检索结果-南通市图书馆

Modification strategies improving the electrochemical and structural stability of high-Ni cathode materials

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2024年第9期96卷 185-205页

作者： yoon Bo Sim Hami Lee Junyoung Mun Ki Jae kim Department of Energy Science Sungkyunkwan UniversitySuwon 16419Republic of Korea School of Advanced Materials Sciencend Engineering Sungkyunkwan UniversitySuwon 16419Republic of Korea SKKU Institute of Energy Sciencend Technology(SIEST) Sungkyunkwan UniversitySuwon 16419Republic of Korea

With the increasing spotlight in electric vehicles,there is a growing demand for high-energy-density batteries to enhance driving ***,several studies have been conducted on high-energy-density LiNi_(x)Co_(y)Mn_(z)O_(2)***,there is a limit to permanent performance deterioration because of side reactions caused by moisture in the atmosphere and continuous microcracks during cycling as the Ni content to express high energy increases and the content of Mn and Co that maintain structural and electrochemical stabilization *** direct modification of the surface and bulk regions aims to enhance the capacity and long-term performance of high-Ni cathode ***,an efficient modification requires a study based on a thorough understanding of the degradation mechanisms in the surface and bulk *** this review,a comprehensive analysis of various modifications,including doping,coating,concentration gradient,and single crystals,is conducted to solve degradation issues along with an analysis of the overall degradation mechanism occurring in high-Ni cathode *** also summarizes recent research developments related to the following modifications,aims to provide notable points and directions for post-studies,and provides valuable references for the commercialization of stable high-energy-density cathode materials.

关键词： High energy density High-Ni cathode materials Degradation Structural stability Lithium-ion battery

Synaptic a-Si:H/a-Ga_(2)O_(3)phototransistor inspired by the phototaxis behavior of organisms with all-optical and all-electrical stimulation modes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2024年第8期17卷 7631-7642页

作者： Youngbin yoon Youngki kim Soowon Choi Jungdae Kwon Myunghun Shin School of Electronics and Information Engineering Korea Aerospace UniversityGoyang10540Republic of Korea Nano Materials Division Korea Institute of Materials ScienceChangwon 51508Republic of Korea Department of Materials Science and Engineering Pusan National UniversityBusan 46241Republic of Korea

To improve neuromorphic computing performance,neuromorphic system components should mimic the behaviors of organic *** this study,a synaptic a-Si:H/a-Ga_(2)O_(3)phototransistor featuring all-optical and-electrical emulation is fabricated in a manner advantageous for complementary metal-oxide-semiconductor process *** phototransistor exhibits excitatory and inhibitory synaptic behaviors under stimulation by both optical and electrical *** mimics several essential synaptic functions,including excitatory postsynaptic current,inhibitory postsynaptic current,short-term memory,long-term memory,pairedpulse facilitation,and spike-timing-dependent *** optical and electrical modulation mechanisms are confirmed to arise from the a-Si:H/a-Ga_(2)O_(3)heterojunction structure and interface effects,and the device is shown to operate at low power in both optical and electrical *** all-optical weight modulation function is applied to the wavelength-differential behavior response of zebrafish,successfully mimicking the color perception process of the ***,to verify the translation of the optoelectrical-derived synaptic behaviors of the phototransistor into artificial neuromorphic computation,handwritten digit image recognition of the Modified National Institute of Standards and Technology dataset is performed by a convolutional neural network,with a demonstrated average learning accuracy of 98.46%.These findings verify the applicability of the synaptic a-Si:H/a-Ga_(2)O_(3)phototransistor in neuromorphic computing.

