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胸腺肽联合无创呼吸机辅助通气治疗COPD合并呼吸衰竭的疗效观察

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疑难病杂志 2024年第3期23卷 308-312页

作者：段小凯孙永香余勇于晓丹樊实真柴卫芳郑州市第一人民医院全科医学科 450004

目的探讨胸腺肽联合无创呼吸机辅助通气治疗慢性阻塞性肺疾病(COPD)合并呼吸衰竭患者的疗效。方法选取2020年1月—2023年1月郑州市第一人民医院全科医学科诊治合并呼吸衰竭的COPD患者80例,依据治疗方案不同分为2组,采用无创呼吸机辅助... 详细信息

目的探讨胸腺肽联合无创呼吸机辅助通气治疗慢性阻塞性肺疾病(COPD)合并呼吸衰竭患者的疗效。方法选取2020年1月—2023年1月郑州市第一人民医院全科医学科诊治合并呼吸衰竭的COPD患者80例,依据治疗方案不同分为2组,采用无创呼吸机辅助通气纳入对照组(n=40),无创呼吸机辅助通气联合胸腺肽治疗患者纳入观察组(n=40)。治疗10 d后,比较2组临床疗效及治疗前后血氧分压(PaO_(2))、二氧化碳分压(PaCO_(2))、动脉血氧饱和度(SaO_(2))、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)、白介素-10(IL-10)、白介素-18(IL-18)、呼吸困难情况(MRC评分)、症状情况(CAT评分)、生活质量(SGRQ评分)。结果观察组临床治疗总有效率95.00%(38/40)高于对照组的77.50%(31/40),差异有统计学意义(χ^(2)=5.165,P=0.023);治疗后观察组PaO_(2)、SaO_(2)、IL-10高于对照组,PaCO_(2)、TNF-α、CRP、IL-18低于对照组(t=4.169、4.173、8.624、6.572、7.294、10.320、6.024,P均<0.001);治疗后,观察组MRC评分、CAT评分、SGRQ评分均低于对照组(t/P=2.715/0.008、5.440/<0.001、12.501/<0.001)。结论胸腺肽联合无创呼吸机辅助通气治疗伴有呼吸衰竭的COPD患者效果良好,可调节免疫炎性反应过程,恢复血气指标,从而改善临床症状,促进生活质量提高。

关键词：慢性阻塞性肺疾病呼吸衰竭胸腺肽无创呼吸机辅助通气疗效

Double casing warhead with sandwiched charge:The axial distribution of fragments velocities

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Defence Technology（防务技术） 2024年第4期34卷 201-216页

作者： Ping Ye yongxiang Dong Qitian sun Peizhuo Shi Wang Yao Yongnan Li Yujing Li Mingze Li State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China

The double casing warhead with sandwiched charge is a novel fragmentation warhead that can produce two groups of fragments with different velocity,and the previous work has presented a calculation formula to determine the maximum fragment *** current work builds on the published formula to further develop a formula for calculating the axial distribution characteristics of the fragment *** this type of warhead,the simulation of the dispersion characteristics of the detonation products at different positions shows that the detonation products at the ends have a much larger axial velocity than those in the middle,and the detonation products have a greater axial dispersion velocity when they are closer to the central *** loading process and the fragment velocity vary with the axial position for both casing layers,and the total velocity of the fragments is the vector sum of the radial velocity and the axial *** the same axial position,the acceleration time of the inner casing is greater than that of the outer *** the same casing,the fragments generated at the ends have a longer acceleration time than the fragments from the *** proposed formula is validated with the X-ray radiography results of the four warheads previously tested experimentally and the 3D smoothedparticle hydrodynamics numerical simulation results of several series of new warheads with different *** formula can accurately and reliably calculate the fragment velocity when the lengthto-diameter ratio of the charge is greater than 1.5 and the thickness of the casing is less than 20%its inner *** work thus provides a key reference for the theoretical analysis and the design of warheads with multiple casings.

关键词： Double casing warhead Sandwiched charge Fragment velocity Rarefaction wave Gurney formula Explosive loading

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大型机场航站楼逐时电耗特性及电耗强度

暖通空调 2024年第8期54卷 108-114,150页

作者：管冬亚陈超孙永祥乔鹏简毅文康春华王颖佳北京工业大学北京北京大兴国际机场北京

以北京市某大型机场航站楼为研究对象,应用皮尔逊相关分析、k均值聚类方法,对2020—2023年实测数据变化特性及其影响因素进行了分析研究,包括逐时电耗特性提取及其电耗强度指标构建。结果表明:航站楼电耗可分为3类,即与建筑规模相关的... 详细信息

