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Migration of the localization wire to the back in patient with nonpalpable breast carcinoma: A case report

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World Journal of Clinical Cases 2021年第26期9卷 7863-7869页

作者： young Jin choi Department of Surgery Chungbuk National University HospitalChungbuk National University College of MedicineCheongju 28644South Korea

BACKGROUND Due to the increasing number of diagnosed nonpalpable breast cancer cases,wire localization has been commonly performed for surgical guidance to remove nonpalpable breast *** report presents a rare case of localized wire migration to a subcutaneous lesion of the upper back in a breast cancer patient undergoing breast-conserving *** SUMMARY A 48-year-old female was scheduled for breast-conserving surgery for left breast *** guided wire localization was performed intraoperatively by surgeon to localize the nonpalpable breast *** axilla sentinel lymph node biopsy,we realized that the wire was not *** wire was not found in the operation field,including the breast and ***-conserving surgery was performed after wire *** chest posteroanterior view revealed that the wire was located on the level of midaxillary *** days after the operation,a serial simple X-ray revealed that the wire was located on the subcutaneous lesion of the *** wire tip was palpable under the skin of the upper back,and the wire was removed under local *** Hooked wire misplacement can lead to fatal *** must consider the possibility of wire migration during breast cancer surgery.

关键词： Breast carcinoma Hooked wire Migration Nonpalpable breast lesion Wire localization Case report

Severe thrombocytopenia before liver transplantation is associated with delayed recovery of thrombocytopenia regardless of donor type

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World Journal of Gastroenterology 2008年第37期14卷 5723-5729页

作者： Jae Hyuck Chang Jong young choi Hyun young Woo Jung Hyun Kwon Chan Ran You Si Hyun Bae Seung Kew yoon Myung-Gyu choi In-Sik Chung Dong Goo Kim Department of Internal Medicine College of Medicine the Catholic University of Korea505 Banpo-Dong Seocho-Gu Seoul 137-040 Korea Department of Surgery College of Medicine the Catholic University of Korea505 Banpo-Dong Seocho-Gu Seoul 137-040 Korea

AIM： To compare the recovery of thrombocytopenia and splenomegaly during long-term follow-up after liver transplantation in patients receiving a living donor transplant or a cadaveric donor transplant. METHODS： This was a retrospective cohort study of 216 consecutive liver transplant patients who survived for 〉 6 mo after transplantation; 169 received a liver transplant from a living donor and 47 from a cadaveric donor. The platelet counts or spleen volumes were examined before transplant, i, 6, and 12 mo after transplant, and then annually until 5 years after transplant. RESULTS： The mean follow-up period was 49 mo （range, 21-66）. Platelet counts increased continuously for 5 years after orthotopic liver transplant. The restoration of platelet counts after transplant was significantly slower in patients with severe pretransplant thrombocytopenia （〈 50000/μL） until 4 years after transplant （P = 0.005）. Donor type did not significantlyaffect the recovery of platelet count and spleen volume in either patient group. In multivariate analysis, pretransplant severe thrombocytopenia （〈 50000/μL） was an independent factor associated with sustained thrombocytopenia （P 〈 0.001, odds ratio 6.314; confidence interval, 2.828-14.095）. Thrombocytopenia reappeared after transplant in seven patients with portal flow disturbance near the anastomosis site. CONCLUSION： Our study suggests that severe thrombocytopenia before transplant is closely associated with delayed recovery of platelet count after transplant and donor type did not affect the recovery of thrombocytopenia. The reappearance of thrombocytopenia after transplant should be considered a possible indicator of flow disturbance in the portal vein.

关键词： Liver transplantation Thrombocytopenia Splenomegaly Hypersplenism

Epidemic obesity in children and adolescents:risk factors and prevention

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Frontiers of Medicine 2018年第6期12卷 658-666页

作者： Eun young Lee Kun-Ho yoon Division of Endocrinology and Metabolism Department of Internal MedicineSeoul St.Mary's HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591Korea Institute of Catholic Ubiquitous Health Care The Catholic University of KoreaSeoul 06591Korea

The prevalence of obesity among children and adolescents (aged 2–18 years) has increased rapidly, with more than 100 million affected in 2015. Moreover, the epidemic of obesity in this population has been an important public health problem in developed and developing countries for the following reasons. Childhood and adolescent obesity tracks adulthood obesity and has been implicated in many chronic diseases, including type 2 diabetes, hypertension, and cardiovascular disease. Furthermore, childhood and adolescent obesity is linked to adulthood mortality and premature death. Although an imbalance between caloric intake and physical activity is a principal cause of childhood and adolescent obesity, environmental factors are exclusively important for development of obesity among children and adolescents. In addition to genetic and biological factors, socioenvironmental factors, including family, school, community, and national policies, can play a crucial role. The complexity of risk factors for developing obesity among children and adolescents leads to difficulty in treatment for this population. Many interventional trials for childhood and adolescent obesity have been proven ineffective. Therefore, early identification and prevention is the key to control the global epidemic of obesity. Given that the proportion of overweight children and adolescents is far greater than that of obesity, an effective prevention strategy is to focus on overweight youth, who are at high risk for developing obesity. Multifaceted, comprehensive strategies involving behavioral, psychological, and environmental risk factors must also be developed to prevent obesity among children and adolescents.

