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Food Science and Human Wellness 2024年第3期13卷 1672-1684页

作者： Ling zhang Wenyu Zou yongyan Hu Honghua Wu Ying Gao Junqing zhang Jia Zheng Department of Endocrinology Peking University First HospitalBeijing 100034China Laboratory Animal Facility Peking University First HospitalBeijing 100034China

Exercise training is critical for the early prevention and treatment of obesity and diabetes mellitus.However,the mechanism with gut microbiota and fecal metabolites underlying the effects of voluntary wheel running on high-fat diet induced abnormal glucose metabolism has not been fully elaborated.C57BL/6 male mice were randomly assigned to 4 groups according to diets(fed with normal chow diet or high-fat diet)and running paradigm(housed in static cage or with voluntary running wheel).An integrative 16S rDNA sequencing and metabolites profiling was synchronously performed to characterize the effects of voluntary wheel running on gut microbiota and metabolites.It showed that voluntary wheel running prevented the detrimental effects of high-fat feeding on glucose metabolism 16S rDNA sequencing showed remarkable changes in Rikenella and Marvinbryantia genera.Metabolic profiling indicated multiple altered metabolites,which were enriched in secondary bile acid biosynthesis signaling.In conclusion,our study indicated that voluntary wheel running significantly improved glucose metabolism and counteracted the deleterious effects of high-fat feeding on body weight and glucose intolerance.We further found that voluntary wheel running could integratively program gut microbiota composition and fecal metabolites changes,and may regulate muricholic acid metabolism and secondary bile acid biosynthesis in high-fat fed mice.

关键词： High-fat diet Voluntary wheel running Gut microbiota Metabolomics Glucose metabolism

Oxygenic iron clusters in ZSM-5 zeolite promote quantum sieving of gaseous hydrogen isotopes

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Science China Chemistry 2024年第4期67卷 1242-1249页

作者： Jingjing zhang yongyan Deng Dongxu Gai Yang Shi Xingwen Feng Peilong Li Yongtao An Xiaoqin Zou Institute of Materials China Academy of Engineering PhysicsMianyang 621907China Faculty of Chemistry Northeast Normal UniversityChangchun 130024China

Isotopic separation is of paramount importance for producing high-purity heavy hydrogen,yet the process remains hugely challenging.Here,we report on an Fe/ZSM-5 zeolite that was able to efficiently separate deuterium from protium via chemical quantum sieving.Structural data showed that four types of Fe species were present in Fe/ZSM-5 and oligomeric Fe-O clusters in the zeolite pores were correlated directly with gas selectivity.Gas adsorption revealed that Fe-O species served as the main adsorption sites and interacted with D_(2) more strongly than with H_(2).D_(2)/H_(2)separation was exemplified using thermal desorption spectroscopy.D_(2)/H_(2) selectivity increased with Fe loading in Fe/ZSM-5 and a selectivity of 32.1 was obtained with an optimal loading of 7 wt%.The shift of desorption temperature supports the chemical affinity-based quantum sieving of D_(2)over H_(2).This study demonstrates an effective strategy for enhancing D_(2)/H_(2) separation and the high selectivity means that Fe/ZSM-5 has strong potential in hydrogen isotope separation.

关键词： iron zeolite hydrogen isotope gas separation quantum sieving thermal desorption

Enantioselective synthesis of tetrasubstituted allenes via addition/arylation tandem reaction of 2-activated 1,3-enynes

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Science China Chemistry 2023年第2期66卷 526-533页

作者： yongyan zhang Jin Wu Lichao Ning Qianping Chen Xiaoming Feng Xiaohua Liu Key Laboratory of Green Chemistry&Technology Ministry of EducationCollege of ChemistrySichuan UniversityChengdu610064China

We report the development of a new class of multifunctional chiral guanidine/Pd(0)catalyst system for 1,4-addition/arylation tandem reaction.A variety of tetra-substituted allenes were readily accessible from three-component“one-pot”transformations of acyclic or cyclic 2-activated 1,3-enynes,malonates and halobenzenes under mild reaction conditions.High levels of yield and enantioselectivity were achieved in the construction of stereogenic center and axis using readily available acyclic guanidineamides.The mechanistic studies suggest that the guanidine/Pd(0)collaboration has obvious synergism to both base-dominated conjugate addition,and Pd(0)-dominated Heck-type reaction.

