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In situ formed Mg(BH_(4))_(2) for improving hydrolysis properties of MgH_(2)

Journal of Magnesium and Alloys 2024年第3期12卷 1204-1214页

作者： yongyang Zhu Mili liu liming Zeng Yin Wang Daifeng Wu Rui Li Qing Zhou Renheng Tang Fangming Xiao Institute of Resources Utilization and Rare Earth Development Guangdong Provincial Key Laboratory of Rare Earth Development and ApplicationGuangdong Academy of SciencesGuangzhou 510650China School of Materials Science and Engineering Guangdong Provincial Key Laboratory of Advanced Energy Storage MaterialsSouth China University of TechnologyGuangzhou 510641China

The hydrolysis of MgH_(2) delivers high hydrogen capacity(15.2 wt%),which is very attractive for real-time hydrogen supply.However,the formation of a surface passivation Mg(OH)_(2) layer and the large excess of H_(2)O required to ensure complete hydrolysis are two key challenges for the MgH_(2) hydrolysis systems.Now,a low-cost method is reported to synthesize MgH_(2)@Mg(BH_(4))_(2) composite via ball-milling MgH_(2) with cheap and widely available B_(2)O_(3)(or B(OH)_(3)).By adding small amounts of B_(2)O_(3),the in-situ formed Mg(BH_(4))_(2) could significantly promote the hydrolysis of MgH_(2).In particular,the MgH_(2)–10 wt%B_(2)O_(3) composite releases 1330.7 mL·g^(−1) H_(2)(close to 80%theoretical hydrogen generation H_(2))in H_(2)O and 1520.4 mL·g^(−1) H_(2)(about 95%)in 0.5 M MgCl_(2) in 60 min at 26℃ with hydrolysis rate of 736.9 mL·g^(−1)·min^(−1) and 960.9 mL·g^(−1)·min^(−1) H_(2) during the first minute of the hydrolysis,respectively.In addition,the MgCl_(2) solution allows repeated use by filtering and exhibits high cycle stability(20 cycles),therefore leading to much reduced capacity loss caused by the excess H_(2)O.We show that by introducing B_(2)O_(3) and recycling the 0.5 M MgCl_(2) solution,the system hydrogen capacity can approach 5.9 wt%,providing a promising hydrogen generation scheme to supply hydrogen to the fuel cells.

关键词： Hydrolysis MgH_(2) Mg(BH_(4))_(2) Hydrogen generation B_(2)O_(3) MgCl_(2)

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Silencing of the long non-coding RNA LINC00265 triggers autophagy and apoptosis in lung cancer by reducing protein stability of SIN3A oncogene

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Oncology Research 2024年第7期32卷 1185-1195页

作者： XIAOBI HUANG CHUNYUAN CHEN yongyang CHEN HONGLIAN ZHOU YONGHUA CHEN ZHONG HUANG YUliu XIE BAIYANG liu YUDONG GUO ZHIXIONG YANG GUANGHUA CHEN WENMEI SU Department of Pulmonary Oncology Affiliated Hospital of Guangdong Medical UniversityZhanjiang524001China Department of Thoracic Surgery Affiliated Hospital of Guangdong Medical UniversityZhanjiang524001China Department of Orthopedics Affiliated Hospital of Guangdong Medical UniversityZhanjiang524001China Guangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-Communicable Diseases Affiliated Hospital of Guangdong Medical UniversityZhanjiang524001China

