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Analysis of prognostic factors and outcomes of gastric cancer in younger patients:A case control study using propensity score methods

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World Journal of Gastroenterology 2014年第12期20卷 3369-3375页

作者： Ki-Han kim yoo-min kim min-Chan kim Ghap-Joong Jung Department of Surgery Dong-A University College of Medicine

AIM:To understand the clinicopathological and prognostic features of gastric cancer in younger and older ***:Between January 2002 and December2008,1667 patients underwent curative gastric *** comparative purposes,the patients were divided into two groups:younger patients who were less than 40 years old(112 patients),and older patients who were 40 years old and older(1555 patients).In both groups,propensity scoring methods were used to select patients with similar disease statuses.A total of224 matched cases,with 112 patients in each group,were included in the final ***:Compared to the older group,the younger group with gastric cancer had a significantly higher percentage of females(P=0.007),poorly differentiated or signet ring cell carcinoma(P<0.001),advanced T stage gastric cancer(P=0.045),and advanced tumornode-metastasis stage cancer(P=0.036).The older group with gastric cancer had more comorbidities(P<0.001).With the exception of the number of lymph node dissection(P<0.001)and retrieved lymph node(P=0.010),there were no statistically significant differences between the postoperative outcomes of the two *** the follow-up period,there were19 recurrences in the younger group and 11 recurrences in the older *** overall five-year survival rates in the younger and older groups were 84.3%and89.6%,respectively(P=0.172).There were no significant differences(P=0.238)in the overall survival of patients with advanced T stage gastric cancer in the two groups,with five-year survival rates of 70.8%in the younger group and 79.5%in the older *** regard to the age-adjusted survival rate,there was significant difference between the two groups(P=0.225).CONCLUSION:In spite of aggressive cancer patterns in the younger group with gastric cancer,the younger group did not have a worse prognosis than the older group in our study.

关键词： Gastric cancer Younger patients Prognosis

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Improvement of type 2 diabetes mellitus after gastric cancer surgery:Short-term outcome analysis after gastrectomy

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World Journal of Gastroenterology 2013年第48期19卷 9410-9417页

作者： Ji Yeong An yoo min kim min Ah Yun Byeong Hee Jeon Sung Hoon Noh Department of Surgery Yonsei University College of Medicine Seodaemun-guSeoul 120-752 South Korea Department of Surgery Dong-A University College of Medicine Busan 602-715 South Korea Department of Clinical Care Graduate School of Nursing Yonsei University Seoul 120-752 South Korea

AIM:To evaluate the effect of gastrectomy on diabetes control in patients with type 2 diabetes mellitus and early gastric ***:Data from 64 patients with early gastric cancer and type 2 diabetes mellitus were prospectively *** patients underwent curative gastrectomy(36 subtotal gastrectomy with gastroduodenostomy,16subtotal gastrectomy with gastrojejunostomy,12 total gastrectomy)and their physical and laboratory data were evaluated before and 3,6 and 12 mo after ***:Fasting blood glucose(FBS),HbA1c,insulin,C-peptide,and homeostasis model assessment-estimated insulin resistance were significantly improved 3mo after surgery,regardless of operation type,and the significant improvement in all measured values,except HbA1c,was sustained up to 12 mo *** 3.1%of patients stopped diabetes medication and had HbA1c<6.0%and FBS<126 mg/dL.54.7%of patients decreased their medication,and had reduced FBS or *** multivariate analysis,good diabetic control was not associated with operation type,but was associated with diabetes ***:Diabetes improved in more than 50%of patients during the first year after gastric cancer *** degree of diabetes control was related to diabetes duration.

关键词： Type 2 diabetes mellitus Gastrectomy Gastric cancer Short-term outcome Glucose control

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A pilot clinical study to evaluate feasibility of using single patient classifier as a prognostic test in stage Ⅱ-Ⅲ gastric cancer patients

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Chinese Journal of Cancer Research 2024年第4期36卷 368-377页

作者： Ji Yeong An Sung Eun Oh Soomin Ahn Hyoung-II kim yoo min kim minah Cho Keun Won Ryu Hong Man yoon Young Kyu Park In Gyu Kwon Sung Hoon Noh Kyung Hee Lee In Cho Myoung Won Son Jong Won kim Young-Woo kim Department of Surgery Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351Republic of Korea Department of Pathology and Translational Genomics Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351Republic of Korea Department of Surgery Yonsei University College of MedicineSeoul 03722Republic of Korea Gastric Cancer Center Yonsei Cancer CenterYonsei University Health SystemSeoul 03722Republic of Korea Center for Gastric Cancer National Cancer CenterGoyang 10408Republic of Korea Department of Surgery Chonnam National University Hwasun HospitalChonnam National University College of MedicineGwangju 58128Republic of Korea Department of Surgery Gangnam Severance HospitalYonsei University College of MedicineSeoul 06273Republic of Korea Department of Hematology-Oncology Yeungnam University Medical CenterDaegu 42415Republic of Korea Department of Surgery Soonchunhyang University College of MedicineBucheon 14584Republic of Korea Department of Surgery Soonchunhyang University Cheonan HospitalSoonchunhyang University College of MedicineCheonan 31151Republic of Korea Department of Surgery Chung-Ang University HospitalChung-Ang University College of MedicineSeoul 06973Republic of Korea

