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Verteporfin fluorescence in antineoplastic-treated pancreatic cancer cells found concentrated in mitochondria

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World Journal of gastrointestinal Oncology 2024年第3期16卷 968-978页

作者： Ying-Qiao zha.g Qing-Hao Liu Lu Liu peng-Yu guo Run-Ze Wang Zhi-Chang ba Department of Radiology Harbin Medical University Cancer HospitalHarbin 150010Heilongjiang ProvinceChina Department of Digestive Internal Medicine Harbin Medical University Cancer HospitalHarbin 150010Heilongjiang ProvinceChina

baCKgROUND Traditional treatments for pancreatic cancer(PC)are *** therapy(PDT)is non-invasive,and proven safe to kill cancer cells,including ***,the mitochondrial concentration of the photosensitizer,such as verteporfin,is *** To investigate the distribution of fluorescence of verteporfin in PC cells treated with antitumor drugs,*** Workable survival rates of PC cells(AsPC-1,BxPC-3)were determined with chemotherapy[doxorubicin(DOX)and gemcitabine(gEM)]and non-chemotherapy[sirolimus(SRL)and cetuximab(CTX)]drugs in vitro,with or without verteporfin,as measured via MTT,flow cytometry,and laser confocal *** cell proliferation was associated with gEM that was more enduring compared with *** laser microscopy allowed observation of gEM-and verteporfin-treated PC cells co-stained with 4’,6-diamidino-2-phenylindole and MitoTracker green to differentiate living and dead cells and subcellular localization of verteporfin,*** Cell survival significantly dropped upon exposure to either chemotherapy drug,but not to SRL or *** cell lines responded similarly to *** intensity of fluorescence was associated with the concentration of *** experiments using gEM showed that survival rates of the PC cells treated with 10μmol/L verteporfin(but not less)were significantly lower relative to nil *** and dead stained cells treated with gEM were *** gEM treatment,verteporfin was observed primarily in the *** Verteporfin was observed in living *** gEM-treated human PC cells,verteporfin was particularly prevalent in the *** study supports further study of PDT for the treatment of PC after neoadjuvant chemotherapy.

关键词： Photodynamic therapy Pancreatic cancer Verteporfin Mitochondria Chemotherapy gemcitabine

The Role of Renewable Protocatechol Acid in Epoxy Coating Modification: Significantly Improved Antibacterial and Adhesive Properties

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Chinese Journal of Polymer Science 2024年第1期42卷 63-72,I0008页

作者： Ming-Xuan Chen Jin-Yue Dai Li-Yue zha.g Shuai-peng Wang Jing-Kai Liu Yong-gang Wu Xin-Wu ba Xiao-Qing Liu School of Chemistry and Materials Science Hebei UniversityBaoding 071000China Ningbo Institute of Materials Technology and Engineering Chinese Academy of SciencesNingbo 315201China Key Laboratory of Marine Materials and Related Technologies Chinese Academy of SciencesNingbo 315201China

It is of great significance to design epoxy coatings with superior antibacterial properties and high adhesive properties, as well as excellent processing, superior durability, and high transparency. However, it is still a challenge because of the common complex design and synthesis. Herein, the bio-based monomer protocatechuic acid(PCA) was used as raw material, the catechol structure with high bonding and antibacterial properties was introduced into the flexible alkane segment of ethylene glycol diglycidyl ether(EgDE) through an efficient, and green method, and it was cured with isophorone diamine(IPDA) to prepare corresponding thermosets. The cured resins exhibited excellent allaround qualities, particularly in bonding and antibacterial. When 30% PCA was added to pure epoxy resin, the adhesion between substrate and coating increased from 4.40 MPa to 13.60 MPa and the antibacterial rate of coating against E. coli and S. aureus could approach 100%. All of this is due to the fact that the catechol structure present in PCA has the ability to interact with various substrates and alter the permeability of bacterial cell membranes. The architecture of this method offers a fresh approach to dealing with the issues of challenging raw material selection and complex synthesis techniques.

