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化学研究 2014年第4期25卷 428-440页

作者：赵迎春张前军卢永仲陈海燕贵州大学化学与化工学院贵州贵阳550025 贵州理工学院药学院贵州贵阳550007

蛋白酪氨酸激酶在肿瘤的形成和增殖中起着关键作用,以蛋白酪氨酸激酶作为肿瘤治疗靶点的研究受到极大关注.本文作者综述了近十年来不同结构的酪氨酸激酶抑制剂的合成以及抗肿瘤活性的研究进展,以期为酪氨酸激酶抑制剂的研究与开发提供参考.

关键词：酪氨酸激酶抑制剂合成生物活性研究进展

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挤压油膜阻尼器柔性转子系统的动态特性

华中科技大学学报（自然科学版） 2001年第3期29卷 67-69页

作者：陆永忠廖道训黄其柏华中科技大学机械科学与工程学院

运用分岔理论对挤压油膜阻尼器滑动轴承柔性Jeffcott转子系统的稳定性和分岔行为进行了研究 .计算结果表明 ,系统能够在一定范围内保持稳定 ,并出现倍周期和准周期分岔现象 ,为有效地控制转子的稳定运行状态提供了理论依据 .

关键词：挤压油膜阻尼器滑动轴承柔性转子系统动力特性稳定性分岔行为

Fucoidan-based dual-targeting mesoporous polydopamine for enhanced MRI-guided chemo-photothermal therapy of HCC via P-selectin-mediated drug delivery

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Asian Journal of Pharmaceutical Sciences 2022年第6期17卷 908-923页

作者： Gaofeng Shu Lin Shen Jiayi Ding Junchao Yu Xiaoxiao Chen Xiaoju Guo Enqi Qiao Yaning Chen Chenying lu Zhongwei Zhao yongzhong Du Minjiang Chen Jiansong Ji Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research Institute of Imaging Diagnosis and Minimally Invasive Intervention ResearchThe Fifth Affiliated Hospital of Wenzhou Medical UniversityLishui 323000China Department of radiology Lishui Hospital of Zhejiang UniversitySchool of MedicineLishui 323000China Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Shaoxing University School of Medcine Shaoxing 312000China

The development of novel theranostic agents with outstanding diagnostic and therapeutic performances is still strongly desired in the treatment of hepatocellular carcinoma(HCC).Here,a fucoidan-modified mesoporous polydopamine nanoparticle dual-loaded with gadolinium iron and doxorubicin(FMPDA/Gd^(3+)/DOX)was prepared as an effective theranostic agent for magnetic resonance imaging(MRI)-guided chemo-photothermal therapy of *** was found that FMPDA/Gd^(3+)/DOX had a high photothermal conversion efficiency of 33.4%and excellent T1-MRI performance with a longitudinal relaxivity(r1)value of 14.966 m M^(-1)·s^(-1).Moreover,the results suggested that FMPDA/Gd^(3+)/DOX could effectively accumulate into the tumor foci by dual-targeting the tumor-infiltrated platelets and HCC cells,which resulted from the specific interaction between fucoidan and overexpressed p-selectin *** excellent tumor-homing ability and MRI-guided chemo-photothermal therapy therefore endowed FMPDA/Gd^(3+)/DOX with a strongest ability to inhibit tumor growth than the respective single treatment ***,our study demonstrated that FMPDA/Gd^(3+)/DOX could be applied as a potential nanoplatform for safe and effective cancer theranostics.

关键词： Mesoporous polydopamine Fucoidan P-selectin target Platelets bridge Cancer theranostics

基于CDIO工程教育理念的制药工程专业《有机化学》翻转课堂教学实践研究

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广东化工 2015年第10期42卷 221-222页

作者：卢永仲张振黄名正吴琴王涛邹树良贵州理工学院制药工程学院贵州贵阳550003

本文基于CDIO工程教育人才培养模式"做中学"的理念,通过翻转课堂进行有机化学教学实践研究。教学过程以人为本,以学生为中心,融知识传授、能力培养、素质教育全面协调发展。

