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Global cold-chain related SARS-CoV-2 transmission identified by pandemic-scale phylogenomics

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Zoological Research 2022年第5期43卷 871-874页

作者： Dalang yu Junwei Zhu Jianing Yang Yi-Hsuan Pan Hailong Mu Ruifang Cao Bixia tang Guangya Duan Zi-Qian hao Long Dai Guo-Ping Zhao Ya-Ping Zhang Wenming Zhao guoqing Zhang Haipeng Li National Genomics Data Center&Bio-Med Big Data Center CAS Key Laboratory of Computational BiologyShanghai Institute of Nutrition and HealthChinese Academy of SciencesShanghai 200031China National Genomics Data Center Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China Key Laboratory of Brain Functional Genomics of Ministry of Education School of Life ScienceEast China Normal UniversityShanghai 200062China State Key Laboratory of Genetic Resources and Evolution Yunnan Laboratory of Molecular Biology of Domestic AnimalsKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China Key Laboratory of Synthetic Biology CAS Center for Excellence in Molecular Plant SciencesInstitute of Plant Physiology and EcologyChinese Academy of SciencesShanghai 200032China School of Life and Health Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhouZhejiang 310024China Shanghai Southgene Technology Co.Ltd Shanghai 201203China University of Chinese Academy of Sciences Beijing 100049China

DEAR EDITOR,The COVID-19 pandemic caused by SARS-CoV-2 continues to pose a tremendous threat to human society. SARS-CoV-2is airborne and transmits primarily through social contact;however, whether cold chain-related transmission has occurred remains highly debated(Han & Liu, 2022;Lewis,2021;Ma et al., 2021;Mallapaty et al., 2021;Pang et al.,2020;wu et al., 2021). Here, we present a novel method and identify two transmission routes based on lineage-specific reductions in the SARS-CoV-2 evolutionary rate.

关键词： primarily EDIT identif

CTP-HBcAg_(18-27)-Tapasin联合佐剂CpG ODN免疫转基因小鼠的免疫应答研究

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中国临床药理学与治疗学 2018年第3期23卷 271-276页

作者：吴姗姗唐余燕陈小华张毅王洁玲汤正好臧国庆余永胜上海交通大学附属第六人民医院感染病科上海200233

目的:观察以非甲基化寡聚脱氧核苷酸基序(CpG oligodeoxynucleotides,CpG ODN)为佐剂联合融合蛋白胞质转导肽(CTP)-HBc Ag18-27-Tapasin免疫乙型病毒性肝炎(hepatitis B virus,HBV)转基因小鼠的免疫反应。方法:HBV转基因小鼠随机分为5组... 详细信息

目的:观察以非甲基化寡聚脱氧核苷酸基序(CpG oligodeoxynucleotides,CpG ODN)为佐剂联合融合蛋白胞质转导肽(CTP)-HBc Ag18-27-Tapasin免疫乙型病毒性肝炎(hepatitis B virus,HBV)转基因小鼠的免疫反应。方法:HBV转基因小鼠随机分为5组,实验组:CTP-HBc Ag18-27-Tapasin+CpG ODN组,对照组:CTP-HBc Ag18-27-Tapasin,干扰素(IFN-α)组,CpG ODN组,空白组为生理盐水组。融合蛋白及CpG ODN经肌肉注射免疫小鼠,流式细胞仪检测病毒特异性T细胞反应(HBV-specific cytotoxic T cell,CTL)变化,全自动免疫分析仪检测血清乙肝表面抗原(hepatitis B virus surface antigen,HBs Ag)水平,ELISA检测T淋巴细胞培养上清白介素(IL)-2、γ-干扰素(IFN-γ)水平,实时荧光定量PCR(real time quantitative polymerase chain reaction,q RT-PCR)检测HBV DNA水平,免疫组化观察HBV转基因小鼠肝脏中HBs Ag水平。结果:CTP-HBc Ag18-27-Tapasin+CpG ODN组中IFN-γ+CD8+双阳性T细胞百分比增高,细胞培养上清IL-2、IFN-γ水平升高,肝脏病理显示炎性细胞增多,免疫组化显示HBs Ag表达水平明显下降,同时对血清HBs Ag及HBV DNA水平进行比较,CTP-HBc Ag18-27-Tapasin有明显抑制作用。结论:CpG-ODN作为佐剂可以增强融合蛋白CTP-HBc Ag18-27-Tapasin诱导的HBV转基因小鼠抗病毒免疫应答。