Objective:Precision medicine approaches emphasize the importance of reliable prognostic tools for guiding individualized therapy *** this study,we evaluated the clinical feasibility of the single patient classifier(SPC)test,a new clinical-grade prognostic assay,in stageⅡ-Ⅲgastric cancer ***:A prospective multicenter study was conducted,involving 237 patients who underwent gastrectomy between September 2019 and August 2020 across nine *** SPC test was employed to stratify patients into risk groups,and its feasibility and performance were *** primary endpoint was the proportion of the cases in which the test results were timely delivered before selecting postoperative ***,3-year disease-free survivals of risk groups were ***:The SPC test met the primary endpoint *** 99.5%of SPC tests were timely delivered to hospitals before the postoperative treatment *** a clinical setting,the median time from the specimen transfer to laboratory to the result delivery to hospital was 4 ***,3-year disease-free survivals were significantly different between risk groups classified with SPC ***:This study highlights the SPC test's feasibility in offering crucial information timely delivered for making informed decisions regarding postoperative treatment *** also provides evidence to support the implementation of a future prospective clinical trial aimed at evaluating the clinical utility of the SPC test in guiding personalized treatment decisions for gastric cancer patients.

关键词： Prognostic test advanced gastric cancer adjuvant chemotherapy feasibility gastrectomy

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Materials and devices for flexible and stretchable photodetectors and light-emitting diodes

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Nano Research 2021年第9期14卷 2919-2937页

作者： Jun-Kyul Song min Sung kim Seungwon yoo Ja Hoon Koo Dae-Hyeong kim Center for Nanoparticle Research Institute for Basic Science(IBS)Seoul 08826Republic of Korea School of Chemical and Biological Engineering and Institute of Chemical Processes Seoul National UniversitySeoul 08826Republic of Korea Interdisciplinary Program for Bioengineering Seoul National UniversitySeoul 08826Republic of Korea Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea

Recently,significant efforts have been directed at overcoming the limitations of conventional rigid optoelectronic devices,particularly their poor mechanical stability under bending,folding,and stretching *** of major approaches for rendering optoelectronic devices mechanically deformable is to replace the conventional electronic/optoelectronic materials with functional nanomaterials or organic materials that are intrinsically flexible/***,advanced device designs and unconventional fabrication methods have also contributed to the development of soft optoelectronic ***,new devices such as bio-inspired curved image sensors,wearable light emitting devices,and deformable bio-integrated optoelectronic devices have been *** this review,recent progress in the development of soft optoelectronic materials and devices is ***,various materials such as nanomaterials,organic materials,and their hybrids that are suitable for developing deformable photodetectors,are ***,the nanomaterials and organic/polymeric materials that are applicable in deformable light-emitting diodes are ***,representative system-level applications of flexible and stretchable photodetectors and light-emitting diodes are reviewed,and future prospects are discussed.

关键词： nanomaterial organic material photodetector light-emitting diode flexible optoelectronics stretchable optoelectronics

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SPARC Local Workshop on “WCRP Grand Challenges and Regional Climate Change”

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Advances in Atmospheric Sciences 2018年第6期35卷 624-627页

作者： Joowan kim Seok-Woo SON Hye-Jin kim Baek-min kim Changhyun yoo Department of Atmospheric Sciences Kongju National University Gongju 32588 Republic of Korea School of Earth and Environmental Sciences Seoul National University Seoul 08826 Republic of Korea Korea Polar Research Institute Incheon 21990 Republic of Korea Department of Climate and Energy Systems Engineering Ewha Womans University Seoul 03760 Republic of Korea

*** SPARC（Stratosphere-Troposphere Processes and their Role in Climate）is one of the core projects of the World Climate Research Program（WCRP）,coordinating international efforts to address relevant issues in clima... 详细信息

关键词： SPARC Local Workshop on WCRP Grand Challenges and Regional Climate Change QBO

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Amputation stump management:A narrative review

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World Journal of Clinical Cases 2022年第13期10卷 3981-3988页