关键词： chiral guanidine tandem reaction three-component“one-pot” synergistic catalysis tetra-substituted allenes

文明互鉴新时期中医药学传承精华守正创新之道

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中国中医基础医学杂志 2024年第1期30卷 4-7页

作者：张志强王永炎中国中医科学院中医临床基础医学研究所北京100700

中医药学作为中华文化的精粹,理应为建设健康中国、实现中华民族伟大复兴的中国梦贡献力量。本文基于文明互鉴历史经验的梳理,直面摆脱传统、追逐西化、淡化国学、悬置中医原象思维的传承荒疏,提出将中医药学守正创新置入文明互鉴的时... 详细信息

中医药学作为中华文化的精粹,理应为建设健康中国、实现中华民族伟大复兴的中国梦贡献力量。本文基于文明互鉴历史经验的梳理,直面摆脱传统、追逐西化、淡化国学、悬置中医原象思维的传承荒疏,提出将中医药学守正创新置入文明互鉴的时代环境中,以史为鉴,参悟经典,确立中医原创思维的主体地位,不断发展、完善中医药学科体系,充分展现中医药学原发创生性的勃勃生机。

关键词：文明互鉴原象思维传承创新

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一种高功率微波发射阵列天线设计和试验

强激光与粒子束 2024年第8期36卷 51-56页

作者：毛永艳张帆田川解江远金兆鑫西安电子工程研究所西安710100 西北工业大学电子信息学院西安710072

设计了一种用于高功率微波发射的S波段波导缝隙阵列天线。采用耦合波导和馈电波导同层排布的方式减小了天线的剖面高度,通过耦合缝隙同向偏置,辐射缝隙按照一定规律排布补偿相位,实现了缝隙单元方向图同相叠加,对缝隙参数、功分器形式... 详细信息

设计了一种用于高功率微波发射的S波段波导缝隙阵列天线。采用耦合波导和馈电波导同层排布的方式减小了天线的剖面高度,通过耦合缝隙同向偏置,辐射缝隙按照一定规律排布补偿相位,实现了缝隙单元方向图同相叠加,对缝隙参数、功分器形式与功率容量的关系进行了仿真分析,并在天线内部充入0.1 MPa SF6气体,提高了天线的功率容量。仿真和试验结果表明,在6.7%带宽内,天线电压驻波比小于1.5,增益达到27 dBi,采用窄谱高功率微波源激励天线并进行了高功率微波发射试验,天线的发射波形与微波源的输出波形具有良好一致性,测试的微波源输出功率为2.67 MW。

关键词：高功率微波功率容量波导缝隙阵列天线 SF6气体微波源

口炎清颗粒联合抗病毒口服液治疗儿童疱疹性口腔炎临床研究

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新中医 2024年第2期56卷 105-108页

作者：张楠李永彦史东梅濮阳市第三人民医院儿童口腔科河南濮阳457000 濮阳市第三人民医院牙周黏膜科河南濮阳457000

目的:观察口炎清颗粒联合抗病毒口服液治疗儿童疱疹性口腔炎的临床效果。方法:将80例疱疹性口腔炎患儿随机分成对照组和研究组各40例。对照组在西药对症治疗的基础上加用抗病毒口服液治疗,研究组在对照组基础上加用口炎清颗粒治疗。治疗... 详细信息