关键词：胞质转导肽抗病毒反应佐剂

乙型肝炎病毒抗原表位特异性细胞毒性T细胞研究进展

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国际流行病学传染病学杂志 2017年第4期44卷 266-269页

作者：吴姗姗唐余燕王洁玲陈小华张毅汤正好臧国庆余永胜上海交通大学附属第六人民医院感染科 200233

急性乙型肝炎患者体内有特异性和多克隆性的CTLs，而慢性乙型肝炎患者体内CTLs很少，只能识别单一抗原表位，因此病毒抗原表位特异性CTL免疫应答不足与HBV的慢性化有关。深入了解HBV抗原特异性CTLs的产生及其在病毒清除中的作用能够为... 详细信息

急性乙型肝炎患者体内有特异性和多克隆性的CTLs，而慢性乙型肝炎患者体内CTLs很少，只能识别单一抗原表位，因此病毒抗原表位特异性CTL免疫应答不足与HBV的慢性化有关。深入了解HBV抗原特异性CTLs的产生及其在病毒清除中的作用能够为新的抗病毒手段提供理论基础。

关键词： T淋巴细胞细胞毒性表位免疫治疗

单纯抗菌药物治疗和联合手术治疗对感染性心内膜炎患者预后的影响

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中华传染病杂志 2022年第10期40卷 591-596页

作者：吴娜顾艳婷陈小华奚敏江红汤正好臧国庆余永胜张毅上海交通大学附属第六人民医院感染病科上海200233 上海交通大学附属第六人民医院超声科上海200233

目的探讨单纯抗菌药物治疗和抗菌药物联合手术治疗对感染性心内膜炎(infective endocarditis, IE)患者预后的影响。方法纳入2011年6月至2021年5月于上海交通大学附属第六人民医院就诊的240例IE患者, 收集其临床资料及预后情况。按治疗... 详细信息

目的探讨单纯抗菌药物治疗和抗菌药物联合手术治疗对感染性心内膜炎(infective endocarditis, IE)患者预后的影响。方法纳入2011年6月至2021年5月于上海交通大学附属第六人民医院就诊的240例IE患者, 收集其临床资料及预后情况。按治疗方式分成单纯抗菌药物治疗组和抗菌药物联合手术治疗组, 比较两组的临床特征及预后, 探讨IE患者的手术时机, 分析两种治疗方式对IE患者预后的影响。统计学分析采用Wilcoxon秩和检验、χ2检验、Kaplan-Meier生存分析和Cox回归分析。结果 240例IE患者中, 单纯抗菌药物治疗组63例, 抗菌药物联合手术治疗组177例。倾向性评分匹配后, 抗菌药物联合手术治疗组1年内病死率为11.1%(4/36), 低于单纯抗菌药物治疗组的33.3%(12/36), 差异有统计学意义(χ2=5.14, P=0.023)。IE患者手术后左室射血分数、左室舒张末期直径、左室短轴缩短率的中位数分别为59%、47 mm、31%, 低于手术前的63%、54 mm、34%, 差异均有统计学意义(Z=6.19、9.36、6.11, 均P0.050)。抗菌药物联合手术治疗组1年累积生存率为94.9%, 高于单纯抗菌药物治疗组的83.2%, 差异有统计学意义(χ2=7.38, P=0.007)。心力衰竭、Pitt菌血症评分≥4分是IE患者1年全因死亡的独立危险因素[风险比(hazard ratio,HR)=5.668、19.392, 均P<0.050], 住院天数、抗菌药物联合手术治疗是降低IE患者1年全因死亡风险的独立相关因素(HR=0.931、0.299, 均P<0.050), 其中Pitt菌血症评分≥4分对IE患者1年预后的影响最大。结论手术治疗可显著改善IE患者的心功能及1年预后。对于心力衰竭、Pitt菌血症评分≥4分的IE患者, 应积极治疗。

关键词：感染性心内膜炎抗菌药物治疗手术治疗预后

The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients

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Science China(Life Sciences) 2016年第9期59卷 930-939,938-939+932-937页

