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Cholecystectomy is independently associated with nonalcoholic fatty liver disease in an Asian population

World Journal of Gastroenterology 2015年第20期21卷 6287-6295页

作者： Min-Sun Kwak Donghee kim Goh Eun Chung Won kim yoon Jun kim Jung-Hwan yoon Department of Internal Medicine Healthcare Research InstituteHealthcare System Gangnam CenterSeoul National University Hospital Department of Internal Medicine Seoul Metropolitan Government Seoul National University Boramae Medical Center Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine

AIM: To investigate the relationship between gallstone disease and nonalcoholic fatty liver disease(NAFLD) in a large Asian population. METHODS: A cross-sectional study including 17612 subjects recruited from general health check-ups at the Seoul National University Hospital, Healthcare System Gangnam Center between January 2010 and December 2010 was conducted. NAFLD and gallstone disease were diagnosed based on typical ultrasonographic findings. Subjects who were positive for hepatitis B or C, or who had a history of heavy alcohol consumption(> 30 g/d for men and > 20 g/d for women) or another type of hepatitis were excluded. Gallstone disease was defined as either the presence of gallstones or previous cholecystectomy, and these two entities(gallstones and cholecystectomy) were analyzed separately. Clinical parameters including body mass index, waist circumference, hypertension, diabetes, smoking status, and regular physical activity were reviewed. Laboratory parameters, including serum levels of gamma-glutamyl transpeptidase, alanine aminotransferase, aspartate aminotransferase, fasting glucose, fasting insulin, total cholesterol, triglycerides, and high-density lipoprotein, were also ***: The mean age of the subjects was 48.5± 11.3 years, and 49.3% were male. Approximately 30.3% and 6.1% of the subjects had NAFLD and gallstone disease, respectively. The prevalence of gallstone disease(8.3% vs 5.1%, P < 0.001), including both the presence of gallstones(5.5% vs 3.4%, P < 0.001) and a history of cholecystectomy(2.8% vs 1.7%, P < 0.001), was significantly increased in the NAFLD group. In the same manner, the prevalence of NAFLD increased with the presence of gallstone disease(41.3% vs 29.6%, P < 0.001). Multivariate regression analysis showed that cholecystectomy was associated with NAFLD(OR = 1.35, 95%CI: 1.03-1.77, P = 0.028). However, gallstones were not associated with NAFLD(OR = 1.15, 95%CI: 0.95-1.39, P = 0.153). The independent association betwee

关键词： Fatty liver Hepatic steatosis Gallbladder Cholelithiasis Gallbladder removal

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Microscopic characteristics of the inferior tarsal muscle and its surroundings in Korean

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International Journal of Ophthalmology(English edition) 2013年第2期6卷 126-130页

作者： Jung Min Park Mee sook Roh Moo Hyun kim Woo Jin Jeung Won Yeol Ryu yoon Hyung Kwon Hee Bae Ahn Department of Ophthalmology Maryknoll Hospital Department of Pathology College of Medicine Dong-A University Department of Cardiology College of Medicine Dong-A University Department of Ophthalmology College of Medicine Dong-A University

AIM: To investigate the detailed microscopic anatomic structures of the lower eyelid in Korean cadavers. METHODS: Eight lower eyelids of 4 formalin-fixed Asian cadavers (4 males; age range, 48-69 years; mean age, 60.2 years) were examined. Three perpendicular dissected sections with a 2mm thickness were obtained from each eyelid to investigate anatomic shapes, size and relationship with surrounding structures. One section was obtained from the midline and 2 the other sections were obtained from a 3mm apart from the lateral and medial tarsus margins. RESULTS: The inferior tarsal muscle fibers were not directly attached to the tarsus but were only linked to the tarsus with enclosed fibrous fascia. The inferior tarsal muscles connected loosely with the capsulopalpebral fascia anteriorly and the conjunctiva posteriorly. The inferior tarsal muscle runs horizontally to the tarsus according to the shape of muscle fibers. The capsulopalpebral fascia consisted of an anterior and posterior layer. The anterior layer reached the orbital septum and subcutaneous fat but the posterior layer forwarded into the tarsus. Lockwood’s ligament was separated from the inferior tarsal muscle and capsulopalpebral fascia or fused into the capsulopalpebral ***: This study suggests that the inferior tarsal muscle which runs horizontally and doesn’t insert directly into the tarsus, plays an important role in the movement and localization of the lower eyelid.

