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A pilot clinical study to evaluate feasibility of using single patient classifier as a prognostic test in stage Ⅱ-Ⅲ gastric cancer patients

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Chinese Journal of Cancer Research 2024年第4期36卷 368-378页

作者： Ji Yeong An sung Eun Oh Soomin Ahn Hyoung-II Kim yoo Min Kim Minah Cho Keun Won Ryu Hong Man yoon Young Kyu Park In Gyu Kwon sung Hoon noh Kyung Hee Lee In Cho Myoung Won Son Jong Won Kim Young-Woo Kim Department of Surgery Samsung Medical Center Sungkyunkwan University School of Medicine Department of Pathology and Translational Genomics Samsung Medical Center Sungkyunkwan University School of Medicine Department of Surgery Yonsei University College of Medicine Gastric Cancer Center Yonsei Cancer CenterYonsei University Health System Center for Gastric Cancer National Cancer Center Department of Surgery Chonnam National University Hwasun Hospital Chonnam National University College of Medicine Department of Surgery Gangnam Severance Hospital Yonsei University College of Medicine Department of Hematology-Oncology Yeungnam University Medical Center Department of Surgery Soonchunhyang University College of Medicine Department of Surgery Soonchunhyang University Cheonan Hospital Soonchunhyang University College of Medicine Department of Surgery Chung-Ang University Hospital Chung-Ang University College of Medicine

Objective: Precision medicine approaches emphasize the importance of reliable prognostic tools for guiding individualized therapy decisions. In this study, we evaluated the clinical feasibility of the single patient classifier(SPC) test, a new clinical-grade prognostic assay, in stage Ⅱ-Ⅲ gastric cancer ***: A prospective multicenter study was conducted, involving 237 patients who underwent gastrectomy between September 2019 and August 2020 across nine hospitals. The SPC test was employed to stratify patients into risk groups, and its feasibility and performance were evaluated. The primary endpoint was the proportion of the cases in which the test results were timely delivered before selecting postoperative treatment. Furthermore, 3-year disease-free survivals of risk groups were ***: The SPC test met the primary endpoint criteria. The 99.5% of SPC tests were timely delivered to hospitals before the postoperative treatment started. In a clinical setting, the median time from the specimen transfer to laboratory to the result delivery to hospital was 4 d. Furthermore, 3-year disease-free survivals were significantly different between risk groups classified with SPC ***: This study highlights the SPC test's feasibility in offering crucial information timely delivered for making informed decisions regarding postoperative treatment strategies. It also provides evidence to support the implementation of a future prospective clinical trial aimed at evaluating the clinical utility of the SPC test in guiding personalized treatment decisions for gastric cancer patients.

关键词： Prognostic test adjuvant chemotherapy advanced gastric cancer feasibility gastrectomy

Efficient nitrate electroreduction over Mn-doped Cu catalyst via regulating N-containing intermediates adsorption configuration

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Science China Chemistry 2024年第6期67卷 1969-1975页

作者： Limin Wu Shunhan Jia Libing Zhang Ruhan Wang Jiaqi Feng Xiaofu sun Buxing Han Beijing National Laboratory for Molecular Sciences CAS Laboratory of Colloid and Interface and ThermodynamicsCAS Research/Education Center for Excellence in Molecular SciencesCenter for Carbon Neutral ChemistryInstitute of ChemistryChinese Academy of SciencesBeijing100190China School of Chemical Sciences University of Chinese Academy of SciencesBeijing100049China College of Chemical Engineering and Environment China University of PetroleumBeijing102249China Shanghai Key Laboratory of Green Chemistry and Chemical Processes School of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai200062China

The electrochemical reduction of NO_(3)^(-)to NH_(3)holds promise for economic and environmental benefits,presenting an energyefficient alternative to the traditional Haber-Bosch ***,challenges exist due to its sluggish kinetics,multiple intermediates,and various reaction *** this study,Mn-doped-Cu catalyst was synthesized and employed for electrochemical NO_(3)^(-)-to-NH_(3)*** doping of Mn into Cu resulted in exceptional performance,achieving a FE of 95.8%and an NH_(3)yield rate of 0.91 mol g^(-1)h^(-1)at-0.6 V in a neutral electrolyte at low NO_(3)^(-)*** experimental studies and theoretical calculations revealed that the Mn dopant enhanced the kinetic rate of NO_(2)~--to-NH_(3)and induced a distinct configuration of**** alteration decreased the energy barrier of*NO-to-*noh,consequently promoting the conversion of NO_(3)^(-)-to-NH_(3).

