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Trend of Storm Surge Induced by Typical Landfall Super Typhoons During 1975–2021 in the Eastern China Sea

Journal of Ocean University of China 2024年第2期23卷 277-286页

作者： LUO Feng wang Yi TAO Aifeng SHI Jian wang yongzhi ZHANG Chi College of Harbour Coastal and Offshore EngineeringHohai UniversityNanjing 210098China Nantong Ocean and Coastal Engineering Research Institute Hohai UniversityNantong 226000China Key Laboratory of Ministry of Education for Coastal Disaster and Protection Hohai UniversityNanjing 210098China College of Meteorology and Oceanography National University of Defense TechnologyChangsha 410073China The First Institute of Oceanography MNRQingdao 266061China

Climate change affects the activity of global and regional tropical cyclones(TCs).Among all TCs,typical super typhoons(STYs)are particularly devastating because they maintain their intensity when landing on the coast and thus cause casualties,economic losses,and environmental damage.Using a 3D tidal model,we reconstructed the typhoon(TY)wind field to simulate the storm surge induced by typical STYs.The TY activity was then analyzed using historical data.Results showed a downtrend of varying degrees in the annual frequency of STYs and TCs in the Western North Pacific(WNP)Basin,with a significant trend change observed for TCs from 1949 to 2021.A large difference in the interannual change in frequency was found between STYs and TCs in the WNP and Eastern China Sea(ECS).Along the coast of EC,the frequency of landfall TCs showed a weak downtrend,and the typical STYs showed reverse micro growth with peak activity in August.Zhejiang,Fujian,and Taiwan were highly vulnerable to the frontal hits of typical STYs.Affected by climate change,the average lifetime maximum intensity(LMI)locations and landfall locations of typical STYs in the ECS basin showed a significant poleward migration trend.In addition,the annual average LMI and accumulated cyclone energy showed an uptrend,indicating the increasing severity of the disaster risk.Affected by the typical STY activity in the ECS,the maximum storm surge area also showed poleward migration,and the coast of North China faced potential growth in high storm surge risks.

关键词： storm surge super typhoons tropical cyclones eastern China Sea poleward migration

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Molecular pathology and clinical implications of diffuse glioma

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Chinese Medical Journal 2022年第24期135卷 2914-2925页

作者： Ruichao Chai Shengyu Fang Bo Pang Yuqing Liu yongzhi wang Wei Zhang Tao Jiang Department of Molecular Neuropathology Beijing Neurosurgical InstituteCapital Medical UniversityBeijing 100070China Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China Research Unit of Accurate Diagnosis Treatmentand Translational Medicine of Brain TumorsChinese Academy of Medical SciencesBeijing 100070China

The prognosis for diffusely infiltrating gliomas at World Health Organization(WHO)grade 2-4 remains dismal due to their heterogeneity.The rapid development of genome-wide molecular-profiling-associated studies has greatly promoted the accuracy of glioma classification.Thus,the latest version of the WHO classification of the central nervous system tumors published in 2021 has incorporated more molecular biomarkers together with histological features for the diagnosis of gliomas.Advanced usage of molecular pathology in clinical diagnostic practice provides also new opportunities for the therapy of patients with glioma,including surgery,radiotherapy and chemotherapy,targeted therapy,immunotherapy,and more precision clinical trials.Herein,we highlight the updates in the classification of gliomas according to the latest WHO guidelines and summarize the clinically relevant molecular markers by focusing on their applications in clinical practice.We also review the advances in molecular features of gliomas,which can facilitate the development of glioma therapies,thereby discussing the challenges and future directions of molecular pathology toward precision medicine for patients with glioma.

关键词： Glioma Molecular pathology tumor classification O^(6)-methylguanine-DNA methyltransferase Therapy

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CHRM3 is a novel prognostic factor of poor prognosis andpromotes glioblastoma progression via activation of oncogenicinvasive growth factors

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肿瘤学研究(英文) 2023年第6期31卷 917-927页

作者： BIN ZHANG JIANYI ZHAO yongzhi wang HUA XU BO GAO GUANGNING ZHANG BIN HAN GUOHONG SONG JUNCHEN ZHANG WEI MENG Department of Neurosurgery Affiliated Hospital of Jining Medical UniversityJiningChina Department of Neurosurgery The City Peoples’Hospital of FuyangFuyangChina Brain Injury Center Department of NeurosurgeryRen Ji HospitalShanghai Jiao Tong University School of MedicineShanghaiChina