关键词： synaptic phototransistor artificial synapse phototaxis neuromorphic computing interface charge state optoelectronic synaptic device

Advances in Wireless,Batteryless,Implantable Electronics for Real‑Time,Continuous Physiological Monitoring

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano-Micro Letters 2024年第3期16卷 254-302页

作者： Hyeonseok kim Bruno Rigo Gabriella Wong yoon Jae Lee Woon‑Hong Yeo IEN Center for Wearable Intelligent Systems and Healthcare Georgia Institute of TechnologyAtlantaGA 30332USA George W.Woodruff School of Mechanical Engineering Georgia Institute of TechnologyAtlantaGA 30332USA School of Electrical and Computer Engineering Georgia Institute of TechnologyAtlantaGA 30332USA Wallace H.Coulter Department of Biomedical Engineering Georgia Tech and Emory University School of MedicineAtlantaGA 30332USA Parker H.Petit Institute for Bioengineering and Biosciences Institute for MaterialsInstitute for Robotics and Intelligent MachinesGeorgia Institute of TechnologyAtlantaGA 30332USA

This review summarizes recent progress in developing wireless,batteryless,fully implantable biomedical devices for real-time continuous physiological signal monitoring,focusing on advancing human health *** considerations,such as biological constraints,energy sourcing,and wireless communication,are discussed in achieving the desired performance of the devices and enhanced interface with human *** addition,we review the recent achievements in materials used for developing implantable systems,emphasizing their importance in achieving multi-functionalities,biocompatibility,and *** wireless,batteryless devices offer minimally invasive device insertion to the body,enabling portable health monitoring and advanced disease ***,we summarize the most recent practical applications of advanced implantable devices for human health care,highlighting their potential for immediate commercialization and clinical uses.

关键词： Implantable electronics Biomedical systems Batteryless devices Wireless electronics Physiological signal monitoring

Aralia elata inhibits neurodegeneration by downregulating O-GlcNAcylation of NF-κB in diabetic mice

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2017年第8期10卷 1203-1211页

作者： Seong-Jae kim Min-Jun kim Mee- Young Ckoi yoon-sook kim Ji-Myong Yoo Eun-Kyung Hong Sunmi Ju Wan-Sung Choi Department of Ophthalmology School of MedicineGyeongsang National University Jinju 52727 Korea Department of Anatomy and Convergence Medical Science School of Medicine Gyeongsang National University Jinju52727 Korea Institute of Health Science Gyeongsang National UniversityJinju 52727 Korea Medvill Co. Ltd. Seoul 08511 Korea Division of Pulmonology and Allergy Department ofInternal Medicine School of Medicine Gyeongsang NationalUniversity Jinju 52727 Korea

AIM： To investigate the role of O-GIcNAcylation of nuclear factor-kappa B （NF-KB） in retinal ganglion cell （RGC） death and analysedthe effect of Aralia elata （AE） on neurodegen- eration in diabetic mice. METHODS： C57BL/6mice with streptozotocin-induced diabetes were fed daily with AE extract or control （CTL） diet at the onset of diabetes mellitus （DM）. Two months af- tar injection of streptozotocin or saline, the degree of cell death and the expression of O-GIcNAc transferase （OGT）, N-acetyl-b-D-glucosaminidase （OGA）, O-GIcNAcylated pro- teins, and O-GIcNAcylation of NF-KB were examined. RESULTS： AE did not affect the metabolic status of diabetic mice. The decrease in the inner retinal thickness （P〈0.001 vs CTL, P〈0.01 vs DM） and increases in RGCs with terminal deoxynucleotidyl transferase-mediated dUTP nick end labelling （P〈0.001 vs CTL, P〈0.0001 vs DM）, glial activation, and active caspase-3 （P〈0.0001 vs CTL, P〈0.0001 vs DM） were blocked in diabetic retinas of AE extract-fed mice. Expression levels of protein O-GIcNAcylation and OGT were increased in diabetic retinas （P〈0.0001 vs CTL）, and the level of O-GIcNAcylation of the NF-KB p65 subunit was higher in diabetic retinas than in controls （P〈0.0001 vs CTL）. AE extract downregulated O-GIcNAcylation of NF-KB and prevented neurodegeneration induced by hyperglycemia （P〈0.0001 vs DM）. CONCLUSION： O-GIcNAcylation of NF-KB is concerned in neuronal degeneration and that AE prevents diabetes-in- duced RGC apoptosis via downregulation of NF-KB O-GI- cNAcylation. Hence, O-GIcNAcylation may be a new object for the treatment of DR, and AE may have therapeutic pos- sibility to prevent diabetes-induced neurodegeneration.

