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Multicellular biomarkers of drug resistance as promis-ing targets for glioma precision medicine and predic-tors of patient survival

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Cancer Drug Resistance 2022年第2期5卷 511-533页

作者： Yuting Lu yongzhao shao Departments of Population Health and Environmental Medicine New York University Grossman School of MedicineNew YorkNY10016USA.

Aim:This study aimed to translate a known drug-resistance mechanism of long-term CSFIR inhibition into multicellu-lar biomarkers that can serve as potential therapeutic targets as well as predictive markers for the survival of glioma ***:Using existing data from a published mouse study of drug resistance in immunotherapy for glioma,we identified mulicellular differentially expressed genes(DEGs)between drug-sensitive and drug-resistant mice and translated the DEGs in mouse genome to human *** constructed correlation gene networks for drug re-sistance in mice and glioma patients and selected candidate genes via concordance analysis of human with mouse gene *** of drug resistance and an associated predictive signature for patient survival were developed using regularized Cox models with data of glioma patients from The Cancer Genome Atlas(TCGA)***-tive performance of the identified predictive signature was evaluated using an independent human dataset from the Chinese Glioma Genome Atlas(CGGA)***:Fourteen genes(CCL22,ADCY2,PDK1,ZFP36,CP,CD2,PLAUR,ACAPI,COL5A1,FAM83D,PBK,FANCA,ANXA7,and TACC3)were identified as genetic biomarkers that were all associated with pathways in glioma progression and drug *** of the 14 genes(CCL22,ADCY2,PDK1,CD2,and COL5A1)were used to construct a signature that is predictive of patient survival in the proneural subtype GBM patients with an AUC under the time-dependent receiver operating characteristic(ROC)of 2-year survival equal to *** signature also shows promising predic-tive accuracy for the survival of LGG patients but not for non-proneural type ***:Our translational approach can utilize gene correlation networks from multiple types of cells in the tu-mor microenvironment of an *** identified biomarkers of drug resistance have good power to predict patient survival in some major subtypes of gliomas(the proneural subtype of GBM and LGG).The expres

关键词： Drug resistance tumor microenvironment translational research strategy multicellular gene correlation network glioma precision medicine

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Genome-Wide Likelihood Ratio Tests under Heterogeneity

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Open Journal of Statistics 2018年第3期8卷 468-478页

作者： Xiaoxia Han yongzhao shao Public Health Sciences Department Henry Ford Health System Detroit MI USA Department of Population Health New York University School of Medicine New York NY USA

The commonly used statistical methods in medical research generally assume patients arise from one homogeneous population. However, the existence and importance of significant heterogeneity have been widely documented. It is well known that common and complex human diseases usually have heterogeneous disease etiology, which often involves interplay of multiple genetic and environmental factors, leading to latent population substructure. Genome-wide association studies (GWAS) is a useful tool to uncover genetic association with disease of interest, while linkage analysis is a commonly used method to identify statistical association between the inheritance of a human disease and inheritance of marker loci that are in linkage with disease causing loci. We propose a likelihood ratio test for genome-wide linkage analysis under genetic heterogeneity using family data. We derive a closed-form formula for the LRT test statistic and provide explicit asymptotic null distribution. The closed form asymptotic distribution allows easy determination of the asymptotic p-values. Our extensive simulation studies indicate that the proposed test has proper type I error and good power under genetic heterogeneity. In order to simplify application of the proposed method for non-statisticians, we develop an R package gLRTH to implement the proposed LRT for genome-wide linkage analysis as well as Qian and shao’s LRT for GWAS under heterogeneity. The newly developed open source R package gLRTH is available at CRAN.

关键词： Genetic Heterogeneity Transmission Heterogeneity Complex Disease Genome-Wide Association Study Genetic Linkage Analysis R Software Package

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On Rotational Robustness of Shapiro-Wilk Type Tests for Multivariate Normality

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Open Journal of Statistics 2014年第11期4卷 964-969页

作者： Richie Lee Meng Qian yongzhao shao Division of Biostatistics New York University School of Medicine New York USA

The Shapiro-Wilk test (SWT) for normality is well known for its competitive power against numerous one-dimensional alternatives. Several extensions of the SWT to multi-dimensions have also been proposed. This paper investigates the relative strength and rotational robustness of some SWT-based normality tests. In particular, the Royston’s H-test and the SWT-based test proposed by Villase?or-Alva and González-Estrada have R packages available for testing multivariate normality;thus they are user friendly but lack of rotational robustness compared to the test proposed by Fattorini. Numerical power comparison is provided for illustration along with some practical guidelines on the choice of these SWT-type tests in practice.