关键词： Epoxy coatings Thermosets Catechol structure Antibacterial High adhesion

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数字化背景下的广播中波发射系统探讨

A hybrid machine learning optimization algorithm for multivariable pore pressure prediction

中国科技纵横 2024年第7期 61-63页

作者：扎西巴旦西藏自治区广播电视局隆子中波转播台西藏山南 856000

数字化时代,广播行业面临巨大变革和挑战.其中,广播中波发射系统作为传统广播系统的重要组成部分,应满足数字化发展的需求.基于此,探讨数字化背景下广播中波发射系统的现状和发展趋势,对相关技术和策略进行分析,提出相应的改进和优化方... 详细信息

数字化时代,广播行业面临巨大变革和挑战.其中,广播中波发射系统作为传统广播系统的重要组成部分,应满足数字化发展的需求.基于此,探讨数字化背景下广播中波发射系统的现状和发展趋势,对相关技术和策略进行分析,提出相应的改进和优化方案,以满足数字化广播的发展需求.

关键词：数字化背景广播中波发射系统

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Petroleum Science 2024年第1期21卷 535-550页

作者： Song Deng Hao-Yu Pan Hai-ge Wang Shou-Kun Xu Xiao-peng Yan Chao-Wei Li Ming-guo peng Hao-Ping peng Lin Shi Meng Cui Fei zhao School of Petroleum and Natural gas Engineering Changzhou UniversityChangzhou213164JiangsuChina Tubular goods Research Institute of CNPC Beijing102249China CNPC Engineering Technology R&D Company Limited Beijing102206China

Pore pressure is essential data in drilling design,and its accurate prediction is necessary to ensure drilling safety and improve drilling *** methods for predicting pore pressure are limited when forming particular structures and *** this paper,a machine learning algorithm and effective stress theorem are used to establish the transformation model between rock physical parameters and pore *** study collects data from three *** 1 had 881 data sets for model training,and Wells 2 and 3 had 538 and 464 data sets for model *** this paper,support vector machine(SVM),random forest(RF),extreme gradient boosting(XgB),and multilayer perceptron(MLP)are selected as the machine learning algorithms for pore pressure *** addition,this paper uses the grey wolf optimization(gWO)algorithm,particle swarm optimization(PSO)algorithm,sparrow search algorithm(SSA),and bat algorithm(ba)to establish a hybrid machine learning optimization algorithm,and proposes an improved grey wolf optimization(IgWO)*** IgWO-MLP model obtained the minimum root mean square error(RMSE)by using the 5-fold cross-validation method for the training *** the pore pressure data in Well 2 and Well 3,the coefficients of determination(R^(2))of SVM,RF,XgB,and MLP are 0.9930 and 0.9446,0.9943 and 0.9472,0.9945 and 0.9488,0.9949 and *** achieves optimal performance on both training and test data,and the MLP model shows a high degree of *** indicates that the IgWO-MLP is an excellent predictor of pore pressure and can be used to predict pore pressure.

关键词： Pore pressure grey wolf optimization Multilayer perceptron Effective stress Machine learning

geology and geochemistry of K-feldspar Veins in Lamprophyre at the Zhenyuan gold Deposit,Yunnan,Southwest China:Implications for gold Mineralization

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Acta geologica Sinica(English Edition) 2024年第1期98卷 104-116页

作者： zha.g Huichao CHAI peng zha.g Hongrui ZHOU Limin HOU Zengqian Key Laboratory of Submarine geosciences Second Institute of OceanographyMinistry of Natural ResourcesHangzhou 310012China Institute of geology Chinese Academy of Geological SciencesBeijing 100037China Key Laboratory of Marine Hazards Forecasting Ministry of Natural ResourcesHohai UniversityNanjing 210024China National Research Center for geoanalysis Beijing 100037China

