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中药复方多靶点治疗流行性感冒的临床价值提升策略

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成都中医药大学学报 2025年第1期48卷 1-8页

作者：明雨王忠王永炎中国中医科学院中医临床基础医学研究所北京100700

流行性感冒是一种具有高度传染性的急性呼吸道疾病,呈现季节性流行的特征,具有严重的致病性和高病死率。流感病毒的高变异性使疫苗难以有效、及时接种,逐渐出现的药物耐药性问题也给流感治疗带来巨大的挑战。中药复方药物能作用于多个... 详细信息

流行性感冒是一种具有高度传染性的急性呼吸道疾病,呈现季节性流行的特征,具有严重的致病性和高病死率。流感病毒的高变异性使疫苗难以有效、及时接种,逐渐出现的药物耐药性问题也给流感治疗带来巨大的挑战。中药复方药物能作用于多个流感的病理环节,如病毒侵入、病毒增殖、系统免疫反应、过度炎症反应、肺组织细胞凋亡等,展现出优于传统单一靶点药物治疗流感的效果,因此在治疗领域展现出良好的应用前景。多种系统生物学研究方法的应用和相关计算机技术的快速发展也加速推动着对中药复方作用机制的研究。本文回顾总结中药复方治疗流行性感冒的研究进展,通过全面理解流行性感冒的相关病理途径以及不同靶向思路和方法,着重于针对复杂临床情况阐明中药复方多靶点治疗机制研究思路与方法,以期为后续不断提升中药复方多靶点治疗流行性感冒及其变异毒株临床价值的科学内涵提供参考。

关键词：流行性感冒中药复方多靶点临床价值突变毒株

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弹丸不同初始误差下枪弹耦合发射动力学分析

火炮发射与控制学报 2025年第1期46卷 7-14页

作者：常昊杨臻方炜郁卫星王国强王永艳中北大学机电工程学院中北大学电气与控制工程学院中国航天三江集团有限公司

为研究弹丸初始误差对某12.7 mm狙击枪发射动力学特性的影响，基于无后坐内弹道理论，建立枪弹耦合仿真模型，运用显式动力学方法进行数值计算，并完成网格无关性验证，得到了弹丸不同初始同轴度及倾斜角误差下弹丸质心偏移、摆角和速... 详细信息

为研究弹丸初始误差对某12.7 mm狙击枪发射动力学特性的影响，基于无后坐内弹道理论，建立枪弹耦合仿真模型，运用显式动力学方法进行数值计算，并完成网格无关性验证，得到了弹丸不同初始同轴度及倾斜角误差下弹丸质心偏移、摆角和速度的变化规律。研究结果表明：弹丸初始状态同轴度或倾斜角误差值越大，沿X、Y方向的质心偏移量及摆角越大，波动也越明显；弹丸挤进膛线后，膛线会对摆角起到一定纠正作用，但最终将稳定在某一角度附近，且初始误差量越大，稳定后摆角越大；初始同轴度误差为0.02 mm时，弹丸质心沿X、Y轴最大偏移量分别为4.06、3.23μm,摆角最终稳定在0.68 mrad左右；初始倾斜角误差为0.1°时，弹丸质心沿X、Y轴最大偏移量分别为2.98、2.26μm,摆角最终稳定在1.25 mrad左右；初始误差对弹丸运动速度影响较小。

关键词：发射动力学枪弹耦合初始误差无后坐力

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The scientific nature of traditional Chinese medicine in the post-modern era

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Journal of Traditional Chinese Medical Sciences 2019年第3期6卷 195-200页

作者： yongyan wang Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100700China

There is a growing need to understand traditional Chinese medicine(TCM)in modern scientific *** possesses the dual attributes of science and the *** present,medical science and technology are progressing,while humanistic ethics are being *** embodies the interaction between imagery and conceptual thinking,which can be explained from the following three aspects:imagery as an internal driving force for cultural rejuvenation,return to the true self and guarding of the root of life,and cosmology(harmony between man and nature).In the post-modern era,“people-oriented”medical values will lead to integrations between science and humanities,holism and reductionism,imagery-based thinking and conceptual thinking,systematic research and descriptive research,and evidence-based medicine and narrative medicine.

关键词： Sinology Image thinking Traditional Chinese medicine Discipline orientation Transformation and innovation

Quantifying the Mechanical Properties of White Sandstone Based on Computer Fractal Theory

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Computer Systems Science & Engineering 2021年第10期39卷 121-131页

作者： Yong wang yongyan wang Nan Qin Sa Huang Le Chang Shunzheng Hou School of Mechanical and Electrical Engineering Qingdao University of Science and TechnologyQingdao266061China

The work presented in this paper was conducted to quantify the relationship between the pore characteristics and mechanical properties of white *** study include tests carried out under the coupling effects of chemical corrosion,temperature,nuclear magnetic resonance,and mechanical *** fractal theory was employed to describe and quantify the characteristics of the growth of pores in white sandstone under the same coupling effect.A custom developed program code,in the MATLAB software platform,was used for calculating the growths of the pores in white sandstone when subjected to coupling *** correlation between the computer fractal dimension of the growth of the pores in rock and characteristics of mechanical damage was accordingly *** results showed that when the temperature was set at a level lower than 100°C,it caused damage to the rock and strength reduction,primarily due to the rates of chemical reactions,the generation,and evolution of pores in the rock mass under the coupling effects of chemical corrosion and ***,it was observed that the higher the value of the computer fractal dimension,the higher the growth of the pores,and the lower the uniaxial compressive strength of the white sandstone.

