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RFC2 may contribute to the pathogenicity of Williams syndrome revealed in a zebrafish model

Journal of Genetics and Genomics 2024年第12期51卷 1389-1403页

作者： Ji-Won Park Tae-Ik Choi Tae-yoon Kim Yu-Ri Lee Dilan Wellalage Don Jaya K.George-Abraham Laurie A.Robak Cristina C.Trandafir Pengfei Liu Jill A.Rosenfeld Tae Hyeong Kim Florence Petit Yoo-Mi Kim Chong Kun Cheon yoonsung Lee Cheol-Hee Kim Department of Biology Chungnam National UniversityDaejeon 34134Republic of Korea Department of Pediatrics The University of Texas at Austin Dell Medical SchoolAustinTX 78723USA Department of Molecular and Human Genetics Baylor College of MedicineHoustonTX 77030USA Baylor Genetics Laboratories HoustonTX 77021USA Department of Pediatrics Kyung Hee University Hospital at GangdongSeoul 05278Republic of Korea Univ.Lille CHU LilleClinique de g en etique Guy FontaineF-59000 LilleFrance Department of Pediatrics Chungnam National University Sejong HospitalSejong 30099Republic of Korea Department of Pediatrics Pusan National University Children’s HospitalYangsan 50612Republic of Korea Research Institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan HospitalYangsan 50612Republic of Korea Clinical Research Institute Kyung Hee University Hospital at GangdongSchool of MedicineKyung Hee UniversitySeoul 05278Republic of Korea

Williams syndrome(WS)is a rare multisystemic disorder caused by recurrent microdeletions on 7q11.23,characterized by intellectual disability,distinctive craniofacial and dental features,and cardiovascular *** studies have explored the roles of individual genes within these microdeletions in contributing to WS ***,we report five patients with WS with 1.4 Mb-1.5 Mb microdeletions that include RFC2,as well as one patient with a 167-kb microdeletion involving RFC2 and six patients with intragenic variants within *** investigate the potential involvement of RFC2 in WS pathogenicity,we generate a rfc2 knockout(KO)zebrafish using CRISPR-Cas9 ***,we generate a KO zebrafish of its paralog gene,rfc5,to better understand the functions of these RFC genes in development and *** rfc2 and rfc5 KO zebrafish exhibit similar phenotypes reminiscent of WS,including small head and brain,jaw and dental defects,and vascular ***-seq analysis reveals that genes associated with neural cell survival and differentiation are specifically affected in rfc2 KO *** addition,heterozygous rfc2 KO adult zebrafish demonstrate an anxiety-like behavior with increased social *** results suggest that RFC2 may contribute to the pathogenicity of WS,as evidenced by the zebrafish model.

关键词： Williams syndrome RFC2 RFC5 Zebrafish Knockout CRISPR-Cas9

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Phase Ⅱ study of R-CVP followed by rituximab maintenance therapy for patients with advanced marginal zone lymphoma:consortium for improving survival of lymphoma(CISL)study

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Cancer Communications 2019年第1期39卷 526-535页