以北京市某大型机场航站楼为研究对象,应用皮尔逊相关分析、k均值聚类方法,对2020—2023年实测数据变化特性及其影响因素进行了分析研究,包括逐时电耗特性提取及其电耗强度指标构建。结果表明:航站楼电耗可分为3类,即与建筑规模相关的基础电耗量、与旅客吞吐量相关的变动电耗量Ⅰ,以及与室外气象条件和旅客吞吐量相关的变动电耗量Ⅱ;k均值聚类分析结果反映了部分设计客流负荷对航站楼主要用电设备系统运行方式及其电耗特性的影响规律,可将日旅客吞吐量分为4级。基于这些分析结果,进一步给出了航站楼日总电耗强度及CO_(2)排放指标的试算值。研究结果可为合理确定各分项用电设备系统的电耗强度降低目标提供参考。

关键词：机场航站楼皮尔逊相关分析 k均值聚类电耗特性电耗强度指标 CO 2排放

Asymmetric Synthesis of Dihydrospirotryprostatin B via a Silica Gel-Mediated Cyclization of Tryptamine-Ynamide

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Chinese Journal of Chemistry 2024年第12期42卷 1355-1359页

作者： Changhong Han Lu Yang Kaizong Yao Sen Zhang Jiayue Fu Hanyang sun Hongsheng Xu Bin Lin Maosheng Cheng yongxiang Liu Key Laboratory of Structure:Based Drug Design and Discovery of Ministry of Education Shenyang Pharmaceutical UniversityShenyangLiaoning 110016China Wuya College of Innovation Shenyang Pharmaceutical UniversityShenyangLiaoning 110016China Institute of Drug Research in Medicine Capital of China BenxiLiaoning 117000China Zhejiang Shapuaisi Pharmaceutical Co. LtdPinghuZhejiang 314299China

Comprehensive Summary An asymmetric synthesis of dihydrospirotryprostatin B was achieved in 15 steps(8 purifications)from *** main feature of our synthetic strategy is the efficient construction of spirocyclic oxindole intermediate containing a chiral quaternary carbon center,involving the silica gel-mediated cyclization of tryptamine-ynamide and oxidation under neat conditions.

关键词： Asymmetric synthesis Alkaloids Dihydrospirotryprostatin B Tryptamine-ynamide Cross-coupling Silica gel-mediated cyclization Oxidation

Characteristics of gut microbiota determine effects of specific probiotics strains in patients with functional constipation

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Chinese Medical Journal 2024年第1期137卷 120-122页

作者： Haohao Zhang Lijuan sun Zhixin Zhao Yao Zhou Yuyao Liu Nannan Zhang Junya Yan Shibo Wang Renlong Li Jing Zhang Xueying Wang Wenjiao Li Yan Pan Meixia Wang Bing Luo Mengbin Li Zhihong sun yongxiang Zhao Yongzhan Nie State Key Laboratory of Targeting Oncology National Center for International Research of Bio-targeting TheranosticsGuangxi Key Laboratory of Bio-targeting TheranosticsCollaborative Innovation Center for Targeting Tumor Diagnosis and TherapyGuangxi Talent Highland of Bio-targeting TheranosticsGuangxi Medical UniversityNanningGuangxi 530021China State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases Xijing Hospital of Digestive DiseasesFourth Military Medical UniversityXi’anShaanxi 710032China Key Laboratory of Resource Biology and Biotechnology in Western China Ministry of EducationSchool of MedicineNorthwest UniversityXi’anShaanxi 710000China Key Laboratory of Dairy Biotechnology and Engineering Ministry of EducationKey Laboratory of Dairy Products ProcessingMinistry of Agriculture and Rural AffairsInner Mongolia Key Laboratory of Dairy Biotechnology and EngineeringInner Mongolia Agricultural UniversityHohhotInner Mongolia 010018China

To the Editor:Probiotics are a promising treatment modality for functional constipation(FC);however,the factors affecting individual responses to probiotics remain *** evidence has identified that there is a strong relationship among the gut microbiota and constipation and related gut-brain axis.[1]The gut microbiota may modulate the gut functions via gut metabolites or trigger the release of gut hormones,such as peptide YY,gastric inhibitory polypeptide,and 5-hydroxytryptamine.[2]In turn,gut hormones affect gut secretion,motility,and sensation through their receptors located on epithelial,enteric,and smooth muscle cells.[2]Based on these findings,exogenous probiotics have been used in patients with constipation;however,few have produced consistent results.[3]In this study,we investigated the efficacy and safety of several specific probiotics strains for constipation,and also examined the potential reasons for the individualized effects of probiotics,which may facilitate interventional decisionmaking for FC patients.

