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Synergistic cytotoxicity of binary combinations of inorganic and organic disinfection byproducts assessed by real-time cell analysis

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Journal of Environmental Sciences 2022年第7期34卷 222-231页

作者： Mengge Fan Longfei Shu Xinran Zhang Miao Yu yongting du Junlang Qiu Xin Yang Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation Technology School of Environmental Science and EngineeringSun Yat-sen UniversityGuangzhou 510006China

Chlorine, chlorine dioxide, and ozone are widely used as disinfectants in drinking water treatments. However, the combined use of different disinfectants can result in the formation of various organic and inorganic disinfection byproducts(DBPs). The toxic interactions, including synergism, addition, and antagonism, among the complex DBPs are still unclear. In this study, we established and verified a real-time cell analysis(RTCA) method for cytotoxicity measurement on Chinese hamster ovary(CHO) cell. Using this convenient and accurate method, we assessed the cytotoxicity of a series of binary combinations consisting of one of the 3 inorganic DBPs(chlorite, chlorate, and bromate) and one of the 32 regulated and emerging organic DBPs. The combination index(CI) of each combination was calculated and evaluated by isobolographic analysis to reflect the toxic interactions. The results confirmed the synergistic effect on cytotoxicity in the binary combinations consisting of chlorite and one of the 5 organic DBPs(2 iodinated DBPs(I-DBPs) and 3 brominated DBPs(Br-DBPs)), chlorate and one of the 4 organic DBPs(3 aromatic DBPs and dibromoacetonitrile), and bromate and one of the 3 organic DBPs(2 I-DBPs and dibromoacetic acid). The possible synergism mechanism of organic DBPs on the inorganic ones may be attributed to the influence of organic DBPs on cell membrane and cell antioxidant system. This study revealed the toxic interactions among organic and inorganic DBPs, and emphasized the latent adverse outcomes in the combined use of different disinfectants.

关键词： Disinfection byproducts(DBPs) Real-time cell analysis(RTCA) Synergistic cytotoxicity

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Recent progress in Prussian blue electrode for electrochromic devices

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Frontiers in Energy 2024年第2期18卷 160-186页

作者： yongting ZHANG Wanzhong LI Hui GONG Qianqian ZHANG Liang YAN Hao WANG Key Laboratory for New Functional Materials of the Ministry of Education Faculty of Materials and ManufacturingBeijing University of TechnologyBeijing 100124China School of Instrument Science and Engineering Southeast UniversityNanjing 210096China Beijing Aerospace Times Laser Inertial Technology Company Beijing 100094China

Great progress has been made in the electrochromic(EC)technology with potential applications in various fields.As one of the most promising EC materials,Prussian blue(PB)has attracted great attention due to its excellent EC performance,such as low cost,easy synthesis,rich color states,chemical stability,suitable redox potential,and fast color-switching kinetics.This review summarizes the recent progress in PB electrodes and devices,including several typical preparation techniques of PB electrodes,as well as the recent key strategies for enhancing EC performance of PB electrodes.Specifically,PB-based electrochromic devices(ECDs)have been widely used in various fields,such as smart windows,electrochromic energy storage devices(EESDs),wearable electronics,smart displays,military camouflage,and other fields.Several opportunities and obstacles are suggested for advancing the development of PB-based ECDs.This comprehensive review is expected to offer valuable insights for the design and fabrication of sophisticated PBbased ECDs,enabling their practical integration into realworld applications.

关键词： Prussian blue electrochromism energy storage smart windows

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Chromosome-scale genomes of Quercus sichourensis and Quercus rex provide insights into the evolution and adaptation of Fagaceae

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Journal of Genetics and Genomics 2024年第5期51卷 554-565页

作者： Xue Liu Weixiong Zhang yongting Zhang Jing Yang Peng Zeng Zunzhe Tian Weibang Sun Jing Cai Shaanxi Key Laboratory of Qinling Ecological Intelligent Monitoring and Protection School of Ecology and EnvironmentNorthwestern Polytechnical UniversityXi'anShaanxi 710072China Yunnan Key Laboratory for Integrative Conservation of Plant Species with Extremely Small Populations Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201China

The Fagaceae,a plant family with a wide distribution and diverse adaptability,has garnered significant interest as a subject of study in plant speciation and adaptation.Meanwhile,certain Fagaceae species are regarded as highly valuable wood resources due to the exceptional quality of their wood.In this study,we present two high-quality,chromosome-scale genome sequences for Quercus sichourensis(848.75 Mb)and Quercus rex(883.46 Mb).Comparative genomics analysis reveals that the difference in the number of plant disease resistance genes and the nonsynonymous and synonymous substitution ratio(Ka/Ks)of protein-coding genes among Fagaceae species are related to different environmental adaptations.Interestingly,most genes related to starch synthesis in the investigated Quercoideae species are located on a single chromosome,as compared to the outgroup species,Fagus sylvatica.Furthermore,resequencing and population analysis of Q.sichourensis and Q.rex reveal that Q.sichourensis has lower genetic diversity and higher deleterious mutations compared to Q.rex.The high-quality,chromosome-level genomes and the population genomic analysis of the critically endangered Q.sichourensis and Q.rex will provide an invaluable resource as well as insights for future study in these two species,even the genus Quercus,to facilitate their conservation.