关键词： White sandstone pore characteristics mechanical properties MATLAB chemical corrosion temperature fractal dimension nuclear magnetic resonance

Research on the Novel Honeycomb-Like Cabin Based on Computer Simulation

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Computer Systems Science & Engineering 2021年第11期39卷 179-195页

作者： Yong wang yongyan wang Songmei Li Nan Qin Peng Du Tongtong Zhou School of Mechanical and Electrical Engineering Qingdao University of Science and TechnologyQingdao266061China

The antiknock capability and thermal protection performance of rescue capsules mainly depend on the structural design of the *** designing a new type of cabin structure,it can resist the impact of explosion shock waves and thermal *** this paper,a new honeycomb-like cabin is proposed;the model has a novel thermal insulation layer ***,the antiknock capabilities and thermal protection analysis are carried out by using computer ***“Autodyn”analysis module in ANSYS Workbench 17.0 has been used to simulate the explosion of TNT with a certain quality in a single *** pressure map over time and the pressure variation curve at different locations for a single room are *** the analysis module“Transient Structural,”the stress and deformation of the honeycomb-like cabin under the blast load are ***“Transient Thermal”analysis module in the finite element software is used to conduct a transient thermal analysis on the cabin *** temperature map and the temperature rise curve of each layer of the cabin cases are *** analysis results indicate that the honeycomb-like cabin design has a good antiknock capability and thermal protection performance,and it can meet the usage requirements of the rescue capsule under dangerous conditions.

关键词： The rescue capsule computer the honeycomb-like cabin the antiknock ability the thermal protection the thermal insulation layer

Shaoma Zhijing granule for children with tic disorders: A rapid health technology assessment

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Journal of Traditional Chinese Medical Sciences 2023年第2期10卷 133-140页

作者： Xing Liao Xue Wu Zhong wang yongyan wang Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing100700China

Objective:To rapidly assess the effectiveness,safety,economy,and applicability of Shaoma Zhijing granule(SZG)for the treatment of children with tic disorders(TD),and provide currently available best evidence for decision-makers of health ***:We conducted a rapid health technology assessment(RHTA)to explore the value of SZG.A systematic literature search in eight literature databases and on three clinical trial registration platforms was *** literature was screened according to eligibility *** screening process and data extraction were conducted by two reviewers,and the quality of the literature was also *** results were summarized,analyzed,and presented in tables or ***:A total of five randomized controlled trials(RCTs)were included in this study,of which one was published in English(in the Journal of Child Psychology and Psychiatry)and four in Chinese *** overall risk of bias for the five RCTs was evaluated as“some concerns.”SZG monotherapy or in combi-nation with tiapride was better than tiapride alone in improving traditional Chinese medicine(TCM)syndromes and tic symptoms,with a daily cost of¥*** events were mainly related to the digestive,respiratory,and neurological systems,but all were ***:Overall,the current RHTA of published,peer-reviewed literature has located a small body of evidence evaluating the use of SZG for the treatment of TD in *** has effects on improving TCM syndromes and tic symptoms;the daily cost is¥67.50e107.22;and all adverse events are ***-quality studies with long-term follow-up should be conducted,so as to provide local evidence and consistently guide and improve scientific decision-making.

关键词： Shaoma Zhijing granule Tic disorders Children Rapid health technology assessment Quality assessment

An MCIA-like complex is required for mitochondrial complex Ⅰ assembly and seed development in maize

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Molecular Plant 2022年第9期15卷 1470-1487页

作者： Gang wang yongyan wang Jiacheng Ni Rongrong Li Fengling Zhu Ruyin wang Qiuzhen Tian Qingwen Shen Qinghua Yang Jihua Tang Monika W.Murcha Guifeng wang National Key Laboratory of Wheat and Maize Crops Science CIMMYT--China Joint Center of Wheat and MaizeCenter for Crop Genome EngineeringCollege of AgronomyHenan Agricultural UniversityZhengzhou 450046China Shanghai Key Laboratory of Bio-Energy Crops School of Life SciencesShanghai UniversityShanghai 200444China School of Agriculture and Biology Shanghai Jiao Tong UniversityShanghai 200240China School of Molecular Sciences&The ARC Centre of Excellence in Plant Energy Biology The University of Western Australia35 Stirling HighwayCrawleyPerthWA 6009Australia The Shennong Laboratory ZhengzhouHenan 450002China