关键词： Aralia elata diabetic retinopathy neurode- generation nuclear factor-kappa B O-GlcNAc O-GlcNAc transferase mice

Computing Resource Allocation for Blockchain-Based Mobile Edge Computing

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computer Modeling in Engineering & Sciences 2024年第7期140卷 863-885页

作者： Wanbo Zhang Yuqi Fan Jun Zhang Xu Ding Jung yoon kim School of Computer Science and Information Engineering Intelligent Interconnected Systems Laboratory of Anhui ProvinceHefei University of TechnologyHefei230601China Anhui Province Key Lab of Aerospace Structural Parts Forming Technology and Equipment Hefei University of TechnologyHefei230009China College of Future Industry Gachon UniversitySeongnam13120South Korea

Users and edge servers are not fullymutually trusted inmobile edge computing(MEC),and hence blockchain can be introduced to provide *** blockchain-basedMEC,each edge server functions as a node in bothMEC and blockchain,processing users’tasks and then uploading the task related information to the *** is,each edge server runs both users’offloaded tasks and blockchain tasks *** that there is a trade-off between the resource allocation for MEC and blockchain ***,the allocation of the resources of edge servers to the blockchain and theMEC is crucial for the processing delay of blockchain-based *** of the existing research tackles the problem of resource allocation in either blockchain or MEC,which leads to unfavorable performance of the blockchain-based MEC *** this paper,we study how to allocate the computing resources of edge servers to the MEC and blockchain tasks with the aimtominimize the total systemprocessing *** the problem,we propose a computing resource Allocation algorithmfor Blockchain-based MEC(ABM)which utilizes the Slater’s condition,Karush-Kuhn-Tucker(KKT)conditions,partial derivatives of the Lagrangian function and subgradient projection method to obtain the *** results show that ABM converges and effectively reduces the processing delay of blockchain-based MEC.

关键词： Mobile edge computing blockchain resource allocation

SARS-CoV-2 aberrantly elevates mitochondrial bioenergetics to induce robust virus propagation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第6期9卷 2702-2715页

作者： Hye Jin Shin Wooseong Lee Keun Bon Ku Gun Young yoon Hyun-Woo Moon Chonsaeng kim Mi-Hwa kim yoon-Sun Yi Sangmi Jun Bum-Tae kim Jong-Won Oh Aleem Siddiqui Seong-Jun kim Department of Convergent Research of Emerging Virus Infection Korea Research Institute of Chemical TechnologyDaejeon 34114Republic of Korea Gyeongnam Biohealth Research Center Gyeongnam Branch InstituteKorea Institute of ToxicologyJinju 52834Republic of Korea Center for Research Equipment Korea Basic Science InstituteCheongjuChungcheongbuk-do 28119Republic of Korea Department of Biotechnology Yonsei UniversitySeoul 03722Republic of Korea Division of Infectious Diseases School of MedicineUniversity of CaliforniaSan DiegoLa JollaCA 92093USA Present address:Department of Microbiology Chungnam National University School of MedicineDaejeon 35015Republic of Korea

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is a‘highly transmissible respiratory pathogen,leading to severe multiorgan ***,knowledge regarding SARS-CoV-2-induced cellular alterations is *** this study,we report that SARSCoV-2 aberrantly elevates mitochondrial bioenergetics and activates the EGFR-mediated cell survival signal cascade during the early stage of viral ***-CoV-2 causes an increase in mitochondrial transmembrane potential via the SARS-CoV-2 RNAnucleocapsid cluster,thereby abnormally promoting mitochondrial elongation and the OXPHOS process,followed by enhancing ATP ***,SARS-CoV-2 activates the EGFR signal cascade and subsequently induces mitochondrial EGFR trafficking,contributing to abnormal OXPHOS process and viral *** EGFR inhibitors remarkably reduce SARS-CoV-2 propagation,among which vandetanib exhibits the highest antiviral *** of SARS-CoV-2-infected cells with vandetanib decreases SARS-CoV-2-induced EGFR trafficking to the mitochondria and restores SARS-CoV-2-induced aberrant elevation in OXPHOS process and ATP generation,thereby resulting in the reduction of SARS-CoV-2 ***,oral administration of vandetanib to SARS-CoV-2-infected hACE2 transgenic mice reduces SARS-CoV-2 propagation in lung tissue and mitigates SARS-CoV-2-induced lung *** also exhibits potent antiviral activity against various SARS-CoV-2 variants of concern,including alpha,beta,delta and omicron,in in vitro cell culture *** together,our findings provide novel insight into SARS-CoV-2-induced alterations in mitochondrial dynamics and EGFR trafficking during the early stage of viral infection and their roles in robust SARS-CoV-2 propagation,suggesting that EGFR is an attractive host target for combating COVID-19.