作者： Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan yu Weiping Lu Chenguang wu Li Qian Jiancheng yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang guoqing Han Chunrong Xu yun Xie Minmin An Wei Zhang Zhixiao Wang yun Cai Qi Fu yu Fu Shuai Zheng Fan Yang Qingfang Hu hao Dai yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping yu Jinxiong She Mei Zhang Tao Yang Department of Endocrinology and Metabolism First Affiliated Hospital of Nanjing Medical University Nanjing 210029 China Barbara Davis Center for Childhood Diabetes University of Colorado Denver Aurora Colorado 80045 USA Key Laboratory of Human Functional Genomics of Jiangsu Province Nanjing Medical University Nanjing 210000 China Department of Isotopic Laboratory of Nanjing Medical University Nanjing 210000 China HLA Laboratory of Jiangsu Province People's Hospital Nanjing 210029 China Department of Endocrinology and Metabolism Nanjing General Hospital of Nanjing Military Command Nanjing 210002 China Department of Endocrinology and Metabolism Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School Nanjing 210008 China Department of Endocrinology and Metabolism Zhongda Hospital Southeast University Nanjing 210009 China Department of Endocrinology and Metabolism Nanjing First Hospital Nanjing 210000 China Department of Endocrinology and Metabolism Nanjing Children's Hospital Nanfing 210008 China Department of Endocrinology and Metabolism The Second Affiliated Hospital of Nanjing Medical University Nanjing 210011 China Department of Endocrinology and Metabolism Nanjing Governmental Hospital Nanjing 210008 China Department of Endocrinology and Metabolism Northern Jiangsu People's Hospital Yangzhou 225001 China Department of Endocrinology and Metabolism Wuxi People's Hospital Wuxi 214023 China Department of Endocrinology and Metabolism Jiangsu Jiangyin People's Hospital Wuxi 214400 China Department of Endocrinology and Metabolism The Affiliated Hospital of Xuzhou Medical College Xuzhou 221006 China Department of Endocrinology and Metabolism Xuzhou Central Hospital Xuzhou 221009 China Department of Endocrinology and Metabolism The First Affiliated Hospital of Soochow University Suzhou 215006 China Department of Endocrinology and Metabolism The Second Affiliated Hospital of Soochow University Suzhou 215004 China Department of Endocri

Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus.

关键词： autoantibodies heterogeneity islet failure type 1 diabetes

Feasibility and physics potential of detecting ^(8)B solar neutrinos at JUNO

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Chinese Physics C 2021年第2期45卷 93-110页

