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Dietary fat-associated osteoarthritic chondrocytes gain resistance to lipotoxicity through PKCK2/STAMP2/FSP27

Bone Research 2018年第3期6卷 238-251页

作者： Sung Won Lee Jee Hyun Rho Sang Yeob Lee Won Tae Chung yoo jin oh Jung Ha Kim Seung Hee yoo Woo Young Kwon Ju Yong Bae Su Young Seo Hokeun Sun Hye Young Kim Young Hyun yoo Department of Rheumatology Dong-A University College of Medicine Department of Anatomy and Cell Biology Dong-A University College of Medicine and Mitochondria Hub Regulation Center Department of Microbiology Dong-A University College of Medicine Department of Statistics Pusan National University

Free fatty acids(FFAs), which are elevated with metabolic syndrome, are considered the principal offender exerting lipotoxicity. Few previous studies have reported a causal relationship between FFAs and osteoarthritis pathogenesis. However, the molecular mechanism by which FFAs exert lipotoxicity and induce osteoarthritis remains largely unknown. We here observed that oleate at the usual clinical range does not exert lipotoxicity while oleate at high pathological ranges exerted lipotoxicity through apoptosis in articular chondrocytes. By investigating the differential effect of oleate at toxic and nontoxic concentrations, we revealed that lipid droplet(LD) accumulation confers articular chondrocytes, the resistance to lipotoxicity. Using high fat diet-induced osteoarthritis models and articular chondrocytes treated with oleate alone or oleate plus palmitate, we demonstrated that articular chondrocytes gain resistance to lipotoxicity through protein kinase casein kinase 2(PKCK2)—six-transmembrane protein of prostate 2(STAMP2)—and fat-specific protein 27(FSP27)-mediated LD accumulation. We further observed that the exertion of FFAs-induced lipotoxicity was correlated with the increased concentration of cellular FFAs freed from LDs, whether FFAs are saturated or not. In conclusion, PKCK2/STAMP2/FSP27-mediated sequestration of FFAs in LD rescues osteoarthritic chondrocytes. PKCK2/STAMP2/FSP27 should be considered for interventions against metabolic OA.

关键词： osteoarthritis remains articular chondrocytes

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Enhanced solid-electrolyte interface efficiency for practically viable hydrogen-air fuel cell systems

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Journal of Energy Chemistry 2025年第1期100卷 356-368页

作者： Venkitesan Sakthivel Dong jin yoo Graduate School Department of Energy Storage/Conversion Engineering (BK21 FOUR) Hydrogen and Fuel Cell Research Center Jeonbuk National University Jeonju Department of Life Science Jeonbuk National University

Proton exchange membrane fuel cells （PEMFCs） provide an appealing sustainable energy system,with the solid-electrolyte membrane playing a crucial role in its overall ***,sulfonated poly（1,4-phenylene ether-ether sulfone）(SPEES),an aromatic hydrocarbon polymer,has garnered considerable attention as an alternative to Nafion ***,the long-term durability and stability of SPEES present a significant *** this context,we introduce a potential solution in the form of an additive,specifically a core–shell-based amine-functionalized iron titanate （A–Fe2TiO5）,which holds promise for improving the lifetime,proton conductivity,and power density of SPEES in *** modified SPEES/A–Fe2TiO5composite membranes exhibited notable characteristics,including high water uptake,enhanced thermomechanical stability,and oxidative ***,the SPEES membrane loaded with 1.2 wt%of A–Fe2TiO5demonstrates a maximum proton conductivity of 155 mS cm-1,a twofold increase compared to the SPEES membrane,at 80°C under 100%relative humidity （RH）.Furthermore,the 1.2 wt%of A–Fe2TiO5/SPEES composite membranes exhibited a maximum power density of 397.37 mW cm-2and a current density of 1148 mA cm-2at 60°C under 100%RH,with an opencircuit voltage decay of 0.05 m V/h during 103 h of continuous *** study offers significant insights into the development and understanding of innovative SPEES nanocomposite membranes for PEMFC applications.

