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Galectin 3-binding protein(LGALS3BP)depletion attenuates hepatic fibrosis by reducing transforming growth factor-β1(TGF-β1)availability and inhibits hepatocarcinogenesis

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Cancer Communications 2024年第10期44卷 1106-1129页

作者： Dae-Hwan Kim Minjeong Sung Myong-Suk park Eun-Gene Sun Sumin yoon Kyung Hyun yoo Kamalakannan Radhakrishnan Sung Yun Jung Woo-Kyun Bae Sang-Hee Cho Ik-Joo Chung Department of Internal Medicine Division of Hematology and OncologyChonnam National University Medical SchoolHwasunSouth Korea Department of Internal Medicine Division of Hematology and OncologyChonnam National University Hwasun HospitalHwasunSouth Korea Combinatorial Tumor Immunotherapy MRC Center Chonnam National University Medical SchoolHwasunSouth Korea National Immunotherapy Innovation Center HwasunSouth Korea BioMedical Sciences Graduate Program Chonnam National UniversityHwasunSouth Korea Department of Biological Science SookmyungWomen’s UniversitySeoulSouth Korea Clinical Vaccine R&D Center Chonnam National UniversityHwasunSouth Korea Department of Biochemistry and Molecular Pharmacology Baylor College of MedicineHoustonTexasUSA

Background:Increased Galectin 3-binding protein(LGALS3BP)serum levels have been used to assess hepatic fibrosis stages and the severity of hepatocellular carcinoma(HCC).Considering the crucial role of transforming growth factor-β1(TGF-β1)in the emergence of these diseases,the present study tested the hypothesis that LGALS3BP regulates the TGF-β1 signaling ***:The expression levels of LGALS3BP and TGFB1 were analyzed in patients with metabolic dysfunction-associated steatohepatitis(MASH)and *** omics techniques,such as RNA-sequencing,transposaseaccessible chromatin-sequencing assay,and liquid chromatography-tandem mass spectrometry proteomics,were used to identify the regulatory mechanisms for the LGALS3BP-TGF-β1 *** effects of altered TGF-β1 signaling by LGALS3BP were investigated in conditional LGALS3BP-knockin and LGALS3BP-knockout ***:In patients with MASH and HCC,the levels of LGALS3BP and TGFB1 exhibited positive *** of LGALS3BP by the inflammatory cytokine interferonαin HCC cells or ectopic overexpression of LGALS3BP in hepatocytes promoted the expression levels of *** fibrosis was observed in the livers of hepatocyte-specific LGALS3BP-knockin mice,with increased TGFB1 ***3BP directly bound to and assembled integrinαV,an integral mediator required for releasing active TGF-β1 from extracellular latent complex with the rearranged F-actin *** released TGF-β1 activated JunB transcription factor,which in turn promoted the TGF-β1 positive feedback ***3BP deletion in the hepatocytes downregulated TGF-β1 signaling and CCl4 induced ***,LGALS3BP depletion hindered hepatocarcinogenesis by limiting the availability of fibrogenic TGF-β***:LGALS3BP plays a crucial role in hepatic fibrosis and carcinogenesis by controlling the TGF-β1 signaling pathway,making it a promising therapeutic target in TGF-β1-related diseases.

关键词： F-actin FAK hepatic carcinogenesis IntegrinαV Interferonα JunB LGALS3BP metabolic dysfuntion-associated steatohepatitis tensile force TGF-β1

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Fatal intratumoral hemorrhage in a patient with hepatocellular carcinoma following successful treatment with atezolizumab/bevacizumab:A case report

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World Journal of Clinical Cases 2024年第22期12卷 5177-5183页

作者： Kyeong-Hoon park Jeong-Ju yoo Sang Gyune Kim Young Seok Kim Department of Gastroenterology and Hepatology Soonchunhyang University School of MedicineBucheon 14584South Korea