作者： Sung Yong Oh Won Seog Kim Jin Seok Kim Seok Jin Kim Dok Hyun yoon Deok-Hwan Yang Won Sik Lee Hyo Jung Kim Ho-Young Yhim Seong Hyun jeong Jong Ho Won Suee Lee Jee Hyun Kong Sung-Nam Lim Jun Ho Ji kyung A.Kwon Gyeong-Won Lee Jae Hoon Lee Ho Sup Lee Ho-Jin Shin Cheolwon Suh Department of Internal Medicine Dong-A University HospitalBusan 49201Republic of Korea Department of Medicine Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351Republic of Korea Division of Hematology Department of Internal MedicineYonsei University College of MedicineSeoul 03722Republic of Korea Department of Oncology Asan Medical CenterUniversity of Ulsan College of MedicineSongpa-guSeoul 05505Republic of Korea Department of Hematology-Oncology Chonnam National University Hwasun HospitalHwasun 58128Republic of Korea Department of Hematology Busan Paik HospitalInje University College of MedicineBusan 04511Republic of Korea Department of Internal Medicine Hallym University Sacred Heart HospitalHallym University College of MedicineAnyang 14068Republic of Korea Department of Internal Medicine Chonbuk National University HospitalJeonju 54907Republic of Korea Department of Hematology-Oncology Ajou University School of MedicineSuwon 16499Republic of Korea Department of Internal Medicine Soonchunhyang University Seoul HospitalSoonchunhyang University College of MedicineSeoul 04401Republic of Korea Division of Hematology-Oncology Department of Internal MedicineWonju Severance Christian HospitalYonsei University College of MedicineWonju 26426Republic of Korea Department of Internal Medicine Haeundae Paik HospitalInje University College of MedicineBusan 48108Republic of Korea Division of Hematology and Oncology Department of Internal MedicineSamsung Changwon HospitalSungkyunkwan University School of MedicineChangwon 51353Republic of Korea Division of Hematology-Oncology Department of Internal MedicineDongnam Institute of Radiological and Medical SciencesBusan 46033Republic of Korea Division of Hematology-Oncology Department of Internal MedicineGyeongsang National University HospitalGyeongsang National University College of MedicineJinju 52727Republic of Korea Department of Internal Medicine Gachon University Gil Medical CenterIncheon 21565Republic of

Background:The response rate and survival improvement for rituximab,a CD20-targeting monoclonal antibody,have been demonstrated in marginal zone lymphoma(MZL)as monotherapy and in combination with chemotherapeutic regimens,yet relapses still occur despite treatment ***,extending the period of remission in MZL patients remains an essential *** multicenter,single-arm,open-label phase II study evaluated the survival efficacy of 2 years of rituximab-maintenance therapy in patients with stage III-IV CD20-positive MZL who had responded to first-line R-CVP(rituximab,cyclophosphamide,vincristine,and prednisolone).The objective of this study was to determine whether rituximab maintenance following R-CVP warrants further ***:Prior to rituximab-maintenance therapy,patients received 6-8 cycles of first-line R-CVP therapy for stage III-IV ***(375 mg/m^(2)),cyclophosphamide(750 mg/m^(2)),and vincristine(1.4 mg/m^(2);maximum 2 mg)were administered via an intravenous infusion on day 1 of each 3-week cycle,while oral prednisolone(100 mg)was given on days 1-5 of each 3-week *** patients who achieved complete response(CR),partial response(PR),or stable disease(SD)to R-CVP treatment,were prescribed rituximab-maintenance therapy which was administered intravenously at a dose of 375 mg/m^(2) every 8 weeks for up to 12 *** primary endpoint was progression-free survival(PFS).Secondary endpoints were overall survival(OS)and treatment ***:47 patients were enrolled,of whom,45(96%)received rituximab-maintenance ***(33%)patients had nodal *** R-CVP first-line therapy,20(44%),22(49%),and 3(7%)patients achieved CR,PR,and SD,*** a median follow-up of 38.2 months,their observed 3-year PFS rate was 81%.During the rituximab-maintenance,6 PR and 1 SD patients achieved CR following the administration of *** LDH and the presence of B symptoms were found to be significant prognostic fac

关键词： Marginal zone Lymphoma Advanced stage Rituximab Cyclophosphamide Vincristine Maintenance Multicenter Open label Survival

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边缘区淋巴瘤晚期患者R-CVP后利妥昔单抗维持治疗的Ⅱ期研究:一项改善淋巴瘤生存协会(CISL)的研究