关键词： Composite membranes

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Measurement of stiffness and damping coefficient of rubber tractor tires using dynamic cleat test based on point contact model

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International Journal of Agricultural and Biological Engineering 2021年第1期14卷 157-164页

作者： Hogil yoo Jooseon oh Woo-jin Chung Hyun-Woo Han Ji-Tae Kim Young-Jun Park yoonna Park Department of Biosystems&Biomaterials Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea Global Smart Farm Convergence Major College of Agriculture and Life SciencesSeoul National UniversitySeoul 08826Republic of Korea Research Institute of Agriculture and Life Sciences College of Agriculture and Life SciencesSeoul National UniversitySeoul 08826Republic of Korea Research and Development Institute Tongyang Moolsan Co.Ltd.Gongju 32530Republic of Korea

The ride vibration of a tractor is affected mostly by the stiffness and damping coefficient of the seat suspension,cabin suspension,cabin rubber mounts,and rubber ***,in the case of rubber tractor tires,the stiffnesses and damping coefficients have not been researched adequately thus far,and it is not simple to measure these *** this study,a method for measuring and analyzing the stiffnesses and damping coefficients of rubber tractor tires,which were the input parameters for the tractor ride vibration simulation,was *** cleat test,proposed in this study,did not require separate and complicated test equipment,unlike the conventional *** test was conducted simply by measuring acceleration under the driving conditions of the vehicle without detaching tires from the vehicle body or setting up additional test *** on the ground-vertical acceleration data obtained,the stiffness was calculated using the logarithmic decrement method,and the damping coefficient was calculated using least squares exponential curve *** result of the cleat test indicated that the front tires had stiffnesses of 486.08-570.69 kN/m and damping coefficients of 4.02-4.52 kN·s/m;the rear tires had stiffnesses of 409.42-483.79 kN/m and damping coefficients of 2.21-2.67 kN·s/*** the test,40 mm height cleats were installed on the track and the speed of the tractor was set to 7 and 10 km/h,which were the most common speeds during the *** study is meaningful in that it has presented a new method that improves the practicality of results,reduces cost,and simplifies the test process for measuring the stiffnesses and damping coefficients of rubber tractor tires.

关键词： ride vibration rubber tractor tire stiffness damping coefficient cleat test point contact model

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Irritable bowel syndrome:Emerging paradigm in pathophysiology

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World Journal of Gastroenterology 2014年第10期20卷 2456-2469页

作者： yoo jin Lee Kyung Sik Park Division of Gastroenterology and Hepatology Department of Internal Medicine Keimyung University School of Medicine Daegu 700-712 South Korea

Irritable bowel syndrome(IBS)is one of the most common gastrointestinal disorders,characterized by abdominal pain,bloating,and changes in bowel *** symptoms cannot be explained by structural abnormalities and there is no specific laboratory test or biomarker for ***,IBS is classified as a functional disorder with diagnosis dependent on the history taking about manifested symptoms and careful physical *** a great deal of research has been carried out in this area,the pathophysiology of IBS is complex and not completely *** factors are thought to contribute to the symptoms in IBS patients;altered gastrointestinal motility,visceral hypersensitivity,and the brain-gut interaction are important classical concepts in IBS *** areas of research in this arena include inflammation,postinfectious low-grade inflammation,genetic and immunologic factors,an altered microbiota,dietary factors,and enteroendocrine *** emerging studies have not shown consistent results,provoking controversy in the IBS ***,certain lines of evidence suggest that these mechanisms are important at least a subset of IBS patients,confirming that IBS symptoms cannot be explained by a single etiological ***,it is important to keep in mind that IBS requires a more holistic approach to determining effective treatment and understanding the underlying mechanisms.

关键词： Pathophysiology Irritable bowel syndrome Inflammation Immunologic Genetics Microbiota Diet Enteroendocrine cell

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Integration of omics studies indicates that species-dependent molecular mechanisms govern male fertility

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Journal of Animal Science and Biotechnology 2023年第3期14卷 1026-1039页

作者： yoo-jin Park Won-Ki Pang Myung-Geol Pang Department of Animal Science&Technology and BET Research Institute Chung-Ang UniversityAnseongGyeonggi‑do17546Republic of Korea

Background Comparative and comprehensive omics studies have recently been conducted to provide a comprehensive understanding of the biological mechanisms underlying ***,because these huge omics datasets often contain irrelevant information,editing strategies for summarizing and filtering the data are necessary prerequisite steps for identifying biomarkers of male ***,we attempted to integrate omics data from spermatozoa with normal and below-normal fertility from boars and bulls,including transcriptomic,proteomic,and metabolomic *** enrichment analysis was conducted and visualized using g:Profiler,Cytoscape,EnrichmentMap,and AutoAnnotation to determine fertility-related biological functions according to *** In particular,gamete production and protein biogenesis-associated pathways were enriched in bull spermatozoa with below-normal fertility,whereas mitochondrial-associated metabolic pathways were enriched in boar spermatozoa with normal *** results indicate that below-normal fertility may be determined by aberrant regulation of protein synthesis during spermatogenesis,and the modulation of reactive oxygen species generation to maintain capacitation and the acrosome reaction governs boar sperm *** Overall,this approach demonstrated that distinct molecular pathways drive sperm fertility in mammals in a species-dependent ***,we anticipate that searching for species-specific signaling pathways may aid in the discovery of fertility-related biomarkers within large omics datasets.