作者： yoo Jin Choo Du Hwan kim min Cheol Chang Department of Physical Medicine and Rehabilitation College of MedicineYeungnam UniversityDaegu 705-717South Korea Department of Physical Medicine and Rehabilitation College of MedicineChung-Ang UniversitySeoul 06973South Korea Department of Physical Medicine and Rehabilitation College of MedicineYeungnam UniversityTaegu 705-717South Korea

In this review intended for medical staff involved in patient rehabilitation,we provided an overview of the basic methods for managing amputation *** the amputation surgery,it is imperative to optimize the remaining physical abilities of the amputee through rehabilitation processes,including postoperative rehabilitation,desensitization,and continuous application of soft or rigid dressings for pain reduction and shaping of the *** on the situation,a prosthesis may be worn in the early stage of recovery or an immediate postoperative prosthesis may be applied to promote stump ***,to maintain the range of motion of the stump and to prevent deformation,the remaining portion of the limb should be positioned to prevent *** exercises should also be performed to improve muscle strength to ensure that the amputee is able to perform activities of daily living,***,clean wound or edema management of the stump is necessary to prevent problems associated with wearing the *** review is expected to contribute to the establishment of basic protocols that will be useful for stump management from the time of completion of amputation surgery to the fitting of a prosthesis to optimize patient recovery.

关键词： Amputation Amputee Management Rehabilitation Stump Review

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Sensitivity of Snowfall Characteristics to Meteorological Conditions in the Yeongdong Region of Korea

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Advances in Atmospheric Sciences 2021年第3期38卷 413-429页

作者： yoo-Jun kim So-Ra IN Hae-min kim Jin-Hwa LEE Kyu Rang kim Seungbum kim Byung-Gon kim High Impact Weather Research Department National Institute of Meteorological SciencesGangneung 25457Korea Operational Systems Development Department National Institute of Meteorological SciencesSeogwipo 63568Korea Department of Atmospheric Environmental Sciences Gangneung-Wonju National UniversityGangneung 25457Korea

This study investigates the characteristics of cold clouds and snowfall in both the Yeongdong coastal and mountainous regions under different meteorological conditions based on the integration of numerical modeling and three-hourly rawinsonde observations with snow crystal photographs for a snowfall event that occurred on 29−30 January *** found that rimed particles predominantly observed turned into dendrite particles in the latter period of the episode when the 850 hPa temperature decreased at the coastal site,whereas the snow crystal habits at the mountainous site were largely needle or rimed *** soundings showed a well-defined,two-layered cloud structure along with distinctive wind-directional shear,and an inversion in the equivalent potential temperature above the low-level cloud *** first experiment with a decrease in lower-layer temperature showed that the low-level cloud thickness was reduced to less than 1.5 km,and the accumulated precipitation was decreased by 87%compared with the control *** difference in precipitation amount between the single-layered experiment and control experiment(two-layered)was not so significant to attribute it to the effect of the seeder−feeder *** precipitation in the last experiment by weakening winddirectional shear was increased by 1.4 times greater than the control experiment specifically at the coastal site,with graupel particles accounting for the highest proportion(~62%).The current results would improve snowfall forecasts in complicated geographical environments such as Yeongdong in terms of snow crystal habit as well as snowfall amount in both time and space domains.

关键词： Yeongdong snow crystal rawinsonde cloud-resolving model

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Inverse correlation between gastroesophageal reflux disease and atrophic gastritis assessed by endoscopy and serology

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World Journal of Gastroenterology 2022年第8期28卷 853-867页

作者： yoo min Han Su Jin Chung Seokha yoo Jong In Yang Ji min Choi Jooyoung Lee Joo Sung kim Department of Internal Medicine and Healthcare Research Institute Seoul National University Hospital Healthcare System Gangnam CenterSeoul 06236South Korea Department of Anesthesiology and Pain Medicine Seoul National University College of MedicineSeoul 03080South Korea Department of Internal Medicine and Liver Research Institute Seoul National University College of MedicineSeoul 03080South Korea

