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Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El baba Ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Christian Mustroph David Gimbel Jonathan Grossberg Daniel L.Barrow Matthew F.Gary Ali M.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

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THE M/PH/1 QUEUE WITH WORKING VACATIONS AND VACATION INTERRUPTION

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Journal of Systems Science and Systems Engineering 2010年第4期19卷 496-503页

作者： Yutaka baba Faculty of Education and Human Sciences Yokohama National University

We study an M/PH/1 queue with phase type working vacation and vacation interruption where the vacation time follows a phase type distribution. The server serves the customers at a lower rate in a vacation period. The server comes back to the regular busy period at a service completion without completing the vacation. Such policy is called vacation interruption. In terms of quasi birth and death process and matrix-geometric solution method, we obtain the stationary queue length distribution. Moreover we obtain the conditional stochastic decomposition structures of queue length and waiting time when the service time distribution in the regular busy period is exponential.

关键词： Working vacation vacation interruption phase type distribution quasi birth and death process matrix-geometric solution stochastic decomposition

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Comparative analysis of the dissolution kinetics of galena in binary solutions of HCl/FeCl_3 and HCl/H_2O_2

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International Journal of Minerals,Metallurgy and Materials 2011年第1期18卷 9-17页

作者： Alafara A.baba Folahan A.Adekola Department of Chemistry University of Ilorin

A comparative study of the dissolution kinetics of galena ore in binary solutions of FeCl3/HCl and H2O2/HCl has been *** dissolution kinetics of the galena was found to depend on leachant concentration,reaction temperature,stirring speed,solid-to-liquid ratio,and particle *** dissolution rate of galena ore increases with the increase of leachant concentration,reaction temperature,and stirring speed,while it decreases with the increase of solid-to-liquid ratio and particle *** activation energy （Ea） of 26.5 kJ/mol was obtained for galena ore dissolution in 0.3 M FeCl3 /8.06 M HCl,and it suggests the surface diffusion model for the leaching reaction,while the Ea value of 40.6 kJ/mol was obtained for its dissolution in 8.06 M H2O2 /8.06 M HCl,which suggests the surface chemical reaction model for the leaching ***,the linear relationship between rate constants and the reciprocal of particle radius supports the fact that dissolution is controlled by the surface reaction in the two ***,the rate of reaction based on the reaction-controlled process has been described by a semiempirical mathematical *** Arrhenius and reaction constants of 11.023 s^-1,1.25×10^-4 and 3.65×10^2 s^-1,8.02×10^ 6 were calculated for the 0.3 M FeCl3/8.06 M HCl and 8.06 M H2O2/8.06 M HCl binary solutions,respectively.

关键词： galena hydrochloric acid chloride compounds hydrogen peroxide dissolution leaching

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Awareness as the Most Effective Measure to Mitigate the Spread of COVID-19 in Nigeria

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Computers, Materials & Continua 2020年第12期65卷 1945-1957页

作者： Isa Abdullahi baba Dumitru Baleanu Department of Mathematical Sciences Bayero UniversityKanoNigeria Department of Mathematics Cankaya UniversityAnkaraTurkey Institute of Space Sciences BucharestRomania

A mathematical model consisting of a system of four nonlinear ordinary differential equations is *** aim is to study the dynamics of the spread of COVID-19 in Nigeria and to show the effectiveness of awareness and the need for relevant authorities to engage themselves more in enlightening people on the significance of the available control measures in mitigating the spread of the *** equilibrium solutions;Disease free equilibrium and Endemic equilibrium solutions were calculated and their global stability analysis was carried *** reproduction ratio(R0)was also obtained,in this research𝑅𝑅0=*** obtained for Nigeria is used to conduct numerical simulations in order to support the analytic result and to show the significance of awareness in controlling the disease *** the simulation result,it was shown that to mitigate the spread of COVID-19 in Nigeria there is need for serious awareness programs to enlighten people on the available control measures;social distancing,self-isolation,use of personal protective equipment(such as face mask,hand globes,overall gown,etc.),regular hand washing using soap or sanitizer,avoiding having contact with person showing the symptoms and reporting any suspected case.