关键词： nitrate reduction electrocatalysis ammonia synthesis N-intermediate green chemistry

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Implementation of remote monitoring system for prediction of tool wear and failure using ART2

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Journal of Central South University 2011年第1期18卷 177-183页

作者： noh Min-Seok HONG Dae sun School of Mechatronics Changwon National University

Remote monitoring of tools for prediction of tool wear in cutting processes was considered, and a method of implementation of a remote-monitoring system previously developed was proposed. Sensor signals were received and tool wear was predicted in the local system using an ART2 algorithm, while the monitoring result was transferred to the remote system via intemet. The monitoring system was installed at an on-site machine tool for monitoring three kinds of tools cutting titanium alloys, and the tool wear was evaluated on the basis of vigilances, similarities between vibration signals received and the normal patterns previously trained. A number of experiments were carried out to evaluate the performance of the proposed system, and the results show that the wears of finishing-cut tools are successfully detected when the moving average vigilance becomes lower than the critical vigilance, thus the appropriate tool replacement time is notified before the breakage.

关键词： tool wear remote monitoring system ART2 neural network machine tool tool replacement time

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Defect-rich spinel ferrites with improved charge collection properties for efficient solar water splitting

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Journal of Advanced Ceramics 2023年第3期12卷 612-624页

作者： Runfa Tan yoo Jae Jeong Qu Li Minje Kang In sun Cho Department of Materials Science&Engineering Ajou UniversitySuwon 16499Republic of Korea Department of Energy Systems Research Ajou UniversitySuwon 16499Republic of Korea

Spinel zinc ferrite(ZnFe_(2)O_(4),ZFO)is a potential photoanode material for photoelectrochemical(PEC)water splitting because of its ideal bandgap(1.9–2.1 eV)and superior chemical stability in aqueous ***,the low charge collection efficiency significantly hinders the improvement in PEC ***,we report an ultrafast and effective flame activation route to enhance the charge collection properties of ***,high-temperature flame(>1300℃)facilitated surface and grain boundary diffusions,increasing the grain size and connectivity of the ZFO ***,the reducing atmosphere of the flame enabled the formation of surface defects(oxygen vacancy and Fe^(2+)),thereby increasing the charge carrier density and surface adsorption ***,these two factors promoted charge transport and transfer kinetics,resulting in a 10-fold increase in the photocurrent density over the unactivated ***,we deposited a thin Al_(2)O_(3)overlayer to passivate the ZFO surface and then the NiFeOx oxygen evolution catalyst(OEC)to expedite hole injection into the *** surface passivation and OEC deposition led to a remarkable photocurrent density of~1 mA/cm^(2)at 1.23 V versus the reversible hydrogen electrode,which is the highest value among all reported ZFO ***,the NiFeOx/Al_(2)O_(3)/F-ZFO photoanode achieved excellent photocurrent stability over 55 h(96%retention)and superior faradaic efficiency(FE>94%).Our flame activation method is also effective in improving the photocurrent densities of other spinel ferrites:CuFe_(2)O_(4)(93 times),MgFe_(2)O_(4)(16 times),and NiFe_(2)O_(4)(12 times).

