检索结果-南通市图书馆

Pharmacological Evidence for the Involvement of Calcium Entry through TRPV1 Channels in Nifedipine-Induced [Ca<sup>2+</sup>]i Elevation in Gingival Fibroblasts

引用

Pharmacology & Pharmacy 2012年第4期3卷 427-432页

作者： Toshimi Hattori Toshiaki Ara yoshiaki fujinami Department of Dental Pharmacology Matsumoto Dental University 1780 Hirooka-Gohbara Shiojiri Japan.

Background: Among anti-hypertension drugs, calcium (Ca2+) antagonists cause gingival overgrowth as a side effect. We previously discovered that this side effect was due to elevation of the calcium concentration in the cytosol ([Ca2+]i). Ca2+ entry through non-selective cation channels (NSCCs) and Ca2+ release from intracellular Ca2+ stores are involved in this [Ca2+]i elevation. Furthermore, we discovered that calcium-sensing receptors (CaSRs) participate in nifedipine-induced [Ca2+]i elevation. Transient receptor potential (TRP) channels have been identified as NSCCs. In the present study, we undertook experiments to determine if TRPV1 channels are present in gingival fibroblasts and to ascertain if nifedipine-activated NSCCs are TRPV1 channels. Methods Normal human gingival fibroblast Gin-1 cells were used. The [Ca2+]i was measured using a video-imaging analysis system with the Ca2+-sensitive fluorescent dye fura-2/AM. Results: The NSCC inhibitor SKF96365 significantly inhibited nifedipine-induced [Ca2+]i elevation. TRPV1 channel agonists such as capsaicin, olvanil and resiniferatoxin concentration-dependently elevated the [Ca2+]i. The TRPV1 channel activator anandamide concentration-dependently increased the [Ca2+]i. The TRPV1 channel antagonists capsazepine, AMG9810, iodoresiniferatoxin, ruthenium red, and SB366791 significantly inhibited nifedipine-induced [Ca2+]i elevation. Conclusion: These results suggest that Ca2+ entry through TRPV1 channels is involved in the nifedipine-induced [Ca2+]i elevation seen in gingival fibroblasts. We describe here a modified version of our ‘calcium trigger theory’.

关键词： Nifedipine Gingival Overgrowth Gingival Fibroblast TRPV1 Channel

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

STRUCTURE AND DYNAMICS OF POLYMERIC MATERIALS IN NANO-SCALE

引用

Chinese Journal of Polymer Science 2011年第1期29卷 43-52页

作者： Toshio Nishi So fujinami Ken Nakajima WPI Advanced Institute for Materials Research Tohoku University

The nano-palpation technique, i.e., nanometer-scale elastic and viscoelastic measurements based on atomic force microscope, is introduced. It is demonstrated to be very useful in analyzing nanometer-scale materials properties for the surfaces and interfaces of various types of soft materials. It enables us to obtain not only structural information but also mechanical information about a material at the same place and at the same time.

关键词： Nano-palpation Atomic force microscope Soft material Young's modulus Viscoelasticity.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Velocity Measurement of Induced Flow by a Laser Focusing Shock Wave

引用

Journal of Thermal Science 2006年第1期15卷 48-53,26页

作者： Hiroyuki HIRAHARA Masaru fujinami Masaaki KAWAHASHI Department of Mechanical Engineering Saitama University 255 Shimo-Okubo Sakura Saitama 338-8570Japan. Graduate School of Science and Engineering Saitama University Japan

The objective of this study is to apply the shock wave for control in a micro channel. The shock wave was generated by a laser focusing of pulsed laser beam in the channel. Using a pulse laser to generate a shock wave, a non-stationary flow was induced in the small space between the parallel plates. The spherical and cylindrical shock propagations were observed with schlieren method. The shock Mach number decreases with time and approaches to unity. As reported in the previous investigations, the shock speed was attenuated in a short distance and time. In the present experiment, It was not found a remarkable difference in the shock speed between the spherical and cylindrical shock experiments. Subsequently, the flow induced by the cylindrical shock wave was studied using PIV technique. A smoke tracer was used in the experiment and its velocity was measured within 100 μs. A numerical simulation was carried out to investigate the momentum relaxation between the gas and smoke particle. A suitable shock initiation model was introduced in the simulation. The experimental results show that a wide acceleration and deceleration zone exist behind the shock wave. Also, the relaxation distance in the experimental data is much longer than that in numerical simulation.

