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In-situ growth of CoNi bimetal anchored on carbon nanoparticle/nanotube hybrid for boosting rechargeable Zn-air battery

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Journal of Energy Chemistry 2022年第3期31卷 348-355,I0010页

作者： Jun Li yongxia wang Zhengyu Yin Rui He Yihao wang Jinli Qiao State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Environmental Science and EngineeringDonghua UniversityShanghai 201620China Shanghai Institute of Pollution Control and Ecological Security Shanghai 200092China

Exploring highly efficient non-precious metal based catalysts for bifunctional oxygen electrode is crucial for rechargeable metal-air batteries.In this study,with MOFs as precursors,a facile coprecipitation method is designed to realize in-situ growth of the CoNi anchored carbon nanoparticle/nanotube(CoNi/N-CNN)hybrid,which can achieve the simultaneous maximum exposure of both oxygen evolution reaction(OER)and oxygen reduction reaction(ORR)active centers.Benefiting from the unique structure,the CoNi/N-CNN catalyst exhibits excellent electrocatalytic performance for ORR(E_(onset)=1.183 V,E_(1/2)=0.819 V)and a low operating voltage of 1.718 V at 10 mA cm^(−2)(Ej=10)for OER.Delightfully,the home-made rechargeable Zn-air battery with CoNi/N-CNN delivers a high discharge power density up to 209 mW cm^(−2),and an outstanding charge–discharge cycling stability.The boosted bifunctional electrocatalytic activity can be ascribed to the strong coupling effect between Co/Ni center sites and defect-rich N-anchored carbon featured with porous and nanotube structure,which can introduce uniformly dispersed active sites,tailored electronic configuration,superb conductivity and convenient charge transfer process.The hybrid non-precious bimetal based electrocatalyst provides the possibility to develop the low-cost and high-efficient ORR/OER bifunctional electrocatalysts in rechargeable metal-air battery.

关键词： Co Ni/N-CNN Bifunctional electrocatalyst Oxygen electrode Rechargeable Zn-air battery

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Cross-Scale Synthesis of Organic High-k Semiconductors Based on Spiro-Gridized Nanopolymers

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Research 2022年第2期2022卷 111-122页

作者： Dongqing Lin Wenhua Zhang Hang Yin Haixia Hu Yang Li He Zhang Le wang Xinmiao Xie Hongkai Hu yongxia Yan Haifeng Ling Jin'an Liu Yue Qian Lei Tang yongxia wang Chaoyang Dong Linghai Xie Hao Zhang Shasha wang Ying Wei Xuefeng Guo Dan Lu Wei Huang Centre for Molecular Systems and Organic Devices(CMSOD) State Key Laboratory of Organic Electronis and Information Displays&Institute of Advanced Materials(AM)Nanjing University of Posts.Telecommunications9 Wenyuan RoadNarnjing 210023China National Symnchrotron Radiationr Laboratory Anhui Provincial Engincering Laboratory of Advanced Functional Polymer FilmCAS Key Laboratory of Soft Matter ChemistryUniversity of Science and Technology of ChinaHgfei 230026China School of Plysics State Key Laboratory of Crystal MaterialsShandong UniversityJinanShardong 250100China Beijing National Laboratony for Molecular Scences National Biomedical Imaging CenterCollege of Chemistry and Molecular EngineeringPeking UniversityBejing 100871China Frontiers Science Center for Flexible Electronics(FSCFE) MIIT Key Laboratory of Flexible Electronics(KLoFE)Northwestern Polytechnical UntiversityXian 710072China State Key Laboratory of Supramolecular Structure and Materias College of Chemistyjilin University2699 Qianjin AvenueChangchun 130012China

High dielectric constants in organic semiconductors have been identified as a central challenge for the improvement in not only piexoelectric,preolecric,and freeltric efcts but also photoclecric conversion eficiency in OPVs,carrier mobility in OFETS,and charge density in charge-trapping memories.Herein,we report an ultralong persistence length(≈41 nm)efet of spiro-fused organic nanopolymers on dielectric properties,together with excitonic and charge carrier behaviors.The state-of-the-art nanopolymers,namely,nanopolyspirogrids(NPSGs),are synthesized via the simple crossscale Friedel-Crafts polygridlization of AjB-type nanomonomers.The high dielectric constant(k=8.43)of NPSG is firstly achieved by locking spiro-polygridization efect that results in the enhancement of dipole polarization.When doping into a polystyrene-based dielectric layer,such a high-k feature of NPSG increases the feld-ffct carrier mobility from 0.20 to 0.90cm^(2)Vl s'in pentacene OFET devices.Meanwhile,amorphous NPSG film exhibits an ultralow energy disorder(<50 meV)for an exellent zero-field hole mobility of 3.94×10^(-1)cm^(2)V^(-1)s^(-1).surpassing most of the amorphousπconjugated polymers Onganic nanopolymers with high dielectric constants open a new way to break through the bottleneck of eficiency and multifunctionality in the blueprint of the fourth generation semiconductors.