关键词： Adaptation Quercus sichourensis Quercusrex Chromosome-scale genome assembly Tandemduplicationgenes Extremelysmallpopulations

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Ultra-high-temperature application of MXene: Stabilization of 2D Ti_(3)C_(2)T_(x) for cross-scale strengthening and toughening of 3D TiC

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Journal of Advanced Ceramics 2024年第1期13卷 1-10页

作者： Lu Liu Guobing Ying Quanguo Jiang Dong Wen Peng Wang Meng Wu Ziying Ji yongting Zheng Xiang Wang Department of Materials Science and Engineering College of Mechanics and MaterialsHohai UniversityNanjing 211100China Key Laboratory of Superlight Materials&Surface Technology Ministry of EducationHarbin Engineering UniversityHarbin 150001China Shenzhen Key Laboratory for Advanced Materials School of Materials Science and EngineeringHarbin Institute of Technology(Shenzhen)Shenzhen 518055China Center for Composite Materials and Structures Harbin Institute of TechnologyHarbin 150001China

Transition metal carbide/nitride cores within MXenes make them considerably useful for ultra-high-temperature reinforcement.However,extensive research on Ti_(3)C_(2)T_(x) MXene has revealed its tendency to undergo a phase transition to TiCy at temperatures above 800℃due to high activity of a superficial Ti atomic layer.Herein,spark plasma sintering of Ti_(3)C_(2)T_(x) and TiC is performed to prevent the Ti_(3)C_(2)T_(x) phase transition at temperatures up to 1900℃through the fabrication of composites at a pressure of 50 MPa.Using a focused ion beam scanning electron microscope to separate layered substances in the composites and examining selected area diffraction spots in a transmission electron microscope enabled identification of non-phase-transitioned MXene.First-principles calculations based on density functional theory indicated the formation of strong chemical bonding interfaces between Ti_(3)C_(2)T_(x) and TiC,which imposed a stability constraint on the Ti atomic layer at the Ti_(3)C_(2)T_(x) surface.Mechanical performance tests,such as three-point bending and fracture toughness analysis,demonstrated that the addition of Ti_(3)C_(2)T_(x) can effectively improve the cross-scale strengthening and toughening of the TiC matrix,providing a new path for designing and developing two-dimensional(2D)carbides cross-scale-enhanced three-dimensional(3D)carbides with the same elements relying on a wide variety of MXenes.

关键词： MXene ultra-high-temperature phase stability interface bonding cross-scale strengthening and toughening structural ceramic composites

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Preliminary evidence for the presence of multiple forms of cell death in diabetes cardiomyopathy

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Acta Pharmaceutica Sinica B 2022年第1期12卷 1-17页

作者： Jinjing Wei yongting Zhao Haihai Liang Weijie du Lihong Wang Department of Endocrinology the First Affiliated Hospital of Jinan UniversityGuangzhou 510630China Department of Endocrinology the Second Affiliated Hospital of Harbin Medical UniversityHarbin 150081China Department of Pharmacology(State-Province Key Laboratories of Biomedicine-Pharmaceutics of China Key Laboratory of Cardiovascular ResearchMinistry of Education)College of PharmacyHarbin Medical UniversityHarbin 150081China

Diabetic mellitus(DM) is a common degenerative chronic metabolic disease often accompanied by severe cardiovascular complications(DCCs) as major causes of death in diabetic patients with diabetic cardiomyopathy(DCM) as the most common DCC. The metabolic disturbance in DCM generates the conditions/substrates and inducers/triggers and activates the signaling molecules and death executioners leading to cardiomyocyte death which accelerates the development of DCM and the degeneration of DCM to heart failure.Various forms of programmed active cell death including apoptosis, pyroptosis, autophagic cell death, autosis,necroptosis, ferroptosis and entosis have been identified and characterized in many types of cardiac disease.Evidence has also been obtained for the presence of multiple forms of cell death in DCM. Most importantly,published animal experiments have demonstrated that suppression of cardiomyocyte death of any forms yields tremendous protective effects on DCM. Herein, we provide the most updated data on the subject of cell death in DCM, critical analysis of published results focusing on the pathophysiological roles of cell death, and pertinent perspectives of future studies.