Glioblastoma(GBM)is the most aggressive cancer of the brain and has a high mortality rate due to the lack of effective treatment strategy.Clarification of molecular mechanisms of GBM’s characteristic invasive growth is urgently needed to improve the poor prognosis.Single-nuclear sequencing of primary and recurrent GBM samples revealed that levels of M3 muscarinic acetylcholine receptor(CHRM3)were significantly higher in the recurrent samples than in the primary samples.Moreover,immunohistochemical staining of an array of GBM samples showed that high levels of CHRM3 correlated with poor prognosis,consistent with The Cancer Genome Atlas database.Knockdown of CHRM3 inhibited GBM cell growth and invasion.An assay of orthotopic GBM animal model in vivo indicated that inhibition of CHRM3 significantly suppressed GBM progression with prolonged survival time.Transcriptome analysis revealed that CHRM3 knockdown significantly reduced an array of classic factors involved in cancer invasive growth,including MMP1/MMP3/MMP10/MMP12 and CXCL1/CXCL5/CXCL8.Taken together,CHRM3 is a novel and vital factor of GBM progression via regulation of multiple oncogenic genes and may serve as a new biomarker for prognosis and therapy of GBM patients.

关键词： Glioblastoma Prognosis CHRM3 MMP CXCL

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Estimating posterior inference quality of the relational infinite latent feature model for overlapping community detection

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Frontiers of Computer Science 2020年第6期14卷 55-69页

作者： Qianchen YU Zhiwen YU Zhu wang Xiaofeng wang yongzhi wang School of Computer Science and Engineering Northwestern Polytechnical UniversityXi’an 710072China Shanxi Provincial Key Laboratory for Embedded System Xi'an 710072China College of Computer Science and Engineering North Minzu UniversityYinchuan 750021China College of Earth Exploration Science and Technology Jilin UniversityChangchun 130025China

Overlapping community detection has become a very hot research topic in recent decades,and a plethora of methods have been proposed.But,a common challenge in many existing overlapping community detection approaches is that the number of communities K must be predefined manually.We propose a flexible nonparametric Bayesian generative model for count-value networks,which can allow K to increase as more and more data are encountered instead of to be fixed in advance.The Indian buffet process was used to model the community assignment matrix Z,and an uncol-lapsed Gibbs sampler has been derived.However,as the community assignment matrix Zis a structured multi-variable parameter,how to summarize the posterior inference results andestimate the inference quality about Z,is still a considerable challenge in the literature.In this paper,a graph convolutional neural network based graph classifier was utilized to help tosummarize the results and to estimate the inference qualityabout Z.We conduct extensive experiments on synthetic data and real data,and find that empirically,the traditional posterior summarization strategy is reliable.

关键词： graph convolutional neural network graph classification overlapping community detection nonparametric Bayesian generative model relational infinite latent feature model Indian buffet process uncollapsed Gibbs sampler posterior inference quality estimation

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Intratumor heterogeneity,microenvironment,and mechanisms of drug resistance in glioma recurrence and evolution

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Frontiers of Medicine 2021年第4期15卷 551-561页

作者： Zhaoshi Bao yongzhi wang Qiangwei wang Shengyu Fang Xia Shan Jiguang wang Tao Jiang Beijing Neurosurgical Institute Capital Medical UniversityBeijing 100050China Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijing 100050China Divison of Life Science Department of Chemical and Biological EngineeringCenter for Systems Biology and Human Healthand State Key Laboratory of Molecular NeuroscienceThe Hong Kong University of Science and TechnologyHong KongChina China National Clinical Research Center for Neurological Diseases Beijing 100050China Division of Life Science Hong Kong University of Science and TechnologyHong KongChina Center of Brain Tumor Beijing Institute for Brain DisordersBeijing 100069China Department of Radiotherapy Beijing Tiantan HospitalCapital Medical UniversityBeijing 100050China