关键词： COVID-19 model equilibrium solution basic reproduction ratio stability analysis numerical simulation Nigeria

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Neoadjuvant treatment for esophageal squamous cell carcinoma

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World Journal of Gastrointestinal Oncology 2014年第5期6卷 121-128页

作者： yoshifumi baba Masayuki Watanabe Naoya yoshida Hideo baba Department of Gastroenterological Surgery Graduate School of Medical Science Kumamoto University Department of Gastroenterological Surgery Cancer Institute Hospital Japanese Foundation for Cancer Research

Squamous cell carcinoma and adenocarcinoma are types of esophageal cancer, one of the most aggressive malignant diseases. Since both histological types present entirely different diseases with different epidemiology, pathogenesis and tumor biology, separate therapeutic strategies should be developed against each type. While surgical resection remains the dominant therapeutic intervention for patients with operable esophageal squamous cell carcinoma(ESCC), alternative strategies are actively sought to reduce the frequency of post-operative local or distant disease recurrence. Such strategies are particularly sought in the preoperative setting. Currently, the optimal management of resectable ESCC differs widely between Western and Asian countries(such as Japan). While Western countries focus on neoadjuvant or definitive chemoradiotherapy, neoadjuvant chemotherapy followed by surgery is the standard treatment in Japan. Importantly, each country and region has established its own therapeutic strategy from the results of local randomized control trials. This review discusses the current knowledge, available data and information regarding neoadjuvant treatment for operable ESCC.

关键词： Esophageal cancer Squamous cell carcinoma Neoadjuvant therapy

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Dissolution kinetics of kaolin mineral in acidic media for predicting optimal condition for alum production

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Journal of Central South University 2017年第2期24卷 318-324页

作者： Folahan A.ADEKOLA Alafara A.baba Sadisu GIRIGISU Department of Industrial Chemistry University of Ilorin

The dissolution kinetics and mechanisms of reaction of Batagbon Kaolin in sulphuric and fluosilicic acids were studied. Leaching temperature, acid concentration, particle size, solid-to-liquid ratio, and stirring speed were selected as process parameters. It is observed that the dissolution rate increases with decreasing particle size and solid-to-liquid ratio, and increases with stirring speed, acid concentration, and leaching temperature. The experimental results indicate that the dissolution rate is of mixed control via hydrogen ion [H＋] action, with reaction order of 0.813 and the reaction kinetics can be expressed as gmt=[1-（1-x）l/3＋y/6[（l-x）l/3＋ 1-2（1-x）2/3]. The activation energy of the process is determined to be 21.6 k J/mol. The level of the product quality is also evaluated.

关键词： kaolin alum sulphuric and fluosilicic acid leaching kinetic model mixed control

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A systematic literature review to explore sustainable energy development practices in Mozambique

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Clean Energy 2023年第6期7卷 1330-1343页

作者： Samuel Aires Master Lazaro Vanessa Fathia baba College of Civil Engineering Taiyuan University of TechnologyNo.79 West Street YingzeTaiyuan 030024ShanxiPR China College of Economics&Management Taiyuan University of TechnologyNo.79 West Street YingzeTaiyuan 030024ShanxiPR China

This study thoroughly evaluates sustainable energy practices in Mozambique,identifies suitable activities and suggests future re-search *** authors meticulously detail the research tasks undertaken to achieve the primary objective of the study,including organizing articles by publication year,journal and conference papers;identifying the most frequently cited articles;and recognizing countries that have made significant contributions to the concept of sustainable *** study highlights the most relevant sustainable energy development practices for Mozambique,identifies suitable activities and suggests future research *** rigorous analysis,six significant areas of sustainable energy development were identified,including renewable energy(RE)resources,environmental science,social sciences,computer science,management and accounting,and Earth and planetary *** study used Scopus as the selected multidisciplinary peer-reviewed citation database on 20 February 2023,resulting in 76 *** study has been conducted nationwide for several months and thoroughly investigates various resources such as hydro,wind,solar,biomass and geothermal *** achieves this by evaluating and characterizing the power generation potential of each RE resource and,in addition,identifying and examining numerous projects at the technical and economic feasibility level to promote the potential of projects and the advantages of RE for the sustainable development of *** findings indicate that for sustainable energy development in Mozambique,it is crucial to introduce more policies to support the effectiveness of RE systems while involving the private *** achieve this,measures such as reducing investment risks,guaranteeing investment returns and establishing a transparent regulatory framework are *** steps will attract substantial investments,resolve conflicts and motivate key stakeholders to actively participate in the p

关键词： developing countries Mozambique sustainable development renewable energy systematic literature review Scopus

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Selective extraction of In(Ⅲ),Ga(Ⅲ) and Zn(Ⅱ) using a novel extractant with phenylphosphinic acid