Background:Long non-coding RNAs are important regulators in cancer biology and function either as tumor suppressors or as oncogenes.Their dysregulation has been closely associated with tumorigenesis.LINC00265 is upregulated in lung adenocarcinoma and is a prognostic biomarker of this cancer.However,the mechanism underlying its function in cancer progression remains poorly understood.Methods:Here,the regulatory role of LINC00265 in lung adenocarcinoma was examined using lung cancer cell lines,clinical samples,and xenografts.Results:We found that high levels of LINC00265 expression were associated with shorter overall survival rate of patients,whereas knockdown of LINC00265 inhibited proliferation of cancer cell lines and tumor growth in xenografts.Western blot andﬂow cytometry analyses indicated that silencing of LINC00265 induced autophagy and apoptosis.Moreover,we showed that LINC00265 interacted with and stabilized the transcriptional co-repressor Switch-independent 3a(SIN3A),which is a scaffold protein functioning either as a tumor repressor or as an oncogene in a context-dependent manner.Silencing of SIN3A also reduced proliferation of lung cancer cells,which was correlated with the induction of autophagy.These observations raise the possibility that LINC00265 functions to promote the oncogenic activity of SIN3A in lung adenocarcinoma.Conclusions:Ourﬁndings thus identify SIN3A as a LINC00265-associated protein and should help to understand the mechanism underlying LINC00265-mediated oncogenesis.

关键词： LINC00265 Autophagy Lung adenocarcinoma(LUAD) Cancer progression Switch-independent 3a(SIN3A)

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Prediction of decline in shale gas well production using stable carbon isotope technique

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Frontiers of Earth Science 2021年第4期15卷 849-859页

作者： Shengxian ZHAO Shujuan KANG Majia ZHENG Shuangfang LU Yunfeng YANG Huanxu ZHANG yongyang liu Ziqiang XIA Chenglin ZHANG Haoran HU Di ZHU Key Laboratory of Deep Oil and Gas China University of Petroleum(East China)Qingdao 266580China School of Geosciences China University of Petroleum(East China)Qingdao 266580China Key Laboratory of Earth and Planetary Physics Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China Shale Gas Institute of PetroChina Southwest Oil&Gasfield Company Chengdu 610000China Suzhou Grand Energy Technology Ltd. Suzhou 215129China

Prediction of shale gas production is a challenging task because of the complex fracture-pore networks and gas flow mechanisms in shale reservoirs.Empirical methods,which are used in the industry to forecast the future production of shale gas,have not been assessed sufficiently to warrant high confidence in their results.Methane carbon isotopic signals have been used for producing gas wells,and are controlled by physical properties and physics-controlling production;they serve as a unique indicator of the gas production status.Here,a workable process,which is combined with a gas isotope interpretation tool(also known as a numerical simulator),has been implemented in Longrnaxi shale gas wells to predict the production decline curves.The numerical simulator,which takes into account a convection-diffu-sion-adsorption model for the matrix and a convection model for fractures in^(13)CH_(4) and ^(12)CH_(4) isotopologues,was used to stabilize the carbon isotope variation in the produced gas to elucidate gas recovery.Combined with the production rates of the four developing wells,the total reserves ranged from 1.72×10^(8) to 2.02×10^(8) m^(3),which were used to constrain the trend of two-segment produc-tion decline curves that exhibited a transition from a hyperbolic equation to an exponential one within 0.82-0.89 year.Two-segment production decline curves were used to forecast future production and estimate ultimate recovery.

关键词： shale gas production decline Longmaxi formation carbon isotope

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基于深度学习的页岩黄铁矿扫描电镜图像分割及环境指示意义:以四川盆地泸州Ⅰ区为例

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地球科学进展 2024年第5期39卷 476-488页

作者：邓乃尔徐浩周文唐小川陈雨露刘永旸刘绍军张益蒋柯刘瑞崟宋威国成都理工大学能源学院(页岩气现代产业学院) 四川成都610059 成都理工大学油气藏地质及开发工程全国重点实验室四川成都610059 成都理工大学计算机与网络安全学院(示范性软件学院) 四川成都610059 中国石油西南油气田公司页岩气研究院四川成都610051 四川大学电子信息学院四川成都610065 贵州省地质调查院贵州贵阳550081