关键词： capsulopalpebral fascia inferior tarsal muscle lower eyelid

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Mechanical characteristics of fused cast basalt tube encased in steel pipe for protecting steel surface

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中国有色金属学会会刊：英文版 2009年第4期19卷 935-940页

作者： Jee-Seok WANG Jong-Do kim Hee-Jong yoon Division of Mechanical and Information Engineering Korea Maritime University Division of Marine System Engineering Korea Maritime University Department of Research and Development Dongdo Basalt Industry Co.Ltd

Because of the various excellent characteristics of cast basalt materials,such as,anti-corrosion,anti-wearing,good hardness,high chemical stability,of which steel may not possess,the steel-basalt composite pipes are used in severe environments for compensating the defects of *** limit of bending moment with which steel-basalt composite pipe may safely endure was calculated and the limit curvature of the composite pipe in the safe range was *** application temperature of steel-basalt pipe was examined due to a different coefficient among basalt,mortar and mild steel.

关键词：玄武岩钢管表面保护机械特性包裹熔铸化学稳定性复合管

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Ion shielding functional separator using halloysite containing a negative functional moiety for stability improvement of Li–S batteries

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Journal of Energy Chemistry 2021年第9期30卷 334-340页

作者： Yong Min Kwon Jihoon kim Kuk Young Cho Sukeun yoon Division of Advanced Materials Engineering&Institute for Rare Metals Kongju National UniversityChungnam 31080Republic of Korea Department of Materials Science and Chemical Engineering Hanyang UniversityGyeonggi 15588Republic of Korea

Lithium–sulfur batteries are one of the attractive next-generation energy storage systems owing to theienvironmental friendliness,low cost,and high specific energy ***,the low electrical conductivity of sulfur,shuttling of soluble intermediate polysulfides between electrodes,and low capacitretention have hampered their commercial *** address these issues,we use a halloysitemodulated(H-M)separator in a lithium–sulfur battery to mitigate the shuttling *** H-M separator acts as a mutual Coulombic repulsion in lithium-sulfur batteries,thereby selectively permitting Lions and efficiently suppressing the transfer of undesired lithium polysulfides to the Li anode sideMoreover,the use of halloysite switches the surface of the separator from hydrophobic to hydrophilicconsequently improving the electrolyte wettability and adhesion between the separator and cathodeWhen sulfur-multi-walled carbon nanotube(S-MWCNT)composites are used as cathode active materialsa lithium–sulfur battery with an H-M separator exhibits first discharge and charge capacities of 1587 an1527 m Ah g-1,***,there is a consistent capacity retention up to 100 cyclesAccordingly,our approach demonstrates an economical and easily accessible strategy for commercialization of lithium–sulfur batteries.

关键词： Li–S batteries Halloysite Ion shielding Negative functional moiety Lithium polysulfides

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Cobalt phosphide nanoarrays with crystalline-amorphous hybrid phase for hydrogen production in universal-pH

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Nano Research 2020年第9期13卷 2469-2477页

作者： Hyunseok yoon Hee Jo Song Bobae Ju Dong-Wan kim School of Civil Environmental and Architectural EngineeringKorea UniversitySeoul 02841Republic of Korea

To accomplish mass hydrogen production by electrochemical water-splitting,it is a necessary to develop robust,highly active,stable,and cost-effective hydrogen evolution reaction(HER)electrocatalysts that perform comparably to Pt in the universal pH *** this work,cobalt phosphide hybrid nanosheets supported on carbon felt(CoP HNS/CF)are presented,which exhibit the superior electrocatalytic hydrogen production under a *** these nanosheets,a single CoP HNS is composed of polycrystalline CoP and oxygen-enriched amorphous Co-O-P *** from its unique nanoarchitecture,as-fabricated CoP HNS/CF exhibits a tremendous electrocatalytic HER activity and outperforms Pt/C as well as state-of-the-art CoP electrocatalysts in *** acidic and neutral media,the CoP HNS/CF shows superior electrocatalytic activity while maintaining its original hybrid crystalline-amorphous phase and *** alkaline medium,the unexpected phase and morphological reorganization of CoP HNS/CF results in outstanding electrocatalytic *** HNS/CF not only achieves high electrocatalytic activity and kinetics,but also a stable and long operating lifetime even under a high current density of 500 mA cm'***,the fabrication of CoP HNS/CF can be scaled up easily,and the large CoP HNS/CF electrode also exhibits similar electrocatalytic activity and stability.