关键词： CDIO 翻转课堂制药工程有机化学

8-取代苯并呋喃[3,2-d]嘧啶类化合物的合成及其体外抗白血病细胞活性研究

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贵州大学学报（自然科学版） 2016年第2期33卷 31-34,56页

作者：杨毓溥张前军许志玲卢永仲王兴东贵州大学化学与化工学院贵州贵阳550025 贵州大学精细化工研究开发中心贵州贵阳550025 贵州理工学院药学院贵州贵阳550007

设计合成14个8-硝基或8-氨基苯并呋喃[3,2-d]嘧啶类目标化合物(2a-g,3a-g),其结构经EI-MS、1H NMR和IR光谱确证。采用MTT法评价目标化合物对人白血病细胞K562体外增殖抑制活性,结果显示所合成化合物对K562细胞均具有一定的抑制作用,且8... 详细信息

设计合成14个8-硝基或8-氨基苯并呋喃[3,2-d]嘧啶类目标化合物(2a-g,3a-g),其结构经EI-MS、1H NMR和IR光谱确证。采用MTT法评价目标化合物对人白血病细胞K562体外增殖抑制活性,结果显示所合成化合物对K562细胞均具有一定的抑制作用,且8-氨基苯并呋喃[3,2-d]嘧啶类化合物的抗增殖活性均高于8-硝基苯并呋喃[3,2-d]嘧啶类化合物。

关键词：苯并呋喃[3,2-d]嘧啶衍生物合成抗白血病细胞

Expression of CENH3 alleles in synthesized allopolyploid Oryza species

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Journal of Genetics and Genomics 2010年第10期37卷 703-711页

作者： Hui Li Li lu Yanfang Heng Rui Qin yongzhong Xing Weiwei Jin National Maize Improvement Center of China Key Laboratory of Crop Genetic Improvement and Genome of Ministry of AgricultureBeijing Key Laboratory of Crop Genetic Improvement China Agricultural University Beijing 100193 China National Key Laboratory of Crop Genetic Improvement and National Center of Plant Gene Research (Wuhan) Huazhong Agricultural University Wuhan 430070 China Key Laboratory of State Ethnic Affairs Commission for Biological Technology College of Life Sciences South-Central University for Nationalities Wahan 430074 China

Synthesized allopolyploids are valuable materials for comparative analyses of two or more distinct genomes, such as the expression changes （activation, inactivation or differential expression） of orthologous genes following allopolyploidization. CENH3 is a centromerespecific histone H3 variant and has been regarded as a central component in kinetochore formation and centromere function. In this study, interspecific hybrids of Oryza genus （AA × CC, AA × CCDD） and their backcross progenies were produced, and the genome constitutions were identified as AC, ACC, ACD, AACD, or AA（CD） by Genomic in situ hybridization （GISH）. We further cloned and sequenced the CENH3 genes from O. sativa （AA）, O. officinalis （CC） and O. latifolia （CCDD）. Sequencing of RT-PCR products revealed that CENH3_C2 and CENH3_D, the two CENH3 alleles from O. latifolia, showed polymophism in several sites, while CENH3_C2 and CENH3_C1 from O. officinalis were different at only two amino acids positions. Moreover, we found that the CENH3 genes from both parents are expressed in interspecific hybrids and their progenies. Specifically, based on our cDNA sequencing data, the ratio of expres- sion level between CENH3_A and CENH3_C1 was approximately 1 in AC and 0.5 in ACC genomes, respectively. As a result, the CENH3 expression patterns shed more light on the inter-coordination between varied centromeric DNA sequences and highly conserved kinetochore protein in synthesized allopolyploids of Oryza genus.