关键词： spinel ferrites flame activation defect-rich surface charge collection photoelectrochemical(PEC) water splitting

The interplay between direct-acting antivirals and hepatocellular carcinoma in chronic hepatitis C

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Hepatoma Research 2020年第3期6卷 15-23页

作者： sun Hong yoo Jung Hyun Kwon Department of Internal Medicine Catholic University Liver Research CenterThe Catholic University of KoreaSeoul 06591Korea

Direct-acting antivirals(DAAs)have been introduced for the treatment of hepatitis C virus,and the sustained virological response rate after DAAs was reported to be over 95%.Because of the high sustained virological response rate,the risk of hepatocellular carcinoma(HCC)was expected to be ***,an unexpected high risk of HCC recurrence after DAA treatment was reported,and thus the dispute about the association of DAA and HCC *** present article reviews the interplay between DAAs and HCC.

关键词： Chronic hepatitis C hepatocellular carcinoma direct-acting antivirals

Extracorporeal membrane oxygenation for lung cancer-related life-threatening hypoxia:A case report

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World Journal of Clinical Cases 2022年第25期10卷 8974-8979页

作者： Seung Soo yoo Shin Yup Lee sun Ha Choi Department of Internal Medicine Kyungpook National UniversityDaegu 41404South Korea Lung Cancer Center Kyungpook National University Chilgok HospitalDaegu 41404South Korea

BACKGROUND Life-threatening hypoxia can occur in patients with lung cancer due to bronchial *** membrane oxygenation(ECMO)can be used as a bridge therapy for patients with severe hypoxia not relieved by conventional mechanical ***,the usefulness of chemotherapy in patients with lung cancer receiving ECMO therapy is not well *** SUMMARY A 53-year-old man visited the emergency room with worsening dyspnea for 1 mo.A series of imaging and diagnostic tests were performed,and stageⅢB(cT4N2M0)lung cancer was eventually *** hospital day 3,he experienced dyspnea and hypoxia that was not relieved with oxygen support via a high-flow nasal *** was initiated because his respiratory condition did not improve even with mechanical *** patient then underwent gemcitabine/cisplatin chemotherapy without dose reduction while on *** two cycles of chemotherapy,there was a decrease in the size of the primary tumor in the right main *** the completion of concurrent chemoradiotherapy,a computed tomography scan revealed further improvement in the right main bronchus *** months after a lung cancer diagnosis,the patient did well without any *** ECMO is a potential bridge therapy for respiratory failure in patients with central airway obstruction secondary to lung cancer.

关键词： Extracorporeal membrane oxygen Lung cancer Hypoxia Respiratory failure Chemoradiotherapy Case report

Injection molding of micro patterned PMMA plate

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Transactions of Nonferrous Metals Society of China 2011年第A1期21卷 148-152页

作者： Yeong-Eun yoo Tae-Hoon KIM Tae-Jin JE Doo-sun CHOI Chang-Wan KIM sun-Kyung KIM Department of Nanomanufacturing Technology KIMM 171 Jang-dong Yusung-gu Daejeon 305-343 Korea Department of Product Design and Manufacturing Seoul National University of Technology

A plastic plate with surface micro features was injection molded to investigate the effect of pressure rise of melt on the replication of the micro structures. Prism pattern, which is used in many optical applications, was selected as a model pattern. The prism pattern is 50 μm in pitch and 108° in the vertical angle. The overall size of the plate was 335 minx213 mm and the thickness of the plate varied linearly from 2.6 mm to 0.7 ram. The prism pattern was firstly machined on the nickel plated core block using micro diamond tool and this machined pattern core was installed in a mold for injection molding of prism patterned plate. Polymethyl methacrylate （PMMA） was used as a molding material. The pressure and temperature of the melt in the cavity were measured at different positions in the cavity and the replication of the pattern was also measured at the same positions. The results show that the pressure or temperature profile through the process depends on the shape and the size of the plate. The replication is affected by the temperature and pressure profiles at the early stage of filling, which is right after the melt reaches the position to be measured.

