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Weak SARS-CoV-2-specific responses of TIGIT-expressing CD8^(+)T cells in people living with HIV after a third dose of a SARS-CoV-2 inactivated vaccine

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Chinese Medical Journal 2023年第24期136卷 2938-2947页

作者： Junyan Jin Xiuwen Wang yongzheng li Xiaodong Yang Hu Wang Xiaoxu Han Jin Sun Zhenglai Ma Junyi Duan Guanghui Zhang Tao Huang Tong Zhang Hao Wu Xin Zhang Bin Su Beijing Key Laboratory for HIV/AIDS Research Sino-French Joint Laboratory for Research on Humoral Immune Response to HIV InfectionClinical and Research Center for Infectious DiseasesBeijing Youan HospitalCapital Medical UniversityBeijing 100069China Biomedical Pioneering Innovation Center(BIOPIC) Peking UniversityBeijing 100871China Tian Yuan Studio Beijing Youan HospitalCapital Medical UniversityBeijing 100069China

Background:T-cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibition motif domains(TIGIT),an inhibitory receptor expressed on T cells,plays a dysfunctional role in antiviral infection and antitumor activity.However,it is unknown whether TIGIT expression on T cells influences the immunological effects of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)inactivated vaccines.Methods:Forty-five people living with HIV(PLWH)on antiretroviral therapy(ART)for more than two years and 31 healthy controls(HCs),all received a third dose of a SARS-CoV-2 inactivated vaccine,were enrolled in this study.The amounts,activation,proportion of cell subsets,and magnitude of the SARS-CoV-2-specific immune response of TIGIT^(+)CD4^(+)and TIGIT^(+)CD8^(+)T cells were investigated before the third dose but 6 months after the second vaccine dose(0W),4 weeks(4W)and 12 weeks(12W)after the third dose.Results:Compared to that in HCs,the frequency of TIGIT^(+)CD8^(+)T cells in the peripheral blood of PLWH increased at 12W after the third dose of the inactivated vaccine,and the immune activation of TIGIT^(+)CD8^(+)T cells also increased.A decrease in the ratio of both T naïve(T_(N))and central memory(T_(CM))cells among TIGIT^(+)CD8^(+)T cells and an increase in the ratio of the effector memory(T_(EM))subpopulation were observed at 12W in PLWH.Interestingly,particularly at 12W,a higher proportion of TIGIT^(+)CD8^(+)T cells expressing CD137 and CD69 simultaneously was observed in HCs than in PLWH based on the activation-induced marker assay.Compared with 0W,SARS-CoV-2-specific TIGIT^(+)CD8^(+)T-cell responses in PLWH were not enhanced at 12W but were enhanced in HCs.Additionally,at all time points,the SARS-CoV-2-specific responses of TIGIT^(+)CD8^(+)T cells in PLWH were significantly weaker than those of TIGIT-CD8^(+)T cells.However,in HCs,the difference in the SARS-CoV-2-specific responses induced between TIGIT^(+)CD8^(+)T cells and TIGIT-CD8^(+)T cells was insignificant at 4W and 12W,except at 0W.Conclusio

关键词： HIV TIGIT T-lymphocytes SARS-CoV-2 Booster vaccination Immunity

Pancreatic steatosis and its correlation with clinicopathological features in patients with pancreatic neuroendocrine neoplasms

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Journal of Pancreatology 2023年第2期6卷 48-54页

作者： yongzheng li Jian Yang Zhiyao Fan Peng Dong Jingjuan Hu Shujie liu Yufan Meng Changhao Gao Xin Gao Chaoyu Pang Hanxiang Zhan Division of Pancreatic Surgery Department of General SurgeryQilu Hospital of Shandong UniversityJinanShandong ProvinceChina Department of Nephrology Shouguang Hospital of Traditional Chinese MedicineWeifangShandong ProvinceChina

Background and objective:The incidence of pancreatic neuroendocrine neoplasms(pNENs)has been increasing year by year,and pancreatic steatosis has been paid more and more attention to by clinicians.Our study aims to reveal the correlation between pancreatic steatosis,clinicopathological parameters,and the prognosis of patients with pNENs.Methods:The clinicopathological data of patients with pNENs who underwent surgical resections in our institution from January 2013 to May 2022 were retrospectively analyzed.The mean computed tomography(CT)values of the pancreas and spleen were used to assess the severity of the pancreatic steatosis.Pearson Chi-square test,T test,Mann Whitney U test,Univariate Cox re-gression,and Multivariate Cox regression were used to explore the relationship between pancreatic steatosis and age,sex,body mass index,tumor type,tumor location,tumor stage,blood lipid,prognosis,and other factors.Results:A total of 122 patients were included in our study,and 19.67%have pancreatic steatosis.The incidence of pancreatic steatosis was significantly higher in patients with fatty liver than in patients without fatty liver(36.8%vs 16.5%,P=.04).In insu-linoma,the incidence of pancreatic steatosis in elderly patients was significantly higher than in young and middle-aged patients(41.7%vs 9.3%,P=.025).There was no significant difference in lipid levels between the pancreatic steatosis group and the non-pancreatic steatosis group(P>.05).Kaplan-Meier curves show that the prognosis of stage III/IV patients was significantly worse than that of stage I/II patients(Pliver than those without fatty liver.There is a high incidence of pancreatic steatosis in elderly patients with insulinoma.American Joint Committee on Cancer(AJCC)stage,but not pancreatic steatosis,significantly affected the prognosis of