作者： Angel Abusleme Thomas Adam Shakeel Ahmad Sebastiano Aiello Muhammad Akram Nawab Ali Fengpeng An Guangpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste Andrej Babic Wander Baldini Andrea Barresi Eric Baussan Marco Bellato Antonio Bergnoli Enrico Bernieri David Biare Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Max Buesken Mario Buscemi Jose Busto Ilya Butorov Anatael Cabrera hao Cai Xiao Cai Yanke Cai Zhiyan Cai Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Jinfan Chang yun Chang Pingping Chen Po-An Chen Shaomin Chen Shenjian Chen Xurong Chen Yi-Wen Chen Yixue Chen yu Chen Zhang Chen Jie Cheng Yaping Cheng Alexander Chepurnov Davide Chiesa Pietro Chimenti Artem Chukanov Anna Chuvashova Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Salvatore Costa Flavio Dal Corso Christophe De La Taille Jiawei Deng Zhi Deng Ziyan Deng Wilfried Depnering Marco Diaz Xuefeng Ding Yayun Ding Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Georgy Donchenko Jianmeng Dong Damien Dornic Evgeny Doroshkevich Marcos Dracos Frédéric Druillole Shuxian Du Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Lukas Fajt Donghua Fan Lei Fan Can Fang Jian Fang Marco Fargetta Anna Fatkina Dmitry Fedoseev Vladko Fekete Li-Cheng Feng Qichun Feng Richard Ford Andrey Formozov Amélie Fournier haonan Gan Feng Gao Alberto Garfagnini Alexandre Göttel Christoph Genster Marco Giammarchi Agnese Giaz Nunzio Giudice Franco Giuliani Maxim Gonchar Guanghua Gong Hui Gong Oleg Gorchakov yuri Gornushkin Marco Grassi Christian Grewing Maxim Gromov Vasily Gromov Minghao Gu Xiaofei Gu yu Gu Mengyun Guan Nunzio Guardone Maria Gul Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo yuhang Guo Paul Hackspacher Caren Hagner Ran Han Yan Yerevan Physics Institute YerevanArmenia UniversitéLibre de Bruxelles BrusselsBelgium Universidade Estadual de Londrina LondrinaBrazil Pontificia Universidade Catolica do Rio de Janeiro RioBrazil Pontificia Universidad Católica de Chile SantiagoChile Universidad Tecnica Federico Santa Maria ValparaisoChile Beijing Institute of Spacecraft Environment Engineering BeijingChina Beijing Normal University BeijingChina China Institute of Atomic Energy BeijingChina Institute of High Energy Physics BeijingChina North China Electric Power University BeijingChina School of Physics Peking UniversityBeijingChina Tsinghua University BeijingChina University of Chinese Academy of Sciences BeijingChina Jilin University ChangchunChina College of Electronic Science and Engineering National University of Defense TechnologyChangshaChina Chongqing University ChongqingChina Dongguan University of Technology DongguanChina Jinan University GuangzhouChina Sun Yat-Sen University GuangzhouChina Harbin Institute of Technology HarbinChina University of Science and Technology of China HefeiChina The Radiochemistry and Nuclear Chemistry Group in University of South China HengyangChina wuyi University JiangmenChina Shandong University JinanChina Institute of Modern Physics Chinese Academy of SciencesLanzhouChina Nanjing University NanjingChina Guangxi University NanningChina East China University of Science and Technology ShanghaiChina School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghaiChina Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghaiChina Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai University TianjinChina wuhan University WuhanChina Xi’an Jiaotong University Xi’anChina Xiamen University XiamenChina School of Physics and Microelectronics Zhengzhou UniversityZhengzhouChina Institute of Physics National Chiao-Tung University Hsinchu National United University Miao-Li Department of Physics National T

The Jiangmen Underground Neutrino Observatory(JUNO)features a 20 kt multi-purpose underground liquid scintillator sphere as its main *** of JUNO's features make it an excellent location for^8B solar neutrino measurements,such as its low-energy threshold,high energy resolution compared with water Cherenkov detectors,and much larger target mass compared with previous liquid scintillator *** this paper,we present a comprehensive assessment of JUNO's potential for detecting^8B solar neutrinos via the neutrino-electron elastic scattering process.A reduced 2 MeV threshold for the recoil electron energy is found to be achievable,assuming that the intrinsic radioactive background^(238)U and^(232)Th in the liquid scintillator can be controlled to 10^(-17)g/*** ten years of data acquisition,approximately 60,000 signal and 30,000 background events are *** large sample will enable an examination of the distortion of the recoil electron spectrum that is dominated by the neutrino flavor transformation in the dense solar matter,which will shed new light on the inconsistency between the measured electron spectra and the predictions of the standard three-flavor neutrino oscillation *** m^(2)_(21)=4.8times10^(-5);(7.5times10^(-5))eV^(2),JUNO can provide evidence of neutrino oscillation in the Earth at approximately the 3sigma(2sigma)level by measuring the non-zero signal rate variation with respect to the solar zenith ***,JUNO can simultaneously measureDelta m^2_(21)using^8B solar neutrinos to a precision of 20% or better,depending on the central value,and to sub-percent precision using reactor antineutrinos.A comparison of these two measurements from the same detector will help understand the current mild inconsistency between the value of Delta m^2_(21)reported by solar neutrino experiments and the KamLAND experiment.

关键词： neutrino oscillation solar neutrino JUNO

Sub-percent precision measurement of neutrino oscillation parameters with JUNO

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Chinese Physics C 2022年第12期46卷 28-49页