BACKGROUND Helicobacter pylori(***)infection is known to prevent the occurrence of gastroesophageal reflux disease(GERD)by inducing gastric mucosal ***,little is known about the relationship between atrophic gastritis(AG)and *** To confirm the inverse correlation between AG and the occurrence and severity of *** Individuals receiving health checkups who underwent upper gastrointestinal endoscopy at Seoul National University Healthcare System Gangnam Center were *** grade of reflux esophagitis was evaluated according to the Los Angeles *** AG(EAG)was categorized into six *** AG(SAG)was defined as pepsinogen I≤70 ng/m L and pepsinogen I/II ratio≤*** association between the extent of EAG and SAG and the occurrence and severity of GERD was evaluated using multivariate logistic regression *** In total,4684 individuals with GERD were compared with 21901 healthy *** multivariate logistic regression analysis,advanced age,male sex,body mass index>23 kg/m2,presence of metabolic syndrome,current smoking,and alcohol consumption were associated with an increased risk of *** for *** immunoglobulin G antibodies was associated with a decreased risk of *** was an inverse correlation between the extent of EAG and occurrence of GERD:Odds ratio(OR),1.01[95%confidence interval(CI):0.90-1.14]in C1,0.87(0.78-0.97)in C2,0.71(0.62-0.80)in C3,0.52(0.44-0.61)in O1,0.37(0.29-0.48)in O2,and 0.28(0.18-0.43)in ***,the extent of EAG showed an inverse correlation with the severity of *** presence of SAG was correlated with a reduced risk of GERD(OR=0.49,95%CI:0.28-0.87,P=0.014).CONCLUSION The extent of EAG and SAG exhibited strong inverse relationships with the occurrence and severity of *** followed by *** infection may be independently protect against GERD.

关键词： Gastroesophageal reflux disease Reflux esophagitis Helicobacter pylori Atrophic gastritis Pepsinogen

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Effects of Cu addition on formability and surface delamination phenomenon in high-strength high-Mn steels

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Journal of Materials Science & Technology 2020年第8期36卷 44-51页

作者： min Chul Jo Jisung yoo min Cheol Jo Alireza Zargaran Seok Su Sohn Nack J.kim Sunghak Lee Center for Advanced Aerospace Materials Pohang University of Science and TechnologyPohang 37673South Korea Graduate Institute of Ferrous Technology Pohang University of Science and TechnologyPohang 37673South Korea Department of Materials Science and Engineering Korea UniversitySeoul 02841South Korea

The formability of austenitic high-Mn steels is a critical issue in automotive applications under nonuniformly-deformed environments caused by dynamic strain *** austenite stabilizing alloying elements in those steels,Cu has been known as an effective element to enhance tensile properties via controlling the stacking fault energy and stability of *** effects of Cu addition on formability,however,have not been sufficiently reported *** this study,the Cu addition effects on formability and surface characteristics in the austenitic high-Mn TRIP steels were analyzed in consideration of inhomogeneous microstructures containing the segregation of Mn and *** reveal determining factors,various mechanical parameters such as total elongation,post elongation,strain hardening rate,normal anisotropy,and planar anisotropy were correlated to the hole-expansion and cup-drawing test *** respect to microstructural parameters,roles of(Mn,Cu)-segregation bands and resultant Cu-rich FCC precipitates on the formability and surface delamination were also discussed.

关键词： High-Mn steel Cu effects Cu-rich FCC phase Hole-expansion test Formability Stretch-flangeablity Surface delamination

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Unusual presentation of granulomatosis with polyangiitis causing periaortitis and consequent subclavian steal syndrome:A case report

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World Journal of Clinical Cases 2021年第6期9卷 1433-1438页

作者： Uiju Cho Sung-Kyung kim Jeong min Ko Jinyoung yoo Department of Pathology St.Vincent’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591South Korea Department of Internal Medicine St.Vincent’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591South Korea Department of Radiology St.Vincent’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591South Korea Department of Hospital Pathology St.Vincent’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591South Korea

BACKGROUND Granulomatosis with polyangiitis(GPA)is a rare autoimmune disease that involves small-to-medium-sized vessels and forms necrotizing vasculitis with granulomatous *** formation of a large vessel lesion in GPA patients has been scarcely reported,and it can cause confusion in the *** SUMMARY A 27-year-old man presented with mild left-sided pleuritic chest pain that started one year *** imaging study revealed up to 2.5 cm-sized two irregular nodular consolidation nodule in the left lower *** nodules showed central ***,there was a periaortic mass occluding the branching porting of the subclavian *** had positive anti-neutrophil cytoplasmic antibodies(ANCAs),but myeloperoxidase-ANCAs and proteinase 3-ANCAs were *** patient also developed symptoms of subclavian vein syndrome during the *** resection of the lung revealed necrotizing vasculitis,destructive parenchymal abscess and surrounding granuloma,and therefore diagnosed of *** patient started on methotrexate and steroid therapy with a relief of *** Here,we present an unusual manifestation of GPA with periaortitis and consequent subclavian steal syndrome,which has never been previously *** case alerts us that we should include GPA in the differential diagnosis of large vessel vasculitis as well as subclavian steal syndrome.

关键词： Granulomatosis with polyangiitides Wegener granulomatosis Systemic vasculitis Subclavian steal syndrome Periaortitis Case report

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