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A novel IRAK4/PIM1 inhibitor ameliorates rheumatoid arthritis and lymphoid malignancy by blocking the TLR/MYD88-mediated NF-κB pathway

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Acta Pharmaceutica Sinica B 2023年第3期13卷 1093-1109页

作者： Sae-Bom yoon Hyowon Hong Hee-Jong Lim Ji Hye choi yoon pyo choi Seong Wook Seo Hyuk Woo Lee Chong Hak Chae Woo-Kyu Park Hyun Young Kim Daeyoung Jeong Tran Quang De Chang-Seon Myung Heeyeong Cho Therapeutics&Biotechnology Division Korea Research Institute of Chemical TechnologyYuseong-guDaejeon 34114Republic of Korea Department of Pharmacology Chungnam National University College of PharmacyYuseong-guDaejeon 34134Republic of Korea Future Medicine Co. Ltd.Rm616 LH-Business Growth CenterSeongnamGyeonggido 13449Republic of Korea Department of Chemistry College of Natural SciencesCan Tho UniversityCan Tho city 9000Viet Nam

Interleukin-1 receptor-associated kinase 4(IRAK4)is a pivotal enzyme in the Toll-like receptor(TLR)/MYD88 dependent signaling pathway,which is highly activated in rheumatoid arthritis tissues and activated B cell-like diffuse large B-cell lymphoma(ABC-DLBCL).Inflammatory responses followed by IRAK4 activation promote B-cell proliferation and aggressiveness of ***,proviral integration site for Moloney murine leukemia virus 1(PIM1)functions as an anti-apoptotic kinase in propagation of ABC-DLBCL with ibrutinib *** developed a dual IRAK4/PIM1 inhibitor KIC-0101 that potently suppresses the NF-κB pathway and proinflammatory cytokine induction in vitro and in *** rheumatoid arthritis mouse models,treatment with KIC-0101 significantly ameliorated cartilage damage and ***-0101 inhibited the nuclear translocation of NF-κB and activation of JAK/STAT pathway in *** addition,KIC-0101 exhibited an anti-tumor effect on ibrutinib-resistant cells by synergistic dual suppression of TLR/MYD88-mediated NF-κB pathway and PIM1 *** results suggest that KIC-0101 is a promising drug candidate for autoimmune diseases and ibrutinib-resistant B-cell lymphomas.

关键词： Drug discovery IRAK4 PIM1 NF-κB pathway Rheumatoid arthritis ABC-DLBCL Ibrutinib resistance Dual inhibitor

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Effect of change of sand properties on travel distance of ricocheted debris

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Defence Technology（防务技术） 2021年第4期17卷 1486-1495页

作者： yoon Keon Kim Woo Chun choi Department of Mechanical Engineering Korea University145 Anam-roSeongbuk-guSeoul02841Republic of Korea

The debris from exploded buildings can ricochet after colliding with the ground,thus increasing the debris travel distance and danger from any associated impacts or *** reduce this danger,the travel distance of ricocheted debris must be accurately *** study analyzed the change in the travel distance of ricocheted concrete debris relative to changes in the properties of a sand *** shear tests were conducted to measure the change in internal friction angle as a function of temperature and water content of the *** element analysis(FEA)was then applied to these variables to predict the speed and angle of the debris after *** FEA results were compared with results of low-speed ricochet experiments,which employed variable temperature and water *** travel distance of the debris was calculated using MATLAB,via trajectory equations considering the drag *** the internal friction angle decreased,the shear stress decreased,leading to deeper penetration of the debris into the *** the loss of kinetic energy increased,the velocity and travel distance of the ricocheted debris *** in the ricochet velocity and travel distance of the debris,according to changes in the internal friction angle,indicated that the debris was affected by the environment.