关键词： Diabetes mellitus Diabetic cardiomyopathy Cell death Apoptosis Autophagic cell death Aautosis Pyroptosis Necroptosis Ferroptosis

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浅谈创新让陶瓷装饰艺术呈现出旺盛的生命力——从中国画说起,以高温颜色釉彩绘装饰艺术为要点

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陶瓷研究 2024年第2期39卷 49-51页

作者：张永婷张永婷陶瓷艺术工作室景德镇333000

陶瓷是陶器和瓷器的统称,由陶到瓷的发展历程充分体现了人类的智慧和创造力。人类在制作陶瓷的过程中发现了装饰美,并通过实践创造了陶瓷装饰,且逐渐使陶瓷装饰成为一门系统的艺术。陶瓷装饰艺术是科学与艺术的结晶,是一代又一代敬仰科... 详细信息

陶瓷是陶器和瓷器的统称,由陶到瓷的发展历程充分体现了人类的智慧和创造力。人类在制作陶瓷的过程中发现了装饰美,并通过实践创造了陶瓷装饰,且逐渐使陶瓷装饰成为一门系统的艺术。陶瓷装饰艺术是科学与艺术的结晶,是一代又一代敬仰科学、敬重艺术的人们,利用科学手段和艺术手法将自己对科学和美学的追求以实体呈现的表现形式,它随着人类文明的进步,随着时代的发展,不断创新,呈现出与时代同步的旺盛的生命力。本文将从中国画说起,以高温颜色釉彩绘装饰艺术为要点,谈谈创新让陶瓷装饰艺术呈现出旺盛的生命力。

关键词：中国画创新陶瓷艺术生命力高温颜色釉彩绘装饰

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浅谈颜色釉在陶瓷装饰中的应用——从陶、釉、瓷的发明说起

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景德镇陶瓷 2024年第1期52卷 109-111页

作者：张永婷不详

在中国陶瓷装饰中,以釉装饰瓷器的历史最为悠久,从古至今延绵不断。颜色釉,随着科学技术的不断进步和人类的审美意识的不断升华,工艺不断创新,色彩不断丰富。颜色釉在陶瓷装饰中的应用,让陶瓷在实现其实用性初衷的同时,彰显了它所具有... 详细信息

在中国陶瓷装饰中,以釉装饰瓷器的历史最为悠久,从古至今延绵不断。颜色釉,随着科学技术的不断进步和人类的审美意识的不断升华,工艺不断创新,色彩不断丰富。颜色釉在陶瓷装饰中的应用,让陶瓷在实现其实用性初衷的同时,彰显了它所具有的科学性和艺术美。

关键词：陶瓷装饰颜色釉传承创新应用

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鄂尔多斯盆地延长组长72油层组陆相页岩纹层及裂缝分布特征的量化表征

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石油科学通报 2024年第1期9卷 21-34页

作者：何宗杭陆子杰李玉段永婷东北大学资源与土木工程学院沈阳110819 东北大学深部工程与智能技术研究院沈阳110819

为明确鄂尔多斯盆地延长组陆相页岩纹层及裂缝分布特征,运用高清摄像、超景深显微镜、IPP软件、分形几何学、蒙特卡罗模拟等多种手段对长72油层组陆相页岩试样纹层及裂缝进行了观测和表征。划分了亮色和暗色纹层两种类型,并通过XRD实验... 详细信息

为明确鄂尔多斯盆地延长组陆相页岩纹层及裂缝分布特征,运用高清摄像、超景深显微镜、IPP软件、分形几何学、蒙特卡罗模拟等多种手段对长72油层组陆相页岩试样纹层及裂缝进行了观测和表征。划分了亮色和暗色纹层两种类型,并通过XRD实验对亮色和暗色纹层矿物组分进行了比较。分别统计了亮色和暗色纹层在宏观、放大20倍和50倍三种观测尺度下的纹层厚度分布规律,分析了不同厚度级(1 mm以下、1~10 mm和10 mm以上)纹层平均厚度的分布规律。表征了裂缝宽度、间距和倾角的分布特征,并结合不同类型纹层分布规律,建立了陆相页岩二维细观结构模型。研究结果表明:(1)亮色纹层中矿物类型以石英、长石等脆性矿物(80%)为主,暗色纹层主要由40%的脆性矿物和40%的黏土矿物组成。(2)陆相页岩总纹层厚度与数量拟合满足指数函数关系,亮色纹层厚度与数量拟合满足幂函数关系,暗色纹层厚度与数量拟合满足对数函数关系。(3)随着观测尺度增大,薄纹层(1 mm以下)出现频率增高,中等纹层(1~10 mm)和厚纹层(10 mm以上)出现频率均降低,且不同类型纹层厚度级与相应纹层平均厚度的对数值间呈现出线性关系,纹层厚度分布具有分形特征。(4)裂缝宽度分布在细观尺度范围内,宽度均值和标准差分别为0.271 mm和0.114 mm,分布较集中,裂缝间距的均值和标准差为8.115 mm和8.448 mm,分布较均匀,裂缝倾角的绝对值与数量拟合满足对数函数。相关研究成果可为纹层状陆相页岩的地质结构模型建立提供基础数据和方法参考。