关键词： dielectric charge amorphous

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Co/Ni dual-metal embedded in heteroatom doped porous carbon core-shell bifunctional electrocatalyst for rechargeable Zn-air batteries

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Materials Reports(Energy) 2022年第2期2卷 68-74页

作者： Jun Li Huaibin Xue Nengneng Xu Xiucheng Zhang yongxia wang Rui He Haitao Huang Jinli Qiao State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Environmental Science and EngineeringDonghua UniversityShanghai201620China Shanghai Zhongfu New Energy Technology Co. LtdScience and Technology Entrepreneurship CenterLingangShanghai201306China Department of Applied Physics Hong Kong Polytechnic UniversityHongkongChina

Rational construction of highly efficient and cheap bifunctional electrocatalysts to boost both oxygen evolution reaction(OER)and oxygen reduction reaction(ORR)is extremely essential for the wide application of rechargeable metal-air battery.In this work,we design a core-shell structural catalyst of CoNi dual-metal embedded in nitrogen doped porous carbon(NPC,CoNi@NPC),which is developed via the pyrolysis of CoNiMOFs,assisting by mesoporous SiO_(2) to effectively inhibit the aggregation of metal sites.Consequently,the asprepared CoNi@NPC manifests good ORR activity with half-wave potential up to 0.77 V.Specifically,the CoNi@NPC gives a very low OER over-potential of merely 101 mV in 6 M KOH along with high stability,outperforming the commercial Pt/C-RuO_(2).Moreover,the home-made zinc air battery with CoNi@NPC air cathode demonstrates excellent stability over long-term charging–discharging test,and delivers the maximum power density of 224 mW cm^(-2).The enhanced high performance of CoNi@NPC bifunctional catalyst for both ORR and OER can be ascribed to its unique core-shell structure and strong synergistic effect between the dual-bimetal active sites and the heteroatom doped carbon.This work opens a new avenue for the rational design of nonprecious metal bifunctional catalysts for rechargeable metal-air battery.

关键词： CoNi@NPC Core shell structure ORR OER Rechargeable zinc air battery

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基于单细胞测序技术解析冠状动脉粥样硬化患者平滑肌细胞的细胞间通信及关键基因

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上海交通大学学报（医学版） 2024年第2期44卷 169-182页

作者：司春婴王建茹李晓辉王永霞关怀敏河南中医药大学第一临床医学院(中西医结合学院) 郑州450003 河南中医药大学第一附属医院心脏中心/国家区域(中医)心血管诊疗中心郑州450003

目的·利用单细胞RNA测序技术(single-cell RNA sequencing,scRNA-Seq)阐释冠状动脉粥样硬化(coronary atherosclerosis,CA)的细胞通信景观,挖掘主导细胞亚群及其关键基因。方法·下载GSE131778数据集并进行预处理、质控、降维聚类及注... 详细信息