黄铁矿作为页岩体系中最具代表性的重矿物之一,对其进行微观特征识别对于页岩沉积环境研究具有重要意义。以四川盆地泸州I区五峰组一龙一,亚段为例,通过岩心矿物实验、扫描电镜观测、网络模型优化和特征参数统计,构建了适用于黄铁矿扫... 详细信息

黄铁矿作为页岩体系中最具代表性的重矿物之一,对其进行微观特征识别对于页岩沉积环境研究具有重要意义。以四川盆地泸州I区五峰组一龙一,亚段为例,通过岩心矿物实验、扫描电镜观测、网络模型优化和特征参数统计,构建了适用于黄铁矿扫描电镜图像分割的网络模型,实现了基于草莓状黄铁矿参数对研究区沉积环境的判断。结果表明:①优化后的UNet-Im模型对草莓状黄铁矿扫描电镜图像的分割精度可达0.863,证明了改进措施的优越性;②对比黄铁矿含量,龙一^(1-3)_(1)小层黄铁矿含量最高,为2.95%,随后降低至龙一^(4)_(1)小层的2.03%以及五峰组的0.83%;③基于草莓状黄铁矿特征参数,推断出黄铁矿沉积环境为深水硫化环境、深水强还原环境、深水强一弱还原环境以及深水还原一次氧化环境。实现了黄铁矿扫描电镜图像的精准化分割,对于提升行业勘探开发智能化具有借鉴意义。

关键词：黄铁矿深度学习沉积环境泸州Ⅰ区

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顾及多模态数据特征关联的城市功能区识别方法——以武汉市为例

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时空信息学报 2024年第1期31卷 74-84页

作者：戴娇胡胜刘宇轩徐永洋吴亮中国地质大学(武汉)地理与信息工程学院武汉430078 华南师范大学北斗研究院佛山528225 中国地质大学(武汉)计算机学院武汉430078 智能地学信息处理湖北省重点实验室(中国地质大学(武汉)) 武汉430078

城市功能区在城市化建设当中扮演着重要的角色,城市功能区建模与分析对于规划城市土地布局和优化土地利用模式有着重要意义。目前在城市功能区建模与分析的研究中,仍存在多模态数据利用率低、关联特征损失大的问题,这导致难以精确捕捉... 详细信息

城市功能区在城市化建设当中扮演着重要的角色,城市功能区建模与分析对于规划城市土地布局和优化土地利用模式有着重要意义。目前在城市功能区建模与分析的研究中,仍存在多模态数据利用率低、关联特征损失大的问题,这导致难以精确捕捉城市空间结构信息。因此,本研究以武汉市中心区域为例,基于街景影像数据和兴趣点数据构建城市功能区识别方法。首先,将研究区域划分为500 m×500 m的格网单元,运用自然语言模型、深度学习、空间插值等方法来提取多维度的城市功能特征;其次,利用核典型相关分析方法提取多模态数据的关联特征,分析不同共享空间维度和相关性的关系;最后,基于建成环境特征、社会经济语义特征、拼接特征及关联特征的多维度特征构建随机森林功能区识别模型,并分别与两种常用数据模态进行对比评价。结果表明,本方法相较于没有顾及关联特征的模型准确度提高了3.4%。研究成果可为政府决策规划、城市发展评估提供帮助,推动城市化建设。

关键词：城市功能区多模态数据融合特征关联核典型相关分析街景兴趣点

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Sustained co-delivery of 5-fluorouracil and cis-platinum via biodegradable thermo-sensitive hydrogel for intraoperative synergistic combination chemotherapy of gastric cancer

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Bioactive Materials 2023年第5期23卷 1-15页

作者： Wen Chen Kun Shi Jie liu Peipei Yang Ruxia Han Meng Pan Liping Yuan Chao Fang yongyang Yu Zhiyong Qian State Key Laboratory of Biotherapy and Cancer Center West China HospitalSichuan University and Collaborative Innovation CenterChengdu610041PR China Department of Gastrointestinal Surgery West China HospitalSichuan UniversityChengdu610041PR China