关键词： Blood lipid Fatty liver Pancreatic neuroendocrine neoplasms Pancreatic steatosis Prognosis

LDV measurements of particle velocity distribution in an annular stripper

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Chinese Journal of Chemical Engineering 2019年第10期27卷 2293-2303页

作者： yongzheng li Xiaolai Zhang Guangwei Zhai Haitao Zhang Tao li Qiwen Sun Weiyong Ying Engineering Research Center of Large Scale Reactor Engineering and Technology Ministry of EducationState Key Laboratory of Chemical EngineeringEast China University of Science and TechnologyShanghai 200237China School of Chemistry and Chemical Engineering Shandong UniversityJinan 250100China State Key Laboratory of Coal liquefaction and Coal Chemical Technology Shanghai 201203China

Particle descent velocities in an annular stripper were measured by a laser Doppler velocimetry(LDV)system.In the radial direction,particle descent velocity was relatively constant in the mid-region of the stripper and increased towards the walls on both sides,exhibiting an anti-U-shaped distribution.Particle descent velocity in the radial mid-region increased with the increase of superficial gas velocity,and the maximum in the outer wall region increased significantly with the increase of solid mass flux.Superficial stripping gas velocity had stronger effect on particle velocity distributions near the stripper gas distributor,and such effect weakened with the increase of the distance from the distributor.Local particle velocity and its radial profiles could be adjusted by changing the superficial stripping gas velocity.Empirical formulas were established to describe the relationships between the local particle velocity and cross-sectional averaged velocity based on the effects of operating conditions and measuring positions.The result showed that the predicted data was in good agreement with the experimental value.

关键词： Annular stripper Flow Hydrodynamics Particle velocity Laser Doppler velocimeter

酒石酸美托洛尔对慢性心力衰竭治疗前后NT-proBNP变化的临床效果

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中国医药指南 2024年第4期22卷 83-86页

作者：李拥政湖北省宜城市人民医院宜城441400

目的分析慢性心力衰竭患者应用酒石酸美托洛尔治疗前后N末端B型利钠肽前体(NT-pro BNP)的变化。方法选取112例本院收治的慢性心力衰竭患者为对象展开研究,入院时间为2022年5月至2023年5月,所有患者通过交替分组法划分成两组,在临床中5... 详细信息

目的分析慢性心力衰竭患者应用酒石酸美托洛尔治疗前后N末端B型利钠肽前体(NT-pro BNP)的变化。方法选取112例本院收治的慢性心力衰竭患者为对象展开研究,入院时间为2022年5月至2023年5月,所有患者通过交替分组法划分成两组,在临床中56例参照组患者使用常规药物治疗,剩余56例试验组患者同时使用酒石酸美托洛尔进行治疗,对比临床疗效和治疗前后的NT-proBNP水平、心功能指标变化。结果治疗后,试验组患者治疗后的NT-proBNP水平低于治疗前,同时低于参照组(P0.05)。结论慢性心力衰竭患者在临床治疗中应用酒石酸美托洛尔,有助于下调NT-proBNP水平,改善心功能。

关键词：酒石酸美托洛尔慢性心力衰竭 N末端B型利钠肽前体

Chemoselective Polymerization of Fully Biorenewableα-Methylene-γ-Butyrolactone Using Organophosphazene/Urea Binary Catalysts Toward Sustainable Polyesters

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CCS Chemistry 2021年第1期3卷 620-630页

作者： Yong Shen Wei Xiong yongzheng li Zhichao Zhao Hua Lu Zhibo li State Key Laboratory Base of Eco-Chemical Engineering College of Chemical EngineeringQingdao University of Science and TechnologyQingdao 266042 Key Laboratory of Biobased Polymer Materials Shandong Provincial Education DepartmentCollege of Polymer Science and EngineeringQingdao University of Science and TechnologyQingdao 266042 Beijing National Laboratory for Molecular Sciences Center for Soft Matter Science and EngineeringKey Laboratory of Polymer Chemistry and Physics of Ministry of EducationCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871

Despite the great potential of biorenewableα-methylene-γ-butyrolactone(MBL)to produce functional,recyclable polyester,the ring-opening polymerization(ROP)of MBL remains a challenge due to the competing polymerization of the highly reactive exocyclic double bond and low-strained five-membered ring.In this contribution,we present the first organocatalytic chemoselective ROP of MBL to exclusively produce functional unsaturated polyester by utilizing a phosphazene base/urea binary catalyst.We show that delicate chemoselectivity can be realized by controlling the temperature and using selected urea catalysts.The obtained polyester can be completely recycled back to its monomer by chemolysis under mild conditions.Experimental and theoretical calculations provide mechanistic insights and indicate that the ROP pathway is kinetically favored by using urea with stronger acidity at low temperatures.