作者： Angel Abusleme Thomas Adam Shakeel Ahmad Rizwan Ahmed Sebastiano Aiello Muhammad Akram Abid Aleem Fengpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste Weidong Bai Nikita Balashov Wander Baldini Andrea Barresi Davide Basilico Eric Baussan Marco Bellato Antonio Bergnoli Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Jose Busto Ilya Butorov Anatael Cabrera Barbara Caccianiga hao Cai Xiao Cai Yanke Cai Zhiyan Cai Riccardo Callegari Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Chi Chan Jinfan Chang yun Chang Guoming Chen Pingping Chen Po-An Chen Shaomin Chen Xurong Chen Yixue Chen yu Chen Zhiyuan Chen Zikang Chen Jie Cheng Yaping Cheng yu Chin Cheng Alexey Chetverikov Davide Chiesa Pietro Chimenti Artem Chukanov Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Flavio Dal Corso Olivia Dalager Christophe De La Taille Zhi Deng Ziyan Deng Wilfried Depnering Marco Diaz Xuefeng Ding Yayun Ding Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Dmitry Dolzhikov Georgy Donchenko Jianmeng Dong Evgeny Doroshkevich Marcos Dracos Frédéric Druillole Ran Du Shuxian Du Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Donghua Fan Lei Fan Jian Fang Wenxing Fang Marco Fargetta Dmitry Fedoseev Zhengyong Fei Li-Cheng Feng Qichun Feng Richard Ford Amélie Fournier haonan Gan Feng Gao Alberto Garfagnini Arsenii Gavrikov Marco Giammarchi Nunzio Giudice Maxim Gonchar Guanghua Gong Hui Gong yuri Gornushkin Alexandre Göttel Marco Grassi Vasily Gromov Minghao Gu Xiaofei Gu yu Gu Mengyun Guan yuduo Guan Nunzio Guardone Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo yuhang Guo Paul Hackspacher Caren Hagner Ran Han Yang Han Miao He Wei He Tobias Heinz Patrick Hellmuth yuekun Heng Rafael Herrera yuenKeung Ho Yerevan Physics Institute YerevanArmenia UniversiéLibre de Bruxelles BrusselsBelgium Universidade Estadual de Londrina LondrinaBrazil Pontificia Universidade Catolica do Rio de Janeiro Rio de JaneiroBrazil Pontificia Universidad Católica de Chile SantiagoChile Universidad Tecnica Federico Santa Maria ValparaisoChile Beijing Institute of Spacecraft Environment Engineering BeijingChina Beijing Normal University BeijingChina China Institute of Atomic Energy BeijingChina Institute of High Energy Physics BeijingChina North China Electric Power University BeijingChina School of Physics Peking UniversityBeijingChina Tsinghua University BeijingChina University of Chinese Academy of Sciences BeijingChina Jilin University ChangchunChina College of Electronic Science and Engineering National University of Defense TechnologyChangshaChina Chongqing University ChongqingChina Dongguan University of Technology DongguanChina Jinan University GuangzhouChina Sun Yat-Sen University GuangzhouChina Harbin Institute of Technology HarbinChina University of Science and Technology of China HefeiChina The Radiochemistry and Nuclear Chemistry Group in University of South China HengyangChina wuyi University JiangmenChina Shandong University JinanChinaand Key Laboratory of Particle Physics and Particle Irradiation of Ministry of EducationShandong UniversityQingdaoChina Institute of Modern Physics Chinese Academy of SciencesLanzhouChina Nanjing University NanjingChina Guangxi University NanningChina East China University of Science and Technology ShanghaiChina School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghaiChina Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghaiChina Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai University TianjinChina wuhan University WuhanChina Xi'an Jiaotong University Xi'anChina Xiamen University XiamenChina School of Physics and Microelectronics Zhengzhou UniversityZhengzhou

JUNO is a multi-purpose neutrino observatory under construction in the south of *** publication presents new sensitivity estimates for the measurement of the △m_(31)^(2),△m_(21)^(2),sin^(2)θ_(12),and sin^(2)θ_(13) oscillation parameters using reactor antineutrinos,which is one of the primary physics goals of the *** sensitivities are obtained using the best knowledge available to date on the location and overburden of the experimental site,the nuclear reactors in the surrounding area and beyond,the detector response uncertainties,and the reactor antineutrino spectral shape constraints expected from the TAO satellite *** is found that the △m_(21)^(2) and sin^(2)θ_(12) oscillation parameters will be determined to 0.5%precision or better in six years of data *** the same period,the △m_(31)^(2) parameter will be determined to about 0.2%precision for each mass ordering *** new precision represents approximately an order of magnitude improvement over existing constraints for these three parameters.