目的·利用单细胞RNA测序技术(single-cell RNA sequencing,scRNA-Seq)阐释冠状动脉粥样硬化(coronary atherosclerosis,CA)的细胞通信景观,挖掘主导细胞亚群及其关键基因。方法·下载GSE131778数据集并进行预处理、质控、降维聚类及注释;利用CellChat包进行细胞通信分析,识别主导细胞亚群。利用FindAllMarker函数,筛选主导细胞亚群与其他细胞亚群间的差异表达基因(differentially expressed genes,DEGs),并构建其蛋白相互作用(protein-protein interaction,PPI)网络,将Degree算法排序前五位的DEGs作为关键基因。将关键基因与CellChat分析出的细胞通信网络进行匹配和挖掘,获取关键基因参与的配体-受体对(ligand-receptor pair,L-R)及其介导的信号通路,并对结果进行可视化。构建动脉粥样硬化小鼠模型,并利用反转录聚合酶链式反应检测关键基因在颈动脉粥样硬化病变处的表达情况。结果·在CA病变处共鉴定出11个细胞亚群,包括平滑肌细胞、内皮细胞、巨噬细胞、单核细胞等。细胞通信分析结果显示,CellChat在11个细胞亚群中检测到70对显著的L-R和26条相关的信号通路;平滑肌细胞处于通信活跃状态,与其他细胞亚群间相互作用的次数和强度最显著,是主导细胞亚群。DEGs筛选结果显示,平滑肌细胞亚群和其他细胞亚群之间共有206个DEGs,其中ITGB2、PTPRC、CCL2、DCN、IGF1被识别为关键基因。关键基因介导的细胞通信分析结果显示:CCL2与ACKR1形成L-R,通过介导CCL信号通路参与平滑肌细胞与内皮细胞间的通信网络;ITGB2分别与ITGAM、ITGAX组成受体复合物,再与C3形成L-R介导补体信号通路,参与平滑肌细胞与巨噬细胞、单核细胞间的通信网络。动物实验对关键基因的验证结果同生物信息学分析的结果一致。结论·平滑肌细胞在CA病理过程中是主导细胞,与其他细胞间有广泛的通信网络,可通过CCL2-ACKR1、C3-(ITGAM+ITGB2)和C3-(ITGAX+ITGB2)介导的CCL和补体信号通路,与内皮细胞、巨噬细胞和单核细胞构建细胞通信网络。

关键词：冠状动脉粥样硬化单细胞RNA测序平滑肌细胞细胞通信

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Overcoming the limitation of in-situ microstructural control in laser additive manufactured Ti-6Al-4V alloy to enhanced mechanical performance by integration of synchronous induction heating

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Journal of Materials Science & Technology 2021年第35期94卷 32-46页

作者： Wei Fan Hua Tan Fengying Zhang Zhe Feng yongxia wang Lai-Chang Zhang Xin Lin Weidong Huang State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi'an 710072China Key Laboratory of Metal High Performance Additive Manufacturing and Innovative Design MIIT ChinaNorthwestern Polytechnical UniversityXi'an 710072China School of Material Science and Engineering Chang'an UniversityXi'an 710064China School of Engineering Edith Cowan University270 Joondalup DriveJoondalupPerthWA 6027Australia

Although a variety of processing routes were developed to in-situ manipulate microstructure for fabricating high-performance Ti-6Al-4 V alloy by directed energy deposition(DED),the in-situ microstructural control ability has been limited and lead to a narrowed mechanical property control range.This work proved the microstructural correlation betweenβ-grains andα-laths resulting from the unique thermal characteristics of DED for the first time and solved such a dilemma through synchronous induction heating assisted laser deposition(SILD)technology.The results confirmed that the laser energy and inductive energy have a different effect on the solidification and solid phase transformation conditions.By adjusting the laser-induction parameters,the microstructural correlation can be tuned;theβ-grains andα-laths can be controlled relatively separately,thereby significantly enhancing the ductility of as-deposited sample(elongation from 14.2%to 20.1%).Furthermore,the mechanical properties of the tuned microstructures are even comparable to that of DED Ti-6Al-4 V with post heat treatment,which indicates that the potential of SILD to be a one-step manufacturing process to fabricate high performance components without post heat treatment.Furthermore,the tensile testing results of the tuned microstructures indicate thatα-lath size is more influential on the mechanical properties than theβ-grain size due to its stronger hindering effect on the slipping of dislocations.This work promotes the understanding of the microstructural formation mechanism in DED titanium alloy and proves that the combination of synchronous induction and laser can expand the ability to control the microstructure and properties of multi-layer deposition.

关键词： Directed energy deposition Additive manufacturing Ti-6Al-4V In-situ microstructural control Mechanical properties

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升陷汤加味对老年晚期肺鳞癌生存率及预后前瞻性研究

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中华中医药学刊 2024年第7期42卷 61-65,I0008页

作者：何晓华马秋云王永霞河北北方学院附属第一医院河北张家口075000

目的探讨升陷汤加味联合安罗替尼对老年晚期肺鳞癌患者的生存情况及预后的影响。方法选取2019年3月—2020年11月医院收治的老年晚期肺鳞癌患者148例,随机分为升陷组和对照组,各74例。对照组给予安罗替尼,升陷组在对照组基础上给予升陷... 详细信息