Gastric cancer is the fifth most common cancer and the third leading cause of cancer death worldwide,posing a severe threat to human health.Surgical resection remains the most preferred option for gastric cancer treatment.However,for advanced gastric cancer,the curative effect of surgical resection is usually limited by the local recurrence,peritoneal carcinomatosis,or distal metastasis.Intraoperative chemotherapy is an attractive in situ adjuvant treatment strategy to reduce the recurrence and metastasis after surgical resection.Here,we designed a 5-fluorouracil(5-FU)and cis-platinum(DDP)co-delivery system based on a biodegradable temperature-sensitive hydrogel(PDLLA-PEG-PDLLA,PLEL)for intraoperative adjuvant combination chemotherapy of gastric cancer.This 5-FU+DDP/PLEL hydrogel system characterized by a special sol-gel phase transition in response to physiological temperature and presented sustained drug release in vitro and in vivo.A strong synergistic cell proliferation inhibition and apoptosis promotion of 5-FU+DDP/PLEL were observed against gastric cancer MKN45-luc cells.After intraperitoneal injection,the dual-drug loaded hydrogel formulation showed superior anti-tumor effects than the single-drug carrying hydrogels and combination of free 5-FU and DDP on the gastric cancer peritoneal carcinomatosis model.The use of hydrogel for dual-drug delivery had benefited to fewer side effects as well.What’s more,we established a mouse model for postsurgical residual tumors and peritoneal carcinomatosis of gastric cancer,in which the intraoperative administration of 5-FU+DDP/PLEL also remarkably inhibited the local recurrence of the orthotopic tumors and the growth of the abdominal metastatic tumors,resulting in an extended lifetime.Hence,this developed dual-drug loaded hydrogel system has great potential in the intraoperative chemotherapy of gastric cancer,that suggests a clinically-relevant and valuable option for postsurgical management of gastric cancer.

关键词： Thermo-sensitive hydrogel Localized drug delivery Sustained release Intraoperative chemotherapy Gastric cancer

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Cell adhesive spectra along surface wettability gradient from superhydrophilicity to superhydrophobicity

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Science China Chemistry 2017年第5期60卷 614-620页

作者： Jingxin Meng Gao Yang Lu liu yongyang Song Lei Jiang Shutao Wang CAS Key Laboratory of Bio-inspired Materials and Interfacial Science CAS Center for Excellence in Nanoscience Technical Institute of Physics and Chemistry Chinese Academy of Sciences Beijing 100190 China University of Chinese Academy of Sciences Beijing 100049 China

Surface wettability is important to design biointerfaces and functional biomaterials in various biological applications. However,to date, it remains some confusions about how cells would response to the surfaces with different wettabilities. Herein,we systematically explore the adhesive spectra of cells to the surface with wettability gradient from superhydrophilicity to superhydrophobicity, clarifying the effect of wettability on cell adhesion. We envision that this study may provide valuable information for the design of biomedical implants with controllable cell adhesion, such as neural interface devices and flexible implant.

关键词： cell adhesive spectra surface wettability gradient nanotopographic interaction trapped air

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Leakage of nuclear material powder from pressure container through a small orifice

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Particuology 2014年第3期12卷 117-123页

作者： Longbo liu Yanmin Wu yongyang Su Hanbing Tang Zhihong Zhang Ping Huang Lili Zhang Lixing Zhang Northwest Institute of Nuclear Technology

Because of the radioactivity and toxic nature of nuclear materials, their containment within oxide matrices, encased in sealed containers, has been proposed as a suitable means for storage and transportation. However, container failures because of cracks or small orifices present a major leakage risk for nuclear materials, consequently posing a significant hazard to the environment and human beings. In this study, terbium oxide powder was used as a nuclear material representative to examine the leakage of nuclear material powder through orifices located at the base of a pressure container. The dependence of the orifice diameter, the powder layer thickness, and the internal pressure of the container on the leakage mechanism and amount was examined. A simplified model correlating the dependence of the above-mentioned parameters to determine the utmost leakage amount was also developed based on the present results. The leakage of the nuclear material powder was assessed by measuring its concentration using an optical particle counter. The diameter of the orifice determined the powder leakage mechanism, which in turn influenced the amount of leakage produced. Comparison studies showed that unlike the changes in the differential pressure, the volume of the container has little effect on the leakage amount. Under sufficiently high internal pressures, the oxide powder can be released as a fine aerosol. The work is not only crucial from the nuclear safety aspect, but is also beneficial for the safe application of powder and nanoparticles.