During adaptive radiation,mitochondria have co-evolved with their hosts,leading to gain or loss of subunits and assembly factors of respiratory *** mitochondrial complex Ⅰ harbors40 nuclearand 9 mitochondrial-encoded subunits,and is formed by stepwise assembly during which different intermediates are integrated via various assembly *** mammals,the mitochondrial complex Ⅰ intermediate assembly(MCIA)complex is required for building the membrane arm ***,plants have lost almost all of the MCIA complex components,giving rise to the hypothesis that plants follow an ancestral pathway to assemble the membrane arm ***,we characterize a maize crumpled seed mutant,crk1,and reveal by map-based cloning that CRK1 encodes an ortholog of human complex Ⅰ assembly factor 1,zNDUFAF1,the only evolutionarily conserved MCIA subunit in ***1 is localized in the mitochondria and accumulates in two intermediate complexes that contain complex Ⅰ membrane arm *** of zNDUFAF1 results in severe defects in complex Ⅰ assembly and activity,a cellular bioenergetic shift to aerobic glycolysis,and mitochondrial ***,we found that zNDUFAF1,the putative mitochondrial import inner membrane translocase ZmTIM17-1,and the isovaleryl-coenzyme A dehydrogenase ZmIVD1 interact each other,and could be co-precipitated from the mitochondria and co-migrate in the same assembly *** of either ZmTIM17-1 or ZmIVD1 could lead to the significantly reduced complex Ⅰ stability and activity as well as defective *** results suggest that zNDUFAF1,ZmTIM17-1 and ZmIVD1 probably form an MCIA-like complex that is essential for the biogenesis of mitochondrial complex Ⅰ and seed development in *** findings also imply that plants and mammals recruit MCIA subunits independently for mitochondrial complex Ⅰ assembly,highlighting the importance of parallel evolution in mitochondria adaptation to their hosts.

关键词： assembly factor CIA30 evolution maize MCIA complex mitochondria seed development

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基于深度神经网络的航炮炮振载荷识别

航空科学技术 2025年第1期36卷 1-10页

作者：黄虎刘翛然王用岩杨建杨智春航空工业成都飞机设计研究所飞行器数字敏捷设计全国重点实验室西北工业大学强度与结构完整性全国重点实验室

飞机在进行结构设计时，需要考虑飞机结构抗炮振设计问题，因此，确定航炮发射时的动载荷大小及时间历程尤为重要。相对于传统的动载荷识别方法，以深度学习技术为支撑的深度神经网络具有强大的拟合能力，对于动载荷的识别具有广阔的应... 详细信息

飞机在进行结构设计时，需要考虑飞机结构抗炮振设计问题，因此，确定航炮发射时的动载荷大小及时间历程尤为重要。相对于传统的动载荷识别方法，以深度学习技术为支撑的深度神经网络具有强大的拟合能力，对于动载荷的识别具有广阔的应用前景。本文从深度神经网络应用的角度出发，建立航炮炮振载荷识别方法，以与某型炮舱结构动力学相似的简化炮舱模型为研究对象，对复杂波形冲击载荷的动载荷环境进行模拟并对简化炮舱试验模型进行激励；从信号处理的角度将有阻尼动力学系统与有限长脉冲响应系统等效，提取对应的特征信号，应用长短期记忆（LSTM）神经网络对简化炮舱模型试验的冲击动载荷进行识别，并从鲁棒性角度对方法的应用性能进行测试。最终，利用本文所建立的方法对实际的某型炮舱在真实炮振载荷环境下受到的冲击波脉动压力载荷进行了识别，验证了该方法在实际应用场景中的适用性，为炮振动载荷这类复杂冲击载荷的识别提供了新的思路和技术途径。

关键词：深度学习载荷识别振动分析特征提取鲁棒性

A partial pathway- and network-based transformation reveals the synergistic mechanism of JA and UA against cerebral ischemia-reperfusion injury

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Protein & Cell 2014年第11期5卷 873-877页

作者： Shanshan Guo Li Guo Yanan Yu Bing Li YingyingZhang Haixia Li Ping Wu Jie wang Ye Yuan Zhong wang yongyan wang Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences Beijing 100700 China Guang'anmen Hospital China Academy of Chinese Medical Sciences Beijing 100700 China Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical Sciences Beijing 100700 China Institute of Information on Traditional Chinese Medicine China Academy of Chinese Medical Sciences Beijing 100700 China

Dear Editor, Ischemic stroke falls under the category of complex diseases, which do not obey the single-gene dominant or single-gene recessive Mendelian pattern of inheritance but rather arises from the combination of numerous genetic variants and environmental factors （Cho et al., 2012）. Given this degree of complexity, a single compound could never be expected to manage or reverse the effects of a stroke. Recently there has been accumulating evidence suggesting that combination therapies could exert a significant effect on areas affected by a cerebral ischemic stroke. Combination therapies that simultaneously impact multiple targets have promise in the control of complex diseases by way of synergy （Li et al., 2011）.

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