目的探讨升陷汤加味联合安罗替尼对老年晚期肺鳞癌患者的生存情况及预后的影响。方法选取2019年3月—2020年11月医院收治的老年晚期肺鳞癌患者148例,随机分为升陷组和对照组,各74例。对照组给予安罗替尼,升陷组在对照组基础上给予升陷汤加味治疗。两组均连续治疗至病情进展或不能耐受药物不良反应。比较两组患者近期临床疗效、治疗前及治疗2个疗程后血清肿瘤标志物[癌胚抗原(carcinoembryonlic antigen, CEA)、细胞角蛋白19片段抗原21-1(cytokeratin 19 fragment antigen21-1,CY21-1)]、预后生存质量[美国东部肿瘤协作组(Eastern Cooperative Oncology Group, ECOG)评分、生活质量(quality of life, QOL)评分法]、治疗期间不良反应发生情况,绘制两组随访的生存曲线[无进展生存期(progression free survival, PFS)、总生存时间(overall survival, OS)]。结果(1)与对照组比较,升陷组患者客观缓解率(objective remission rate, ORR)、疾病控制率(disease control rate, DCR)均显著升高(P0.05)。(5)生存情况:升陷组患者PFS中位数为11个月(95%CI:9.76~12.24),OS中位数13个月(95%CI:12.03~13.97);对照组患者PFS中位数为7个月(95%CI:6.298~7.702),OS中位数为10个月(95%CI:9.16~10.84)。升陷组患者的PFS、OS均高于对照组(PFS:χ^(2)=5.316,P=0.021;OS:χ^(2)=4.921,P=0.027),差异均有统计学意义。结论老年晚期肺鳞癌患者应用升陷汤加味联合安罗替尼治疗可提高疾病控制率,下调血清肿瘤标志物,改善预后,延长生存周期,且不增加不良反应发生率,具有一定临床应用价值。

关键词：晚期肺鳞癌升陷汤老年安罗替尼生存分析预后

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G蛋白β2亚基对结直肠癌细胞转移能力的影响

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新乡医学院学报 2024年第7期41卷 619-624,630页

作者：刘荣王永霞新乡医学院基础医学院病理学系河南新乡453003

目的探讨G蛋白β2亚基(GNB2)对结直肠癌细胞体外迁移和体内转移能力的影响及机制。方法将对数生长期人胚肾细胞293FT随机分为对照组和shGNB2组,对照组293FT细胞转染PSPAX2、PMD2G、Control质粒,shGNB2组293FT细胞转染PSPAX2、PMD2G、shG... 详细信息

目的探讨G蛋白β2亚基(GNB2)对结直肠癌细胞体外迁移和体内转移能力的影响及机制。方法将对数生长期人胚肾细胞293FT随机分为对照组和shGNB2组,对照组293FT细胞转染PSPAX2、PMD2G、Control质粒,shGNB2组293FT细胞转染PSPAX2、PMD2G、shGNB2质粒,分别收集病毒上清液。将对数生长期人结直肠癌细胞HCT116、RKO按随机数字表法分为对照组和shGNB2组,应用293FT细胞对照组病毒上清液转染对照组HCT116和RKO细胞,应用293FT细胞shGNB2组病毒上清液转染shGNB2组HCT116和RKO细胞,应用实时荧光定量聚合酶链反应法检测对照组和shGNB2组HCT116、RKO细胞中GNB2 mRNA的表达,Western blot法检测对照组和shGNB2组HCT116、RKO细胞中GNB2、波形蛋白(Vimentin)、神经钙黏蛋白(N-cadherin)和E-钙黏蛋白(E-cadherin)的表达,划痕愈合实验检测对照组和shGNB2组HCT116、RKO细胞划痕愈合率,Transwell小室实验检测对照组和shGNB2组HCT116、RKO细胞迁移细胞数。分别取对照组和shGNB2组HCT116细胞2×106个注射于裸鼠皮下,3周后取出皮下肿瘤,剪成1 mm 3大小的组织块。按随机数字表法将8只4~5周龄雌性裸鼠分为对照组和shGNB2组,每组4只;将对照组HCT116细胞皮下瘤组织块接种于对照组裸鼠回盲部肠浆膜处,shGNB2组HCT116细胞皮下瘤组织块接种于shGNB2组裸鼠回盲部肠浆膜处;记录裸鼠死亡时间,取出肝脏,观察肝脏肿瘤转移数。结果shGNB2组HCT116、RKO细胞中GNB2 mRNA和蛋白相对表达量显著低于对照组(P<0.01)。培养48 h时,shGNB2组HCT116、RKO细胞划痕愈合率显著低于对照组(P<0.01),shGNB2组HCT116、RKO细胞迁移数显著少于对照组(P<0.01)。shGNB2组裸鼠肝内转移瘤数显著少于对照组(P<0.05)。shGNB2组HCT116、RKO细胞中Vimentin、N-cadherin蛋白相对表达量显著低于对照组,E-cadherin蛋白相对表达量显著高于对照组(P<0.01)。结论干扰GNB2表达可有效抑制结直肠癌细胞的转移能力,其机制可能是GNB2通过调控上皮间质转化过程来参与结直肠癌细胞的转移。

