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The effects of anti-vascular endothelial growth factor agents on human retinal pigment epithelial cells under high glucose conditions

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International Journal of Ophthalmology(English edition) 2017年第2期10卷 203-210页

作者： Jong Rok Oh Jung Woo Han yoon kyung kim Young-Hoon Ohn Tae Kwann Park Department of Ophthalmology Soonchunhyang UniversityCollege of MedicineSoonchunhyang University Bucheon HospitalBucheonKorea

AIM： To investigate the effects of high glucose levels and anti-vascular endothelial growth factor（VEGF） agents（bevacizumab,ranibizumab and aflibercept） on retinal pigment epithelium（RPE） ***： ARPE-19 cells were cultured at different glucose levels（5.5 mmol/L,25 mmol/L,and 75 mmol/L）.Cell viability was evaluated by MTT assay at 3d after treatment with *** migration ability was measured by wound healing assay at 3d.A cell death detection kit was used to assess apoptosis at 3 and 14 *** proliferation was assessed by EdU assay at *** culture medium was treated with anti-VEGF agents at clinically relevant *** experiment was then repeated at a different glucose ***： The viability and migration of ARPE-19 cells were significantly decreased in the presence of 75 mmol/L as compared to 5.5 mmol/L *** percentage of TUNEL-positive cells was significantly increased and the proliferative potential was decreased with 75 mmol/L compared to 5.5 mmol/L *** were no significant differences in the results between 25 mmol/L and 5.5 mmol/L *** the presence of 75 mmol/L glucose,the groups treated with anti-VEGF showed decreased cell viability and proliferation and increased ***,there were no significant differences between the anti-VEGF ***： High glucose level decreases the viability,wound healing ability,and proliferation of RPE cells,while increasing ***,anti-VEGF agents interfered with the physiological functions of RPE cells under high-glucose conditions,accompanied by decreases in cell viability and proliferation.

关键词： retinal pigment epithelium anti-vascularendothelial growth factor high glucose

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In situ synthesis of chemically bonded NaTi2（PO4）3/rGO 2D nanocomposite for high-rate sodium-ion batteries

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Nano Research 2016年第6期9卷 1844-1855页

作者： Ha-kyung Roh Hyun-kyung kim Myeong-Seong kim Dong-Hyun kim kyung yoon Chung Kwang Chul Roh Kwang-Bum kim Department of Material Science & Engineering Yonsei University 50 Yonsei-ro Seodaemun-gu Seou103722 Republic of Korea Department of Materials Science and Metallurgy University of Cambridge 27 Charles Babbage Road Cambridge CB30FS UK Center for Energy Convergence Korea Institute of Science and Technology 5 Hwarang-ro 14-gil Seongbuk-gu Seou102792 Republic of Korea Energy & Environmental Division Korea Institute of Ceramic Engineering & Technology 101 Soho-ro Jinju-si Gyeongsangnam-do 52851 Republic of Korea

A phase-pure NaTi2（PO4）3/reduced graphene oxide （rGO） nanocomposite was prepared using a microwave-assisted one-pot method and subsequent heat treatment. The well-crystallized NaTi2（PO4）3 nanoparticles （30-40 nm） were uniformly precipitated on rGO templates through Ti-O-C bonds. The chemical interactions between the NaTi2（PO4）3 nanoparticles and rGO could immobilize the NaTi2（PO4）3 nanoparticles on the rGO sheets, which might be responsible for the excellent electrochemical performance of the nanocomposite. The NaTi2（PO4）B/rGO nanocomposite exhibited a specific capacity of 128.6 mA-h.g-1 approaching the theoretical value at a 0.1 C-rate with an excellent rate capability （72.9% capacity retention at 50 C-rate） and cycling performance （only 4.5% capacity loss after 1,000 cycles at a high rate of 10 C）. These properties were maintained even when the electrodes were prepared without the use of an additional conducting agent. The excellent sodium storage properties of the NaTi2（PO4）B/rGO nanocomposite could be attributed to the nano-sized NaTi2（PO4）3 particles, which significantly reduced the transport lengths for Na＋ ions, and an intimate contact between the NaTi2（PO4）3 particles and rGO due to chemical bonding.