Glioma is the most common lethal tumor of the human brain.The median survival of patients with primary World Health Organization grade IV glioma is only 14.6 months.The World Health Organization classification of tumors of the central nervous system categorized gliomas into lower-grade gliomas and glioblastomas.Unlike primary glioblastoma that usually develop de novo in the elderly,secondary glioblastoma enriched with an isocitrate dehydrogenase mutant typically progresses from lower-grade glioma within 5-10 years from the time of diagnosis.Based on various evolutional trajectories brought on by clonal and subclonal alterations,the evolution patterns of glioma vary according to different theories.Some important features distinguish the normal brain from other tissues,e.g.,the composition of the microenvironment around the tumor cells,the presence of the blood-brain barrier,and others.The underlying mechanism of glioma recurrence and evolution patterns of glioma are different from those of other types of cancer.Several studies correlated tumor recurrence with tumor heterogeneity and the immune microenvironment.However,the detailed reasons for the progression and recurrence of glioma remain controversial.In this review,we introduce the different mechanisms involved in glioma progression,including tumor heterogeneity,the tumor microenvironment and drug resistance,and their pre-clinical implements in clinical trials.This review aimed to provide new insights into further clinical strategies for the treatment of patients with recurrent and secondary glioma.

关键词： glioma evolution mechanism strategies tumor heterogeneity secondary glioma

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Optimum Location of Tube Blank in Electromagnetic Bulging

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Journal of Materials Science & Technology 2001年第1期17卷 117-118页

作者： Zhiheng ZHAO Chunfeng LI yongzhi wang Yuying YANG School of Materials Science and Engineering Harbin institute of TechnologyHarbin 150001China

Using analytical method, this paper gets ’the mutual inductance between coil and workpiece in tube blank electromagnetic bulging. According to this, we obtain the optimum locations of tube blank with different length... 详细信息

关键词： electromagnetic bulging mutual inductance experimental data analytical method the optimum

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基于数字孪生的建设工程项目管理数字化

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土木工程学报 2024年第7期57卷 106-128页

作者：宫志群王永志廖少明中国建设基础设施有限公司北京100044 同济大学上海200092

我国大型建设项目具有规模大、工序复杂交叉、信息碎片化、劳动力短缺等问题,对传统项目管理方式形成了挑战,项目管理数字化需求十分迫切,其中数字孪生是当前实现项目管理数字化的重要手段。通过研究数字孪生的内涵、孪生映射以及数字... 详细信息

我国大型建设项目具有规模大、工序复杂交叉、信息碎片化、劳动力短缺等问题,对传统项目管理方式形成了挑战,项目管理数字化需求十分迫切,其中数字孪生是当前实现项目管理数字化的重要手段。通过研究数字孪生的内涵、孪生映射以及数字孪生成熟度评价,并结合南通绕城高速公路项目的应用实践,总结并提出基于数字孪生的建设项目管理数字化转型的实现路径、技术手段及建议。主要结论如下:(1)基于数字孪生内涵,构建了建设项目管理的数字孪生模型及考虑生命周期、模型映射、功能和数据完备性的四维度数字孪生成熟度评价模型。(2)采用BIM、GIS、UAV和IoT技术集成,在BIM“一模到底”理念下构建以BIM为数据载体的高速公路项目的数字孪生模型,实现孪生体虚实精准映射。(3)基于数字孪生的工程项目管理数字化具有提升组织管理能力、管理效益提升、提升工程质量、项目数字资产价值再生等意义。(4)为切实推动建设项目管理数字化,需根据项目特点,着力解决项目结合、理念转变、组织保障和技术支撑等问题。

关键词：建设项目管理数字孪生数字化建筑信息模型

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骨骼风痛片的综合质量评价

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中国药房 2024年第8期35卷 948-954页

作者：吉顺莉周虹王永智殷晓芹南通大学附属医院药学部江苏南通226001 海安市人民医院药剂科江苏南通226600 南京中医药大学药学院南京210023

目的建立测定骨骼风痛片中原薯蓣皂苷等11种成分含量的方法,同时进行化学计量学分析及熵权优劣解距离(EW-TOPSIS)法分析,以综合评价骨骼风痛片的质量。方法采用高效液相色谱法。以Agilent Eclipse Plus C18为色谱柱,以乙腈-0.2%磷酸溶... 详细信息