关键词：结直肠癌 G蛋白β2亚基迁移转移

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Carbon‐based metal‐free catalysts for electrochemical CO2 reduction: Activity, selectivity, and stability

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Carbon Energy 2021年第1期3卷 24-49页

作者： Israr Masood ul Hasan Luwei Peng Jianfeng Mao Ruiman He yongxia wang Jing Fu Nengneng Xu Jinli Qiao State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Environmental Science and EngineeringDonghua UniversityShanghaiChina Shanghai Institute of Pollution Control and Ecological Security ShanghaiChina Institute for Superconducting and Electronic Materials Australian Institute of Innovative MaterialsUniversity of WollongongWollongongNew South WalesAustralia School of Materials Science and Engineering Tongji UniversityShanghaiChina Department of Chemical Engineering University of Louisiana at LafayetteLafayetteLouisianaUSA Institute for Materials Research and Innovation University of Louisiana at LafayetteLafayetteLouisianaUSA

Zero or negative emissions of carbon dioxide(CO2)is the need of the times,as inexorable rising and alarming levels of CO2 in the atmosphere lead to global warming and severe climate change.The electrochemical CO2 reduction(eCO2R)to value‐added fuels and chemicals by using renewable electricity provides a cleaner and more sustainable route with economic benefits,in which the key is to develop clean and economical electrocatalysts.Carbon‐based catalyst materials possess desirable properties such as high offset potential for H2 evolution and chemical stability at the negative applied potential.Although it is still challenging to achieve highly efficient carbon‐based catalysts,considerable efforts have been devoted to overcoming the low selectivity,activity,and stability.Here,we summarize and discuss the recent progress in carbon‐based metal‐free catalysts including carbon nanotubes,carbon nanofibers,carbon nanoribbons,graphene,carbon nitride,and diamonds with an emphasis on their activity,product selectivity,and stability.In addition,the key challenges and future potential approaches for efficient eCO2R to low carbon‐based fuels are highlighted.For a good understanding of the whole history of the development of eCO2R,the CO2 reduction reactions,principles,and techniques including the role of electrolytes,electrochemical cell design and evaluation,product selectivity,and structural composition are also discussed.The metal/metal oxides decorated with carbon‐based electrocatalysts are also summarized.We aim to provide insights for further development of carbon‐based metal‐free electrocatalysts for CO2 reduction from the perspective of both fundamental understanding and technological applications in the future.

关键词： activity carbon‐based catalyst CO2 electrochemical reduction selectivity stability

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HPLC指纹图谱结合多指标含量测定的养阴生肌肠溶胶囊质量评价研究

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中国中医药信息杂志 2024年第6期31卷 130-135页

作者：王永霞刘效栓李季文豆金彦甘肃中医药大学药学院甘肃兰州730000 甘肃省中医院甘肃兰州730050

目的建立养阴生肌肠溶胶囊HPLC指纹图谱,测定龙胆苦苷、芍药内酯苷、芍药苷、甘草苷、盐酸小檗碱、吴茱萸碱和吴茱萸次碱的含量,为其质量控制提供参考。方法按照制备工艺对组方药物进行水解和醇沉,将样品内容物溶于70%甲醇进行供试品溶... 详细信息