目的:观察口炎清颗粒联合抗病毒口服液治疗儿童疱疹性口腔炎的临床效果。方法:将80例疱疹性口腔炎患儿随机分成对照组和研究组各40例。对照组在西药对症治疗的基础上加用抗病毒口服液治疗,研究组在对照组基础上加用口炎清颗粒治疗。治疗1周后,评估2组临床疗效和药物不良反应(ADR)发生率,并比较治疗前后中医证候评分,血清炎症因子[肿瘤坏死因子-α (TNF-α)、白细胞介素-2 (IL-2)、白细胞介素-6 (IL-6)]及免疫指标[CD4^(+)/CD8^(+)、血清免疫球蛋白A (IgA)]水平。结果:治疗后,研究组总有效率为95.00%,对照组为80.00%,2组比较,差异有统计学意义(P0.05)。结论:口炎清颗粒联合抗病毒口服液治疗小儿疱疹性口腔炎效果确切,可明显改善中医证候,有效抑制机体炎症反应,改善患者免疫功能。

关键词：疱疹性口腔炎口炎清颗粒抗病毒口服液炎症因子免疫功能

Soluble CD163 and CD163 Expression on Monocytes Associated with Chronic Hepatitis B Inflammation and HBsAg Loss

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Journal of Clinical and Translational Hepatology 2022年第6期10卷 1059-1067页

作者： Peilin Xie Bilian Yao Dao Huang yongyan Chen Qiming Gong Xinxin zhang Department of Infectious Diseases Research Laboratory of Clinical VirologyRuijin HospitalShanghai Jiao Tong Univer-sity School of MedicineShanghaiChina Department of General Practice Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Geriatrics Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Infectious Diseases Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina

Background and Aims:Monocyte/macrophage-associat-ed CD163 is an indicator of the severity of liver inflam-mation and cirrhosis,but the difference of soluble CD163(sCD163)levels in chronic hepatitis B(CHB)patients and hepatitis B surface antigen(HBsAg)-loss patients is un-clear.Herein,we aimed to compare the sCD163 levels in CHB patients and HBsAg-loss patients with or without an-tiviral treatment.Methods:sCD163 and CD163 expres-sion on monocytes were compared among four groups,healthy subjects,treatment-naïve CHB patients,sponta-neous HBsAg-loss patients,and treatment-related HBsAg-loss patients.The correlation between sCD163 levels and clinical parameters in CHB patients was analyzed.A group of 80 patients with hepatitis B virus(HBV)infection and liver biopsy were recruited.Results:sCD163 levels were higher in the CHB group than in the other three groups.sCD163 levels were higher in treatment-related HBsAg-loss patients than in spontaneous HBsAg-loss patients.sCD163 levels were negatively correlated with hepatitis B e-antigen(HBeAg)and HBsAg levels in HBeAg-positive patients.Liv-er biopsy results further demonstrated that sCD163 levels were elevated in CHB patients with substantial inflamma-tion(A≥2)or fibrosis(F≥2).The sCD163 model was more sensitive in predicting inflammation than other noninvasive models.Its levels were higher in patients with normal ala-nine aminotransferase levels and significant inflammation(A≥2)than in patients with no or mild inflammation.Con-clusions:sCD163 and CD163 expression on monocytes were associated with CHB inflammation and HBsAg loss,and may be used as markers to predict HBV-specific im-mune activation.

关键词： CD163 Hepatitis B virus HBsAg loss Monocytes Immune activa-tion

茶多酚、鱼骨粉复合制剂对福瑞鲤生长性能、消化及抗氧化能力的影响

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饲料工业 2024年第4期45卷 44-50页

作者：杨梓欣邓泳妍张文琦孔晴邹记兴吕利群唐汇娟华南农业大学海洋学院广东广州510640 上海海洋大学国家水生动物病原库上海201306 上海海洋大学水产科学国家级实验教学示范中心上海201306

研究以福瑞鲤(Cyprinus carpio FFRC)幼鱼为研究对象,研究茶多酚、鱼骨粉制成的复合制剂(商品名“血停”)对福瑞鲤生长、体成分、抗氧化性能以及消化器官组织结构的影响。研究选取180尾健康、大小[(1.92±0.01)g]均匀的福瑞鲤,随机分为... 详细信息

