Human Pathology Kanazawa University Graduate School of MedicineKanazawa 920-8640Japan Division of Pathology Kanazawa University HospitalKanazawa 920-8641Japan Department of Gastroenterology Kouseiren Takaoka HospitalTakaoka 933-8555Japan Department of Pathology Kouseiren Takaoka HospitalTakaoka 933-8555Japan Department of Gastroenterology Kanazawa University Graduate School of MedicineKanazawa 920-8640 Japan

AIM:To investigate histological and immunohistochemical differences in hepatitis between autoimmune hepatitis(AIH)and primary biliary cirrhosis(PBC)with AIH ***:Liver needle biopsies of 41 PBC with AIH features and 43 AIH patients were *** activity of periportal and lobular inflammation was scored0(none or minimal activity)to 4(severe),and the degree of hepatitic rosette formation and emperipolesis was semiquantatively scored *** infiltration of mononuclear cells positive for CD20,CD38,CD3,CD4,and CD8 and positive for immunoglobulins(IgG,IgM,and IgA)at the periportal areas(interface hepatitis)and in the hepatic lobules(lobular hepatitis)were semiquantitatively scored in immunostained liver sections(score 0-6).Serum aspartate aminotransferase(AST),immunoglobulins,and autoantibodies at the time of liver biopsy were correlated with the histological and immunohistochemical scores of individual ***:Lobular hepatitis,hepatitic rosette formation,and emperipolesis were more extensive and frequent in AIH than in ***3+,CD4+,and CD8+cell infiltration scores were higher in the hepatic lobules and at the interface in AIH but were also found in *** degree of mononuclear cell infiltration correlated well with the degree of interface and lobular hepatitis in PBC,but to a lesser degree in ***20+cells were mainly found in the portal tracts and,occasionally,at the interface in both *** AST correlated well with the hepatocyte necroinflammation and mononuclear cell infiltration,specifically CD38+cells in *** correlation existed between autoantibodies and inflammatory cell infiltration in PBC or *** most AIH cases were IgG-predominant at the interface,PBC cases were divided into IgM-predominant,IgM/IgGequal,and IgG-predominant types,with the latter sharing several features with ***:These results suggest that the hepatocellular injuries associated with interface and lobular hepatitis in AIH and PBC with inte

关键词： Primary biliary cirrhosis Autoimmune hepa-titis Interface hepatitis Lobular hepatitis Plasma cell subclass

Therapeutic Application of High-Frequency rTMS Combined with Intensive Occupational Therapy for Pediatric Stroke Patients with Upper Limb Hemiparesis: A Case Series Study

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Journal of Behavioral and Brain Science 2013年第2期3卷 188-193页

作者： Masachika Niimi Wataru kakuda Toru Takekawa Ryo Momosaki Takatoshi Hara Hiroshi Ito Yumi Kameda Masahiro Abo Department of Rehabilitation Medicine The Jikei University School of Medicine Tokyo Japan

Low-frequency repetitive transcranial magnetic stimulation (LF-rTMS) applied to the non-lesional hemisphere is reported to significantly improve motor function of the affected upper limb in adult stroke patients with hemiparesis. For pediatric stroke patients, the beneficial effects of LF-rTMS have been already confirmed in a randomized controlled study. However, there is no report of therapeutic application of high-frequency rTMS (HF-rTMS) in this patient population. In this case series study, we introduced HF-rTMS combined with intensive occupational therapy (OT) in two pediatric hemiparetic patients. We studied two children (8- and 9-year-old boys, both right-handed) with post-stroke upper limb hemiparesis (chronic phase). Both patients underwent 22 treatment sessions of HF-rTMS/OT during 15-day hospitalization. The HF-rTMS was applied over the lesional motor cortex at a frequency of 10Hz for 15 minutes in each session. One session of intensive OT consisted of 30-min one-to-one training and 30-min self-exercise. Motor function of the affected upper limb was serially evaluated with Fugl-Meyer Assessment (FMA), Wolf Motor Function Test (WMFT), Simple Test for Evaluating hand Function (STEF), and Ten-second Test. Neither of the patients showed any adverse effects. Both patients showed improvement of motor function in the affected upper limb and were able to use the affected upper limb in some activities of daily living. In the two post-stroke pediatric patients, HF-rTMS/OT was safe and improved upper limb muscle function. Confirmation of these effects in a larger population is needed.