关键词： Integrated signaling pathways Male fertility Metabolomics Proteomics Spermatozoa transcriptomics

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A Novel Goodness of Fit Test Spectrum Sensing Using Extreme Eigenvalues

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Chinese Journal of Electronics 2020年第6期29卷 1201-1206页

作者： LI He ZHAO Wenjing LIU Chang jin Minglu yoo Sang-Jo School of Information and Communication Engineering Dalian University of Technology Department of Information and Communication Engineering Inha University

The existing Goodness of fit(GoF) test based spectrum sensing algorithms mostly use samples or energies as observations to make decisions,which can hardly achieve satisfactory performance especially when the Primary user(PU) signals are highly ***,the eigenvalue of covariance matrix can reflect signal correlations *** by this,we study the distribution of eigenvalue and propose an eigenvalue based GoF spectrum sensing *** the proposed scheme,we use the ratios of maximum to minimum eigenvalue as observations and thus it can bring performance improvements through capturing correlation of PU *** also provide the related theoretical analysis for the proposed *** results show that the proposed method overcomes the problem of noise uncertainty and achieves performance improvement over the classical samples-based GoF test.

关键词： eigenvalue based GoF spectrum sensing algorithm GoF test based spectrum sensing algorithm primary user signal covariance matrix eigenvalue Radio links and equipment eigenvalues and eigenfunctions signal detection Algebra goodness of fit test spectrum sensing algorithm Linear algebra (numerical analysis) signal sampling signal denoising radio spectrum management correlation methods covariance matrices Signal detection signal correlation

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Comparing vocal structures of the parasitic and nonparasitic groups in Cuculinae

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Avian Research 2017年第4期8卷 238-242页

作者： Heeyoung Kim jin-Won Lee Jeong-Chil yoo Korea Institute of Ornithology and Department of Biology Kyung Hee UniversitySeoul 02447Republic of Korea

Background: Avian brood parasitism is a breeding strategy in which brood parasites lay their eggs in the nest of other *** behavior is closely related to aspects of the biological evolution of the parasitic species such as reduced female body size and plumage color ***,not much is known whether it is associated with the evolution of ***: We collected samples of the typical male calls of 67 species belonging to the sub?family *** the calls,we measured five acoustic parameters for each samples to test the differences in vocal structures between parasitic and nonparasitic *** control for potential phylogenetic effects,we also performed phylogenetic independent contrast ***: We found that vocal structures were relatively similar among the parasitic species with a tendency to simple and low?frequency *** addition,harmonic structures were observed more frequently in the nonparasitic ***: Overall,these results support the idea that brood parasitic behavior with associated ecological condi?tions may play a role in vocal evolution,a better understanding of which may greatly improve our knowledge of vocal diversification in non?oscine birds.

关键词： Brood parasitism Cuculinae Non-oscine bird Vocal evolution

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Prognostic value of 18-fluorodeoxyglucose positron emission tomography-computed tomography in resectable colorectal cancer

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World Journal of Gastroenterology 2012年第36期18卷 5072-5077页

作者： Jang Eun Lee Sang Woo Kim jin Su Kim Kyu Yong Choi Won Kyung Kang Seong Taek oh Ie Ryung yoo Sung Hoon Kim Department of Internal Medicine Seoul St.Mary's HospitalCollege of MedicineThe Catholic University of South KoreaSeoul 137-701South Korea Department of Surgery College of MedicineThe Catholic University of South KoreaSeoul 137-701South Korea Department of Radiology Seoul St.Mary's HospitalCollege of MedicineThe Catholic University of South KoreaSeoul 137-701South Korea