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癌症 2020年第3期39卷 118-128页

作者： Sung Yong Oh Won Seog Kim Jin Seok Kim Seok Jin Kim Dok Hyun yoon Deok‑Hwan Yang Won Sik Lee Hyo Jung Kim Ho‑Young Yhim Seong Hyun jeong Jong Ho Won Suee Lee Jee Hyun Kong Sung‑Nam Lim Jun Ho Ji kyung A.Kwon Gyeong‑Won Lee Jae Hoon Lee Ho Sup Lee Ho‑Jin Shin Cheolwon Suh Department of Internal Medicine Dong-A University HospitalBusan 49201Republic of Korea Department of Medicine Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351Republic of Korea Division of Hematology Department of Internal MedicineYonsei University College of MedicineSeoul 03722Republic of Korea Department of Oncology Asan Medical CenterUniversity of Ulsan College of MedicineSongpa‑guSeoul 05505Republic of Korea Department of Hematology‑Oncology Chonnam National University Hwasun HospitalHwasun 58128Republic of Korea Department of Hematology Busan Paik HospitalInje University College of MedicineBusan 04511Republic of Korea Department of Internal Medicine Hallym University Sacred Heart HospitalHallym University College of MedicineAnyang 14068Republic of Korea Department of Internal Medicine Chonbuk National University HospitalJeonju 54907Republic of Korea Department of Hematology‑Oncology Ajou University School of MedicineSuwon 16499Republic of Korea Department of Internal Medicine Soonchunhyang University Seoul HospitalSoonchunhyang University College of MedicineSeoul 04401Republic of Korea Division of Hematology‑Oncology Department of Internal MedicineWonju Severance Christian HospitalYonsei University College of MedicineWonju 26426Republic of Korea Department of Internal Medicine Haeundae Paik HospitalInje University College of MedicineBusan 48108Republic of Korea Division of Hematology and Oncology Department of Internal MedicineSamsung Changwon HospitalSungkyunkwan University School of MedicineChangwon 51353Republic of Korea Division of Hematology‑Oncology Department of Internal MedicineDongnam Institute of Radiological and Medical SciencesBusan 46033Republic of Korea Division of Hematology‑Oncology Department of Internal MedicineGyeongsang National University HospitalGyeongsang National University College of MedicineJinju 52727Republic of Korea Department of Internal Medicine Gachon University Gil Medical CenterIncheon 21565Republic of

背景与目的利妥昔单抗是一种靶向CD20的单克隆抗体,在治疗边缘区淋巴瘤(marginal zone lymphoma,MZL)中可以单药或联合化疗使用,可提高缓解率和生存率,但治疗后仍可能会复发。因此,仍需探索如何延长MZL患者的缓解期的治疗方案。这项多... 详细信息

背景与目的利妥昔单抗是一种靶向CD20的单克隆抗体,在治疗边缘区淋巴瘤(marginal zone lymphoma,MZL)中可以单药或联合化疗使用,可提高缓解率和生存率,但治疗后仍可能会复发。因此,仍需探索如何延长MZL患者的缓解期的治疗方案。这项多中心、单臂、开放标签的Ⅱ期研究评估了对一线R-CVP(rituximab,cyclophosphamide,vincristine,and prednisolone;利妥昔单抗、环磷酰胺、长春新碱和泼尼松龙)治疗有反应的Ⅲ–Ⅳ期CD20阳性MZL患者进行利妥昔单抗维持治疗2年的生存率。本研究旨在明确R-CVP后利妥昔单抗维持治疗的策略是否有进一步研究的价值。方法在利妥昔单抗维持治疗之前,Ⅲ–Ⅳ期MZL患者应接受6–8周期的R-CVP一线治疗。每个周期为3周,第1 d静脉输注利妥昔单抗(375 mg/m^2)、环磷酰胺(750 mg/m^2)和长春新碱(1.4 mg/m^2;最大2 mg),第1–5 d口服泼尼松龙(100 mg)。对R-CVP治疗达到完全缓解(complete response,CR)、部分缓解(part response,PR)或疾病稳定(stable response,SD)的患者进行利妥昔单抗维持治疗,每8周静脉注射利妥昔单抗375mg/m^2,直到12个周期。主要终点为无进展生存期(progression-free surviva,PFS),次要终点为总生存期(overall survival,OS)和治疗安全性。结果共纳入47例患者,其中45(96%)例接受了利妥昔单抗维持治疗。15(33%)例患者有淋巴结MZL。在进行R-CVP一线治疗后,分别有20(44%)例、22(49%)例和3(7%)例的患者达到了CR、PR和SD。中位随访38.2个月后,患者的3年PFS率为81%。在利妥昔单抗维持治疗期间,R-CVP治疗后有6例PR和1例SD患者获得CR。LDH升高和B症状是PFS的重要预后因素(P=0.003),3年OS率为90%。利妥昔单抗维持治疗的耐受性良好,常见的治疗性不良事件为感觉性神经病(18%)、肌痛(13%)、疲劳(9%)和中性粒细胞减少(9%)。结论一线R-CVP治疗后利妥昔单抗维持治疗在Ⅲ–Ⅳ期MZL患者中不仅表现出较好的PFS,而且药物毒性反应评价良好。