关键词： micro-blast wave laser focusing flow visualization PIV.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

NANOMECHANICAL MAPPING OF CARBON BLACK REINFORCED NATURAL RUBBER BY ATOMIC FORCE MICROSCOPY

引用

Chinese Journal of Polymer Science 2007年第1期25卷 35-41页

作者： Toshio Nishi Hideyuki Nukaga So fujinami Ken Nakajima Department of Organic and Polymeric Materials Graduate School of Science and EngineeringTokyo Institute of Technology2-12-1 O-okayamaMeguro-kuTokyo 152-8552Japan

Atomic force microscopy （AFM） has the advantage of obtaining mechanical properties as well as topographic information at the same time. By analyzing force-distance curves measured over two-dimensional area using Hertzian contact mechanics, Young＇s modulus mapping was obtained with nanometer-scale resolution. Furthermore, the sample deformation by the force exerted was also estimated from the force-distance curve analyses. We could thus reconstruct a real topographic image by incorporating apparent topographic image with deformation image. We applied this method to carbon black reinforced natural rubber to obtain Young＇s modulus distribution image together with reconstructed real topographic image. Then we were able to recognize three regions; rubber matrix, carbon black （or bound rubber） and intermediate regions. Though the existence of these regions had been investigated by pulsed nuclear magnetic resonance, this paper would be the first to report on the quantitative evaluation of the interfacial region in real space.

关键词： AFM, Natural rubber Carbon black Young's modulus Force-distance curve.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

RECENT PROGRESS OF NANO-MECHANICAL MAPPING

引用

Chinese Journal of Polymer Science 2009年第1期27卷 37-47页

作者： Toshio Nishi Sae Nagai So fujinami Ken Nakajima WPI Advanced Institute for Materials Research Tohoku University 2-I-1KatahiraAoba-kuSendaiMiyagi 980-8577Japan

Nano-mechanical mapping by atomic force microscopy has been developed as an useful application to measure mechanical properties of soft materials at nanometer *** date,the Hertzian theory was used for analyzing force- distance curves as the simplest model among several contact mechanics between elastic ***,the preexisting methods based on this theory do not consider the adhesive interaction in principle,which cannot be neglected in the ambient condition.A new analytical method was introduced...

关键词： Atomic force microscopy Nano-mechanical mapping Force-distance curve JKR theory

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Retinal imaging in inherited retinal diseases

引用

Annals of Eye Science 2020年第3期5卷 30-49页

作者： Michalis Georgiou Kaoru fujinami Michel Michaelides UCL Institute of Ophthalmology University College LondonLondonUK Moorfields Eye Hospital NHS Foundation Trust LondonUK Laboratory of Visual Physiology Division of Vision ResearchNational Institute of Sensory OrgansNational Hospital Organization Tokyo Medical CenterTokyoJapan

Inherited retinal diseases(IRD)are a leading cause of blindness in the working age *** advances in ocular genetics,retinal imaging and molecular biology,have conspired to create the ideal environment for establishing treatments for IRD,with the first approved gene therapy and the commencement of multiple therapy *** scope of this review is to familiarize clinicians and scientists with the current landscape of retinal imaging in *** we present in a comprehensive and concise manner the imaging findings of:(I)macular dystrophies(MD)[Stargardt disease(ABCA4),X-linked retinoschisis(RS1),Best disease(BEST1),pattern dystrophy(PRPH2),Sorsby fundus dystrophy(TIMP3),and autosomal dominant drusen(EFEMP1)],(II)cone and cone-rod dystrophies(GUCA1A,PRPH2,ABCA4 and RPGR),(III)cone dysfunction syndromes[achromatopsia(CNGA3,CNGB3,PDE6C,PDE6H,GNAT2,ATF6],blue-cone monochromatism(OPN1LW/OPN1MW array),oligocone trichromacy,bradyopsia(RGS9/R9AP)and Bornholm eye disease(OPN1LW/OPN1MW),(IV)Leber congenital amaurosis(GUCY2D,CEP290,CRB1,RDH12,RPE65,TULP1,AIPL1 and NMNAT1),(V)rod-cone dystrophies[retinitis pigmentosa,enhanced S-Cone syndrome(NR2E3),Bietti crystalline corneoretinal dystrophy(CYP4V2)],(VI)rod dysfunction syndromes(congenital stationary night blindness,fundus albipunctatus(RDH5),Oguchi disease(SAG,GRK1),and(VII)chorioretinal dystrophies[choroideremia(CHM),gyrate atrophy(OAT)].