关键词： neutrino oscillation reactor antineutrino precision measurement JUNO

骨质疏松性椎体压缩骨折椎体强化术后康复治疗指南(2022版)

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中华创伤杂志 2022年第11期38卷 961-972,F0003页

作者：许正伟郝定均程黎明贺宝荣陈伯华陈晨陈飞陈建陈其昕杜良杰范顺武方忠冯世庆高延征关海山官众江华姜为民蒋电明蒋军蒋阅贺利军贺园李波李涛李建军李喜功梁益建林斌刘斌刘波刘勇刘志斌卢旭华马超钱列全仁夫桑宏勋申海波舒均孙宏慧孙天胜谭军唐明星陶笙滕红林田耘田纪伟王强王新伟吴建煌谢沛根许卫红颜滨杨勇殷国勇于晓兵曾玉红张国庆张晓勃赵杰朱悦西安交通大学附属红会医院西安710054 同济大学附属同济医院上海200065 青岛大学附属医院青岛266000 山西白求恩医院太原030032 中南大学湘雅二医院长沙410012 银川国龙医院银川750003 浙江大学医学院附属第二医院杭州310003 中国康复研究中心北京100068 浙江大学医学院邵逸夫医院杭州310016 华中科技大学同济医学院附属同济医院武汉430030 天津医科大学总医院天津300052 河南省人民医院郑州450003 山西医科大学第二医院太原030031 青海大学附属医院西宁810001 广西医科大学第一附属医院南宁530021 苏州大学附属第一医院苏州215006 重庆医科大学附属第三医院重庆401120 南京鼓楼医院南京210008 辽宁省人民医院沈阳110067 西安市第五人民医院西安710082 贵州省人民医院贵阳550499 四川大学华西医院成都610044 浙江大学医学院附属第一医院杭州310003 成都市第三人民医院成都610014 联勤保障部队第九○九医院漳州363099 内蒙古医科大学附属医院呼和浩特010107 北京积水潭医院北京100035 西藏自治区人民医院拉萨850010 延安大学附属医院延安716099 海军军医大学第二附属医院上海200003 徐州市中心医院徐州221009 上海交通大学医学院附属仁济医院上海200120 浙江中医药大学附属江南医院(萧山中医院) 杭州311201 南方医科大学深圳医院深圳518101 北京市顺义区医院北京101312 昆明医科大学第二附属医院昆明650106 中国人民解放军总医院第七医学中心北京100026 同济大学附属东方医院上海200120 中南大学湘雅医院长沙410008 中国人民解放军总医院海南分院三亚572013 温州医科大学附属第一医院温州325015 北京大学第三医院北京100191 南京江北医院南京210044 宜兴市人民医院宜兴214221 中山大学附属第三医院广州510630 福建医科大学附属第一医院福州350004 深圳市第二人民医院深圳518025 郑州市骨科医院郑州450015 江苏省人民医院南京210029 大连大学附属中山医院大连116001 上海交通大学医学院附属第九人民医院上海200011 中国医科大学附属第一医院沈阳110001

骨质疏松性椎体压缩骨折(OVCF)可导致患者腰背部疼痛,严重者可伴发侧后凸畸形、神经功能损伤等并发症,影响患者日常活动能力和生活质量。椎体强化术是治疗OVCF的有效方法,但椎体强化术并不能纠正骨代谢失衡,无法改善骨质疏松状态,术后... 详细信息

骨质疏松性椎体压缩骨折(OVCF)可导致患者腰背部疼痛,严重者可伴发侧后凸畸形、神经功能损伤等并发症,影响患者日常活动能力和生活质量。椎体强化术是治疗OVCF的有效方法,但椎体强化术并不能纠正骨代谢失衡,无法改善骨质疏松状态,术后常发生腰背痛、脊柱活动受限及椎体再骨折等并发症。术后系统、规范的康复治疗可提高疗效和骨质疏松症的治疗效果、降低椎体再骨折发生风险、增加患者依从性、提高患者生存质量。但目前缺乏针对OVCF椎体强化术后康复治疗的相关临床治疗指南,导致治疗方法混杂、治疗效果参差不齐。为了规范OVCF椎体强化术后的康复治疗,中国医师协会骨科医师分会脊柱创伤学组牵头并组织相关专家,借鉴美国骨科医师协会(AAOS)公布的相关临床指南,遵循科学性、实用性和先进性原则,制订了《骨质疏松性椎体压缩骨折椎体强化术后康复治疗指南(2022版)》,针对OVCF患者椎体强化术后康复治疗的10个相关重要问题提出基于循证医学证据的建议。