Lamprophyres typically appear in hydrothermal gold *** relationship between lamprophyres and gold deposits is investigated *** researchers suggest that the emplacement of lamprophyres triggers gold mineralization,whereas others hypothesize that the formation of lamprophyres increases the fertility of mantle sources and ore-forming fluids.K-feldspar veins,with ages between those of lamprophyres and gold deposits,appear in lamprophyres in ***,K-feldspar veins are ideal for investigating the relationship between lamprophyres and gold *** in K-feldspar veins has lower Mg#,Ni,and Cr contents and higher TiO2,Li,ba,Sr,Sc,Zr,Nb,and Cs contents than phlogopite in *** in-situ Sr isotopic values of apatites(0.7063–0.7066)in K-feldspar veins are within the range for apatites(0.7064–0.7078)from *** large-ion lithophile element concentrations and low Nb and Ta concentrations in phlogopite from lamprophyres,in addition to high(87Sr/86Sr)i values of apatite(0.7064–0.7078),indicate that the magma parental to these phlogopite and apatite crystals is derived from an enriched *** veins are genetically correlated with lamprophyres,whereas sulfide mineral assemblage and trace element compositions of pyrite in K-feldspar veins suggest that K-feldspar veins in lamprophyres are not directly related to gold mineralization of the Zhenyuan deposit.

关键词： lamprophyre K-feldspar vein apatite Sr isotope gold Zhenyuan deposit Yunnan

恒流充电有限柱体电极浓度分布及扩散诱导应力解析分析

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物理学报 2024年第15期73卷 225-234页

作者：彭颖吒张锴郑百林同济大学航空航天与力学学院上海200092

常见的柱状电极模型中,在轴向方向一般采用无限长假设广义平面应变分析方法,本文考虑恒流充电下有限柱形电极模型,基于力-化耦合一般方程,推导出位移与扩散诱导应力解析解.有限柱体电极中浓度分布由仅考虑径向扩散和仅考虑轴向扩散两部... 详细信息

常见的柱状电极模型中,在轴向方向一般采用无限长假设广义平面应变分析方法,本文考虑恒流充电下有限柱形电极模型,基于力-化耦合一般方程,推导出位移与扩散诱导应力解析解.有限柱体电极中浓度分布由仅考虑径向扩散和仅考虑轴向扩散两部分叠加求解.将浓度函数代入力学方程,使用Boussinesq-Papkovich函数得到应力分量解析解.计算了表面自由柱状电极中浓度和应力场,并将其结果与有限元软件计算的结果进行对比计算.结果表明,理论解和数值解中浓度分布一致,应力分量趋势一致数值相差较小,在荷电状态为17.9%时径向应力在中心处相对误差最大约为4%.本文分析了不同长径比柱状电极中径向和轴向单向扩散对应力场的影响,结果表明,随着长径比的增大,轴向扩散对浓度分布影响下降,径向扩散对应力场影响上升.

关键词：锂离子电池有限柱体电极扩散诱导应力 Boussinesq-Papkovich 函数

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Correlation of work function and stacking fault energy through Kelvin probe force microscopy and nanohardness in diluteα-magnesium

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Journal of Magnesium and Alloys 2024年第1期12卷 237-250页

作者： Yigit Türe Ali Arslan Kaya Hüseyin Aydin Jiang peng Servet Turan Eskisehir Technical University Porsuk Vocational SchoolElectronics and Automation DepartmentProgram of MechatronicsEskisehirTurkey Mugla Sitki Kocman University Engineering FacultyMetallurgy and Materials Engineering DepartmentMuglaTurkey Hüseying Aydın TUBITAK MRCTurkey Jiang peng Chongqing UniversityChina Eskisehir Technical University Engineering FacultyMaterials Science and Engineering DepartmentEskisehirTurkey

Electronic interactions of the group 2A elements with magnesium have been studied through the dilute solid solutions in binary Mg-Ca,Mg-Sr and Mg-ba *** investigation incorporated the difference in the‘Work Function'(ΔWF)measured via Kelvin Probe Force Microscopy(KPFM),as a property directly affected by interatomic bond types,*** electronic structure,nanoindentation measurements,and Stacking Fault Energy values reported in the *** was shown that the nano-hardness of the solid-solutionα-Mg phase changed in the order of Mg-Ca>Mg-Sr>***,it was shown,by also considering the nano-hardness levels,that SFE of a solid-solution is closely correlated with its‘Work Function'***-hardness measurements on the eutectics andΔWF difference between eutectic phases enabled an assessment of the relative bond strength and the pertinent electronic structures of the eutectics in the three *** withΔWF and at least qualitative verification of those computed SFE values with some experimental measurement techniques were considered important as those computational methods are based on zero Kelvin degree,relatively simple atomic models and a number of *** asserted by this investigation,if the results of measurement techniques can be qualitatively correlated with those of the computational methods,it can be possible to evaluate the electronic structures in alloys,starting from binary systems,going to ternary and then multi-elemental *** investigation has shown that such a qualitative correlation is *** all,the SFE values are not treated as absolute values but rather become essential in comparative investigations when assessing the influences of alloying elements at a fundamental level,that is,free electron density *** study indicated that the principles of‘electronic metallurgy'in developing multi-elemental alloy systems can be followed via practical experimental methods,i.e.ΔWF measurements using KPF