关键词： alterations aberrant thereby

Metabolic relationships between marine red algae and algae‑associated bacteria

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Marine Life Science & Technology 2024年第2期6卷 298-314页

作者： Kyung Hyun kim Jeong Min kim Ju Hye Baek Sang Eun Jeong Hocheol kim Hwan Su yoon Che Ok Jeon Department of Biological Sciences and Biotechnology Hannam UniversityDaejon 34054Republic of Korea Department of Life Science Chung-Ang UniversitySeoul 06974Republic of Korea Department of Biological Sciences Sungkyunkwan UniversitySuwon 16419Republic of Korea

Mutualistic interactions between marine phototrophs and associated bacteria are an important strategy for their success-ful survival in the ocean,but little is known about their metabolic ***,bacterial communities in the algal sphere(AS)and bulk solution(BS)of nine marine red algal cultures were analyzed,and Roseibium and Phycisphaera were identified significantly more abundantly in AS than in *** metabolic features of Roseibium RMAR6-6(isolated and genome-sequenced),Phycisphaera MAG 12(obtained by metagenomic sequencing),and a marine red alga,Porphyridium purpureum CCMP1328(from GenBank),were analyzed ***6-6 has the genetic capability to fix nitrogen and produce B vitamins(B1,B2,B5,B6,B9,and B12),bacterioferritin,dimethylsulfoniopropionate(DMSP),and phenylacetate that may enhance algal growth,whereas MAG 12 may have a limited metabolic capability,not producing vitamins B9 and B12,DMSP,phenylacetate,and siderophores,but with the ability to produce bacitracin,possibly modulating algal *** CCMP1328 lacks the genetic capability to fix nitrogen and produce vitamin B12,DMSP,phenylacetate,and *** was shown that the nitrogen-fixing ability of RMAR6-6 promoted the growth of ***-pureum,and DMSP reduced the oxidative stress of *** metabolic interactions between strain RMAR6-6 and *** CCMP1328 were also investigated by the transcriptomic analyses of their monoculture and *** together,potential metabolic relationships between Roseibium and *** were *** study provides a bet-ter understanding of the metabolic relationships between marine algae and algae-associated bacteria for successful growth.

关键词： Metabolic relationship Marine red algae Symbiotic bacteria Roseibium Phycisphaera Porphyridium

Efficacy of adjuvant mitomycin-C and triamcinoloneimpregnated nasal packing for endoscopic dacryocystorhinostomy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2024年第3期17卷 480-484页

作者： Sang yoon kim Christopher B Chambers Jung Hyo Ahn Department of Ophthalmology Pusan National University Yangsan HospitalPusan National University School of MedicineResearch Institute for Convergence of Biomedical Science and TechnologyYangsanGyeongnam 50612Republic of Korea Department of Ophthalmology Harborview Medical CenterUniversity of Washington MedicineSeattleWashington 98109USA