关键词：边缘区淋巴瘤晚期利妥昔单抗环磷酰胺长春新碱维持多中心开放标签生存

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膝关节Rosenberg位片上影像学分级与内侧开放楔形胫骨高位截骨术术后临床疗效的关系探讨

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实用骨科杂志 2019年第10期25卷 878-878页

作者： kyung Wook Nha Seung Min Oh yoon Won Ha Manoj Kumar Patel Ji Hyun Seo Byung Hoon Lee 黄景星(整理) 王浩浩(整理) 张民(整理) 不详山西医科大学第二医院

目的探讨与内侧开放楔形胫骨高位截骨术(open-wedge high-tibialosteotomy,OWHTO)术后临床疗效最密切相关的影像学分级方法,并找出与OWHTO预后相关的有利和不利因素。方法分析79例膝骨关节炎伴固有胫骨内翻畸形的患者,均接受OWHTO治疗... 详细信息

目的探讨与内侧开放楔形胫骨高位截骨术(open-wedge high-tibialosteotomy,OWHTO)术后临床疗效最密切相关的影像学分级方法,并找出与OWHTO预后相关的有利和不利因素。方法分析79例膝骨关节炎伴固有胫骨内翻畸形的患者,均接受OWHTO治疗。根据改良关节镜下Outerbridge分级以及影像学Kellgren-Lawrence(K-L)分级进行骨关节炎严重程度评估,影像学检查包括站立前后位(anteroposterior,AP)及屈曲45°后前(posteroanterior,PA)负重位(Rosenberg位)。临床疗效采用牛津膝关节评分(Oxford knee score,OKS)进行评估,包括术前和术后2年的随访。采用多元回归分析相关数据。结果随访2年,OKS评分均值由(20±4)分提高到(39±5)分(P<0.001)。平均机械胫股角由内翻的(6.9±3.4)°变为外翻的(2.7±2.8)°,胫骨近端内侧角(medial proximal tibial angle,MPTA)由(85.6±2.4)°变为(92.9±3.7)°(P<0.001)。术前膝关节站立前后位上K-L分级为(2.4±0.9)分,Rosenberg位上K-L分级为(2.8±0.9)分(P=0.003),关节镜下改良Outerbridge骨关节炎分级为(3.4±0.7)分。在多元回归分析中,Rosenberg位下K-L分级(P=0.01)、术后MPTA值(P=0.01)与术后2年随访的OKS评分呈显著负相关(P=0.01)。结论采用三种不同的骨关节炎分级方案(分别是改良关节镜下Outerbridge分级、站立前后位的K-L分级、Rosenberg位的K-L分级)来确定HTO手术指证,其中基于Rosenberg位的K-L分级与OWHTO术后OKS评分呈显著负相关,这与Rosenberg位下股骨髁与胫骨髁距离最近有关。说明基于Rosenberg位的K-L分级对HTO手术指证评估以及对晚期膝骨关节炎患者临床疗效的评估具有重要意义。

关键词：胫骨高位截骨术骨关节炎影像学分级牛津膝关节评分

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全髋关节表面置换术后股骨近端骨密度的变化

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中华外科杂志 2007年第16期45卷 1091-1094页

作者：廉永云 Yoo Myung-chul 裴福兴程惊秋冯卫 Choyoon-je KimGung-il ChunSung-wook 四川大学华西医院骨科 Department of Orthopedic Surgery kyung Hee University Hospital Seoul 130702 Korea 卫生部移植工程与移植免疫重点实验室