关键词： synthesized allopolyploid Oryza genus CENH3 gene expression

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超声影像组学在肝包虫病分型中的应用研究

临床超声医学杂志 2024年第5期26卷 353-359页

作者：张旭辉索朗拉姆邱甲军任叶蕾王逸非卢强李永忠蔡迪明四川大学华西医院超声医学科成都市610041 西藏自治区疾病预防控制中心华西生物医学大数据中心

目的基于超声影像组学构建机器学习模型,探究其在鉴别囊型肝包虫病与泡型肝包虫病中的应用价值。方法选取于我院及四川省甘孜藏族自治州石渠县经病理结果(金标准)或“四川省包虫病专家组”依据临床结果及专家共识(银标准)确诊的肝包... 详细信息

目的基于超声影像组学构建机器学习模型,探究其在鉴别囊型肝包虫病与泡型肝包虫病中的应用价值。方法选取于我院及四川省甘孜藏族自治州石渠县经病理结果(金标准)或“四川省包虫病专家组”依据临床结果及专家共识(银标准)确诊的肝包虫病患者4976例,共纳入23 452张超声图像,其中囊型肝包虫病图像8557张,泡型肝包虫病图像14 895张。按病灶类型以8∶2比例将超声图像随机分为训练集18 762张与独立测试集4690张。使用Pyradiomics(3.1.0)提取超声图像的影像组学特征,对训练集及独立测试集超声图像均使用相同的提取器;使用极小化极大、标准分数及均值方法对影像组学特征进行特征缩放,使用主成分分析和Pearson相关系数进行特征降维,使用方差分析、递归特征消除、相关特征法及克鲁斯卡尔-沃利斯法筛选最佳影像组学特征。基于支持向量机(SVM)、自编码器(AE)、线性判别分析(LDA)、随机森林(RF)、逻辑回归(LR)、自适应增强(AB)、决策树(DT)、朴素贝叶斯(NB)8种分类器构建鉴别肝包虫病分型的最佳机器学习模型。训练集中,以十折交叉验证策略训练模型。绘制受试者工作特征(ROC)曲线分析不同分类器中最佳机器学习模型在训练集及独立测试集中鉴别肝包虫病分型的诊断效能。结果从每张超声图像中共提取1130个影像组学特征,经特征选择动态筛选出1~40个最佳影像组学特征,并以此建立最佳机器学习模型。ROC曲线分析显示,RF模型在训练集及独立测试集中鉴别肝包虫病分型的曲线下面积分别为0.82、0.86,均高于SVM、AE、LDA、LR、AB、DT、NB模型,差异均有统计学意义(均P<0.05)。结论基于超声影像组学的RF模型对鉴别肝包虫病分型的诊断效能最佳,有助于肝包虫病精准超声诊断。

关键词：超声检查影像组学肝包虫病分型机器学习

维普期刊数据库博看期刊

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改良奶山羊公羔肥育的肉用性能研究

畜牧兽医学报 1989年第2期20卷 107-111页

作者：曹斌云渊锡潘李建文雒鸣峰关郁芬罗军吕永忠杜宏均张芳莉西北农业大学奶山羊研究室千阳县畜牧局

用80只改良奶山羊断奶公羔,分四组日粮比较其肥育的肉用性能,结果表明,第三组效果较好。四组试验羊8月龄宰前重平均达到了27.60±1.44千克,胴体重12.56±1.07千克,净肉重9.05±0.73千克,眼肌面积11.52±1.50平方厘米,屠宰率45.45±1.45... 详细信息

用80只改良奶山羊断奶公羔,分四组日粮比较其肥育的肉用性能,结果表明,第三组效果较好。四组试验羊8月龄宰前重平均达到了27.60±1.44千克,胴体重12.56±1.07千克,净肉重9.05±0.73千克,眼肌面积11.52±1.50平方厘米,屠宰率45.45±1.45％,肉骨比3.32±0.13,净肉率34.35±0.96％。混合肉样的失水率为20.10％,弹硬度58.20％,干物质27.21％,粗脂肪12.86％,粗蛋白14.49％。肾脂中亚油酸(C_(18:2))占3.67％,眼肌中为5.85％,股二头肌中含8.57％。肉样中含量丰富的氨基酸有丙氨酸(32.5％),赖氨酸(8.6％),甘氨酸(8.6％),亮氨酸(6.3％),脯氨酸(4.6％),其中必需氨基酸含50.61％。以上这些特点在营养中具有重要作用。分析还表明,奶山羊公羔肥育的经济效益显著。

