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Decomposition behavior of yttria-stabilized zirconia and its effect on directed energy deposited Ti-based composite material

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Journal of Materials Science & Technology 2022年第17期112卷 138-150页

作者： Gwanghyo Choi Won Seok Choi yoon sun lee Dahye Kim Ji Hyun sung Seungjun An Chang-Seok Oh Amine Hattal Madjid Djemai Brigitte Bacroix Guy Dirras Pyuck-Pa Choi Department of Materials Science and Engineering Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea 3D Additive Manufacturing Application Tech.Center Korea Institute of Industrial TechnologyDaegu 42994Republic of Korea InssTek Co. Daejeon 04763Republic of Korea Korea Institute of Materials Science 797 ChangwondaeroChangwon 51508Republic of Korea UniversitéSorbonne Paris Nord Laboratoire des Sciences des Procédés et des MatériauxLSPMCNRSUPR 3407F-93430VilletaneuseFrance Z3Dlab Parc Technologique26 Rue des SablonsMontmagny 95360France CNRS UPR3407Laboratoire des Sciences des Procédés et des MatériauxLSPMUniversitéSorbonne Paris NordF-93430VilletaneuseFrance

We report on the microstructure and the strengthening mechanisms of additively manufactured parts fabricated by directed energy deposition of Ti-6Al-4V(Ti64)powders blended with yttria-stabilized zirconia(YSZ)*** specimens showed refined microstructures as compared to bare as-deposited Ti64,where theαand columnar priorβgrain sizes decreased with increasing YSZ *** YSZ nanoparticles decomposed during the deposition process and led to the formation of yttrium oxide and some excess oxygen in the Ti64 *** decrease in the sizes of the priorβgrains could be attributed to the increasing amount of dissolved oxygen and yttrium,which promoted constitutional ***,the reduction in the size of theαgrains could be ascribed to a shift of the onset of theβ→α+βtransformation to a higher temperature and shorter time with increasing concentration of dissolved ***,the contributions of the underlying strengthening mechanisms for the as-deposited specimens were quantitatively determined.

关键词： Additive manufacturing Directed energy deposition Metal matrix composites Titanium alloys Yttrium-stabilized zirconia

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ESR2–HDA6 complex negatively regulates auxin biosynthesis to delay callus initiation in Arabidopsis leaf explants during tissue culture

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Plant Communications 2024年第7期5卷 200-214页

作者： Kyounghee lee Hobin yoon Ok-sun Park Jongbu Lim Sang-Gyu Kim Pil Joon Seo Department of Chemistry Seoul National UniversitySeoul 08826Korea Research Institute of Basic Sciences Seoul National UniversitySeoul 08826Korea Interdisciplinary Program in Agricultural Biotechnology Seoul National UniversitySeoul 08826Korea Plant Genomics and Breeding Institute Seoul National UniversitySeoul 08826Korea Department of Biological Sciences KAISTDaejeon 34141Korea

Plants exhibit an astonishing ability to regulate organ regeneration upon *** of leaf explants promotes the biosynthesis of indole-3-acetic acid(IAA),which is polar-transported to excised regions,where cell fate transition leads to root founder cell specification to induce de novo root *** regeneration capacity of plants has been utilized to develop in vitro tissue culture ***,we report that IAA accumulation near the wounded site of leaf explants is essential for callus formation on 2,4-dichlorophenoxyacetic acid(2,4-D)-rich callus-inducing medium(CIM).Notably,a high concentration of 2,4-D does not compensate for the action of IAA because of its limited efflux;rather,it lowers IAA biosynthesis via a negative feedback mechanism at an early stage of in vitro tissue culture,delaying callus *** auxin negative feedback loop in CIM-cultured leaf explants is mediated by an auxin-inducible APETALA2 transcription factor,ENHANCER OF SHOOT REGENERATION 2(ESR2),along with its interacting partner HISTONE DEACETYLASE 6(HDA6).The ESR2–HDA6 complex binds directly to,and removes the H3ac mark from,the YUCCA1(YUC1),YUC7,and YUC9 loci,consequently repressing auxin biosynthesis and inhibiting cell fate transition on 2,4-D-rich *** findings indicate that negative feedback regulation of auxin biosynthesis by ESR2 and HDA6 interferes with proper cell fate transition and callus initiation.