关键词：骨质疏松脊柱骨折骨折压缩性康复指南椎体强化术

严重创伤患者紧急救治血液保障模式与输血策略中国专家共识(2024版)

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中华创伤杂志 2024年第10期40卷 865-881页

作者：卢尧李阳张雷英唐昊敬慧丹王耀丽贾向志巴立卞茂红蔡丹蔡辉蔡晓红查占山陈秉宇陈大庆陈凤陈国安陈海鸣陈静陈敏陈青陈舒陈玺程金凤褚晓凌崔红旺崔欣达珍戴莹邓素容董伟群范为民冯珂付丹晖付涌水傅奇傅雪梅甘佳甘新宇高伟巩怀证桂嵘郭庚韩宁郝一文何武兵洪强侯瑞琴侯卫胡婕胡培阳胡熙胡晓玉黄光斌黄婕黄象艳黄远帅浑守永蒋学兵金平赖冬乐爱平黎红梅李碧娟李翠莹李代红李海宏李贺李辉李剑平李宁李喜莹李湘民李小飞李晓娟李志强李忠俊李尊严梁华钦梁晓华廖冬发廖群廖燕林甲进刘春霞刘凤华刘培贤刘铁梅刘小信刘志伟刘中砥陆华栾建凤骆建军骆群吕定丰吕琪吕先萍马爱军马立强马曙轩马现君马小刚马晓莉毛国庆穆士杰聂少林欧阳淑娟欧阳锡林潘春球潘健潘晓华彭磊彭涛钱宝华乔姝秦莉任颖任召祺戎瑞明苏常山孙明伟孙文武孙振威唐海平唐晓峰唐长玖陶翠华田志彬汪娟王宝燕王春燕王革非王海燕王鸿捷王鹏王鹏里王秋实王晓宁王新华王学锋王勇王勇军王远杰王志华韦少俊魏亚明文键波文军吴江吴巨峰夏爱军夏飞夏荣谢珏邢颜超熊雁徐峰徐永柱许永安晏永和燕备战杨江杨江存杨军杨新文杨勇毅姚春艳叶明亮尹昌林尹明尹文于连玲于淑红余泽波郁毅刚喻安永袁红袁燚张婵张进军张军张凯张磊冰张泉张荣江张三明张生吉张硕张伟张伟东张晰张兴文章桂喜章晓军赵国庆赵建鹏赵树铭郑蓓蓓郑山根周华友周吉成周砺宏周谋周小玉周雪莲周源周政周祖皇朱海燕朱培元朱长举祝丽丽王正国蒋建新汪德清兰炯采王全立于洋张连阳文爱清中华医学会临床输血学分会中华医学会创伤学分会创伤急救与多发伤学组中华医学会灾难医学分会青年学组陆军军医大学陆军特色医学中心重庆400042 陆军军医大学陆军特色医学中心创伤与化学中毒全国重点实验室重庆400042 中国人民解放军总医院第一医学中心北京100853 军事医学研究院卫生勤务与血液研究所北京100850 浙江大学医学院附属第二医院杭州310009 安徽医科大学第一附属医院合肥230022 湘潭市中心医院湘潭411100 中国医学科学院北京协和医学院输血研究所成都610052 上海交通大学医学院附属瑞金医院上海200025 海军军医大学第一附属医院上海200433 浙江省人民医院杭州310014 温州医科大学附属第二医院温州325027 内蒙古自治区人民医院呼和浩特010017 武汉市血液中心武汉430030 南昌大学第一附属医院南昌330006 河北医科大学第三医院石家庄050051 乌鲁木齐市血液中心乌鲁木齐830000 南京大学医学院附属鼓楼医院南京210008 浙江省血液中心杭州310052 重庆两江新区人民医院重庆401121 株洲市中心医院株洲412000 福建省疾病预防控制中心福州350012 海南医学院第一附属医院海口570102 贵州省血液中心贵阳550001 西藏自治区血液中心拉萨850000 中国人民解放军联勤保障部队第九二〇医院昆明650000 重庆医科大学附属永川医院重庆402160 昆明医科大学第一附属医院昆明650032 江西省血液中心南昌330052 宁夏医科大学总医院银川750001 福建医科大学附属协和医院福州350001 广州市第一人民医院广州510080 重庆市血液中心重庆400015 成都市血液中心成都610042 中国医学科学院北京协和医院北京100730 中国人民解放军西部战区总医院成都610083 华中科技大学同济医学院附属同济医院武汉430030 山东省血液中心济南250014 中南大学湘雅三医院长沙410013 山西医科大学第一医院太原030001 上海同济大学附属东方医院上海200120 中国医科大学附属第一医院沈阳110001 福建省立医院福州350001 厦门大学附属第一医院厦门361003 北京大学人民医院北京100044 青海省血液中心西宁810007 浙江省天台县人民医院天台317200 昆明市儿童医院昆明650228 安徽省血液中心合肥230031 重庆大学附属中心医院重庆市急救医疗中心重庆400014 湖南省人民医院(湖南师范大学附属第一医院) 长沙410001 中国人民解放军联勤保障部队第九六〇医院济南250031 西南医科大学附属医院泸州646000 山东第一医科大学附属省立医院济南250021 中国人民解放军总医院第六医学中心北京100048 余姚市人民医院余姚315400 厦门医学院附属第二医院厦门361005 重庆市垫江县人民医院重庆408300 中南大学湘雅医院长沙410008 空军军医大学空军特色医学中心北京100142 天津市第一中心医院天津300192 山西省中西医结合医院太原030013 安徽医科大学第二附属医院合肥230601 辽宁省血液中心沈阳110044 中国医学科学院肿瘤医院北京100021 首都医科大学附属北京友谊医院北京100050 兰州大学第二医院兰州730030 上海市第六人民医院上海201599 陆军军医大学第二附属医院重庆400037 北华大学附属医院吉林132000 广州血液中心广州510095 大连市血液中心大连116001 广西医科大学第三附属医院南宁530007 兰州大学第一医院兰州730030 哈尔滨医科大学附属第一医院哈尔滨150010 山西医科大学第二医院太原030000 吉林大学中日联谊医院长春130062 山东第一医科大学第一附属医院(山东省千佛山医院) 济南250013 浙江大学医学院附属邵逸夫医院杭州310016 重庆医科大学附属第二医院重庆400010 中国人民解放军东部战区总医院南京210002 中国人民解放军联勤保障部队第九〇三医院杭州310013 中国人民解放军总医院第五医学中心北京100071 宁波大学附属第一医院宁波315010 天津大学应急医学研究院天津300072 郑州大学第一附属医院郑州450052 河北省血液中心石家庄050004 中国人民解放军联勤保障部队第九〇〇医院福州350025 首都医科大学附属北京儿童医院北京100045 山东大学齐鲁医院济南250012 西藏自治区人民医院拉萨850000 河南省红十字血液中心郑州450012 荆州市中心血站荆州434099 空军军医大学第二附属医院西安710038 株洲市中心血站株洲412007 湖南省肿瘤医院/中南大学湘雅医