关键词：奶山羊肥育肉品质公羔

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《有机化学》混合式学习的教学实施

广东化工 2014年第5期41卷 173-173,175页

作者：吴琴卢永仲贵州理工学院制药工程学院贵州贵阳550003

在高等教育信息化逐步深入的背景下,混合式学习正在为高校教学改革提供一种新的思路和方法。以有机化学课程为例,针对该课程的特点和存在的问题,阐述了在日常教学中使用混合式学习的必要性,并从课程导入、教学活动组织实施、学习支持和... 详细信息

在高等教育信息化逐步深入的背景下,混合式学习正在为高校教学改革提供一种新的思路和方法。以有机化学课程为例,针对该课程的特点和存在的问题,阐述了在日常教学中使用混合式学习的必要性,并从课程导入、教学活动组织实施、学习支持和教学评价等几个方面对其进行了研究。

关键词：混合式学习有机化学教学实施

B-cell-derived IL-10 promotes allergic sensitization in asthma regulated by Bcl-3

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Cellular & Molecular Immunology 2023年第11期20卷 1313-1327页

作者： Guojun Qian Wenxia Jiang Donglin Sun Zhun Sun Anning Chen Hongwei Fang Jingyao Wang yongzhong Liu Zhinan Yin Haiming Wei Hao Fang Xiaoren Zhan Affiliated Cancer Hospital/Institute and GMU-GIBH Joint School of Life Sciences of Guangzhou Medical University The Guangdong-Hong Kong-Macao Joint Laboratory for Cell Fate Regulation and DiseasesState Key Laboratory of Respiratory Disease511436GuangzhouChina Shanghai Institute of Nutrition and Health Chinese Academy of Sciences200031ShanghaiChina Department of Anesthesiology Zhongshan HospitalFudan University200032ShanghaiChina Shanghai Cancer Institute Renji HospitalShanghai Jiao Tong University School of Medicine200032ShanghaiChina Zhuhai People’s Hospital Biomedical Translational Research InstituteJinan University510632GuangzhouChina Institute of Immunology University of Science and Technology of China230000HefeiChina Department of Anesthesiology Minhang HospitalFudan University201100ShanghaiChina Key Laboratory of Anesthesiology(Shanghai Jiao Tong University) Ministry of Education200001ShanghaiChina

Aeroallergen sensitization,mainly mediated by lung epithelium and dendritic cells(DCs),is integral to allergic asthma pathogenesis and ***-10 has a dual role in immune responses,as it inhibits myeloid cell activation but promotes B-cell responses and epithelial cell ***,we report a proinflammatory function of B-cell-derived IL-10 modulated by Bcl-3 in allergic ***,Bcl-3^(−/−)mice showed elevated IL-10 levels and were found to be highly vulnerable to allergic asthma induced by house dust mites(HDMs).IL-10 had a positive correlation with the levels of the DC chemoattractant CCL-20 in HDM-sensitized mice and in patients with asthma and induced a selective increase in CCL-20 production by mouse lung epithelial *** of IL-10 or IL-10 receptors during sensitization dampened both HDM-induced sensitization and asthma ***-10 levels peaked 4 h post sensitization with HDM and IL-10 was primarily produced by B cells under Bcl-3–Blimp-1–Bcl-6 *** lacking B-cell-derived IL-10 displayed decreased lung epithelial CCL-20 production and diminished DC recruitment to the lungs upon HDM sensitization,thereby demonstrating resistance to HDM-induced ***,responses to HDM stimulation in Bcl-3^(−/−)mice lacking B-cell-derived IL-10 were comparable to those in Bcl-3^(+/+)*** results revealed an unexpected role of B-cell-derived IL-10 in promoting allergic sensitization and demonstrated that Bcl-3 prevents HDM-induced asthma by inhibiting B-cell-derived IL-10 ***,targeting the Bcl-3/IL-10 axis to inhibit allergic sensitization is a promising approach for treating allergic asthma.

关键词： Bcl-3 Plasma cell IL-10 Allergic sensitization Airway inflammation Asthma