关键词： auxin biosynthesis negative feedback loop ESR2 HDA6 YUCCA chromatin modification

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100 W-class green hydrogen production from ammonia at a dual-layer electrode containing a Pt-Ir catalyst for an alkaline electrolytic process

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Journal of Energy Chemistry 2024年第6期93卷 352-360,I0009页

作者： Donghyun yoon sunki Chung Minjun Choi Eunhyeok Yang Jaeyoung lee School of Earth Sciences and Environmental Engineering Gwangju Institute of Science and Technology(GIST)Gwangju 61005Republic of Korea International Future Research Center of Chemical Energy Storage and Conversion Processes GISTGwangju 61005Republic of Korea Ertl Center for Electrochemistry and Catalysis GISTGwangju 61005Republic of Korea TKG Huchems Co.Ltd 963Sangam-roYeosu-siJeollanam-do 59614Republic of Korea

Ammonia allows storage and transport of hydrogen over long distances and is an attractive potential hydrogen *** decomposition has recently been used for the conversion of ammonia to hydrogen and is regarded as a future technology for production of CO_(2)-free pure ***,a heterostructural Pt-Ir dual-layer electrode is developed and shown to achieve successful long-term operation in an ammonia electrolyzer with an anion exchange membrane(AEM).This electrolyzer consisted of eight membra ne electrode assemblies(MEAs)with a total geometric area of 200 cm~2 on the anode side,which resulted in a hydrogen production rate of 25 L h~(-1).We observed the degradation in MEA performance attributed to changes in the anode catalyst layer during hydrogen production via ammonia ***,we demonstrated the relationship between the ammonia oxidation reaction(AOR)and the oxygen evolution reaction(OER).

关键词： Ammonia oxidation Dual-layer catalyst Green hydrogen Electrolytic process Oxygen evolution reaction

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Modification strategies improving the electrochemical and structural stability of high-Ni cathode materials

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Journal of Energy Chemistry 2024年第9期96卷 185-205页

作者： yoon Bo Sim Hami lee Junyoung Mun Ki Jae Kim Department of Energy Science Sungkyunkwan UniversitySuwon 16419Republic of Korea School of Advanced Materials Science and Engineering Sungkyunkwan UniversitySuwon 16419Republic of Korea SKKU Institute of Energy Science and Technology(SIEST) Sungkyunkwan UniversitySuwon 16419Republic of Korea

With the increasing spotlight in electric vehicles,there is a growing demand for high-energy-density batteries to enhance driving ***,several studies have been conducted on high-energy-density LiNi_(x)Co_(y)Mn_(z)O_(2)***,there is a limit to permanent performance deterioration because of side reactions caused by moisture in the atmosphere and continuous microcracks during cycling as the Ni content to express high energy increases and the content of Mn and Co that maintain structural and electrochemical stabilization *** direct modification of the surface and bulk regions aims to enhance the capacity and long-term performance of high-Ni cathode ***,an efficient modification requires a study based on a thorough understanding of the degradation mechanisms in the surface and bulk *** this review,a comprehensive analysis of various modifications,including doping,coating,concentration gradient,and single crystals,is conducted to solve degradation issues along with an analysis of the overall degradation mechanism occurring in high-Ni cathode *** also summarizes recent research developments related to the following modifications,aims to provide notable points and directions for post-studies,and provides valuable references for the commercialization of stable high-energy-density cathode materials.