关键词： Pediatric Stroke Repetitive Transcranial Magnetic Stimulation Occupational Therapy Upper Limb Hemiparesis Motor Recovery

DEVELOPMENT OF A BIDENTATE LIGAND BASED ON DECAFLUORO-3-PHENYL-3-PENTANOL:STERIC EFFECT OF PENTAFLUOROETHYL GROUPS ON THE STEREOMUTATION OF OEQUATORIAL C-APICAL SPIROPHOSPHORANES

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DEVELOPMENT OF A BIDENTATE LIGAND BASED ON DECAFLUORO-3-PHEN...

第17届国际磷化学大会

作者： Y.Yamamoto K.I.kakuda S.Matsukawa H.Yamamichi Department of Chemistry Graduate School of ScienceHiroshima University 1-3-1 KagamiyamaHigashi-hiroshima 739-8526Japan Department of Chemistry Graduate School of ScienceHiroshima University 1-3-1 KagamiyamaHigashi-hiroshima 739-8526Japan Institute for Advanced Materials Research Hiroshima University 1-3-1 KagamiyamaHigashi-hiroshima 739-8530Japan Department of Chemistry Graduate School of ScienceHiroshima University 1-3-1 KagamiyamaHigashi-hiroshima 739-8526Japan

＜正＞1,1,1,2,2,4,4,5,5,5-Decafluoro-3-phenyl-3-pentanol （1） was prepared from pentafluoro -propiophenone via the Cannizzaro-type disproportionation reaction.1 Dimetallated 1 （i.e., 2） was

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施硅对稻田土壤氮矿化的影响(英文)

浙江农业学报 2001年第3期13卷 133-140页

作者：符建荣 Ho Ando Kenichi kakuda 浙江省农业科学院土壤肥料研究所浙江杭州310021 日本山形大学农学部生物生产系

供试土壤分别采自日本山形县农业试验场 (土壤A)和鹤冈市吉田农户的水稻田 (土壤B)。将两种水稻土分别与硅酸钙和硅酸混合 ,在密闭条件下恒温培养 4周 ,测定施硅对土壤氮矿化的影响。在培养土壤中加入15N标记硫酸铵以评价施硅对加入土... 详细信息

供试土壤分别采自日本山形县农业试验场 (土壤A)和鹤冈市吉田农户的水稻田 (土壤B)。将两种水稻土分别与硅酸钙和硅酸混合 ,在密闭条件下恒温培养 4周 ,测定施硅对土壤氮矿化的影响。在培养土壤中加入15N标记硫酸铵以评价施硅对加入土壤中氮去向的影响。结果表明 :在培养 1周内 ,施用硅酸钙 1g·kg- 1,2g·kg- 1与不施硅相比 ,土壤pH增加 0 .2～ 0 .3,NH4 + N总积累量分别增加 2 0 % ,2 6% (土壤A)和 9% ,11% (土壤B) ,土壤氮净矿化速率分别增加 2 6% ,35%(土壤A)和 13% ,13% (土壤B)。处理间差异在培养开始后的第 1周大于第 4周。硅酸对土壤pH及氮矿化速率没有影响。两种硅肥对施入土壤中氮的去向均无明显影响。研究结果揭示 ,硅酸钙促进土壤氮矿化的原因不是硅元素本身。

关键词：硅肥水稻土壤氮矿化

New combination test for hepatitis C virus genotype and viral load determination using Amplicor GT HCV MONITOR test v2.0

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World Journal of Gastroenterology 2005年第4期11卷 469-475页