●AIM:To compare the success rate and complications of adjuvant use of mitomycin C and triamcinoloneimpregnated biodegradable nasal packing(TABP)in endoscopic dacryocystorhinostomy(DCR).And to evaluate the efficacy of combining intraoperative mitomycin C and TABP for endoscopic DCR.●METHODS:A total of 198 eyes of 148 patients who underwent endoscopic DCR for acquired nasolacrimal duct obstruction were retrospectively *** patients were randomly divided into three groups:Group A included patients treated without intraoperative mitomycin C but with TABP,Group B included patients treated without triamcinolone but with intraoperative mitomycin C and normal saline-impregnated nasal packing,and Group C included patients treated with intraoperative mitomycin C and TABP.●RESULTS:The results revealed no significant difference in the overall success rates between Groups A(86.8%)and B(89.2%;P=0.377).However,Group C(97.5%)showed a significantly higher overall success rate than Groups A and *** incidence of granulomas was significantly lower in group C(5%)than in Groups A(20.8%)and B(15.2%;P=0.009).Other complications,such as crust,synechiae,and revision surgery,did not differ significantly among the three groups.●CONCLUSION:The combination of intraoperative mitomycin C and TABP effectively prevents granulomas and enhances surgical success ***,there is no statistically significant difference observed between the use of mitomycin C or TABP alone.

关键词： dacryocystorhinostomy endoscopic mitomycin C triamcinolone biodegradable

Photo-induced crosslinked and anti-PD-L1 peptide incorporated liposomes to promote PD-L1 multivalent binding for effective immune checkpoint blockade therapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第3期14卷 1428-1440页

作者： Youngjoo Lee Sukyung Song Suah Yang Jinseong kim Yujeong Moon Nayeon Shim Hong Yeol yoon Sehoon kim Man Kyu Shim Kwangmeyung kim KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoul 02841Republic of Korea Medicinal Materials Research Center Biomedical Research DivisionKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea College of Pharmacy Graduate School of Pharmaceutical SciencesEwha Womans UniversitySeoul 03760Republic of Korea Department of Bioengineering Korea UniversitySeoul 02841Republic of Korea

Immune checkpoint blockade(ICB)therapy targeting PD-L1 via monoclonal antibody(m Ab)has shown extensive clinical benefits in the diverse types of advanced ***,most patients are completely refractory to ICB therapy owing to the PD-L1 recycling ***,we propose photo-induced crosslinked and anti-PD-L1 peptide incorporated liposomes(immune checkpoint blockade liposomes;ICB-LPs)to promote PD-L1 multivalent binding for inducing lysosomal degradation of PD-L1 in tumor *** ICB-LPs are prepared by formulation of DC_(8,9)PC with photo-polymerized diacetylenic moiety,1,2-dipalmitoylphosphatidylcholine(DPPC)and anti-PD-L1peptide(D-form NYSKPTDRQYHF)-conjugated DSPE-PEG_(2k)(anti-PD-L1-DSPE-PEG_(2k))in a molar ratio of 45:45:10,followed by cross-linking of liposomal bilayer upon UV *** 10 mol% antiPD-L1-DSPE-PEG_(2k)incorporated ICB-LPs have a nano-sized lipid bilayer structure with an average diameter of 137.7±1.04 nm,showing a high stability in serum ***,the ICB-LPs efficiently promote the multivalent binding with PD-L1 on the tumor cell membrane,which are endocytosed with aim to deliver PD-L1 to the lysosomes,wherein the durable PD-L1 degradation is observed for72 h,in contrast to anti PD-L1 m Abs showing the rapid PD-L1 recycling within 9 *** in vitro coculture experiments with CD8^(+)T cells show that ICB-LPs effectively enhance the T cell-mediated antitumor immune responses against tumor cells by blocking the PD-L1/PD-1 *** ICB-LPs are intravenously injected into colon tumor-bearing mice,they efficiently accumulate within the targeted tumor tissues via both passive and active tumor targeting,inducing a potent T cell-mediated antitumor immune response by effective and durable PD-L1 ***,this study demonstrates the superior antitumor efficacy of crosslinked and anti-PD-L1 peptide incorporated liposome formulation that promotes PD-L1 multivalent binding for trafficking of PD-L1 toward

关键词： Cancer immunotherapy Immune checkpoint blockade PEGylated liposome Crosslinked lipid nanoparticles Anti-PD-L1 peptide Tumor-targeting PD-L1 multivalent binding Lysosomal PD-L1 degradation