关键词： Ricochet Exploded debirs Environmental change Sand Temperature Water content Internal friction angle Travel distance

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Roles of lignin biosynthesis and regulatory genes in plant development

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Journal of Integrative Plant Biology 2015年第11期57卷 902-912页

作者： Jinmi yoon Heebak choi Gynheung An Crop Biotech Institute Kyung Hee University Department of Life Science Pohang University of Science and Technology Graduate School of Biotechnology Kyung Hee University

Lignin is an important factor affecting agricultural traits, biofuel production, and the pulping industry. Most lignin biosynthesis genes and their regulatory genes are expressed mainly in the vascular bundles of stems and leaves, preferentially in tissues undergoing Iignification. Other genes are poorly expressed during normal stages of development, but are strongly induced by abiotic or biotic stresses. Some are expressed in non-lignifying tissues such as the shoot apical meristem. Alterations in lignin levels affect plant develop- ment. Suppression of lignin biosynthesis genes causes abnormal phenotypes such as collapsed xylem, bending stems, and growth retardation. The loss of expression by genes that function early in the lignin biosynthesis pathway results in more severe developmental phenotypes when compared with plants that have mutations in later genes. Defective lignin deposition is also associated with phenotypes of seed shattering or brittle culm. MYB and NAC transcriptional factors function as switches, and some homeobox proteins negatively control lignin biosynthesis genes. Ectopic deposition caused by overexpression of lignin biosynthesis genes or master switch genes induces curly leaf formation and dwarfism.

关键词： Development lignin rice

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Parameterization of below-cloud scavenging for polydisperse fine mode aerosols as a function of rain intensity

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Journal of Environmental Sciences 2023年第10期132卷 43-55页

作者： Chang Hoon Jung Hyung-Min Lee Dasom Park Young Jun yoon Yongjoo choi Junshik Um Seoung Soo Lee Ji Yi Lee Yong pyo Kim Department of Health Management Kyungin Women’s UniversityIncheon 21041Korea Department of Environmental Science and Engineering Ewha Woman’s UniversitySeoulKorea Department of Environmental Engineering Konkuk UniversitySeoulKorea Korea Polar Research Institute IncheonKorea Department of Environment Hankuk University of Foreign StudiesYonginKorea Department of Atmospheric Sciences Pusan National UniversityBusanKorea Earth System Science Interdisciplinary Center University of MarylandCollege ParkMDUSA Research Center for Climate Sciences Pusan National UniversityBusanKorea Department of Chemical Engineering and Materials Science Ewha Womans UniversitySeoulKorea

The below-cloud aerosol scavenging process by precipitation is one of the most important mechanisms to remove aerosols from the *** to its complexity and dependence on both aerosol and raindrop sizes,wet scavenging process has been poorly treated,especially during the removal of fine *** makes the numerical simulation of below-cloud scavenging in large-scale aerosolmodels *** consider the slip effects of submicron particles,a simplified expression for the diffusion scavenging was developed by approximating the Cunningham slip correction *** derived analytic solution was parameterized as a simple power function of rain intensity under the assumption of the lognormal size distribution of *** resultant approximated expression was compared to the observed data and the results of previous studies including a 3D atmospheric chemical transport model *** with the default GEOS-Chem coefficient of 0.00106R0.61 and the observation-based coefficient of 0.0144R0.9268,the coefficient of a and b in∧m=aRb spread in the range of 0.0002-0.1959 for a and 0.3261-0.525 for b over a size distribution of GSD of 1.3–2.5 and a geometric mean diameter of 0.01-2.5μ***,this study showed that the scavenging coefficient varies widely by orders of magnitude according to the size distribution of particles and rain *** study also demonstrated that the obtained simplified expression could consider the theoretical approach of aerosol *** proposed analytic approach showed that results can be effectively applied for reduced computational burden in atmospheric modeling.

关键词： Below-cloud scavenging Polydisperse aerosol Parameterization Cunningham correction factor Scavenging coefficient

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Reaction mechanism and additional lithium storage of mesoporous MnO_(2) anode in Li batteries

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Journal of Energy Chemistry 2021年第2期30卷 276-284,I0010页

作者： Jaesang yoon Woosung choi Taewhan Kim Hyunwoo Kim Yun Seok choi Ji Man Kim Won-Sub yoon Department of Energy Science Sungkyunkwan UniversitySuwon 16419South Korea Department of Chemistry Sungkyunkwan UniversitySuwon 16419South Korea

Nanostructured transition metal oxides,employed as anode materials for lithium-ion batteries,exhibit a higher capacity than the theoretical capacity based on the conversion *** date,the reasons behind this phenomenon are *** the one-step evolution of anode material for lithium-ion batteries,it is essential to understand the lithium storage reaction mechanism of the anode ***,we provide a detailed report on the lithium storage and release mechanism of MnO2,using synchrotron-based X-ray techniques.X-ray diffraction and X-ray absorption spectroscopy results indicate that during the first discharge,MnO2 is reduced in the order of MnO2→LixMnO2(1