关键词： obesity children adolescents epidemiology risk factor prevention

Effect of intra-arterial infusion with triolein emulsion on rabbit liver

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World Journal of Gastroenterology 2014年第39期20卷 14442-14449页

作者： Yong-Woo Kim young Mi Park Sik yoon Hak Jin Kim Do yoon Park Byung Mann Cho Seon Hee choi Department of Radiology Research Institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan Hospital Pusan National University College of Medicine Yangsan 626-770 South Korea Department of Radiology Busan Paik Hospital Inje University Pusan 614-735 South Korea Department of Anatomy Pusan National University College of Medicine and Biomedical Research Institute Pusan 602-739 South Korea Department of Radiology Pusan National University College of Medicine and Biomedical Research Institute Pusan 602-739 South Korea Department of Pathology Pusan National University College of Medicine and Biomedical Research Institute Pusan 602-739 South Korea Preventive Medicine Pusan National University College of Medicine and Biomedical Research Institute Pusan 602-739 South Korea Pusan National University Postgraduate School Pusan National University Pusan 602-739 South Korea

AIM: To determine whether intra-arterial infusion of triolein emulsion has biochemical and histopathologic effect on rabbit liver.

关键词： Triolein Emulsions Hepatology Liver dysfunction Histopathology

Toward genetic transformation of mitochondria in mammalian cells using a recoded drug-resistant selection marker

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Journal of Genetics and Genomics 2011年第4期38卷 173-179页

作者： young Geol yoon Michael Duane Koob Mitochondria Hub Regulation Center and Department of Anatomy and Cell Biology Dong-A University College of Medicine 3-1 Dongdaesin-dongSeo-gu Busan 602-714 Republic of Korea Department of Laboratory Medicine and Pathology and Institute of Human Genetics University of Minnesota Medical School 420 Delaware St. S.E.Minneapolis MN 55455 USA

Due to technical difficulties,the genetic transformation of mitochondria in mammalian cells is still a *** this report,we described our attempts to transform mammalian mitochondria with an engineered mitochondrial genome based on selection using a drug resistance *** the standard drug-resistant neomycin phosphotransferase confers resistance to high concentrations of G418 when targeted to the mitochondria,we generated a recoded neomycin resistance gene that uses the mammalian mitochondrial genetic code to direct the synthesis of this protein in the mitochondria,but not in the nucleus（mitochondrial version）.We also generated a universal version of the recoded neomycin resistance gene that allows synthesis of the drug-resistant proteins both in the mitochondria and *** we transfected these recoded neomycin resistance genes that were incorporated into the mouse mitochondrial genome clones into mouse tissue culture cells by electroporation,no DNA constructs were delivered into the *** found that the universal version of the recoded neomycin resistance gene was expressed in the nucleus and thus conferred drug resistance to G418 selection,while the synthetic mitochondrial version of the gene produced no background drug-resistant cells from nuclear *** recoded synthetic drug-resistant genes could be a useful tool for selecting mitochondrial genetic transformants as a precise technology for mitochondrial transformation is developed.

关键词： Mitochondrial codon Recode Mitochondrial transformation Selection marker G418 Neo^R

Circulating levels of vitamin D and colorectal adenoma: A case-control study and a meta-analysis

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World Journal of Gastroenterology 2015年第29期21卷 8868-8877页

作者： yoon Ji choi young Ha Kim Chang Ho Cho Sung Hi Kim Jung Eun Lee Department of Food and Nutrition Sookmyung Women’s University Department of Pathology Daegu Catholic University Medical Center Department of Family Medicine Daegu Catholic University Medical Center

AIM: To examine the association between circulating 25-hydroxyvitamin D [25(OH)D] levels and colorectal adenoma in a case-control study and a meta-analysis. METHODS: We conducted a matched case-control study(112 cases and 112 matched controls) and combined 15 studies, including our study, in a metaanalysis. The study-specific odds ratios(ORs) and 95% confidence intervals(CIs) were pooled using a randomeffects model. In total, 5454 colorectal adenomas and 6656 controls were included in the meta-analysis. RESULTS: In a meta-analysis including 14 previous studies and our study, we observed a significant inverse association between circulating 25(OH)D levels and colorectal adenoma(OR = 0.68; 95%CI: 0.54-0.82) when comparing the highest category with the lowest category. Stratification by adenoma location(proximal or distal adenoma) showed similar estimates. When we stratified by study region, the ORs(95%CIs) were 0.70(0.52-0.88) in the US and 0.66(0.34-0.97) in Asia. CONCLUSION: These data suggest an inverse association between circulating 25(OH) Dlevels and colorectal adenoma in both Western and Asian populations.