关键词： NaTi2(PO4)dreducedgraphene oxide (rGO)nanocomposite chemical bonding energy-efficiency in situ synthesis high-rate sodium-ion batteries

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The Role of Relative Spinal Motion during Feline Galloping for Speed Performance

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Journal of Bionic Engineering 2014年第4期11卷 517-528页

作者： Young Kook kim Jongwon Park Byungho yoon kyung-Soo kim Soohyun kim Robotics Program Korea Advanced Institute of Science and Technology (KAIST) Daejeon 305-701 Republic of Korea Department of Mechanical Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon 305-701 Republic of Korea

Felines use their spinal column to increase their running speed at rapid locomotion performance. However, its motion profile behavior during fast gait locomotion has little attention. The goal of this study is to examine the relative spinal motion profile during two different galloping gait speeds. To understand this dynamic behavior trend, a dynamic motion of the feline animal （Felis catus domestica） was measured and analyzed by motion capture devices. Based on the experiments at two different galloping gaits, we observed a significant increase in speed （from 3.2 m.s-1 to 4.33 m.s-1） during the relative motion profile synchronization between the spinal （range： 118.86~ to 168.00~） and pelvic segments （range： 46.35~ to 91.13~） during the hindlimb stance phase （time interval： 0.495 s to 0.600 s）. Based on this discovery, the relative angular speed profile was applied to understand the possibility that the role of the relative motion match during high speed locomotion generates bigger ground reaction force.

关键词： feline galloping galloping gait pattern relative spinal motion speed performance phase match

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Treatment of intractable orbital implant exposure with a large conjunctival defect by secondary insertion of the implant after preceding dermis fat graft

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International Journal of Ophthalmology(English edition) 2013年第2期6卷 193-197页

作者： Hyun kyung kim Tae yoon La Department of Ophthalmology St. Vincent's Hospital College of Medicine The Catholic University of Korea

AIM: To report a procedure and results of a two-stage operation to manage intractable extensive orbital implant exposure with a large conjunctival defect which was difficult to treat with dermis fat grafts due to repeated graft necrosis. METHODS: A retrospective chart review of four patients who had extensive orbital implant exposures with large conjunctival defects and had past histories of repeated autologous or preserved dermis graft failures was done. As a first-stage operation, the problematic pre-existing orbital implants were removed and autologous dermis fat grafts alone were performed on the defect area. Four months later, new orbital implants were secondarily inserted after confirmation of graft survival. The size of the conjunctival defects and state of the extraocular muscles were checked preoperatively. Success of the operations and complications were ***: The mean size of the conjuctival defects was 17.3mm×16.0mm, and the mean time from the initial diagnosis of orbital implant exposure to implant removal and autologous dermis fat graft was 20.8 months. After implant removal and autologous dermis fat graft, no graft necrosis was observed in any patients. Also, implant exposure or fornix shortening was not observed in any patients after new orbital implant insertion. CONCLUSION: The secondary insertion of a new orbital implant after pre-existing implant removal and preceding dermis fat graft is thought to be an another selective management of intractable orbital implant exposure in which dermis fat grafts persistently fail.

关键词： conjunctival defect dermis fat graft orbital implant exposure

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A Unified Buffering Management with Set Divisible Cache for PCM Main Memory

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Journal of Computer Science & Technology 2016年第1期31卷 137-146页

作者： Mei-Ying Bian Su-kyung yoon Jeong-Geun kim Sangjae Nam Shin-Dug kim Department of Computer Science Yonsei University Seoul 120-749 Korea

This research proposes a phase-change memory （PCM） based main memory system with an effective combi- nation of a superblock-based adaptive buffering structure and its associated set divisible last-level cache （LLC）. To achieve high performance similar to that of dynamic random-access memory （DRAM） based main memory, the superblock-based adaptive buffer （SABU） is comprised of dual DRAM buffers, i.e., an aggressive superblock-based pre-fetching buffer （SBPB） and an adaptive sub-block reusing buffer （SBRB）, and a set divisible LLC based on a cache space optimization scheme. According to our experiment, the longer PCM access latency can typically be hidden using our proposed SABU, which can significantly reduce the number of writes over the PCM main memory by 26.44%. The SABU approach can reduce PCM access latency up to 0.43 times, compared with conventional DRAM main memory. Meanwhile, the average memory energy consumption can be reduced by 19.7%.