目的评价全髋关节表面置换术对股骨近端骨量变化的影响。方法 2002年7月至2005年6月,对行全髋关节表面置换术(表面置换组)和人工全髋关节置换术(全髋置换组)各26例患者作为研究对象,均在术前、术后3、6、12和24个月时对股骨近端按 Gruen... 详细信息

目的评价全髋关节表面置换术对股骨近端骨量变化的影响。方法 2002年7月至2005年6月,对行全髋关节表面置换术(表面置换组)和人工全髋关节置换术(全髋置换组)各26例患者作为研究对象,均在术前、术后3、6、12和24个月时对股骨近端按 Gruen 分区设为7个测量感兴趣区,表面置换组加股骨颈外上和内下区,应用双能 X 线吸收测定仪测定骨密度,比较两组术前和术后股骨近端骨密度变化。结果术后3、6、12和24个月时,表面置换组股骨近端骨密度分别降低5.8%、4.9%、2.6%和0.4%;测量感兴趣区1的骨密度术后6个月时降至89.7%,至24个月时增至103.8%;测量感兴趣区7的骨密度术后6个月时降至95.1%,24个月时增至103.7%;股骨颈部骨密度在术后6个月时即可恢复至术前水平,股骨颈外上区的骨密度术后3个月时降至97.1%,术后24个月时增至107.4%(P<0.05);股骨颈内下区的骨密度术后24个月时增至117.9%(P<0.05)。全髋置换组股骨近端骨密度分别降低7.0%、10.6%、1.0%和4.1%。测量感兴趣区1的骨密度术后6个月降至90.8%,术后24个月时为94.4%;测量感兴趣区7术后3个月降至94.2%,术后24个月时为96.7%。结论全髋关节表面置换术后股骨近端骨量可以得到有效保存和恢复。

关键词：关节成形术,置换,髋骨密度髋关节表面置换术

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An Earth-mass planet in a time of COVID-19:KMT-2020-BLG-0414Lb

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Research in Astronomy and Astrophysics 2021年第9期21卷 243-261页

作者： Weicheng Zang Cheongho Han Iona Kondo Jennifer C.Yee Chung-Uk Lee Andrew Gould Shude Mao Leandro de Almeida Yossi Shvartzvald Xiangyu Zhang Michael D.Albrow Sun-Ju Chung Kyu-Ha Hwang Youn Kil Jung yoon-Hyun Ryu In-Gu Shin Sang-Mok Cha Dong-Jin Kim Hyoun-Woo Kim Seung-Lee Kim Dong-Joo Lee Yongseok Lee Byeong-Gon Park Richard W.Pogge John Drummond Thiam-Guan Tan JoséDias do Nascimento Júnior Dan Maoz Matthew T.Penny Wei Zhu Ian A.Bond Fumio Abe Richard Barry David P.Bennett Aparna Bhattacharya Martin Donachie Hirosane Fujii Akihiko Fukui Yuki Hirao Yoshitaka Itow Rintaro Kirikawa Naoki Koshimoto Man Cheung Alex Li Yutaka Matsubara Yasushi Muraki Shota Miyazaki Greg Olmschenk Clément Ranc Nicholas J.Rattenbury Yuki Satoh Hikaru Shoji Stela Ishitani Silva Takahiro Sumi Daisuke Suzuki Yuzuru Tanaka Paul J.Tristram Tsubasa Yamawaki Atsunori Yonehara Andreea Petric Todd Burdullis Pascal Fouqué Department of Astronomy Tsinghua UniversityBeijing 100084China Department of Physics Chungbuk National UniversityCheongju 28644Republic of Korea Department of Earth and Space Science Graduate School of ScienceOsaka UniversityToyonakaOsaka 560-0043Japan Center for Astrophysics j Harvard&Smithsonian 60 Garden St.CambridgeMA 02138USA Korea Astronomy and Space Science Institute Daejon 34055Republic of Korea University of Science and Technology Korea(UST)217 Gajeong-ro Yuseong-guDaejeon 34113Republic of Korea Max-Planck-Institute for Astronomy Königstuhl 1769117 HeidelbergGermany Department of Astronomy Ohio State University140 W.18th Ave.ColumbusOH 43210USA National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Universidade Federal do Rio Grande do Norte(UFRN) Departamento de F´1sica59078-970NatalRNBrazil Department of Particle Physics and Astrophysics Weizmann Institute of ScienceRehovot 76100Israel University of Canterbury Department of Physics and AstronomyPrivate Bag 4800Christchurch 8020New Zealand School of Space Research Kyung Hee UniversityYonginKyeonggi 17104Republic of Korea Possum Observatory PatutahiGisbourneNew Zealand Perth Exoplanet Survey Telescope PerthAustralia School of Physics and Astronomy Tel-Aviv UniversityTel-Aviv 6997801Israel Department of Physics and Astronomy Louisiana State UniversityBaton RougeLA 70803 USA Canadian Institute for Theoretical Astrophysics University of Toronto60 St George StreetTorontoON M5S 3H8Canada Institute of Natural and Mathematical Sciences Massey UniversityAuckland 0745New Zealand Institute for Space-Earth Environmental Research Nagoya UniversityNagoya 464-8601Japan Code 667 NASA Goddard Space Flight CenterGreenbeltMD 20771USA Department of Astronomy University of MarylandCollege ParkMD 20742USA Department of Physics University of AucklandPrivate Bag 92019AucklandNew Zealand Department of Earth and Planetary Science Graduate School of ScienceThe University of Tokyo7-3-1 Hongo