关键词： Nuclear materials Powder Leakage Risk assessment

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Cyclophosphamide loaded thermo-responsive hydrogel system synergize with a hydrogel cancer vaccine to amplify cancer immunotherapy in a prime-boost manner

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Bioactive Materials 2021年第10期6卷 3036-3048页

作者： Fan Yang Kun Shi Ying Hao Yanpeng Jia Qingya liu Yu Chen Meng Pan Liping Yuan yongyang Yu Zhiyong Qian State Key Laboratory of Biotherapy and Cancer Center Collaborative Innovation Center for BiotherapyWest China HospitalSichuan UniversityChengdu610041PR China Department of Gastrointestinal Surgery West China HospitalSichuan UniversityChengdu610041PR China

Although neoantigen-based cancer vaccines show great potential in cancer immunotherapy due to their ability to induce effective and long-lasting anti-tumor immunity,their development is hindered by the limitations of neoantigens identification,low immunogenicity,and weak immune response.Cyclophosphamide(CTX)not only directly kills tumors but also causes immunogenic cell death,providing a promising source of antigens for cancer vaccines.Herein,a combined immunotherapy strategy based on temperature-sensitive PLEL hydrogel is designed.First,CTX-loaded hydrogel is injected intratumorally into CT26 bearing mice to prime anti-tumor immunity,and then 3 days later,PLEL hydrogels loaded with CpG and tumor lysates are subcutaneously injected into both groins to further promote anti-tumor immune responses.The results confirm that this combined strategy reduces the toxicity of CTX,and produces the cytotoxic T lymphocyte response to effectively inhibit tumor growth,prolong survival,and significantly improve the tumor cure rate.Moreover,a long-lasting immune memory response is observed in the mice.About 90%of the cured mice survive for at least 60 days after being re-inoculated with tumors,and the distant tumor growth is also well inhibited.Hence,this PLEL-based combination therapy may provide a promising reference for the clinical promotion of chemotherapy combined with cancer vaccines.

关键词： Immunotherapy Thermo-responsive hydrogels Immunogenic cell death Cancer vaccine Cyclophosphamide

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MMC-MTDC Transmission System with Partially Hybrid Branches

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CES Transactions on Electrical Machines and Systems 2021年第2期5卷 124-132页

作者： yongyang Chen Shangzhi Pan Meng Huang Zili Zhu Yushuang liu Xiaoming Zha School of Electrical Engineering and Automation Wuhan UniversityWuhanChina College of Electrical Engineering Zhejiang UniversityHangzhouChina

This paper proposes a hybrid submodule modular multilevel converter(MMC)topology which is suitable for multi terminal direct current(MTDC)transmission systems.Each arm of the proposed MMC topology consists of a half-bridge submodule(HBSM)branch and two parallel full-bridge submodule(FBSM)branches.Comparing with the conventional MTDC transmission system,the proposed topology can selectively block the DC fault current and isolate the corresponding fault line without expensive DC circuit breakers(DCCBs).Thus,the influence range of the DC fault can be reduced and the reliability of the power supply can be improved as well.The corresponding modulation and voltage balancing strategies are developed for the proposed hybrid MMC topology.The feasibility of the proposed topology and control strategy is verified in the MATLAB/Simulink simulation.

关键词： Hybrid modular multilevel converter multi terminal networks high voltage dc(HVDC)transmission

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