BACKGROUND Atezolizumab/bevacizumab is emerging as the new standard for advanced hepatocellular carcinoma(HCC),with ongoing real-world implementation to study its *** the use of atezolizumab/bevacizumab increases,various side effects have been reported in clinical practice,most notably increased bleeding caused by *** SUMMARY In this case report,we present a rare and fatal case of intratumoral hemorrhage in a patient with advanced HCC following successful treatment with atezolizumab/bevacizumab.A 63-year-old male diagnosed with HCC initially underwent four cycles of intra-arterial ***,follow-up abdominal computed tomography(CT)revealed disease ***,the treatment plan was modified to atezolizumab/*** the fifth cycle of atezolizumab/bevacizumab,CT showed partial regression of *** week later,he visited the emergency room due to severe abrupt abdominal *** CT revealed focal rupture of HCC in the medial segment inferior portion with active bleeding and a large amount of *** was performed on the same day,and embolization of A4 and A8 branches using lipiodol and gelfoam was *** successful hemostasis,the patient subsequently developed liver failure and *** Atezolizumab/bevacizumab for advanced HCC suggests that intratumoral hemorrhage may be crucial despite good tumor response after immunotherapy,emphasizing the continuous monitoring of this side effect.

关键词： Adverse events Atezolizumab Bevacizumab Complication Hemorrhage Bleeding Hepatocellular carcinoma Case report

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A pilot clinical study to evaluate feasibility of using single patient classifier as a prognostic test in stage Ⅱ-Ⅲ gastric cancer patients

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Chinese Journal of Cancer Research 2024年第4期36卷 368-377页

作者： Ji Yeong An Sung Eun Oh Soomin Ahn Hyoung-II Kim yoo Min Kim Minah Cho Keun Won Ryu Hong Man yoon Young Kyu park In Gyu Kwon Sung Hoon Noh Kyung Hee Lee In Cho Myoung Won Son Jong Won Kim Young-Woo Kim Department of Surgery Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351Republic of Korea Department of Pathology and Translational Genomics Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351Republic of Korea Department of Surgery Yonsei University College of MedicineSeoul 03722Republic of Korea Gastric Cancer Center Yonsei Cancer CenterYonsei University Health SystemSeoul 03722Republic of Korea Center for Gastric Cancer National Cancer CenterGoyang 10408Republic of Korea Department of Surgery Chonnam National University Hwasun HospitalChonnam National University College of MedicineGwangju 58128Republic of Korea Department of Surgery Gangnam Severance HospitalYonsei University College of MedicineSeoul 06273Republic of Korea Department of Hematology-Oncology Yeungnam University Medical CenterDaegu 42415Republic of Korea Department of Surgery Soonchunhyang University College of MedicineBucheon 14584Republic of Korea Department of Surgery Soonchunhyang University Cheonan HospitalSoonchunhyang University College of MedicineCheonan 31151Republic of Korea Department of Surgery Chung-Ang University HospitalChung-Ang University College of MedicineSeoul 06973Republic of Korea

Objective:Precision medicine approaches emphasize the importance of reliable prognostic tools for guiding individualized therapy *** this study,we evaluated the clinical feasibility of the single patient classifier(SPC)test,a new clinical-grade prognostic assay,in stageⅡ-Ⅲgastric cancer ***:A prospective multicenter study was conducted,involving 237 patients who underwent gastrectomy between September 2019 and August 2020 across nine *** SPC test was employed to stratify patients into risk groups,and its feasibility and performance were *** primary endpoint was the proportion of the cases in which the test results were timely delivered before selecting postoperative ***,3-year disease-free survivals of risk groups were ***:The SPC test met the primary endpoint *** 99.5%of SPC tests were timely delivered to hospitals before the postoperative treatment *** a clinical setting,the median time from the specimen transfer to laboratory to the result delivery to hospital was 4 ***,3-year disease-free survivals were significantly different between risk groups classified with SPC ***:This study highlights the SPC test's feasibility in offering crucial information timely delivered for making informed decisions regarding postoperative treatment *** also provides evidence to support the implementation of a future prospective clinical trial aimed at evaluating the clinical utility of the SPC test in guiding personalized treatment decisions for gastric cancer patients.