关键词： micro prism pattern injection molding replication pressure profile temperature profile

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Pharmacokinetics and tissue distribution of a novel PDE5 inhibitor,SK-3530,in rats

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Acta Pharmacologica Sinica 2007年第8期28卷 1247-1253页

作者： Hye-hyun yoo Nam-sun KIM Guang-jin Im Dong-hyun KIM Bioanalysis and Biotransformation Research Center Korea Institute of Science & Technology Seoul 136-791Korea Life Science RD Center SK ChemicalsGyeonggi-do 440-300Korea

Aim:To investigate the pharmacokinetic profile and tissue distribution of a novelphosphodiesterase type 5 inhibitor,5-ethyl-2-{5-[4-（2-hydroxy-ethyl）-piperazine-1-sulfonyl]-2-propoxy-phenyl}-7-propyl-3,5-dihydro-pyrrolo（3,2-d）pyrimidin-4-one（SK-3530）,in rats after administration of the14C-labeled ***:The pharmacokinetic parameters of SK-3530 were measured based on the totalradioactivity and parent SK-3530 concentration in rat plasma after intravenousand oral *** tissue distribution of total radioactivity after a singleoral administration of[14C]SK-3530 at a dose of 40 mg/kg was *** protein binding rates of SK-3530 were assessed by in vitro and ex ***:The total radioactivity profiles showed linear *** maximum plasma concentration and area under the curve of the parent SK3530were 10%-20% compared to those of the total *** the oral admin-istration of[14C]SK-3530,the radioactivity was widely distributed in all tissues,and the tissue/plasma ratio of the radioactivity 1 h after administration was calcu-lated as 0.5-2.6 with the exception of excretory organs.A relatively high penetra-tion was shown in the adrenal glands,liver,and *** vitro and ex vivo plasmaprotein binding assay by ultrafiltration showed a considerably high binding rateof more than 97%.Conclusion:SK-3530 was relatively well absorbed in the gas-trointestinal tract and showed linear pharmacokinetics over the investigated ***-3530 had low oral bioavailability due to a high,first-pass metabolism.

关键词： SK-3530 PDE5 inhibitor pharmacokinetics tissue distribution rats

Helicobacter pylori infection is not associated with nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2016年第8期22卷 2592-2600页

作者： Myong Ki Baeg Seung Kew yoon sun-Hye Ko Yong-sun noh In-Seok Lee Myung-Gyu Choi Department of Internal Medicine The Catholic University of Korea College of Medicine

AIM: To determine whether Helicobacter pylori (H. pylori) infection confers a higher risk of Nonalcoholic fatty liver disease (NAFLD).METHODS: Healthy people who underwent health screening were analyzed retrospectively. Inclusion criteria were age ≥ 20 years, history of H. pylori infection, and recorded insulin level. Participants were classified as H. pylori positive or negative according to 13C urea breath tests. NAFLD was defined using the hepatic steatosis index (HSI) and NAFLD liver fat score (NAFLD-LFS). Those with an HSI > 36 or NAFLD-LFS > -0.640 were considered to have NAFLD. Multivariable logistic regression was performed to identify risk factors for ***: Three thousand six hundred and sixty-three people were analyzed and 1636 (44.7%) were H. pylori positive. H. pylori infection was associated with older age, male gender, hypertension, higher body mass index, and a dyslipidemic profile. HSI differed significantly between H. pylori positive and negative subjects (median 33.2, interquartile range (IQR) 30.0-36.2 for H. pylori-positive vs median 32.6, IQR 29.8-36.0 for negative participants, P = 0.005), but NAFLD-LSF did not [median -1.7, IQR -2.4 - -0.7 vs median -1.8, IQR -2.4-(-0.7), respectively, P = 0.122]. The percentage of people with NAFLD did not differ between infected and uninfected groups: HIS, 26.9% vs 27.1%, P = 0.173; NAFLD-LFS, 23.5% vs 23.1%, P = 0.778. H. pylori infection was not a risk factor, but C-reactive protein concentration and smoking were significant risk factors for ***: H. pylori infection is not a risk factor for NAFLD as indicated by HSI or NAFLD-LFS. Prospective, large-scale studies involving liver biopsies should be considered.

关键词： Helicobacter pylori Nonalcoholic fatty liver disease Hepatic steatosis index Nonalcoholic fatty liver disease liver fat score Urea breath test