目的建立测定骨骼风痛片中原薯蓣皂苷等11种成分含量的方法,同时进行化学计量学分析及熵权优劣解距离(EW-TOPSIS)法分析,以综合评价骨骼风痛片的质量。方法采用高效液相色谱法。以Agilent Eclipse Plus C18为色谱柱,以乙腈-0.2%磷酸溶液为流动相进行梯度洗脱,流速为1.0 mL/min,柱温为30℃,检测波长为203 nm(0~28 min,原薯蓣皂苷、甲基原薯蓣皂苷、伪原薯蓣皂苷、薯蓣皂苷)、280 nm(28~60 min,儿茶素、表儿茶素、甘草素、美迪紫檀素、6-姜辣素、8-姜酚、10-姜酚),进样量为10μL。以表儿茶素为内参物,采用一测多评(QAMS)法计算原薯蓣皂苷、甲基原薯蓣皂苷、伪原薯蓣皂苷、薯蓣皂苷、儿茶素、甘草素、美迪紫檀素、6-姜辣素、8-姜酚和10-姜酚的含量,并与外标法检测结果进行比较;采用SPSS 26.0、SIMCA14.1软件进行主成分分析和正交偏最小二乘法-判别分析,以变量重要性投影(VIP)值大于1为标准,筛选影响质量的差异标志物;采用EW-TOPSIS法对15批样品的质量进行综合评价。结果高效液相色谱结合QAMS法测得原薯蓣皂苷、甲基原薯蓣皂苷、伪原薯蓣皂苷、薯蓣皂苷、儿茶素、甘草素、美迪紫檀素、6-姜辣素、8-姜酚和10-姜酚的含量分别为6.330~10.863、1.150~2.274、0.431~0.740、2.818~4.823、0.826~1.510、0.043~0.094、0.079~0.231、0.479~1.020、0.146~0.288、0.118~0.318 mg/g,与外标法比较差异均无统计学意义(P>0.05);15批样品可分为3组,S1~S6、S7~S10、S11~S15分别聚为一组;原薯蓣皂苷、表儿茶素、薯蓣皂苷、6-姜辣素的VIP值均大于1;15批样品的最优解欧氏贴近度(Ci)为0.1635~0.7037,其中S11~S15样品的Ci值均大于0.6。结论所建QAMS法准确、简便,结合化学计量学分析及EW-TOPSIS法可用于综合评价骨骼风痛片的质量;原薯蓣皂苷、表儿茶素、薯蓣皂苷和6-姜辣素可能是影响骨骼风痛片质量的差异标志物;S11~S15样品的质量较好。

关键词：骨骼风痛片一测多评法化学计量学分析熵权优劣解距离法含量测定差异标志物

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基于WebGIS的广播电视无线发射台站管理系统设计与实现

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电视技术 2024年第6期48卷 208-210页

作者：王永志胶州市融媒体中心山东青岛266300

确保无线电波的质量和安全播出是广播电视行业的基本要求,依赖无线发射台站的高效管理。传统的基于客户端的台站管理系统因其高成本、低效率等缺点逐渐不能满足当前的需求。因此,提出基于WebGIS(Web Geographic Information System)的... 详细信息

确保无线电波的质量和安全播出是广播电视行业的基本要求,依赖无线发射台站的高效管理。传统的基于客户端的台站管理系统因其高成本、低效率等缺点逐渐不能满足当前的需求。因此,提出基于WebGIS(Web Geographic Information System)的广播电视无线发射台站管理系统,旨在提升广播电视无线发射台站的管理能力。首先阐述系统特点,其次设计系统的总体结构,分析系统的主要功能模块,最后研究各功能模块的实现。

关键词：无线发射台站浏览器 WebGIS

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身体与道德:高校生态人格塑造的离身认知与具身转向

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江苏高教 2024年第5期 92-96页

作者：陈娜燕柏振平王永智西北大学马克思主义学院西安730070 运城学院马克思主义学院山西运城044006 南京理工大学马克思主义学院南京210014

人与自然和谐共生的现代化需要以人格的生态化推进为先导,生态人格是应对中国环境问题的必然选择,也是对人类文明生态转向的积极回应。大学生作为中国式现代化事业的建设者和接班人,理应具备资源节约、环境友好的生态人格。当下高校生... 详细信息

人与自然和谐共生的现代化需要以人格的生态化推进为先导,生态人格是应对中国环境问题的必然选择,也是对人类文明生态转向的积极回应。大学生作为中国式现代化事业的建设者和接班人,理应具备资源节约、环境友好的生态人格。当下高校生态人格塑造存在虚假需要与真实需要、工具理性与价值理性、外部环境与内在秩序、知善能力与行善意向等一系列矛盾,究其原因在于传统生态文明教育的重知观念和离身方式。以具身认知修正离身认知所表现出来的机械唯物主义弊端,需要重视认知主体与场域在认知产生中的作用,打造“心理场”“教育场”“文化场”“实践场”等育人场,织补新时代大学生人格的生态缺失,促进个体人格发展的完满,从而成长为新时代生态型高素质人才。

关键词：生态人格知行结合离身认知具身转向

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