关键词：陆相页岩纹层类型多尺度分形维数细观裂缝

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癌症治疗相关高血压患者血压管理的证据总结

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中国护理管理 2024年第6期24卷 886-891页

作者：魏永婷席祖洋田书梅彭家芹三峡大学第一临床医学院/宜昌市中心人民医院手术室湖北省宜昌市443003 三峡大学第一临床医学院/宜昌市中心人民医院护理部湖北省宜昌市443003 三峡大学第一临床医学院/宜昌市中心人民医院心内科湖北省宜昌市443003

目的:系统检索并汇总国内外癌症治疗相关高血压患者血压管理的相关证据,为临床护理实践提供参考。方法:按照6S模型,在循证指南网站及相关数据库中系统检索关于癌症治疗相关高血压患者血压管理的证据总结、临床决策、推荐实践、指南、系... 详细信息

目的:系统检索并汇总国内外癌症治疗相关高血压患者血压管理的相关证据,为临床护理实践提供参考。方法:按照6S模型,在循证指南网站及相关数据库中系统检索关于癌症治疗相关高血压患者血压管理的证据总结、临床决策、推荐实践、指南、系统评价、专家共识、科学立场声明等,检索时限为建库至2024年1月。对纳入文献进行质量评价并提取、总结、形成证据。结果:共纳入16篇文献,其中指南6篇、专家共识5篇、临床决策1篇、系统评价1篇、科学立场声明3篇,从建立多学科团队、风险评估及预防、血压监测、治疗及管理策略4个方面形成了27条证据。结论:该研究总结了癌症治疗相关高血压患者血压管理的证据,医护人员在证据应用时可充分考虑临床实际情境及循证证据,不断完善血压管理方案,改善患者结局。

关键词：肿瘤癌症高血压血压管理证据总结循证护理

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亚稀褶红菇对SD大鼠肾功能的影响

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菌物学报 2024年第4期43卷 130-137页

作者：叶建方刘泳廷刘佳朱凯吴长艳郑冲贵州省疾病预防控制中心贵州贵阳550004

以SD大鼠为研究对象,用霍恩氏法(Horn法)计算亚稀褶红菇的半数致死剂量(LD50),测定亚稀褶红菇对大鼠尿素氮(BUN)、肌酐(CREA)、钾(K)、钠(Na)、氯(Cl)、白细胞(WBC)计数及分类、尿蛋白、尿糖和潜血水平的影响,并对左侧肾脏进行病理学观... 详细信息

以SD大鼠为研究对象,用霍恩氏法(Horn法)计算亚稀褶红菇的半数致死剂量(LD50),测定亚稀褶红菇对大鼠尿素氮(BUN)、肌酐(CREA)、钾(K)、钠(Na)、氯(Cl)、白细胞(WBC)计数及分类、尿蛋白、尿糖和潜血水平的影响,并对左侧肾脏进行病理学观察。亚稀褶红菇对雌性SD大鼠的LD50及95%可信区间(95%CI)为271(169–441)mg/kg,雄性SD大鼠的LD50及95%CI为233(143–378)mg/kg;与对照组比,各亚稀褶红菇组SD大鼠BUN、CREA、K、WBC计数、中性粒细胞比例、尿蛋白、尿糖和潜血的发生率及严重程度均增加;各亚稀褶红菇组SD大鼠Na和Cl均降低;各亚稀褶红菇组大鼠SD肾小管坏死,表现为上皮细胞空泡变性和水样变性,刷状缘消失,管腔内可见脱落的上皮细胞;且随着亚稀褶红菇剂量的增加,各指标变化更显著。亚稀褶红菇可导致SD大鼠肾损伤,并呈剂量反应关系。

关键词：毒菌半数致死剂量(LD50) 血常规尿常规肾病理改变

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