严重创伤患者对救治时效性要求极高,输血在此类患者的紧急救治阶段发挥着不可替代的作用。越来越多的循证医学证据和临床经验表明,早期输注低效价O型全血或平衡比例红细胞、血浆和血小板等成分血的止血复苏策略将使严重创伤大出血患者... 详细信息

严重创伤患者对救治时效性要求极高,输血在此类患者的紧急救治阶段发挥着不可替代的作用。越来越多的循证医学证据和临床经验表明,早期输注低效价O型全血或平衡比例红细胞、血浆和血小板等成分血的止血复苏策略将使严重创伤大出血患者获益。然而,当前国内血液保障模式不能完全满足临床对严重创伤患者紧急救治输血的时效性和有效性需求。针对我国严重创伤紧急救治血液保障模式与输血策略中存在的关键问题,中华医学会临床输血学分会、中华医学会创伤学分会创伤急救与多发伤学组和中华医学会灾难医学分会青年学组组织国内输血医学和创伤救治专家,基于循证医学证据并结合Delphi法专家咨询投票,共同制订《严重创伤患者紧急救治血液保障模式与输血策略中国专家共识(2024版)》,从血液保障模式和输血策略两个方面共提出10条推荐意见,为严重创伤紧急救治阶段的输血复苏提供参考,以期进一步提高严重创伤患者的救治成功率。

关键词：创伤和损伤急救输血专家共识