关键词： organocatalyst ring-opening polymerization polyester sustainable polymer recyclability

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声呐透声窗结构的减振降噪优化设计

中国造船 2024年第2期65卷 63-73页

作者：孔德冬夏茂龙李永正张海华刘双张宇阳江苏科技大学镇江212100 中国船舶科学研究中心上海分部上海200011 深海技术科学太湖实验室连云港中心连云港222000

随着对声呐透声窗结构综合性能提升需求的日益增长,有效结合优化设计方法达到减振降噪目的是透声窗结构设计的重点研究领域之一。采用遗传算法对声呐透声窗结构的减振降噪开展多目标优化;基于Sobol法利用最优拉丁超立方技术对透声窗结... 详细信息

随着对声呐透声窗结构综合性能提升需求的日益增长,有效结合优化设计方法达到减振降噪目的是透声窗结构设计的重点研究领域之一。采用遗传算法对声呐透声窗结构的减振降噪开展多目标优化;基于Sobol法利用最优拉丁超立方技术对透声窗结构进行灵敏度分析,辨识关键因子,确定优化设计变量,建立透声窗结构多目标优化模型及方法,并对该方法进行鲁棒性验证;基于NSGA-Ⅱ法对该多目标问题进行求解得到优化结果,并和传统透声窗模型进行流激振动对比。结果表明:在减小结构质量的基础上,结构表面均方振速大幅降低,减振降噪效果得到显著提升,实现了对声呐透声窗低振动和轻量化的设计目标。

关键词：声呐透声窗最优拉丁超立方 NSGA-Ⅱ方法减振降噪

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基于准静态法的船体梁极限强度试验设计方法

船舶工程 2024年第3期46卷 42-47,80页

作者：王珂王加明李金鹏秦闯李永正雷银慧江苏科技大学船舶与海洋工程学院江苏镇江212003

为了应对采用传统试验法求解船体梁极限强度问题时存在的成本较高的情况,有必要在开展试验之前进行预设计。针对船体梁极限强度试验预设计问题,采用四点弯曲理论对船体梁极限强度开展试验设计,给出具体的试验工装设计方案和加载方案,并... 详细信息

为了应对采用传统试验法求解船体梁极限强度问题时存在的成本较高的情况,有必要在开展试验之前进行预设计。针对船体梁极限强度试验预设计问题,采用四点弯曲理论对船体梁极限强度开展试验设计,给出具体的试验工装设计方案和加载方案,并采用准静态法分析该方案在中拱状态下的极限强度。将采用该方法所得计算结果与理想状态下的数值计算结果相对比对比,结果发现误差仅为0.08%,表明该试验设计方案可靠、可行。研究结果可为船体梁极限强度试验的开展提供参考。

关键词：船体梁极限强度准静态法试验设计

表皮设计的去工业化——以垃圾焚烧发电厂建筑为例

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建筑技艺(中英文) 2024年第4期30卷 96-100页

作者：李其郅肖新怡李泳征 UUA建筑师事务所

在“去工业化”建筑设计的背景下，通过采用新颖的表皮技术、表皮材料和装配工艺，创造出更具地域性、生态友好的“去工业化”建筑设计，使工业建筑更好地与周围环境和谐共生。

关键词：表皮设计工业建筑去工业化垃圾焚烧发电厂

间二甲苯气相氨氧化反应行为及原料利用率分析

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石油化工 2024年第1期53卷 33-40页

作者：李勇征冯冰钟思青顾龙勤杨为民中石化(上海)石油化工研究院有限公司绿色化工与工业催化国家重点实验室上海201208

利用固定床反应装置研究了间二甲苯气相氨氧化制备间苯二甲腈(IPN)的反应行为。考察了反应n(NH_(3))∶n(间二甲苯)(氨比)、n(空气)∶n(间二甲苯)(空比)、温度、停留时间等反应工艺参数对间二甲苯转化率及产物分布的影响,构建了间二甲苯... 详细信息

利用固定床反应装置研究了间二甲苯气相氨氧化制备间苯二甲腈(IPN)的反应行为。考察了反应n(NH_(3))∶n(间二甲苯)(氨比)、n(空气)∶n(间二甲苯)(空比)、温度、停留时间等反应工艺参数对间二甲苯转化率及产物分布的影响,构建了间二甲苯气相氨氧化反应路径,并分析了不同工况条件下间二甲苯(碳)、O_(2)、NH_(3)沿各反应路径的利用情况。实验结果表明,间二甲苯氨氧化生成IPN的过程由一系列复杂的平行-连串反应所构成;深度氧化以及NH_(3)燃烧消耗了大量的碳、O_(2)、NH_(3);合适的反应氨比、空比、温度和停留时间有助于提高原料的有效利用率;利用分区强化的反应新工艺,可有效减少NH_(3)和O_(2)的损耗。

关键词：气相氨氧化间苯二甲腈反应网络