关键词： High energy density High-Ni cathode materials Degradation Structural stability Lithium-ion battery

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Biochemical consequences of glucocerebrosidase 1 mutations in Parkinson’s disease

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Neural Regeneration Research 2024年第4期19卷 725-727页

作者： Jeong Hyun yoon Chiao-Yin lee Anthony HV Schapira Department of Clinical and Movement Neurosciences University College London Institute of Neurology Faculty of Medicine Imperial College London Aligning Science Across Parkinson's(ASAP)Collaborative Research Network

Parkinson’s disease(PD,OMIM#168600)is a common neurodegenerative disorder with a global prevalence of approximately 8.5 *** is characterized by four cardinal motor symptoms:bradykinesia,rigidity,resting tremor,and subsequently by postural *** usually involves non-motor symptoms such as rapid eye movement sleep disorder,dementia,anosmia,and autonomic *** gene glucocerebrosidase 1(GBA1),which encodes the lysosomal enzyme glucocerebrosidase(GCase)(IUBMB:EC 3.***.1.45),shows strong linkage with PD;variants of GBA1 are the commonest genetic association with PD(Sidransky et al.,2009).Several mechanisms may underlie the relationship between GBA1 mutations/variants and the molecular pathology of PD(Figure 1A and B).

关键词： cerebro consequences

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Advances in Wireless,Batteryless,Implantable Electronics for Real‑Time,Continuous Physiological Monitoring

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Nano-Micro Letters 2024年第3期16卷 254-302页

作者： Hyeonseok Kim Bruno Rigo Gabriella Wong yoon Jae lee Woon‑Hong Yeo IEN Center for Wearable Intelligent Systems and Healthcare Georgia Institute of TechnologyAtlantaGA 30332USA George W.Woodruff School of Mechanical Engineering Georgia Institute of TechnologyAtlantaGA 30332USA School of Electrical and Computer Engineering Georgia Institute of TechnologyAtlantaGA 30332USA Wallace H.Coulter Department of Biomedical Engineering Georgia Tech and Emory University School of MedicineAtlantaGA 30332USA Parker H.Petit Institute for Bioengineering and Biosciences Institute for MaterialsInstitute for Robotics and Intelligent MachinesGeorgia Institute of TechnologyAtlantaGA 30332USA

This review summarizes recent progress in developing wireless,batteryless,fully implantable biomedical devices for real-time continuous physiological signal monitoring,focusing on advancing human health *** considerations,such as biological constraints,energy sourcing,and wireless communication,are discussed in achieving the desired performance of the devices and enhanced interface with human *** addition,we review the recent achievements in materials used for developing implantable systems,emphasizing their importance in achieving multi-functionalities,biocompatibility,and *** wireless,batteryless devices offer minimally invasive device insertion to the body,enabling portable health monitoring and advanced disease ***,we summarize the most recent practical applications of advanced implantable devices for human health care,highlighting their potential for immediate commercialization and clinical uses.

关键词： Implantable electronics Biomedical systems Batteryless devices Wireless electronics Physiological signal monitoring

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A novel AIE-NIR-II nano-contrast agent for monitoring and evaluating kidney transplant

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National Science Review 2024年第4期11卷 15-16页

作者： Yuan-Yuan Zhao Bokyeong Hwang Yeju lee Juyoung yoon Department of Chemistry and Nanoscience Ewha Womans University

Kidney transplantation is a life-saving approach for treating end-stage renal diseases (ESRDs)[1]. However, the scarcity of donor kidneys has resulted in an increasing number of ESRD patients being stuck on the transp... 详细信息

关键词： TIME

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SARS-CoV-2 aberrantly elevates mitochondrial bioenergetics to induce robust virus propagation