关键词： constipation patients sensation

Environmental connections of novel avian-origin H7N9 influenza virus infection and virus adaptation to the human

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Science China(Life Sciences) 2013年第6期56卷 485-492页

作者： LI Jun YU XinFen PU XiaoYing XIE Li sun yongxiang XIAO HaiXia WANG FenJuan DIN Hua WU Ying LIU Di ZHAO GuoQiu LIU Jun PAN JingCao Hangzhou Center for Disease Control and Prevention Xiaoshan Center for Disease Control and Prevention Laboratory of Protein Engineering and Vaccine Tianjin Institute of Industrial BiotechnologyChinese Academy of Sciences CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of Sciences Network Information Center Institute of MicrobiologyChinese Academy of Sciences National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention

A novel H7N9 influenza A virus has been discovered as the causative identity of the emerging acute respiratory infection cases in Shanghai,*** virus has also been identified in cases of infection in the neighboring area Hangzhou City in Zhejiang *** this study,epidemiologic,clinical,and virological data from three patients in Hangzhou who were confirmed to be infected by the novel H7N9 influenza A virus were collected and *** respiratory specimens and chicken feces from a contacted free market were tested for influenza virus by real-time reverse transcription PCR(RT-PCR) and *** clinical features of the three cases were similar featured with high fever and severe respiratory symptoms;however,only one of the patients died.A certain degree of diversity was observed among the three Hangzhou viruses sequenced from human samples compared with other reported H7N9 influenza A *** sequences of the novel avian-origin H7N9 influenza viruses from Hangzhou City contained important amino acid substitutions related to human *** of the Hangzhou viruses had gained a novel amino acid substitution(Q226I) in the receptor binding region of *** importantly,the virus sequenced from the chicken feces had a 627E substitution in the PB2 protein instead of the mammalian-adapted 627K substitution that was found in the PB2 proteins from the Hangzhou viruses from the three ***,the newly-emerging H7N9 virus might be under adaptation pressure that will help it "jump" from avian to human *** significance of these substitutions needs further exploration,with both laboratory experiments and extensive field surveillance.

关键词： A型流感病毒病毒感染人类环境禽流感起源逆转录聚合酶链反应呼吸道症状连接

单侧双通道脊柱内镜治疗腰椎椎管狭窄症的临床疗效

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中国医科大学学报 2023年第12期52卷 1144-1146页

作者：段星宇母心灵孙永香新乡医学院研究生院河南新乡453000 郑州市第一人民医院骨科郑州450000 郑州市第一人民医院全科医学科郑州450000

选取2020年1月1日至2022年6月17日于郑州市第一人民医院骨科行单侧双通道脊柱内镜(UBE)手术治疗的腰椎椎管狭窄症患者97例。所有患者均顺利完成手术,手术时间(47.16±1.62)min,住院时间(7.6±1.7)d。与术前比较,术后3 d、1个月、3个月,... 详细信息

选取2020年1月1日至2022年6月17日于郑州市第一人民医院骨科行单侧双通道脊柱内镜(UBE)手术治疗的腰椎椎管狭窄症患者97例。所有患者均顺利完成手术,手术时间(47.16±1.62)min,住院时间(7.6±1.7)d。与术前比较,术后3 d、1个月、3个月,疼痛视觉模拟评分及Oswesry功能障碍指数评分均降低,差异均有统计学意义(均P<0.05)。末次随访改良MacNab标准评价优良率为84.5%。在腰椎椎管狭窄症的微创治疗中,UBE具有临床疗效优、学习周期短等显著优势,值得在临床上推广。

关键词：单侧双通道脊柱内镜技术腰椎椎管狭窄症微创临床疗效

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从苏联气田分布规律得到的启示

天然气工业 1990年第6期10卷 21-26页

作者：孙永祥中国石油天然气总公司石油勘探开发科学研究院

本文概述了苏联合气区的地质特征,总结了苏联气田的分布规律。在此基础上,针对我国目前天然气勘探、研究中存在的问题,提出了要重视在地台区、老地层和褶皱带内找气以及加强天然气地质学基础理论研究的看法和意见。

关键词：气田苏联天然气

学科交叉融合背景下的计算机通识课程教学改革与实践——以山东农业大学为例

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科技资讯 2022年第12期20卷 143-147页

作者：孙永香于群孙倩山东农业大学信息科学与工程学院山东泰安271018

在当今智能时代,学科交叉融合是科学技术发展的必然趋势,是产生重大科技成果的突破点,这已经成为世界高等教育的共识。山东农业大学是一所农林特色高校,其计算机通识课程的主要教学目标是培养学生计算思维能力,为本科各专业学生利用计... 详细信息

在当今智能时代,学科交叉融合是科学技术发展的必然趋势,是产生重大科技成果的突破点,这已经成为世界高等教育的共识。山东农业大学是一所农林特色高校,其计算机通识课程的主要教学目标是培养学生计算思维能力,为本科各专业学生利用计算机技术,分析、设计和解决该专业中的复杂工程问题提供有力依据。因此,计算机通识课程在跨学科融合创新和新农科建设中发挥着极其重要的作用。在分析高校计算机通识教育意义和现状的基础上,结合办学特色和人才培养目标,在学科交叉融合背景下对计算机通识课程进行教学改革探索。

关键词：学科交叉融合计算机通识课程教学改革融合创新