目的建立养阴生肌肠溶胶囊HPLC指纹图谱,测定龙胆苦苷、芍药内酯苷、芍药苷、甘草苷、盐酸小檗碱、吴茱萸碱和吴茱萸次碱的含量,为其质量控制提供参考。方法按照制备工艺对组方药物进行水解和醇沉,将样品内容物溶于70%甲醇进行供试品溶液制备,采用Agilent5HC-C18(2)色谱柱(250mm×4.6mm,5μm)进行分析,流动相为乙腈-0.1%磷酸水溶液,梯度洗脱,流速1.0 mL/min,柱温30℃,检测波长230 nm。采用OriginPro2021、《中药色谱指纹图谱相似度评价系统》(2012版)、SIMCA14.1软件及SPSS25.0统计软件对结果进行聚类分析、相似度评价及主成分分析。结果建立了养阴生肌肠溶胶囊HPLC指纹图谱及同时测定7个成分的方法,13批样品指纹图谱共标定25个共有峰,相似度良好(r≥0.994),聚类分析、主成分分析均将13批样品分为2类;7个成分在各自范围内线性关系良好(r≥0.9991),加样回收率为95.77%~103.80%,RSD为1.0%~2.5%。结论本研究建立的HPLC指纹图谱和含量测定方法简便可靠、重复性好,可为全面、有效地控制养阴生肌肠溶胶囊的质量提供依据。

关键词：养阴生肌肠溶胶囊指纹图谱高效液相色谱法含量测定

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儿童下呼吸道感染病原菌种类调查及并发哮喘的预测模型构建

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中国病原生物学杂志 2024年第7期19卷 768-772页

作者：徐金梅张德强王永霞张利兵扬州大学附属医院儿科江苏扬州225000

目的探讨儿童下呼吸道感染病原菌种类调查及并发哮喘的预测模型构建。方法选取2020年6月至2023年7月诊治的178例下呼吸道感染患儿作为研究对象,对所有患儿开展细菌分离培养,对分离获取的病原菌实施药物敏感试验;并根据患儿治疗期间是... 详细信息

目的探讨儿童下呼吸道感染病原菌种类调查及并发哮喘的预测模型构建。方法选取2020年6月至2023年7月诊治的178例下呼吸道感染患儿作为研究对象,对所有患儿开展细菌分离培养,对分离获取的病原菌实施药物敏感试验;并根据患儿治疗期间是否继发哮喘分为哮喘组(n=36)和非哮喘组(n=142);采用Logistic回归模型分析影响下呼吸道感染患儿继发哮喘的危险因素,并建立综合指数模型;采用ROC曲线分析综合指数预测下呼吸道感染患儿继发哮喘的AUC值、敏感度及特异度。结果 178例下呼吸道感染患儿经细菌培养分离出186株病原菌,其中革兰阳性菌共61株(32.80%),革兰阴性菌共117株(65.73%)。药敏结果显示,金黄色葡萄球菌对万古霉素无耐药性,对青霉素G的耐药率最高,其次为环丙沙星、左氟沙星;肺炎链球菌对亚胺培南、万古霉素无耐药性,对青霉素G的耐药率最高,其次为左氟沙星、苯唑西林;表皮葡萄球菌对亚胺培南、万古霉素无耐药性,对苯唑西林的耐药率最高,其次为青霉素、四环素;大肠埃希菌对亚胺培南无耐药性,对氨曲南的耐药性最高,其次为氨苄西林、头孢曲松;肺炎克雷伯菌对亚胺培南无耐药性,对美罗培南无耐药性,对氨苄西林的耐药性最高,其次为氨曲南、头孢噻肟;铜绿假单胞菌对亚胺培南无耐药性,对氨苄西林的耐药性最高,其次为头孢哌酮、头孢呋辛。哮喘组与非哮喘组在性别、年龄、下呼吸道感染病程、体质量、早产、分娩方式、喂养方式等基线资料比较中,差异无统计学意义(P>0.05);而在哮喘家族史、父母吸烟史、过敏史、IgE、CysLTs、25-(OH)D3等比较中,差异有统计学意义(P<0.05)。Logistic回归模型分析显示,哮喘家族史、父母吸烟史、过敏史及IgE、CysLTs升高和25-(OH)D3下降是影响下呼吸道感染患儿继发哮喘的危险因素(P<0.05)。综合指数预测下呼吸道感染患儿继发哮喘的AUC为0.971;敏感度为91.70%;特异度为93.70%。结论儿童下呼吸道感染以金黄色葡萄球菌、肺炎链球菌、表皮葡萄球菌、大肠埃希菌、肺炎克雷伯菌、铜绿假单胞菌多见,且哮喘家族史、父母吸烟史、过敏史及IgE、CysLTs、25-(OH)D3水平会对继发哮喘产生影响,依据这些危险因素构建综合指数模型对预测下呼吸道感染患儿继发哮喘具有较高的效能。

关键词：儿童下呼吸道感染病原菌哮喘预测模型

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