关键词： Mesoporous MnO_(2) Reaction mechanism Electrolyte-derived surface layer Synchrotron-based X-ray techniques Anode Li battery

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Adsorption properties of polycarboxylate ether-based superplasticizer on cement particles and their resultant dispersion

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Frontiers of Structural and Civil Engineering 2022年第4期16卷 506-514页

作者： Jinyoung yoon Byoung Il choi Jae Hong KIM Department of Structural Engineering Research Korea Institute of Civil Engineering and Building Technology(KICT)Goyang 10223Republic of Korea System Safety Research Department Korea Shipbuilding and Offshore EngineeringSeongnam 13591Republic of Korea Department of Civil and Environmental Engineering Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea

The cement dispersion performance of a polycarboxylate(PCE)-based superplasticizer is highly related to their adsorption behaviors as a function of *** study evaluated effects of PCEs on rheological properties of cementitious ***,characteristics of PCEs were characterized via permeation chromatography(GPC)and Fourier-transform infrared spectrometry(FT-IR).The adsorption behavior of single and blended PCEs on cementitious composites was identified using total organic carbon analyzer(TOC).Based on the measurement of PCE adsorption,the changes of rheological properties of cementitious materials as well as the number of dispersed cement particles were characterized using a rheometer and laser spectroscopy,*** experimental results support the systematic mechanism of PCE adsorption,cement dispersion,and the decrease in viscosity of cementitious materials.

关键词： adsorption polycarboxylate superplasticizer rheology dispersion

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Regular truss structure model equivalent to continuum structure

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International Journal of Agricultural and Biological Engineering 2015年第5期8卷 151-161页

作者： Won choi JeongJae Lee Seongsoo yoon Department of Rural Systems Engineering College of Agriculture and Life SciencesSeoul National UniversitySeoul 151-921South Korea Department of Rural Systems Engineering Research Institute of Agriculture and Life SciencesCollege of Agriculture and Life SciencesSeoul National UniversitySeoul 151-921South Korea Department.of Agricultural and Rural Engineering College of AgricultureLife and Environments SciencesChungbuk National UniversityChungbuk 362-763South Korea

It is difficult to solve the structural problems related to agricultural engineering,due to the wide ranges of the means of related variables and complex structural *** these reasons,discrete models are required that are able to replace or simplify solid structure components used in traditional analysis ***,the objective of this study was to develop a regular truss structure model that behaves the same way as a solid *** was assumed that if a unit element consists of truss elements with each hinge at the end of the element and the size of the element is infinitesimal,the stress distribution and displacement field will be constant throughout the domain of the unit ***,the behavior of the truss element was assumed to be in a linear state in a two-dimensional *** law of energy conservation,based on the theory of elasticity,was applied to determine the equilibrium conditions between discretized and solid *** restrictive condition that we obtained revealed that applications are limited to only ideal elastic materials with a Poisson’s ratio of 1 to *** volumetric ratio of the equivalent truss to the continuum structures was 3:1,regardless of the size or number of the *** calculate the internal stress and strain of the unit element,the geometric relationships of each truss member,which has its own role against different stress directions,were *** calculated von Misses stresses were used to verify this *** concentrations,as explained based on Saint Venant’s principle,were also observed in the equivalent truss structure *** main stress paths,indicating the areas where reinforcement bars should be placed,were successfully shown without the requirement that each element be transformed in the direction of principal stress;this was done by eliminating elements with only compressive and near-zero stresses.

关键词： structural analysis regular mesh equivalent truss structure model discretized element energy method

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Investigations of an Air Starting Motor of Marine Medium-Speed Diesel Engine with Numerical Analyses

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Journal of Thermal Science 2010年第2期19卷 148-153页

作者： Yeon Won Lee yoon Hwan choi Deog Hee Doh Division of Mechanical Eng. Pukyong National Univ.San 100 Division of Mechanical and Information Eng.