关键词： Prognostic test advanced gastric cancer adjuvant chemotherapy feasibility gastrectomy

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Irritable bowel syndrome:Emerging paradigm in pathophysiology

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World Journal of Gastroenterology 2014年第10期20卷 2456-2469页

作者： yoo jin Lee Kyung Sik park Division of Gastroenterology and Hepatology Department of Internal Medicine Keimyung University School of Medicine Daegu 700-712 South Korea

Irritable bowel syndrome(IBS)is one of the most common gastrointestinal disorders,characterized by abdominal pain,bloating,and changes in bowel *** symptoms cannot be explained by structural abnormalities and there is no specific laboratory test or biomarker for ***,IBS is classified as a functional disorder with diagnosis dependent on the history taking about manifested symptoms and careful physical *** a great deal of research has been carried out in this area,the pathophysiology of IBS is complex and not completely *** factors are thought to contribute to the symptoms in IBS patients;altered gastrointestinal motility,visceral hypersensitivity,and the brain-gut interaction are important classical concepts in IBS *** areas of research in this arena include inflammation,postinfectious low-grade inflammation,genetic and immunologic factors,an altered microbiota,dietary factors,and enteroendocrine *** emerging studies have not shown consistent results,provoking controversy in the IBS ***,certain lines of evidence suggest that these mechanisms are important at least a subset of IBS patients,confirming that IBS symptoms cannot be explained by a single etiological ***,it is important to keep in mind that IBS requires a more holistic approach to determining effective treatment and understanding the underlying mechanisms.

关键词： Pathophysiology Irritable bowel syndrome Inflammation Immunologic Genetics Microbiota Diet Enteroendocrine cell

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Reliability and validity of tongue color analysis in the prediction of symptom patterns in terms of East Asian Medicine

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Journal of Traditional Chinese Medicine 2016年第2期36卷 165-172页

作者： Young-Jae park jin-Moo Lee Seung-Yeon yoo Young-Bae park Department of Diagnosis and Biofunctional Medicine College of Korean MedicineKyung Hee UniversitySeoul 134-727Korea Department of Diagnosis and Biofunctional Medicine Kyung Hee University Hospital at GangdongSeoul 134-727Korea Department of Oriental Gynecology College of Korean MedicineKyung Hee UniversitySeoul 134-727Korea Department of Women Health Clinic Kyung Hee University Hospital at GancldonaSeoul 134-727Knrpa

OBJECTIVE:To examine whether color parameters of tongue inspection(TI)using a digital camera was reliable and valid,and to examine which color parameters serve as predictors of symptom patterns in terms of East Asian medicine(EAM).METHODS:Two hundred female subjects'tongue substances were photographed by a mega-pixel digital *** with the photographs,the subjects were asked to complete Yin deficiency,Phlegm pattern,and Cold-Heat pattern *** three sets of digital imaging software,each digital image was exposure-and white balance-corrected,and finally L*(luminance),a*(red-green balance),and b*(yellow-blue balance)values of the tongues *** examine intra-and inter-rater reliabilities and criterion validity of the color analysis method,three raters were asked to calculate color parameters for 20 digital image ***,four hierarchical regression models were ***:Color parameters showed good or excellent reliability(0.627-0.887 for intra-class correlation coefficients)and significant criterion validity(0.523-0.718 for Spearman's correlation).In the hierarchical regression models,age was a significant predictor of Yin deficiency(β=0.192),and b*value of the tip of the tongue was a determinant predictor of Yin deficiency,Phlegm,and Heat patterns(β=-0.212,-0.172,and-0.163).Luminance(L*)was predictive of Yin deficiency(β=-0.172)and Cold(β=0.173)***:Our results suggest that color analysis of the tongue using the L*a*b*system is reliable and valid,and that color parameters partially serve as symptom pattern predictors in EAM practice.