关键词： cobalt phosphide self-supporting electrocatalyst hydrogen evolution reaction universal-ph large-scale

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Electrical characteristics and detailed interfacial structures of Ag/Ni metallization on polycrystalline thermoelectric SnSe

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Journal of Materials Science & Technology 2019年第5期35卷 711-718页

作者： Yeongseon kim Younghwan Jin Giwan yoon In Chung Hana yoon Chung-Yul Yoo Sang Hyun Park Separation and Conversion Materials Laboratory Korea Institute of Energy Research 152 Gajeong-ro Yuseong-gu Daejeon 34129 Republic of Korea School of Electrical Engineering Korea Advanced Institute of Science and Technology 291 Daehak-ro Yuseong-gu Daejeon 34142 Republic of Korea Department of Physics Chungnam National University 99 Daehak-ro Yuseong-gu Daejeon 34134 Republic of Korea School of Chemical and Biological Engineering Seoul National University 1 Gwanak-ro Gwanak-gu Seoul 08826 Republic of Korea

SnSe is a promising thermoelectric material with a high figure of merit in single crystal form, which has stimulated continuous research on polycrystalline SnSe. In this study, we investigated a metallization techniques for polycrystalline SnSe to achieve highly efficient and practical SnSe thermoelectric modules. The Ag/Ni metallization layers were formed on pristine polycrystalline SnSe using various deposition technique: sputter coating Ni, powder Niand foil Ni by spark plasma sintering. Structural analysis demonstrated that the microstructure and con tact resistance could be different according to the metallization process, despite using the same metals. The Ag/Ni metallization layer using foil Ni acted as an effective diffusion barrier and minimized electrical contact resistance (2.3×10^-4Ωcm^2). A power loss in the thermoelectric module of only 5% was demonstrated using finite element simulation.

关键词： Thermoelectric Metallization Electric contact material Interface microstructure SnSe

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Reactive Core-Shell Bottlebrush Copolymer as Highly Effective Additive for Epoxy Toughening

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Chinese Journal of Polymer Science 2021年第12期39卷 1626-1633页

作者： Junsoo Moon yoon Huh Seonghwan kim Youngson Choe Joona Bang Department of Chemical and Biological Engineering Korea UniversitySeoul 02841Republic of Korea Department of Chemical Engineering Pusan National UniversityPusan 46241Republic of Korea

Herein,we designed a core-shell structured bottlebrush copolymer(BBP),which is composed of rubbery poly(butyl acrylate)(PBA)core and an epoxy miscible/reactive poly(glycidyl methacrylate)(PGMA)shell,as an epoxy tougheni ng age *** PGMA shell allows BBP to be uniformly dispersed within the epoxy matrix and to react with the epoxy groups,while the rubbery PBA block simultaneously induced nanocavitation effect,leading to improvement of mechanical properties of the epoxy *** mechanical properties were measured by the adhesion performance test,and the tensile and fracture test using universal testing *** BBP additives were added to the epoxy resin,a sign ifica nt improveme nt in the adhesion stren gth(2-fold increase)and fracture toughness(2-fold in crease in Kic and 5-fold in crease in Gic)compared to the neat epoxy was *** contrast,linear additives exhibited a decrease in adhesion strength and no improvement of fracture toughness over the neat *** a difference in mechanical performance was investigated by comparing the morphologies and fracture surfaces of the epoxy resins containing linear and BBP additives,confirming that the nanocavitation effect and void formation play a key role in strengthening the BBP-modified epoxy resins.

关键词： Bottlebrush polymer ROMP Additive Adhesion Epoxy toughening

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Hepatitis B viral load affects prognosis of hepatocellular carcinoma

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World Journal of Gastroenterology 2014年第34期20卷 12039-12044页

作者： Su Jong Yu yoon Jun kim Department of Internal Medicine and Liver Research Institute Seoul National University College of MedicineSeoul 110-744South Korea