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2702-2715页

作者： Hye Jin Shin Wooseong lee Keun Bon Ku Gun Young yoon Hyun-Woo Moon Chonsaeng Kim Mi-Hwa Kim yoon-sun Yi Sangmi Jun Bum-Tae Kim Jong-Won Oh Aleem Siddiqui Seong-Jun Kim Department of Convergent Research of Emerging Virus Infection Korea Research Institute of Chemical TechnologyDaejeon 34114Republic of Korea Gyeongnam Biohealth Research Center Gyeongnam Branch InstituteKorea Institute of ToxicologyJinju 52834Republic of Korea Center for Research Equipment Korea Basic Science InstituteCheongjuChungcheongbuk-do 28119Republic of Korea Department of Biotechnology Yonsei UniversitySeoul 03722Republic of Korea Division of Infectious Diseases School of MedicineUniversity of CaliforniaSan DiegoLa JollaCA 92093USA Present address:Department of Microbiology Chungnam National University School of MedicineDaejeon 35015Republic of Korea

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is a‘highly transmissible respiratory pathogen,leading to severe multiorgan ***,knowledge regarding SARS-CoV-2-induced cellular alterations is *** this study,we report that SARSCoV-2 aberrantly elevates mitochondrial bioenergetics and activates the EGFR-mediated cell survival signal cascade during the early stage of viral ***-CoV-2 causes an increase in mitochondrial transmembrane potential via the SARS-CoV-2 RNAnucleocapsid cluster,thereby abnormally promoting mitochondrial elongation and the OXPHOS process,followed by enhancing ATP ***,SARS-CoV-2 activates the EGFR signal cascade and subsequently induces mitochondrial EGFR trafficking,contributing to abnormal OXPHOS process and viral *** EGFR inhibitors remarkably reduce SARS-CoV-2 propagation,among which vandetanib exhibits the highest antiviral *** of SARS-CoV-2-infected cells with vandetanib decreases SARS-CoV-2-induced EGFR trafficking to the mitochondria and restores SARS-CoV-2-induced aberrant elevation in OXPHOS process and ATP generation,thereby resulting in the reduction of SARS-CoV-2 ***,oral administration of vandetanib to SARS-CoV-2-infected hACE2 transgenic mice reduces SARS-CoV-2 propagation in lung tissue and mitigates SARS-CoV-2-induced lung *** also exhibits potent antiviral activity against various SARS-CoV-2 variants of concern,including alpha,beta,delta and omicron,in in vitro cell culture *** together,our findings provide novel insight into SARS-CoV-2-induced alterations in mitochondrial dynamics and EGFR trafficking during the early stage of viral infection and their roles in robust SARS-CoV-2 propagation,suggesting that EGFR is an attractive host target for combating COVID-19.

关键词： alterations aberrant thereby

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Delphi study for developing a checklist of adverse events associated with acupotomy

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Journal of Integrative Medicine 2024年第5期22卷 579-587页

作者： Hyungsun Jun Haebeom lee Sang-Hoon yoon Chan-Young Kwon Damin Jeon Jun-Hwan lee Jungtae leem Department of Diagnostics College of Korean MedicineWonkwang UniversityIksan 54538Republic of Korea Days Inc. Seoul 06247Republic of Korea Chung-Yeon Korean Medicine Clinic Seoul 06224Republic of Korea Department of Oriental Neuropsychiatry Dong-Eui University College of Korean MedicineBusan 47227Republic of Korea Chonnam National University Hwasun Hospital Hwasun 58128Republic of Korea KM Science Research Division Korea Institute of Oriental MedicineDaejeon 34054Republic of Korea Department of Korean Convergence Medical Science KIOM SchoolUniversity of Science&Technology(UST)Daejeon 34054Republic of Korea Department of Physical Medicine and Rehabilitation Spaulding Rehabilitation HospitalHarvard Medical SchoolBostonMA 02115USA Research Center of Traditional Korean Medicine College of Korean MedicineWonkwang UniversityIksan 54538Republic of Korea