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Chinese Journal of Chemical Engineering 2016年第2期24卷 232-236页

作者： Yuji Sasaki Naoki Matsuo Tatsuya Oshima yosh.nari baba Department of Applied Chemistry Faculty of EngineeringUniversity of Miyazaki

A new extractant, [N,N-di（2-ethylhexyl）aminolmethylphenylphosphinic acid （DEAPP）, was synthesized to de- velop the mutual separation techniques of In（Ⅲ）, Ga（Ⅲ） and Zn（Ⅱ）. The extraction selectivity for In（Ⅲ）, Ga（Ⅲ） and Zn（Ⅱ） with DEAPP was higher than that of the commercial phosphorus acid extractants such as D2EHPA and PC-88A. The extraction selectivity for metal ions in 1 mob L 1 aqueous ammonium nitrate solution with DEAPP was in the following order： In（Ⅲ）〉 Ga（Ⅲ）〉 Zn（Ⅱ）. These selective extraction behaviors indicate that the amino moiety of DEAPP plays an important role in the mutual separation of ln（Ⅲ）, Ga（Ⅲ） and Zn（ll）. The extraction equilibria of In（Ⅲ）, Ga（Ⅲ） and Zn（Ⅱ） with DEAPP （ = HR） were expressed by the following reactions： In3＋＋ 2（HR）2 InR3（HR）＋ 3H＋, Ga3＋＋ 1.5（HR）2 ＋ N- = GaR2（HR）（NO3）＋ 2H＋, and Zn2＋ 4- 2（HR）2 ZnR2 （HR） 2 determined 4- 2H＋. The extraction equilibrium constants of In（Ⅲ）, Ga（Ⅲ） and Zn（Ⅱ） with DEAPP were to be Kex, M = 1.7 × 104 [*** 1], 4.17 [（***-1）s], and 1.55 × 10 2 [-], respectively.

关键词： Liquid-liquid extraction Phosphinic acid Indium(Ⅲ) Gallium(Ⅲ) Zinc(Ⅱ) Mutual separation Extraction equilibrium

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A hydrophobic peptide fraction that enhances the water dispersibility of curcumin

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Asian Journal of Pharmaceutical Sciences 2016年第5期11卷 631-640页

作者： Risa Yamashita Tatsuya Oshima yosh.nari baba Department of Applied Chemistry Faculty of EngineeringUniversity of Miyazaki

The present study describes the complexation between curcumin(Cur) and a peptide mixture(Pep). Pep was prepared by enzymatic hydrolysis of casein and used as an excipient for poorly water-soluble Cur. An aqueous solution of Pep and an acetone solution of Cur were mixed and lyophilized to obtain a white-yellow powder of the peptide and Cur complex(CurPep). The water dispersibility of Cur was enhanced by the complexation with Pep. Pep was fractionated using ammonium sulfate precipitation and ultrafiltration to identify which peptides preferentially interact with Cur. Relatively hydrophobic peptides with high molecular weights(>5 k Da) were more effective in enhancing the water dispersibility of Cur than other fractions. Cur-Pep dispersed under acidic and neutral conditions, at which amphoteric Pep is positively or negatively charged. Cur-Pep exists as a hydrocolloid with particle size 160–330 nm in aqueous media.

关键词： Curcumin Peptide Dispersibility Complexation Hydrocolloid

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Experiment and simulation of turbulent flow in local scour around a spur dyke

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International Journal of Sediment Research 2009年第1期24卷 33-45页

作者： Hajime NAKAGAWA Kenji KAWAIKE Yasuyuki baba Disaster Prevention Research Institute Kyoto University

The turbulent flow in the local scour hole around a single non-submerged spur dyke is investigated with both experimental and numerical methods. The experiments are conducted under clear-water scour regime with an impermeable spur dyke. The scour geometry and flow velocities are measured in details with a high-resolution laser displacement meter,electro-magnetic velocimetries and PIV(Particle image velocimetry). A 3D non-linear k-ε model is developed to simulate the complex local flow field around the scour area. The numerical model is formulated using FVM(Finite volume method) on a collocated unstructured mesh,capable of resolving complex geometries and boundaries. It is found that the simulation results are reasonably consistent with those of the experimental measurements. Based on the study results,the nature of the flow structure around a spur dyke with local scour hole is analyzed.

关键词： Spur dyke Local scour 3D flow Non-linear k-ε model Unstructured mesh

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