AIM:To assess the prognostic value of preoperative 18 fluorodeoxyglucose positron emission tomography(FDG-PET)/computed tomography(CT) in patients with resectable colorectal ***:One hundred sixty-three patients with resectable colorectal cancer who underwent FDG-PET/CT before surgery were *** data including pathologic stage at presentation,histology,treatment,disease-free survival and the maximum standardized uptake value(SUVmax) of the primary tumor on FDG-PET/CT were retrospectively *** follow up duration was 756(range,419-1355).The primary end point was disease-free ***:Twenty-five of 163 patients(15.3%) had *** median SUVmax values of the recurrence and no-recurrence groups were 8.9(range,5-24) and 8.2(range,0-23,P = 0.998).Receiver operating characteristic(ROC) curve analysis showed no significant association between SUVmax and recurrence(area under the curve = 0.5,P = 0.998,95% CI:0.389-0.611).Because a statistically significant value was not found,SUVmax was dichotomized at its median of *** disease-free survival curve was analyzed using the median SUVmax(8.6) as the cut *** and multivariate analysis did not provide evidence that disease-free survival rates for the subgroups defined by the median SUVmax were significantly different(P = 0.52,P = 0.25).CONCLUSION:Our study suggests that the high FDG uptake of primary mass in resectable colorectal cancer doesn't have a significant relationship with tumor recurrence and disease-free survival.

关键词： Positron-emission tomography Colorectalneoplasms Disease-free survival Recurrence Prognosis

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Synthesis, characterization and electrocatalytic studies of palladium–manganese oxyhydroxide nanocomposite towards direct ethylene glycol fuel cell

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Chinese Science Bulletin 2014年第27期59卷 3413-3419页

作者： Ramanujam Kannan Ae Rhan Kim Dong jin yoo R&D Education Center for Specialized Graduate School of Hydrogen and Fuel Cells Engineering Chonbuk National University Chonju Joellabuk-do 561-756 Korea Department of Energy Storage/Conversion Engineering Hydrogen and Fuel Cell Research Center Graduate SchoolChonbuk National University Chonju Joellabuk-do 561-756Korea Department of Chemistry Chonbuk National UniversityChonju Joellabuk-do 561-756 Korea

The palladium nanoparticle grafted manganese oxyhydroxide nanorod(MON) electrocatalyst has been synthesized and tested for the electrooxidation of ethylene glycol(EG) in an alkaline medium. The MON was prepared using the hydrothermal method and the Pd nanoparticles were coated on the MON using an in situ reduction method. The nanocatalyst thus prepared was characterized by powder X-ray diffraction, scanning electron microscopy, high resolution transmission electron microscopy, energy dispersive X-ray spectroscopy and electrochemical methods. The microscopic studies confirm the formation of MON and reveal that the Pd nanoparticles were grafted uniformly on the MON. In the voltammetric studies, the Pd/MON catalyst exhibited a six-fold improved peak current for ethylene glycol electrooxidation compared with the C/Pd. The EG electrooxidation reaction performances of the Pd/MON nanocatalyst in the alkaline solutions containing different quantities of EG were tested through cyclic voltammetry. The catalytic removal of the poisonous intermediates formed during electrooxidation of EG was explained. The present study shows that MON can act as an active support for the Pd nanocatalyst.

关键词：钯纳米粒子氢氧化锰乙二醇化学研究燃料电池纳米复合合成高分辨透射电子显微镜

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Regulation of epithelial function, differentiation, and remodeling in the epididymis

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Asian Journal of Andrology 2016年第1期18卷 3-9页

作者： Sylvie Breton Ye Chun Ruan yoo-jin Park Bongki Kim Center for Systems Biology Program in Membrane Biology/Nephrology Division Massachusetts General Hospital Boston MA 02114 and Harvard Medical School Boston MA 02115 USA Epithelial Cell Biology Research Centre School of Biomedical Sciences Faculty of Medicine The Chinese University of Hong Kong Hong Kong China

The epididymis is a single convoluted tubule lined by a pseudostratified epithelium. Specialized epididymal epithelial cells, the so-called principal, basal, narrow, and clear cells, establish a unique luminal environment for the maturation and storage of spermatozoa. The epididymis is functionally and structurally divided into several segments and sub-segments that create regionally distinct luminal environments. This organ is immature at birth, and epithelial cells acquire their fully differentiated phenotype during an extended postnatal period, but the factors involved in this complex process remain incompletely characterized. In the adult epididymis, the establishment of an acidic luminal pH and low bicarbonate concentration in the epididymis contributes to preventing premature activation of spermatozoa during their maturation and storage. Clear cells are proton-secreting cells throughout the epididymis, but principal cells have distinct acid/base transport properties, depending on their localization within the epididymis. Basal cells are located in all epididymal segments, but they have a distinct morphology depending on the segment and species examined. How this structural plasticity of basal cells is regulated is discussed here. Also, the role of luminal factors and androgens in the regulation of epithelial cells is reviewed in relation to their respective localization in the proximal versus distal regions of the epididymis. Finally, we describe a novel role for CFTR in tubulogenesis and epithelial cell differentiation.

关键词： basal cells clear cells principal cells pseudostratified epithelia transepithelial transport

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