研究以福瑞鲤(Cyprinus carpio FFRC)幼鱼为研究对象,研究茶多酚、鱼骨粉制成的复合制剂(商品名“血停”)对福瑞鲤生长、体成分、抗氧化性能以及消化器官组织结构的影响。研究选取180尾健康、大小[(1.92±0.01)g]均匀的福瑞鲤,随机分为对照组和试验组,每组3个重复,对照组投喂商品饲料,试验组在商品饲料的基础上添加0.8%的复合制剂,在循环水系统下养殖8周。结果表明,添加复合制剂对福瑞鲤的生长、形体指标、体成分以及血清生化指标均无影响(P>0.05),但能显著提高福瑞鲤肠道脂肪酶活性以及肝脏和血清的过氧化氢酶(CAT)活性(P0.05);试验组福瑞鲤的肠道肌层厚度、绒毛高度显著低于对照组,绒毛宽度显著高于对照组(P0.05)。上述结果表明,该复合制剂对福瑞鲤的生长性能没有负面影响,可提高福瑞鲤的消化、抗氧化能力,可作为一种潜在的饲料添加剂。

关键词：福瑞鲤茶多酚鱼骨粉复合制剂生长抗氧化

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铝工业赤泥用于脱硫技术现状及展望

中国有色冶金 2024年第2期53卷 34-41页

作者：闫飞飞刘万超练以诚李永艳张立志中铝环保节能集团有限公司北京101300 中铝环保节能集团有限公司北京技术中心北京101300 北京铝能清新环境技术有限公司北京101300

以铝工业赤泥作为原料制备工业脱硫剂,具有来源丰富、价格低廉、理论硫容高等优点,在低成本脱硫的同时,达到了“以废制废”的目的。本文总结了铝工业赤泥在脱硫方面的应用,全面综述了赤泥干法、湿法脱除SO_(2)和H_(2)S的技术现状,从活... 详细信息

以铝工业赤泥作为原料制备工业脱硫剂,具有来源丰富、价格低廉、理论硫容高等优点,在低成本脱硫的同时,达到了“以废制废”的目的。本文总结了铝工业赤泥在脱硫方面的应用,全面综述了赤泥干法、湿法脱除SO_(2)和H_(2)S的技术现状,从活性组分利用效率、能量消耗、工艺复杂程度、后续环境问题等几个维度分析对比了几种研究方向各自的优劣,并展望了未来工业化应用可能遇到的问题和进一步研究方向。指出在湿法浆液脱除烟气中SO_(2)方面,仍需克服管道堵塞、低效率、高能耗、以及由此产生的大量稀盐处理等技术性难题,同时应对其含有的过渡金属的反应机理和活化手段进行研究;在干法脱除H_(2)S方面,需进一步从低成本活化氧化铁的途径、极端工况环境下的适用性、废脱硫剂的资源化、以及与其他工业固废的协同处理等方面展开研究。

关键词：铝工业赤泥消纳赤泥脱硫干法脱硫湿法脱硫 SO_(2) H_(2)S 赤泥综合利用

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《黄帝内经》精理论临床价值

光明中医 2024年第5期39卷 860-863页

作者：张向玉张瑞娟郭铭嘉田永衍甘肃中医药大学基础医学院甘肃兰州730000 河西学院丝绸之路中医药研究中心甘肃张掖340000

人体之精虚衰是脏腑功能减退的关键,精的盛衰不仅决定体质差异还影响情志变化,甚至影响发病。先后天之精的不足与精的失泄异常是精失常的主要表现,伴随而来的是精与气、血、津液、神关系的紊乱。在治疗上,要补精、固精、疏精。探讨《黄... 详细信息

人体之精虚衰是脏腑功能减退的关键,精的盛衰不仅决定体质差异还影响情志变化,甚至影响发病。先后天之精的不足与精的失泄异常是精失常的主要表现,伴随而来的是精与气、血、津液、神关系的紊乱。在治疗上,要补精、固精、疏精。探讨《黄帝内经》中的精理论,以便为相关临床治疗提供参考。

关键词：《黄帝内经》先天之精后天之精中医学