We report the discovery of KMT-2020-BLG-0414 Lb,with a planet-to-host mass ratio q2=0.9-1.2×10-5=3-4 q⊕at 1σ,which is the lowest mass-ratio microlensing planet to *** with two other recent discoveries(4?q/q⊕?6),it fills out the previous empty sector at the bottom of the triangular(log s,log q)diagram,where s is the planet-host separation in units of the angular Einstein radiusθ***,these discoveries call into question the existence,or at least the strength,of the break in the mass-ratio function that was previously suggested to account for the paucity of very low-q *** to the extreme magnification of the event,Amax~1450 for the underlying single-lens event,its light curve revealed a second companion with q3~0.05 and|log s3|~1,i.e.,a factor~10 closer to or farther from the host in *** measurements of the microlens parallaxπE and the angular Einstein radiusθE allow estimates of the host,planet and second companion masses,(M1,M2,M3)~(0.3 M⊙,1.0 M⊕,17 MJ),the planet and second companion projected separations,(a⊥,2,a⊥,3)~(1.5,0.15 or 15)au,and system distance DL~1 *** lens could account for most or all of the blended light(I~19.3)and so can be studied immediately with high-resolution photometric and spectroscopic observations that can further clarify the nature of the *** planet was found as part of a new program of high-cadence follow-up observations of high-magnification *** detection of this planet,despite the considerable difficulties imposed by COVID-19(two KMT sites and OGLE were shut down),illustrates the potential utility of this program.