关键词： Medicine East Asian Traditional Complementary therapies Tongue inspection Yin deficiency Symptom pattern

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Electrical characteristics and detailed interfacial structures of Ag/Ni metallization on polycrystalline thermoelectric SnSe

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Journal of Materials Science & Technology 2019年第5期35卷 711-718页

作者： Yeongseon Kim Younghwan jin Giwan yoon In Chung Hana yoon Chung-Yul yoo Sang Hyun park Separation and Conversion Materials Laboratory Korea Institute of Energy Research 152 Gajeong-ro Yuseong-gu Daejeon 34129 Republic of Korea School of Electrical Engineering Korea Advanced Institute of Science and Technology 291 Daehak-ro Yuseong-gu Daejeon 34142 Republic of Korea Department of Physics Chungnam National University 99 Daehak-ro Yuseong-gu Daejeon 34134 Republic of Korea School of Chemical and Biological Engineering Seoul National University 1 Gwanak-ro Gwanak-gu Seoul 08826 Republic of Korea

SnSe is a promising thermoelectric material with a high figure of merit in single crystal form, which has stimulated continuous research on polycrystalline SnSe. In this study, we investigated a metallization techniques for polycrystalline SnSe to achieve highly efficient and practical SnSe thermoelectric modules. The Ag/Ni metallization layers were formed on pristine polycrystalline SnSe using various deposition technique: sputter coating Ni, powder Niand foil Ni by spark plasma sintering. Structural analysis demonstrated that the microstructure and con tact resistance could be different according to the metallization process, despite using the same metals. The Ag/Ni metallization layer using foil Ni acted as an effective diffusion barrier and minimized electrical contact resistance (2.3×10^-4Ωcm^2). A power loss in the thermoelectric module of only 5% was demonstrated using finite element simulation.

关键词： Thermoelectric Metallization Electric contact material Interface microstructure SnSe

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Characteristics of fever and response to antipyretic therapy in military personnel with adenovirus-positive community acquired pneumonia

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Military Medical Research 2020年第3期7卷 324-334页

作者： Hongseok yoo Jimi Oh Chul park Division of Pulmonary and Critical Care Medicine Department of Internal MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351South Korea Department of Anesthesiology and Pain Medicine Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea Division of Pulmonary Medicine Department of Internal MedicineWonkwang University HospitalIksan 54538South Korea

Background:In 2014,an outbreak of adenoviral pneumonia occurred in the Korean military training ***,there are limited data on the characteristics of the fever and its response to antipyretic therapy in immunocompetent adults with adenovirus-positive community-acquired pneumonia(CAP).Methods:The medical records of the patients who were admitted to the Armed Forces Chuncheon Hospital for the treatment of CAP between January 2014 and December 2016 were retrospectively *** patients were divided into three groups,namely,the adenovirus-positive(Adv)group,the adenovirus-negative(Non-Adv)group and the unknown pathogen group,according to the results of a polymerase chain reaction(PCR)test and sputum culture used to measure adenovirus and other bacteria or viruses in respiratory *** evaluated and compared the demographics,clinicolaboratory findings and radiological findings upon admission between the two ***:Out of the 251 military personnel with CAP during the study periods,67 were classified into the Adv group,while 134 were classified into the Non-Adv group and 50 were classified into the unknown pathogen *** patients in the Adv group had a longer duration of fever after admission((3.2±1.6)d vs.(1.9±1.2)d vs.(2.2±1.5)d,P=0.018)and symptom onset((5.8±2.2)d vs.(3.9±2.5)d vs.(3.7±2.0)d,P=0.006)than patients in the Non-Adv and unknown pathogen groups,*** patients in the Adv group had a higher mean temperature at admission(37.8±0.3 vs.37.3±0.3 vs.37.3±0.3,P=0.005),and more patients were observed over 40 and 39 to 40(14.9%vs.2.2%vs.4.0%,35.8%vs.3.7%vs.6.0%,P<0.001)than those in the Non-Adv and unknown pathogen groups,*** Adv group more commonly had no response or exhibited adverse events after antipyretic treatment compared to the Non-Adv group(17.9%vs.1.5%,35.0%vs.4.3%,P<0.001,P=0.05,respectively).In addition,the time from admission to overall clinical stabilization was significantly longer in the patients

关键词： Adenovirus Fever Response to antipyretic treatment

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Orthotic approach to prevention and management of diabetic foot:A narrative review

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World Journal of Diabetes 2022年第11期13卷 912-920页