关键词： Multivariate Normality R Packages Robust Power Shapiro-Wilk Test Rotational Robustness

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A Tight Prediction Interval for False Discovery Proportion under Dependence

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Open Journal of Statistics 2012年第2期2卷 163-171页

作者： Shulian Shang Mengling Liu yongzhao shao Division of Biostatistics New York University School of Medicine New York USA

The false discovery proportion (FDP) is a useful measure of abundance of false positives when a large number of hypotheses are being tested simultaneously. Methods for controlling the expected value of the FDP, namely the false discovery rate (FDR), have become widely used. It is highly desired to have an accurate prediction interval for the FDP in such applications. Some degree of dependence among test statistics exists in almost all applications involving multiple testing. Methods for constructing tight prediction intervals for the FDP that take account of dependence among test statistics are of great practical importance. This paper derives a formula for the variance of the FDP and uses it to obtain an upper prediction interval for the FDP, under some semi-parametric assumptions on dependence among test statistics. Simulation studies indicate that the proposed formula-based prediction interval has good coverage probability under commonly assumed weak dependence. The prediction interval is generally more accurate than those obtained from existing methods. In addition, a permutation-based upper prediction interval for the FDP is provided, which can be useful when dependence is strong and the number of tests is not too large. The proposed prediction intervals are illustrated using a prostate cancer dataset.

关键词： Multiple Testing False Discovery Proportion False Discovery Rate Weak Dependence Correlated Test Statistics High-Dimensional Data Analysis Prediction Interval Upper Prediction Bound Permutation-Based Method

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Expression of miR-16 is not a suitable reference for analysis of serum microRNAs in melanoma patients

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Journal of Biomedical Science and Engineering 2012年第11期5卷 647-651页

作者： Erica B. Friedman Shulian Shang Nathaniel H. Fleming Eleazar Vega-Saenz de Miera Eva Hernando yongzhao shao Iman Osman Department of Dermatology New York University New York USA Division of Biostatistics New York University New York USA Interdisciplinary Melanoma Cooperative Group New York University New York USA

Background: The evolving paradigm shift towards the molecular characterization of melanoma has expanded to include studies of microRNA (miRNA) expression. As miR-16 has been utilized as a normalizer in serum-based miRNA studies in several cancers, we evaluated miR-16 expression as a potential reference for normalization of serum miRNA expression in melanoma patients. Methods: 143 primary cutaneous melanoma patients who presented to New York University (NYU) Langone Medical Center for surgical resection of AJCC stage I-III disease were studied. In addition, sera samples from 60 control subjects were utilized including 22 healthy volunteers, 13 rheumatoid arthritis patients, 20 non-melanoma cancer patients (10 renal cell carcinoma and 10 bladder cancer), and 5 Atypical Mole Syndrome patients. The Kruskal-Wallis test (k = 6) or Wilcoxon test (k = 2) with Bonferroni correction was used for analyses of miR-16 expression in melanoma patients compared to various control groups, using raw Ct values directly. The Kruskal-Wallis test was used to compare miR-16 expression across stages of melanoma. The equivalence test for independent samples was used to test the equivalence of miR-16 expression among different groups. Results: No significant differential expression of miR-16 was observed between melanoma patients and healthy volunteers (Wilcoxon test, p = 0.37). However, miR-16 did show a significant difference in expression as it related to stage of melanoma (p = 0.015). Additionally, the equivalence test was unable to confirm equivalent expression of miR-16 in any melanoma versus control group pair. Conclusion: Our data indicate that miR-16 cannot be used as a universal normalizer in sera studies of melanoma patients.

关键词： MicroRNA Melanoma Normalization Reference Gene

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浅谈我院科研管理工作存在的问题及对策探讨

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中国卫生标准管理 2021年第3期12卷 44-47页

作者：徐梅红邵永钊蔡宝缄厦门市海沧医院科教科福建厦门361026

医疗卫生事业属于重要公共事业,科研管理工作比较复杂,会直接影响医院的未来发展,还会影响经济效益和社会效益。在市场经济环境下,传统科研管理方式没有考虑到时代特征,且没有结合内外部环境,因此无法完全满足医疗科技的发展需求。为提... 详细信息