作者： Motokazu Mukaide Yasuhito Tanaka Hirokazu kakuda Kei Fujiwara Fuat Kurbanov Eturo Orito Kentaro Yoshioka Kiyotaka Fujise Shoji Harada Takazumi Kozaki Kazuo Takemura Kazumasa Hikiji Masashi Mizokami SRL Inc. 5-6-50ShinmachiHino-shiTokyo 191-0002Japan Department of Clinical Molecular Informative Medicine Nagoya City University Graduate School of Medical Sciences KawasumiMizuhoNagoya 467-8601Japan Department of Internal Medicine and Molecular Science Nagoya City University Graduate School of Medical Sciences KawasumiMizuhoNagoya 467-8601Japan Department of Clinical Molecular Informative Medicine Nagoya City University Graduate School of Medical Sciences KawasumiMizuhoNagoya 467-8601 Japan Third Department of Internal Medicine Nagoya University School of Medicine65 TsurumaShowaNagoya 466-8550Japan Division of Gastroenterology and Hepatology Department of Internal Medicine (Kashiwa) The Jikei University School of Medicine163-1KashiwashitaKashiwaChiba 277-8567Japan SRL Inc. 5-6-50ShinmachiHmo-shiTokyo 191-0002Japan

AIM: To develop a new sensitive and inexpensive hepatitis C virus (HCV) combination test (HCV Guideline test) that enables the determination of HCV genotypes 1, 2 and 3, and simultaneous determination of HCV viral load using commercial Amplicor GT HOV MONITOR test v2.0 (microwell version). METHODS: The HCV Guideline test used the PCR product generated in commercial Amplicor GT HCV Monitor test v2.0 for viral load measurement using microwell plate version of Amplicor HCV Monitor and also captured on separate plates containing capture probes and competitive oligonucleotide probes specific for HCV genotypes 1, 2 and 3, The HCV genotype was subsequently determined using the biotin-labeled PCR product and five biotin-labeled HCV-specific probes. RESULTS: The sensitivity of the HCV Guideline test was 0.5 KIU/mL. Specificity of the HCV Guideline test was confirmed by direct sequencing of HCV core region and molecular evolutionary analyses based on a panel of 31 samples. The comparison of the HCV Guideline test and an in-house HCV core genotyping assay using 252 samples from chronic hepatitis C patients indicated concordant results for 97.2% of samples (59.5% genotype 1, 33.7% genotype 2, 6.0% genotype 3, and 0.8% mixed genotypes). Similarly, the HCV Guideline test showed concordance with a serological test, and the serological test failed to assign any serotype in 12.7% of the samples, indicating a better sensitivity of the HCV Guideline test. CONCLUSION: Clinically, both viral load and genotypes (1, 2 and 3) have been found to be major predictors of antiviral therapy outcome regarding chronic hepatitis C based on guidelines and they are, in normal circumstances, performed as separate stand-alone assays. The HCV Guideline test is a useful method for screening large cohorts in a routine clinical setting for determining the treatment regimen and for predicting the outcome of antiviral therapy of chronic hepatitis C.

关键词： Hepatitis CVirus HCV Guideline test Viral Load Genotype

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从神权天皇制到象征天皇制的法社会学研究

太平洋学报 2008年第7期16卷 46-58页

作者： [日] 角田猛之牛牪(译) 日本关西大学法学部西南政法大学法学院

宪法之下的天皇制虽然已经从战前的神权天皇制转换为现在的象征天皇制,但象征天皇制之下的天皇所具有的"神格"与"人格"的冲突,以及由此产生的对日本宪政的解释中的民族主义和自由主义的冲突,依然对现今的日本政治与社会及其未来的发展... 详细信息

宪法之下的天皇制虽然已经从战前的神权天皇制转换为现在的象征天皇制,但象征天皇制之下的天皇所具有的"神格"与"人格"的冲突,以及由此产生的对日本宪政的解释中的民族主义和自由主义的冲突,依然对现今的日本政治与社会及其未来的发展方向产生重大影响。天皇制对日本社会而言是一种仪式性、宗教性要素,由此不断地酝酿、强化历史地形成的民族性的国民意识。