关键词： memory hierarchy memory structure,cache memory buffer management

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A Study on Energy Saving Rate for Variable Speed Condition of Multistage Centrifugal Pump

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Journal of Thermal Science 2015年第6期24卷 566-573页

作者： Sang-Ho Suh Rakibuzzaman kyung-Wuk kim Hyoung-Ho kim In Sik yoon Min-Tae Cho Department of Mechanical Engineering Soongsil University Dooch Co. 295 Sagok-ri Jangan- Myeon Hwaseong-si Gyeonggi-do 445-942 South Korea

Centrifugal pumps are being widely used in many industrial and commercial *** of these pumps are being operated at constant speed but could provide energy savings through adjustable speed *** purpose of this study was to get the energy saving rates of the multistage centrifugal pump with variable speed *** this investigation an experimental set up of variable flow and pressure system was made to get energy saving rates and numerical analyses are applied to validate the pump *** energy saving and therefore the cost saving depends on the specific duty cycle of which the machine *** cycle is the proportion of time during which a component,device and system is *** duty cycle segmented into different flow rates and weighting the average value for each segment by the interval *** system was operated at 50%or less of the pump *** input power of the system was carried out by pump characteristics curve of each operating *** energy consumption was done by the product of specific duty cycle and the input power of the system for constant speed and variable speed drive *** total energy consumed for constant speed drive pump was 75,770 k *** and for variable speed drive pump was 31,700 k *** total energy saving of the system was 44,070 k *** or 58.16%***,this paper suggests a method of implementing an energy saving on variable-flow and pressure system of the multistage centrifugal pump.

关键词： Multistage Centrifugal Pump Performance Analysis Energy saving rate SST Model Duty Cycle

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Inverse Problem of Flame Surface Properties of Wood using a Repulsive Particle Swarm Optimization Algorithm

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Journal of Thermal Science 2015年第2期24卷 173-178页

作者： kyung-Beom yoon Won-Hee Park Korea Conformity Laboratories 199Gasan-digital 1-roGeumcheon-guSeoul 153-803Korea Korea Railroad Research Institute 176 Cheoldobangmulgwan-roUiwang-siGyeonggi-do 437-757Korea Korea University of Science and Technology (UST) 217 Gajeong-roYuseong-guDaejeon 305-350 Korea

The convective heat transfer coefficient and surface emissivity before and after flame occurrence on a wood specimen surface and the flame heat flux were estimated using the repulsive particle swarm optimization algorithm and cone heater test results. The cone heater specified in the ISO 5660 standards was used, and six cone heater heat fluxes were tested. Preservative-treated Douglas fir 21 mm in thickness was used as the wood specimen in the tests. This study confirmed that the surface temperature of the specimen, which was calculated using the convective heat transfer coefficient, surface emissivity and flame heat flux on the wood specimen by a repulsive particle swarm optimization algorithm, was consistent with the measured temperature. Considering the measurement errors in the surface temperature of the specimen, the applicability of the optimization method considered in this study was evaluated.

