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Learning to predict single-wall carbon nanotube-recognition DNA sequences

npj Computational Materials 2019年第1期5卷 1085-1091页

作者： yoona yang Ming Zheng Anand Jagota Department of Chemical&Biomolecular Engineering Lehigh UniversityBethlehemPA 18015USA Materials Science and Engineering Division National Institute of Standards and TechnologyGaithersburgMD 20899USA Department of Bioengineering Lehigh UniversityBethlehemPA 18015USA

DNA/single-wall carbon nanotube(SWCNT)hybrids have enabled many applications because of their special ability to disperse and sort SWCNTs by their chirality and *** work has been done to discover sequences which recognize specific chiralities of SWCNT,and significant progress has been made in understanding the underlying structure and thermodynamics of these ***,de novo prediction of recognition sequences remains essentially impossible and the success rate for their discovery by search of the vast single-stranded DNA library is very ***,we report an effective way of predicting recognition sequences based on machine learning analysis of existing experimental sequence data *** input feature construction methods(position-specific,term-frequency,combined or segmented term frequency vector,and motif-based feature)were used and *** transformed features were used to train several classifier algorithms(logistic regression,support vector machine,and artificial neural network).Trained models were used to predict new sets of recognition sequences,and consensus among a number of models was used successfully to counteract the limited size of the data *** were tested using aqueous two-phase *** data thus acquired were used to retrain the models by adding an experimentally tested new set of predicted sequences to the original *** frequency of finding correct recognition sequences by the trained model increased to>50% from the~10% success rate in the original training data set.

关键词： carbon recognition thermodynamics

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Anti-inflammatory Effects of Ampelopsis Japonica Root on Contact Dermatitis in Mice

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Chinese Journal of Integrative Medicine 2022年第8期28卷 719-724页

作者： yoona Oh Hongbum Lee Beodeul yang Sura Kim Hyunwoo Jeong Hyungwoo Kim Division of Pharmacology School of Korean MedicinePusan National UniversityGyeongnam50612South Korea Department of Pathology College of Korean MedicineDongshin UniversityJeonnam58245South Korea

Objective:To investigate the anti-inflammatory potential of Ampelopsis japonica on contact dermatitis(CD).Methods:A total of 38 Balb/c mice were divided into 5 groups by using a random number table:normal mice(n=6),CID model mice(n=8),CD mice treated with 3 or 30 mg/kg of the ethanol extract of ***(EEAJ,n=8)and 7.5 mg/kg dexamethasone treated CD mice(DEX,n=8).CD was induced using topical application of 1-fluoro-2,4-dinitrofluorobenzene in *** and DEX were topically applied to the shaved skin of each mouse for 6 days,and the effects of EEAJ and DEX on skin lesions and color,histopathological abnormalities such as epidermal hyperplasia and immune cell infiltration,and tumor necrosis factor(TNF)-α,interleukin-6(IL-6),and monocyte chemoattractant protein-1(MCP-1)production were *** effects on changes in body weights and spleen/body weight ratio were also ***:EEAJ at 30 mg/kg significantly prevented scaling,erythema and enlargement of skin weight compared to using carbon *** also prevented epithelial hyperplasia and immune cell infiltrations induced by repeated application of DNFB(P<0.01).In addition,EEAJ significantly lowered levels of TNF-α,IL-6 and MCP-1(P<0.05 or P<0.01).The anti-inflammatory effects of EEAJ were similar to those of ***:*** may be a new therapeutic agent with the potential to reduce or replace corticosteroids and its mechanisms are closely related to regulation of TNF-α production.

关键词： Ampelopsis japonica Chinese medicine inflammation dermatosis contact dermatitis

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4-Hydroxycinnamic acid attenuates neuronal cell death by inducing expression of plasma membrane redox enzymes and improving mitochondrial functions

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Food Science and Human Wellness 2023年第4期12卷 1287-1299页

作者： Sujin Park yoona Kim Jaewang Lee Hyunsoo Seo Sang-Jip Nam Dong-Gyu Jo Dong-Hoon Hyun Department of Life Science Ewha Womans UniversitySeoul 03760South Korea Department of Chemistry and Nano Science Ewha Womans UniversitySeoul 03760South Korea School of Pharmacy Sungkyunkwan UniversitySuwon 16419South Korea

Many approaches to neurodegenerative diseases that focus on amyloid-βclearance and gene therapy have not been *** therapeutic applications focus on enhancing neuronal cell survival during the pathogenesis of neurodegenerative diseases,including mitochondrial *** membrane(PM)redox enzymes are crucial in maintaining cellular physiology and redox homeostasis in response to mitochondrial *** phytochemicals are known to induce the expression of detoxifying enzymes under stress *** this study,mechanisms of neuroprotective effects of 4-hydroxycinnamic acid(HCA)were examined by analyzing cell survival,levels of abnormal proteins,and mitochondrial functions in two different neuronal *** protected two neuronal cells exhibited high expression of PM redox enzymes and the consequent increase in the NAD^(+)/NADH *** cultured with HCA showed delayed apoptosis and decreased oxidative/nitrative damage accompanied by decreased ROS production in the *** increased the mitochondrial complexes I and II activities and ATP ***,HCA increased mitochondrial fusion and decreased mitochondrial ***,HCA maintains redox homeostasis and energy metabolism under oxidative/metabolic stress *** findings suggest that HCA could be a promising therapeutic approach for neurodegenerative diseases.

关键词： NADH-quinone oxidoreductase 1(NQO1) Cytochrome b5 reductase 4-Hydroxycinnamic acid Neuroprotection Improved mitochondrial functions

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