关键词： Mg alloys Dilute alloys Work function Stacking fault energy Kelvin probe force microscopy Short range order Miedema Nanoindentation Eutectics

Anomalous bond lengthening in compressed magnetic doped semiconductor ba(Zn_(0.95)Mn_(0.05))_(2)As_(2)

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Journal of Semiconductors 2024年第4期45卷 36-41页

作者： Fei Sun Yi peng guoqiang zhao Xiancheng Wang Zheng Deng Changqing Jin Institute of Physics Chinese Academy of SciencesBeijing 100190China School of Physics University of Chinese Academy of SciencesBeijing 101408China Center for High Pressure Science and Technology Advanced Research Beijing 100094Chin

Applying pressure has been evidenced as an effective method to control the properties of semiconductors,owing to its capability to modify the band configuration around Fermi ***,structural evolutions under external pres-sures are required to analyze the *** high-pressure structure of a magnetic doped semiconductor ba(Zn_(0.95)Mn_(0.05))_(2)As_(2)is studied with combination of in-situ synchrotron X-ray diffractions and diamond anvil *** materials become ferromagnetic with Curie temperature of 105 K after further 20%K *** title material undergoes an isostruc-tural phase transition at around 19 *** the transition pressure,it is remarkable to find lengthening of Zn/Mn-As bond within Zn/MnAs layers,since chemical bonds are generally shortened with applying *** with the bond stretch,interlayer As-As distances become shorter and the As-As dimers form after the phase *** further compres-sion,Zn/Mn-As bond becomes shortened due to the recovery of isotropic compression on the Zn/MnAs layers.

关键词： magnetic semiconductor high-pressure in-situ X-ray diffraction phase transition

Strong ferroelectric and luminescence properties of 0-3 type 0.8baTiO_(3)-0.2CaTiO_(3):Pr^(3+)composite ceramics prepared by cold sintering process

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Journal of Advanced Ceramics 2024年第7期13卷 1002-1010页

作者： Xiaocui Rao Xueling Yang Renbing Sun peng Du Hai Jiang Yao Huang Laihui Luo Department of Microelectronics Science and Engineering School of Physical Science and TechnologyNingbo UniversityNingbo 315211China College of Materials Science and Engineering Ningbo University of TechnologyNingbo 315016China

0-3 type ferroelectric-phosphor composite ceramics cannot be prepared by the traditional solid-state sintering(SSS)method due to the strong chemical reaction between ferroelectrics and phosphors during high-temperature *** cold sintering process(CSP)may solve this issue by densifying ceramics at ultralow sintering *** this work,dense 0-3 type 0.8baTiO3-0.2CaTiO3:Pr^(3+)(0.8BT-0.2CT:Pr^(3+))binary composite ceramics were fabricated at an ultralow temperature of 225℃via CSP with the ba(OH)2·8H2O hydrated *** effects of the ba(OH)2·8H2O content,sintering temperature,and sintering time on the microstructure and densification of the ceramics were *** density of the composite ceramics prepared by the optimized sintering parameters reaches 89%.Both energy-dispersive X-ray(EDX)spectroscopy and X-ray diffraction(XRD)confirm the existence of BT and CT:Pr^(3+)phases in the prepared ceramics.A strong ferroelectric performance is obtained,and the luminescent properties of CT:Pr^(3+)are preserved for the ***,the 0.8BT-0.2CT:Pr^(3+)composite ceramics prepared by CSP have stronger photoluminescence and photo-stimulated luminescence than their counterparts prepared by cold sintering assistance(CSA)and SSS ***,CSP is a promising method for combining luminescent and ferroelectric properties into 0-3 type composite ceramics.

关键词： single-step densification cold sintering composite ceramics ferroelectric luminescence