Background Acupotomy,a more invasive procedure than acupuncture,involves the use of a thicker needle with an integrated knife at the tip,necessitating safety *** aimed to define relevant adverse events(AEs)and create a standardized form of the ACUPOtomy-related AEs CHECKlist(ACUPOCHECK).Methods Before conducting the Delphi process,a systematic review and pilot prospective study were conducted to gather information on previously reported *** these data,pilot versions of the ACUPOCHECK and Delphi questionnaires were *** Delphi questionnaire involved selecting types of AE for inclusion,establishing separate criteria for acupotomy-related AEs,and achieving a consensus on AE *** Korean doctors with experience in acupotomy or AE research were recruited to participate in each Delphi *** was considered to have been reached if the critical value for the content validity ratio met or exceeded *** The final ACUPOCHECK was developed using four rounds of the Delphi method and one face-to-face consensus *** included 12 local AEs(pain,hemorrhage,bruise,hematoma,edema,pruritus,rash,infection,nerve damage,dysesthesia,movement impairment,and pneumothorax)and 14 systemic AEs(disease aggravation,needle fatigue,sleepiness,procedural nausea,procedural vomiting,procedural headache,procedural dizziness,sweating,procedural shock,syncope,dyspnea,procedural pain,sleep disorder,and postprocedural infection).Separate criteria were established for pain,hemorrhage and bruising:pain was defined as pain that occurrs during daily activities and persists for longer than 72 h,hemorrhage as bleeding that continues for≥3 min despite pressure application,and bruising as having a bruise with a diameter of≥3 ***-ended descriptions were allowed for AEs not covered by the checklist,and severity and causality were assessed using the Common Terminology Criteria for Adverse Events and modified World Health Organization-Uppsala Monitoring C

关键词： Acupotomy Delphi technique Patient safety Safety management Adverse event

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Factor analysis of recent major heatwaves in East Asia

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Geoscience Frontiers 2024年第1期15卷 374-383页

作者： Arim yoon Jeongwon Kim Jooyeop lee Hyun Min sung Je-Woo Hong Seung-Ki Min Junhong lee Jinkyu Hong Ecosystem-Atmosphere Process Laboratory Department of Atmospheric SciencesYonsei UniversitySeoul 03722Republic of Korea National Institute of Meteorological Sciences Jeju 63568Republic of Korea Korea Adaptation Center for Climate Korea Environment InstituteSejong 30121Republic of Korea Division of Environmental Science and Engineering Pohang University of Science and TechnologyPohang 37673Republic of Korea Max Planck Institute for Meteorology Hamburg 20146Germany Institute for Convergence Research and Education in Advanced Technology Yonsei UniversitySeoulRepublic of Korea

Heatwaves(HWs)present a major hazard to our society and more extreme heatwaves are expected with future climatic ***,it is important to improve our understanding of the underlying processes that drive HWs,in order to boost our socioeconomic-ecological *** this study,we quantified the influences of key driving factors(large-scale atmospheric circulation,soil moisture,and sea surface temperature)and their synergies on recent heatwaves in East *** conducted a factor separation analysis for three recent HW events by constraining the key factors in the regional Weather Research and Forecasting model with their climatologies or pseudo-observations in different *** study showed distinct spatial variations in the HW-controlling factors in East *** synergistic interaction of large-scale circulation and soil moisture was the most important factors in the 2013 Chinese *** the 2018 HWs in Korea and Japan,the same stagnant large-scale atmospheric circulation played a dominant role in driving the HW *** land-atmosphere coupling via soil moisture,its interaction with circulation,and SST exhibited stronger influences during the Korean HW than the Japanese *** analysis also revealed temporal variations in the factors driving Korean and Chinese HWs due to typhoon passage and other multiple processes over heterogeneous surfaces(i.e.,topographically induced Foehn winds,large-scale warm advection from the warm ocean,spatial differences in soil moisture).Our findings suggest that future heatwave-related studies should consider interactive contributions of key factors,their interplay with surface heterogeneities of complex terrain.

关键词： Heatwave East Asia Large-scale circulation Soil moisture Sea surface temperature Synergistic impacts

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