关键词： Retinal imaging inherited retinal disease retinitis pigmentosa macular dystrophy leber congenital amaurosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Focus on using nanopore technology for societal health,environmental,and energy challenges

引用

Nano Research 2022年第11期15卷 9906-9920页

作者： Izadora Mayumi fujinami Tanimoto Benjamin Cressiot Sandra J.Greive Bruno Le Pioufle Laurent Bacri Juan Pelta LAMBE CNRSUniv EvryUniversitéParis-Saclay91025Evry-CourcouronnesFrance LuMIn CNRSInstitut d'AlembertENS Paris-SaclayUniversitéParis-Saclay91190Gif-sur-YvetteFrance LAMBE CNRSCY Cergy Paris Université95000CergyFrance DreamPore S.A.S. 33 Boulevard du Port 95000CergyFrance

With an increasing global population that is rapidly ageing,our society faces challenges that impact health,environment,and energy *** this ageing comes an accumulation of cellular changes that lead to the development of diseases and susceptibility to *** impacts not only the health system,but also the global *** the population increases,so does the demand for energy and the emission of pollutants,leading to a progressive degradation of our *** in turn impacts health through reduced access to arable land,clean water,and breathable *** monitoring approaches to assist in environmental control and minimize the impact on health are urgently needed,leading to the development of new sensor technologies that are highly sensitive,rapid,and *** sensing is a new technology that helps to meet this purpose,with the potential to provide rapid point-of-care medical diagnosis,real-time on-site pollutant monitoring systems to manage environmental health,as well as integrated sensors to increase the efficiency and storage capacity of renewable energy *** this review we discuss how the powerful approach of nanopore based single-molecule,or particle,electrical promises to overcome existing and emerging societal challenges,providing new opportunities and tools for personalized medicine,localized environmental monitoring,and improved energy production and storage systems.

关键词： electric sensor nanoparticles environment biomarkers energy storage

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Characterization of Surface Mechanical Properties of Block Copolymers Using Atomic Force Microscopy

Characterization of Surface Mechanical Properties of Block C...

引用

2011年全国高分子学术论文报告会

作者： So fujinami Ken NAKAJIMA Toshio NISHI WPI Advanced Institute for Materials Research Tohoku University

＜正＞Using AFM related techniques including nanomechanical mapping and dynamic AFM, we have investigated the surface mechanical properties of poly（styrene-b-ethylene-co-butylene-b-styrene）（SEBS） triblock copolymer.

关键词： AFM nanomechanical mapping morphology mechanical properties

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Visualization of nano-mechanical mapping of MWCNTs/natural rubber nanocomposites by AFM force measurement

Visualization of nano-mechanical mapping of MWCNTs/natural r...

引用

2009年全国高分子学术论文报告会

作者： So fujinami Ken NAKAJIMA Toshio NISHI WPI Advanced Institute for Materials Research Tohoku University2-1-1KatahiraAoba-kuSendai 980-8577 Japan

＜正＞Nano-mechanical mapping was visualized by atomic force microscopy force *** obtained the topological and mechanical properties at the same point and the same *** theory was successful used to analyze the force-distance *** materials Young’s modulus distribution and adhesive energy distribution were obtained with high lateral *** images roughly have inverse relationship,but not *** means that material properties of different origin were separately visualized by this measurement.

关键词： nano-mechanical mapping AFM force measurement

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Influence of Intermolecular Hydrogen Bonding to Spin Crossover Property of Iron （111） Complexes with a N3O2 Pentadentate Ligand and a Monodentate Ligand

引用

Journal of Chemistry and Chemical Engineering 2013年第4期7卷 285-291页

作者： Keishiro Murakami Masataka Koike Takeshi fujinami Naohide Matsumoto Yukinari Sunatsuki Graduate School of Science and Technology Kumamoto University Kumamoto 860-8555 Japan Department of Chemistry Faculty of Science Okayama University Okayama 700-8530 Japan

Three iron （III） complexes with the formula of [Feat（X）L2]BPh4 were studied, in which a pentadentate Schiff-base ligand （H2L2 = bis （3-methoxysalicylideneiminopropyl） methylamine） and a counter anion BPh4 were fixed, and three monodentate ligands, 3-Mepy （3-methylpyridine）, 4-NH2py （4-aminopyridine）, and 2-Meim （2-methylimidazole） were used as the axial ligand X. The temperature dependence of magnetic susceptibility measurements demonstrated that [Fem（3-Mepy）L2]BPh4 showed a gradual spin equilibrium between HS （high-spin）（S = 5/2） and LS （low-spin）（S = 1/2） states, [Fem（4-NH2py）L2]BPh4 showed a steep SCO （spin crossover） and [FeIH（2-Melm）L2]BPh4 was in the HS state even at 100 K. The single crystal X-ray analyses demonstrated that [FelH（4-NH2py）L2]BPh4 has an one-dimensional chain structure constructed by intermolecular hydrogen bonding between 4-amino group of 4-NH2py and methoxy oxygen of adjacent molecular-cation. The crystal structure of [FenI（3-Mepy）L2]BPh4 has no such intermolecular interaction and its SCO site behaves independently, and the crystal structure of [FeIII（2-Meim）L2]BPh4 has a NH...n interaction between imidazole group of 2-Meim of cation and a phenyl group of anion BPh4. The result demonstrates that the intermolecular hydrogen bonding affects SCO profile significantly.

关键词： Spin crossover Fe Oil) complex intermolecular hydrogen bonding pentadentate ligand.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：