关键词： Repulsive particle swarm optimization Cone calorimeter Flame heat flux Flame surface properties

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Optimization of Pyrolysis Properties using TGA and Cone Calorimeter Test

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Journal of Thermal Science 2013年第2期22卷 168-173页

作者： Won-Hee Park kyung-Beom yoon Eco-Transport Systems Research Division Korea Railroad Research Institute Department of Mechanical Engineering Chung-Ang University

The present paper describes an optimization work to obtain the properties related to a pyrolysis process in the solid material such as density, specific heat, conductivity of virgin and char, heat of pyrolysis and kinetic parameters used for deciding pyrolysis rate. A repulsive particle swarm optimization algorithm is used to obtain the pyrolysis-related properties. In the previous study all properties obtained only using a cone calorimeter but in this paper both the cone calorimeter and thermo gravimetric analysis (TGA) are used for precisely optimizing the pyrolysis properties. In the TGA test a very small mass is heated up and conduction and heat capacity in the specimen is negligible so kinetic parameters can first be optimized. Other pyrolysis-related properties such as virgin/char specific heat and conductivity and char density are also optimized in the cone calorimeter test with the already decided parameters in the TGA test.

关键词： Pyrolysis properties Thermogravimetric analysis Cone calorimeter Repulsive particle swarmoptimization

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Striping and Scheduling for Large Scale Multimedia Servers

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Journal of Computer Science & Technology 2004年第6期19卷 885-895页

作者： kyung-OhLee Jun-HoPark yoon-YoungPark DepartmentofComputerScience SunmoonUniversity100TangJeonMyunKalsanRiAsansiChunNam336-840Korea

When designing a multimedia server, several things must be decided: which scheduling scheme to adopt, how to allocate multimedia objects on storage devices, and the round length with which the streams will be serviced. Several problems in the designing of large-scale multimedia servers are addressed, with the following contributions: (1) a striping scheme is proposed that minimizes the number of seeks and hence maximizes the performance; (2) a simple and efficient mechanism is presented to find the optimal striping unit size as well as the optimal round length, which exploits both the characteristics of VBR streams and the situation of resources in the system; and (3) the characteristics and resource requirements of several scheduling schemes are investigated in order to obtain a clear indication as to which scheme shows the best performance in realtime multimedia servicing. Based on our analysis and experimental results, the CSCAN scheme outperforms the other schemes. It is believed that the results are of value in the design of effective large-scale multimedia servers. Keywords realtime multimedia - storage server - scheduling - data placement - buffer management - variable bit rate This work was supported in part by the University IT Research Center Project and Sunmoon University Research Project.kyung-Oh Lee is an associate professor in the Faculty of Computer and Information Sciences, Sunmoon University, Korea. He received his B.S., M.S. and Ph.D. degrees in computer science from Seoul National University in 1989, 1994 and 1999, respectively. His current research interests include multimedia system, database, mobile communication. He is a member of KIPS (Korea Information Processing Society).Jungho-Ho Park is a professor in the Divisions of Computer and Information Sciences, Sunmoon University, Korea. He received his M.S. and Ph.D. degrees in computer science from Osaka University in 1987 and 1990, respectively. His current research interests include d

关键词： realtime multimedia storage server scheduling data placement buffer management variable bit rate

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Salt Tolerance in Rice: Focus on Mechanisms and Approaches

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Rice science 2017年第3期24卷 123-144页

作者： Inja Naga Bheema Lingeswara REDDY Beom-Ki kim In-Sun yoon kyung-Hwan kim Taek-Ryoun KWON Genetic Engineering Division Department of Agricultural Biotechnology National Institute of Agricultural Sciences Rural Development Administration Jeonju-54874 South Korea

Salt tolerance is an important constrain for rice, which is generally categorized as a typical glycophyte. Soil salinity is one of the major constraints affecting rice production worldwide, especially in the coastal areas. Susceptibility or tolerance of rice plants to high salinity is a coordinated action of multiple stress responsive genes, which also interacts with other components of stress signal transduction pathways. Salt tolerant varieties can be produced by marker-assisted selection or genetic engineering by introducing salt-tolerance genes. In this review, we have updated on mechanisms and genes which can help in transferring of the salt tolerance into high-yielding rice varieties. We have focused on the need for integrating phenotyping, genomics, metabolic profiling and phenomics into transgenic and breeding approaches to develop high-yielding as well as salt tolerant rice varieties.

关键词： rice mechanism salinity salt tolerance yield gene protein

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