关键词： gravitational lensing:micro

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基于辣椒基因组测序探究辣味在种群中的进化

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辣椒杂志 2014年第2期12卷 40-50页

作者： Seungill Kim Minkyu Park Seon-In Yeom Yong-Min Kim Je Min Lee Hyun-Ah Lee Eunyoung Seo Jaeyoung Choi Kyeongchae Cheong Ki-Tae Kim Kyongyong Jung Gir-Won Lee Sang-Keun Oh Chungyun Bae Saet-Byul Kim Hye-Young Lee Shin-Young Kim Myung-Shin Kim Byoung-Cheorl Kang Yeong Deuk Jo Hee-Bum Yang Hee-Jin jeong Won-Hee Kang Jin-kyung Kwon Chanseok Shin Jae Yun Lim June Hyun Park Jin Hoe Huh June-Sik Kim Byung-Dong Kim Oded Cohen Ilan Paran Mi Chung Suh Saet Buyl Lee Yeon-Ki Kim Younhee Shin Seung-Jae Noh Junhyung Park Young Sam Seo Suk-yoon Kwon Hyun A Kim jeong Mee Park Hyun-Jin Kim Sang-Bong Choi Paul W Bosland Gregory Reeves Sung-Hwan Jo Bong-Woo Lee Hyung-Taeg Cho Hee-Seung Choi Min-Soo Lee Yeisoo Yu Yang Do Choi Beom-Seok Park Allen van Deynze Hamid Ashrafi Theresa Hill Woo Taek Kim Hyun-Sook Pai Hee kyung Ahn Inhwa Yeam James J Giovannoni Jocelyn K C Rose Iben Sφrensen Sang-Jik Lee Ryan W Kim Ik-Young Choi Beom-Soon Choi Jong-Sung Lim Yong-Hwan Lee Doil Choi 刘峰张西露 Department of Plant Science Seoul National University Plant Genomics and Breeding Institute Seoul National University Department of Agricultural Biotechnology Seoul National University Department of Bioinformatics and Life Science Soongsil University Vegetable Breeding Research Center Seoul National University Agricultural Research Organization Institute of Plant Science Volcani Center Bet DaganIsrael. Agricultural Research Organization Institute of Plant Science Volcani Center Bet DaganIsrael Department of Bioenergy Science and Technology Chonnam National University Genomics Genetics Institute GreenGene BioTech Inc. Codes Division Insilicogen Inc. Ginseng Resources Research Laboratory Korea Ginseng Corporation Korea Research Institute of Bioscience and Biotechnology Division of Bioscience and Bioinformatics Myongji University Department of Plant and Environmental Sciences New Mexico State University Chile Pepper Institute New Mexico State University Seeders Inc. Department of Biological Sciences Seoul National University Arizona Genomics Institute University of Arizona Agricultural Genome Center National Academy of Agricultural Science Rural Development Administration Seed Biotechnology Center University of California Davis Davis California USA Department of Systems Biology Yonsei University Department of Horticulture and Breeding Andong National University US Department of Agriculture-Agricultural Research Service Robert W. Holley Center Ithaca New York USA Boyce Thompson Institute for Plant Research Cornell University Ithaca New York USA Department of Plant Biology Cornell University Ithaca New York USA Biotechnology Institute Nongwoo Bio Yeoju Korea Genome Center University of California Davis Davis California USA National Instrumentation Center for Environmental Management Seoul National University Seoul Korea 湖南省蔬菜研究所

辣椒(Capsicum annuum)是美洲最古老的驯化作物之一,在全世界被广泛种植。本研究对CM334(墨西哥地方品种)进行了全基因组测序和组装(覆盖度为186.6×),同时还对另外两个栽培种和一个野生种分别进行了重测序和从头(de novo)测序。结果表... 详细信息

辣椒(Capsicum annuum)是美洲最古老的驯化作物之一,在全世界被广泛种植。本研究对CM334(墨西哥地方品种)进行了全基因组测序和组装(覆盖度为186.6×),同时还对另外两个栽培种和一个野生种分别进行了重测序和从头(de novo)测序。结果表明辣椒基因组大小约为番茄的4倍,辣椒基因组上存在大量gypsy转座子和花椰菜病毒家族元件的积累。结合转录组综合分析认为,辣椒素合成酶基因表达模式的改变及新功能化是导致辣椒素生物合成的原因,研究还发现辣椒与番茄在乙烯合成及果实成熟调控方面存在明显不同的分子模式。辣椒参考基因组的发布为辣椒营养品质和药用价值的改善提供了重要平台。

关键词：基因组测序辣椒素参考基因 Capsicum 转座子辣椒果实分子模式生物合成基因表达模式基因组大小

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髌腱近端信号增高:8具尸体样本的MR成像与组织学特征的相关性及临床MR影像特征的研究

引用

国际医学放射学杂志 2015年第6期 608-608页

作者： S.J.Yun W.Jin Y.K.Park G.Y.Kim S.H.yoon S.Y.Park 屈瑾 Department of Radiology Kyung Hee University Hospital at GangdongKyung Hee University School of Medicine

摘要目的研究髌腱近端(p PT)后部T1WI信号强度(SI)持续性增高的原因。方法 8例尸体行MRI检查,后行大体组织学检查。另有84例病人,无外伤史或膝关节前部疼痛,比

关键词： MR 近端髌腱尸体

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