Hepatocellular carcinoma(HCC)is a complex disease that is dually challenging to treat due to underlying chronic liver disease in addition to the cancer *** prognosis of patients with HCC is determined by intrahepatic tumor status and reserved hepatic *** B virus(HBV)is an established major risk factor of HCC development,and HBV viral load is being increasingly recognized as a prognostic factor in the presence of established *** HBV viral load may affect the prognosis of HBV-related HCC patients in several ***,it is associated with more frequent recurrence of HBV-related HCC after ***,it is associated with more occurrence and severity of potentially life-threatening HBV ***,it is associated with more worsened liver function,which limits the therapeutic options for HBV-related ***,directly or indirectly,can induce *** patients with a high HBV DNA level and subsequent active hepatitis,adhesion molecules expressed on the sinusoidal cells are up-regulated and may increase intrahepatic *** progression after treatment can lead to a poor prognosis by reducing number of normal functioning ***,high HBV viral load can affect the prognosis of patientswith HCC by frequent recurrence after treatment for HCC and deterioration of hepatic function associated with HCC *** meta-analysis showed that antiviral treatment reduces HCC recurrence and liver-related mortality after curative therapy of *** the strong relationship between high HBV DNA load and poor survival outcome of HCC patients due to cancer progression,it is expected that long-term antiviral therapy results in the sustained HBV suppression,control of inflammation,reduction in HCC progression,and eventually in improved overall survival.

关键词： Hepatitis B virus DNA Hepatocellular carcinoma Progression Prognosis

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Recent applications of chemosensitivity tests for colorectal cancer treatment

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World Journal of Gastroenterology 2014年第44期20卷 16398-16408页

作者： Yong Sik yoon Jin Cheon kim Department of Surgery University of Ulsan College of Medicine Institute of Innovative Cancer Research and Asan Institute for Life Sciences Asan Medical Center

The evaluation of therapeutic efficacy is necessary to predict the outcome of patients with metastatic colorectal cancer(CRC). In these patients, there is a critical need for predictive chemosensitivity assays and biomarkers to optimize efficacy and minimize toxicity. The introduction of targeted agents has improved the progression-free survival and overall survival of patients with metastatic disease. However, approximately 50% of patients do not show a positive response to chemotherapy and the selection of patients likely to respond to a specific regimen remains challenging. Cell culturebased chemosensitivity tests use autologous viable tumor cells to evaluate susceptibility to specific agents in vitro and predict their direct effects. Adenosine triphosphate-based assays and methyl thiazolyl-diphenyltetrazolium bromide-based assays are used widely as sensitivity tests because of their short assay period, technical simplicity, and the requirement of small amount of specimen. Among protein- and gene-based chemosensitivity assays, assessment of KRAS mutation status predicts the response to epidermal growth factor receptor-targeted therapy in CRC patients. The validation of predictive and prognostic markers enables the selection of therapeutic regimens with optimal efficacy and minimal toxicity for each patient, which has been termed personalized treatment. This review summarizes currently available predictive and prognostic chemosensitivity tests for metastatic CRC.

关键词： Colorectal adenocarcinomas Colorectal cancer Chemotherapy In vitro assays Molecular targeted therapy Individualized therapy

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Anomaly Detection Using Data Rate of Change on Medical Data

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Computers, Materials & Continua 2024年第9期80卷 3903-3916页

作者： Kwang-Cheol Rim Young-Min yoon Sung-Uk kim Jeong-In kim AI Convergence Research Institute Chosun UniversityGwangju61452Republic of Korea Interdisciplinary Program of Architectural Studies Chonnam UniversityGwangju61186Republic of Korea AINTCHAIN SOFT Co. Ltd.Mokpo-si58750Republic of Korea BK21 Human Resources Development Project Group Chosun UniversityGwangju61452Republic of Korea

The identification and mitigation of anomaly data,characterized by deviations from normal patterns or singularities,stand as critical endeavors in modern technological landscapes,spanning domains such as Non-Fungible Tokens(NFTs),cyber-security,and the burgeoning *** paper presents a novel proposal aimed at refining anomaly detection methodologies,with a particular focus on continuous data *** essence of the proposed approach lies in analyzing the rate of change within such data streams,leveraging this dynamic aspect to discern anomalies with heightened precision and *** empirical evaluation,our method demonstrates a marked improvement over existing techniques,showcasing more nuanced and sophisticated result ***,we envision a trajectory of continuous research and development,wherein iterative refinement and supplementation will tailor our approach to various anomaly detection scenarios,ensuring adaptability and robustness in real-world applications.

关键词： Anomaly data anomaly detection medical anomaly data cyber security rate of change

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