医疗卫生事业属于重要公共事业,科研管理工作比较复杂,会直接影响医院的未来发展,还会影响经济效益和社会效益。在市场经济环境下,传统科研管理方式没有考虑到时代特征,且没有结合内外部环境,因此无法完全满足医疗科技的发展需求。为提升医院科研管理效果,必须深入分析管理工作存在的问题,通过创新管理模式、建立激励机制、创造良好的科研环境、注重限额申报课题管理,加大领导层面重视度,全面促进科研管理事业的发展,全面提升医院诊疗水平。此次研究主要是按照医院科研管理实践,提出科研管理工作的创新思路,全面加强医院的市场竞争实力,希望能够对相关人员起到参考性价值。

关键词：科研管理影响因素管理模式课题管理科研经费绩效机制

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基于专利数据挖掘的空气净化技术分析与研究

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上海环境科学 2016年第6期35卷 253-259,262页

作者：高杰张强龙华刘永召邵玉斌昆明理工大学信息工程与自动化学院

从专利分析的角度，采用数据挖掘的方法从技术发展现状、技术区域分布、技术竞争主体、技术重热点领域4个方面对国内外空气净化技术的专利数据进行了挖掘分析，探究了国内外空气净化技术的整体发展情况。分析结果表明，国内外空气净化... 详细信息

从专利分析的角度，采用数据挖掘的方法从技术发展现状、技术区域分布、技术竞争主体、技术重热点领域4个方面对国内外空气净化技术的专利数据进行了挖掘分析，探究了国内外空气净化技术的整体发展情况。分析结果表明，国内外空气净化技术整体发展势头良好、技术发展速度快、技术创新空间大、技术领域内各项专利的整体申请数量普遍增多;国内外空气净化技术专利在全球范围内整体上呈现出区域分布不均、局部地区集中的特点；技术竞争主体以企业类型为主，整体专利在竞争主体内的分布相对分散，“产-学-研”模式存在一定程度上的脱节，企业和研究机构的合作强度及合作密度有待进一步提高：基于光催化、离子化、热光电联合催化等催化方式的空气净化方法、空气过滤材料的制备方法及制作工艺以及空气净化系统的智能控制（调节）方法等技术增长率高、技术关联性强，属于空气净化技术领域的重热点技术，企业及相关研究机构应重点关注。

关键词：空气净化技术数据挖掘专利分析关联分析聚类分析

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Research on Time Synchronization Technology of Heterogeneous Network in Distribution Network Based on 5G

Research on Time Synchronization Technology of Heterogeneous...

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第三十九届中国控制会议

作者： Xiong Wen shao Shuai Lao yongzhao Cui Shijie Xu Quan Guangzhou Power Supply Bureau Co. Ltd. State Key Laboratory of Robotics Shenyang Institute of AutomationChinese Academy of Sciences Institutes for Robotics and Intelligent Manufacturing Chinese Academy of Sciences Electric Power Research Institute CSG.

At present, high-precision time synchronization technology plays an important role in many industries. In smart grid, wide area measurement system（WAMS）, event sequence recording（SOE）, and fault recording all need unified reference time for synchronization, which improves the application level of power grid accident analysis and stability control, and improves the power supply network efficiency. It can improve grid reliability and efficiency. This paper designs the time synchronization technology of heterogeneous network in distribution network with the help of 5G URLLC network technology. It can switch clock types according to different synchronization regions, and can coordinate time synchronization between heterogeneous networks, without additional protocol overhead and equipment development cost, and has good network compatibility.

关键词： Distribution network communication time synchronization Heterogeneous network 5G

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废油基钻井液处理及油回收技术研究

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油气田环境保护 2007年第1期17卷 8-12页

作者：许毓史永照邵奎政吴百春刘光全谢水祥中国石油天然气集团公司环境工程技术中心华北油田公司第二采油厂大庆油田有限责任公司勘探分公司

目前现场处理废油基钻井液一般采用集中填埋或回注地层方法,这不仅难以解决其污染问题,同时也浪费了其中所含有的大量柴油资源。通过大量的实验室和现场试验研究,使用“化学热洗-析油-离心”处理工艺,油回收率达到84%以上;研制开发出的... 详细信息

目前现场处理废油基钻井液一般采用集中填埋或回注地层方法,这不仅难以解决其污染问题,同时也浪费了其中所含有的大量柴油资源。通过大量的实验室和现场试验研究,使用“化学热洗-析油-离心”处理工艺,油回收率达到84%以上;研制开发出的清油剂-凝聚剂-絮凝剂化学热洗配方体系,适用于多种废油基钻井液的回收油处理,具有较好的工业推广应用前景。

关键词：废物油基钻井液处理化学热洗离心回收技术

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CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen shao-Long Chen shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

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