关键词：天皇制宪政文化国家仪式

中国内蒙自治区马饲育环境土壤中马红球菌的分布(英文)

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中国兽医学报 2008年第1期28卷 40-44页

作者：丁壮 Shinji TAKAI Hiroo MADARAME 常爽黄海楠霍晓伟高明华谭忠田高双成 Fumiko HATORI Yukako SASAKI Tsutomu kakuda Shiro TSUBAKI 吉林大学畜牧兽医学院吉林长春130062 北里大学兽医畜产学部兽医卫生学教研室日本十和田034-8628 麻布大学兽医学部附属动物医院日本神奈川1-17-71 内蒙古民族大学动物科技学院内蒙古通辽028000 扎兰屯农牧学校内蒙古满洲里021400 满洲里市兽医站内蒙古满洲里021400 陈旗兽医站内蒙古呼伦贝尔市021500

对中国内蒙古自治区饲育马土壤环境中马红球菌的分布知之甚少;为此,在中国内蒙古通辽近郊、内蒙古南部锡林郭勒盟大草原、内蒙古东部呼伦贝尔大草原等马场共收集了108份土壤样品进行了马红球菌的检测。结果,锡林郭勒盟大草原和呼伦贝尔... 详细信息

对中国内蒙古自治区饲育马土壤环境中马红球菌的分布知之甚少;为此,在中国内蒙古通辽近郊、内蒙古南部锡林郭勒盟大草原、内蒙古东部呼伦贝尔大草原等马场共收集了108份土壤样品进行了马红球菌的检测。结果,锡林郭勒盟大草原和呼伦贝尔大草原的马红球菌分离率为25.9%～30.0%,通辽近郊土壤中分离率高达82.3%。这说明在通辽近郊马红球菌的分离菌数是草原土壤中马红球菌分离菌数的10倍。应用PCR技术检测了488株的毒力相关基因,相对分子质量分别为15000～17000(VapA)和20000(VapB)。所有的分离株都未检出毒力相关基因。这些无毒力分离株的质粒资料显示,各种大小的潜在质粒的发生率为13.3%～21.5%。本研究结果截然不同于我们新近对蒙古国的调查结论:马红球菌在蒙古国乌兰巴托的马群中不存在。造成这一差异的原因可能在于蒙古国的游牧生活和内蒙古的非游牧生活。

关键词：马红球菌内蒙古饲育马土壤

几种新型有机肥对菜用毛豆产量、品质及化肥氮利用率的影响

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浙江大学学报（农业与生命科学版） 2008年第3期34卷 289-295页

作者：叶静安藤丰符建荣佐佐木由佳角田宪一浙江省农业科学院环境资源与土壤肥料研究所浙江杭州310021 日本山形大学农学部日本鹤冈997-8555

通过田间试验研究4种有机废弃物中的KEON(KCl可提取态氮)和PEON(磷酸缓冲液可提取态氮)2种形态的有机氮对菜用毛豆生长及化肥氮利用率的影响.结果表明:施用鸡粪和豆粕混合肥与单施化肥相比,地上部分干物质重分别提高20·4%和33·2%,籽... 详细信息

通过田间试验研究4种有机废弃物中的KEON(KCl可提取态氮)和PEON(磷酸缓冲液可提取态氮)2种形态的有机氮对菜用毛豆生长及化肥氮利用率的影响.结果表明:施用鸡粪和豆粕混合肥与单施化肥相比,地上部分干物质重分别提高20·4%和33·2%,籽粒中的蛋白质含量分别提高17·8%和16·2%,达到显著差异水平;与单施化肥相比,毛豆产量分别提高38·0%和32·5%.有机肥中的KEON和PEON与化学氮肥利用率呈正相关,其相关系数分别达到0·88和0·87(P<0·05).与单施化肥相比,施用鸡粪和豆粕混合肥的当季化学氮肥利用率可分别提高94·9%和67·4%.

关键词：菜用毛豆有机肥 ^15N同位素氮肥利用率