作者： Min Cheol Chang yoo jin Choo In Sik park Myung Woo park Du Hwan Kim Rehabilitation Medicine Yeungnam UniversityDaegu 42415South Korea Korean Podiatry and Pedorthics Institute Goyang 10442South Korea Physical Medicine and Rehabilitation Chung-Ang UniversitySeoul 06973South Korea

Diabetic foot is a common complication affecting more than one-fifth of patients with *** not treated in time,it may lead to diabetic foot ulcers or Charcot *** the management of diabetic foot,shoe modifications and orthoses can be used to reduce pressure on the affected foot or provide the foot with increased *** addition,the shoe modifications and orthotic devices can relieve patient discomfort during *** shoe modifications include changing the insole material,modifying the heel height,adding a steel shank or rocker sole,and using in-depth ***,a walking brace or ankle-foot orthosis can be used to reduce the pressure on the affected *** purpose of this narrative review was to provide a reference guide to support clinicians in prescribing shoe modifications and foot orthoses to treat diabetic foot ulcers and Charcot arthropathy.

关键词： Diabetic foot Foot ulcers Charcot arthropathy Shoes Foot orthosis

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Goal-Based Automated Code Generation in Self-Adaptive System

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Journal of Computer Science & Technology 2010年第6期25卷 1118-1129页

作者： Joonhoon Lee Jeongmin park Giljong yoo Eunseok Lee Department of Electrical and Computer Engineering Sungkyunkwan University Department of Software Engineering Dongyang Mirae University

System administrator deals with many problems,as computing environment becomes increasingly *** with an ability to recognize system states and adapt to resolve these problems offer a *** experience and knowledge are required to build a self-adaptive ***-adaptive systems have inherent *** paper proposes a technique that automatically generates the code for the self-adaptive *** the system is easier to ***-adaptive systems of previous research required high system resource *** operation could be invoked by external factors such as *** propose an improved self-adaptive system approach and apply it to video conference system and robot *** compared the lines of code,the number of classes created by the *** have confirmed this enhanced approach to be effective in reducing these development metrics.

关键词： self-adaptive self-healing goal graph activation switch error detection

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Efficient thermal management and all-season energy harvesting using adaptive radiative cooling and a thermoelectric power generator

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能源化学:英文版 2023年第9期84卷 496-501页

作者： Chanil park Woohwa Lee Choyeon park Sungmin park Jaeho Lee Yong Seok Kim Youngjae yoo Advanced Materials Division Korea Research Institute of Chemical Technology(KRICT)Daejeon 34114Republic of Korea Department of Mechanical and Aerospace Engineering University of CaliforniaIrvineCA 92617United States Department of Advanced Materials Engineering Chung-Ang UniversityAnseong 17546Republic of Korea

Passive daytime radiative cooling(PDRC) is useful for thermal management because it allows an object to emit terrestrial heat into space without the use of additional *** produce sub-ambient temperatures under direct sunlight,PDRC materials are designed to reduce their absorption of solar energy and to enhance their long-wavelength infrared(LWIR) *** recent years,many photonic structures and polymer composites have been studied to improve the cooling system of ***,in cold weather(i.e. during winter in cold climates),buildings need to be kept warm rather than cooled due to heat *** overcome this limitation,temperature-responsive radiative cooling is a promising *** the present study,adaptive radiative cooling(ARC) film fabricated from a polydimethylsiloxane/hollow SiO_(2) microsphere/thermochromic pigment composite was *** found that the ARC film absorbed solar radiation under cold conditions while exhibiting radiative cooling at ambient temperatures above 40℃.Thus,in outdoor experiments,the ARC film achieved sub-ambient temperatures and had a theoretical cooling power of 63.2 W/m~2 in hot *** also demonstrated that radiative cooling with an energy harvesting system could be used to improve the energy management of buildings,with the thermoelectric module continuously generating output power using the ARC ***,we believe that our proposed ARC film can be employed for efficient thermal management of buildings and all-season energy harvesting in the near future.

关键词： Thermal management Daytime radiative cooling Temperature-adaptive film Thermoelectric device Energy harvesting

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