The marine medium-speed diesel engines are started by two methods;one is the electric motors,and the other air starting *** though air starting motor is dependent of the engine types and sizes,it has been widely used in this area due to its simplicity,convenience and *** purpose of this paper is to give the designing parameters in order to make a proper "Air Starting Motor" using *** aerodynamic approaches were given to understand the internal flow characteristics of the air starting *** addition,we have carried out the investigation of effects of tip *** the calculations the tip clearance of air starting motor has been varied between 0,2.8,4.3 and 5.7% of blade *** results of computation are the tip clearance increased to 2.8%,the torque decreased 24%,and there was no more large changes when the clearances increased to 4.3% and 5.7%.

关键词： Medium-Speed Diesel Engine Air Starting Motor CFD Tip Clearance Influences

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Grade-4 commercially pure titanium with ultrahigh strength achieved by twinning-induced grain refinement through cryogenic deformation

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Journal of Materials Science & Technology 2021年第7期66卷 193-201页

作者： Seong-Woo choi Jae Sukjeong Jong Woo Won Jae Keun Hong yoon Suk choi Titanium Department.Korea Institute of Materials Science Changwon51508Republic of Korea School of Materials Science and Engineering Pusan National UniversityPusan.46241Republic of Korea Materials and Manufacturing Development Team Doosan Heavy Industries and ConstructionChangwon51711Republic of Korea

The yield strength of commercially pure(CP) Ti of ASTM grade 4, the strongest among all the CP-Ti grades, is too low for structural applications that require high-strength materials. Here, we demonstrate the strengthening of grade-4 CP Ti by cryogenic-temperature rolling(CTR), which enables deformation twinning in grade-4 CP Ti to achieve twinning-induced grain refinement. CTR activated {11.22} twinning and {10.12} twinning, which are the most common twinning systems in pure Ti, whereas room-temperature rolling(RTR) did not activate any twinning system. CTR with imposing an area reduction of just 30% significantly increased the yield strength of the CP Ti to 946 MPa, which is not achievable through typical processes performed at or above room temperature and is comparable to that of commercial Ti-6 Al-4 V. The significant increase in strength was due to microstructural strengthening caused by twinning-induced grain refinement, combined with dislocation accumulation. In contrast to RTR, CTR greatly increased the stress concentration at grain boundaries(GBs), which caused the unusual activation of twinning in the grade-4 CP Ti by facilitating twin nucleation at GBs. The stress concentration increased because CTR activated the slip to a lesser extent compared to RTR, thereby reducing the strain compatibility between neighboring grains. These results will contribute to development of ultrahigh-strength CP Ti and may thereby extend its use to structural applications that require high-strength materials.

关键词： Titanium Twinning Cryogenic deformation Grain refinement Tensile properties

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100 W-class green hydrogen production from ammonia at a dual-layer electrode containing a Pt-Ir catalyst for an alkaline electrolytic process

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Journal of Energy Chemistry 2024年第6期93卷 352-360,I0009页

作者： Donghyun yoon Sunki Chung Minjun choi Eunhyeok Yang Jaeyoung Lee School of Earth Sciences and Environmental Engineering Gwangju Institute of Science and Technology(GIST)Gwangju 61005Republic of Korea International Future Research Center of Chemical Energy Storage and Conversion Processes GISTGwangju 61005Republic of Korea Ertl Center for Electrochemistry and Catalysis GISTGwangju 61005Republic of Korea TKG Huchems Co.Ltd 963Sangam-roYeosu-siJeollanam-do 59614Republic of Korea

Ammonia allows storage and transport of hydrogen over long distances and is an attractive potential hydrogen *** decomposition has recently been used for the conversion of ammonia to hydrogen and is regarded as a future technology for production of CO_(2)-free pure ***,a heterostructural Pt-Ir dual-layer electrode is developed and shown to achieve successful long-term operation in an ammonia electrolyzer with an anion exchange membrane(AEM).This electrolyzer consisted of eight membra ne electrode assemblies(MEAs)with a total geometric area of 200 cm~2 on the anode side,which resulted in a hydrogen production rate of 25 L h~(-1).We observed the degradation in MEA performance attributed to changes in the anode catalyst layer during hydrogen production via ammonia ***,we demonstrated the relationship between the ammonia oxidation reaction(AOR)and the oxygen evolution reaction(OER).

关键词： Ammonia oxidation Dual-layer catalyst Green hydrogen Electrolytic process Oxygen evolution reaction

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