关键词： 25-hydroxyvitamin D levels Colorectaladenoma Cancer prevention

Seroepidemiology of echovirus 30 in Korean children

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World Journal of Pediatrics 2017年第6期13卷 611-614页

作者： Joo young Lee Yumi Seo Ui yoon choi Jong-Hyun Kim Jin Han Kang Department of Pediatrics College of MedicineThe Catholic University of KoreaSeoulRepublic of Korea

Background:Although aseptic meningitis associated with echovirus type 30 has emerged as a global public health concern,no data have been reported on children's immune status against echovirus type *** current study aimed to investigate the seropositivity among Korean children for antibodies against echovirus ***:Two hundred and fifty residual serum samples were collected at ***'s *** were categorized by age into four groups:group 1 (3 months-2 years),group 2 (3-6 years),group 3 (7-10 years) and group 4 (11-15 years).Neutralizing antibodies against echovirus 30 were ***:Seroprotective neutralizing antibodies against echovirus 30 were detected in 129 (49%) *** rates were 23%,48%,55% and 73% in groups 1-4,*** antibody titers,1:256-1:512 was the highest neutralizing antibody titer range in group 2,while 1:1024-1:2048 in group 3 and *** the seropositive individuals in group 3 and 4,6% and 12% had neutralizing antibody titers of 1:2048,***:The seropositivity rate increased significantly with age..The distribution of neutralizing antibody titers varied by age group,and higher ranges of neutralizing antibody titers were observed in higher age *** findings suggest high susceptibility to echovirus 30 infection in children younger than 2 years *** 30 infection in childhood may have contributed to increased neutralizing antibody titers with age.

关键词： echovirus 30 Korea seroepidemiology

A model and simulation of cathode flooding and drying on unsteady proton exchange membrane fuel cell

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Journal of Central South University 2012年第9期19卷 2572-2577页

作者： A.Bakhtiar KIM young-Bok YOU Jin-Kwang yoon Jung-In choi Kwang-Hwan Refrigeration and Air-Conditioning Engineering Pukyong National University Department of Automotive Dong-Pusan Collage University Department of Mechanical Engineering Pukyong National University

A water balance has a significant impact on the overall system performance in proton exchange membrane fuel *** actual fuel cell application has a dynamic electrical load which means also dynamic electrical ***,since this electrical current is known,the water production from the fuel cell reaction is also able to be *** long as the fuel cell water transportation model is provided,the present liquid water inside the porous medium is also able to be modeled.A model of the liquid water saturation level in a fuel cell in unsteady load condition was *** model is a series of the water transportation model of water saturation level for the final output of proton exchange membrane(PEM) fuel cell to predict the flooding or drying of PEM fuel *** simulation of vehicle fuel cell in different dynamic load profiles and different inlet air conditions was done using this *** simulation result shows that PEM fuel cell with different dynamic load profiles has different liquid water saturation level *** means that a dynamic load fuel cell requires also a dynamic input air humidification.

关键词： model simulation flooding unsteady condition fuel cell

Glucose metabolism and neurogenesis in the gerbil hippocampus after transient forebrain ischemia

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Neural Regeneration Research 2016年第8期11卷 1254-1259页

作者： Dae young Yoo Kwon young Lee Joon Ha Park Hyo young Jung Jong Whi Kim Yeo Sung yoon Moo-Ho Won Jung Hoon choi In Koo Hwang Department of Anatomy and Cell Biology College of Veterinary Medicineand Research Institute for Veterinary ScienceSeoul National University Department of Anatomy College of Veterinary Medicine and Institute of Veterinary ScienceKangwon National University Department of Neurobiology School of MedicineKangwon National University

Recent evidence exists that glucose transporter 3（GLUT3） plays an important role in the energy metabolism in the *** previous studies have been conducted using focal or hypoxic ischemia models and have focused on changes in GLUT3 expression based on protein and m RNA levels rather than tissue *** the present study,we observed change in GLUT3 immunoreactivity in the adult gerbil hippocampus at various time points after 5 minutes of transient forebrain *** the sham-operated group,GLUT3 immunoreactivity in the hippocampal CA1 region was weak,in the pyramidal cells of the CA1 region increased in a time-dependent fashion 24 hours after ischemia,and in the hippocampal CA1 region decreased significantly between 2 and 5 days after ischemia,with high level of GLUT3 immunoreactivity observed in the CA1 region 10 days after *** a double immunofluorescence study using GLUT3 and glial-fibrillary acidic protein（GFAP）,we observed strong GLUT3 immunoreactivity in the ***3 immunoreactivity increased after ischemia and peaked 7 days in the dentate gyrus after ischemia/*** a double immunofluorescence study using GLUT3 and doublecortin（DCX）,we observed low level of GLUT3 immunoreactivity in the differentiated neuroblasts of the subgranular zone of the dentate gyrus after ***3 immunoreactivity in the sham-operated group was mainly detected in the subgranular zone of the dentate *** results suggest that the increase in GLUT3 immunoreactivity may be a compensatory mechanism to modulate glucose level in the hippocampal CA1 region and to promote adult neurogenesis in the dentate gyrus.

关键词： nerve regeneration transient forebrain ischemia glucose transporter 3 pyramidal cells astrocytes neuroblasts neural regeneration