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T1 theorem for Besov and Triebel-Lizorkin spaces

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Science China mathematics 2005年第5期48卷 657-665页

作者： DENG Donggao & han yongsheng department of mathematics, Zhongshan university, Guangzhou 510275, China department of mathematics, auburn university, alabama, 36849, usa Dept. of Math. Zhongshan Univ. Guangzhou 510275 China Dept. of Math. Auburn Univ. Alabama 36849 United States

Using the discrete Calderon type reproducing formula and the PlancherelPolya characterization for the Besov and Triebel-Lizorkin spaces, the T1 theorem for the Besov and Triebel-Lizorkin spaces was proved.

关键词： T1 theorem Besov and Triebel-Lizorkin spaces Calderon reproducing formula Plancherel-Polya inequalities.

Phomaketals A and B,pentacyclic meroterpenoids from a eupC overexpressed mutant strain of Phoma sp.

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Chinese Chemical Letters 2024年第7期35卷 350-354页

作者： Chuan Li Yangyang han Yanan Zhai Ke Li Xingzhong Liu Zhuan Zhang Cai Jia yongsheng Che NHC Key Laboratory of Biotechnology of Antibiotics Institute of Medicinal BiotechnologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China State Key Laboratory of Toxicology&Medical Countermeasures Beijing Institute of Pharmacology&ToxicologyBeijing 100850China department of Microbiology College of Life SciencesNankai UniversityTianjin 300071China

Phomaketals A(1)and B(2),two tropolonic meroterpenoids with the unprecedented pentacyclic skeletons,were isolated from the solid-substrate fermentation cultures of a eupC overexpressed mutant strain of the fungus Phoma sp.,together with a biogenetically related secondary metabolite pughiinin B(3),and the known one noreupenifeldin B(4).The structures of 1–3 were elucidated primarily by nuclear magnetic resonance(NMR)*** absolute configurations of 1 and 2 were assigned by electronic circular dichroism calculations and the calculated NMR with DP4+analysis,while that of 3 was established by single-crystal X-ray diffraction analysis using Cu Kα***,phomaketals A(1)and B(2)could be derived from the hypothetical tropolonic sesquiterpene intermediates neosetophomone B(6)and 9-R-neosetophomone B(6),respectively,via different reactions *** 1 showed antiproliferative effect only against the SUPB15 cells,with an 50%inhibitory concentration(IC50)value of 4.85μmol/L,while the co-isolated known meroterpenoid 4 displayed potent effects against three tumor cell lines,SUPB15,EL4,and H9,showing IC50values of 0.36–27.08μmol/L.

关键词： Phoma sp. Tropolonic sesquiterpenes Biosynthetic pathways Hetero-Diels–Alder Cytotoxicity

Geometry and Hardy spaces on spaces of homogeneous type in the sense of Coifman and Weiss

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Science China mathematics 2017年第11期60卷 2199-2218页

作者： han YanChang han yongsheng LI Ji School of Mathematical Sciences South China Normal University department of mathematics Auburn University department of mathematics Macquarie University

It is known that the space of homogeneous type introduced by Coifman and Weiss(1971) provides a very natural setting for establishing a theory of Hardy spaces. This paper concentrates on how the geometrical conditions of the space of homogeneous type play a crucial role in building a theory of Hardy spaces via the Littlewood-Paley functions.

关键词： spaces of homogeneous type Hardy space singular integrals Carleson measure space BMO

Surface and internal magnetic domain structures of Fe-Ga alloy rods

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Science China(Technological Sciences) 2013年第1期56卷 36-39页

作者： han YuNan LI yongsheng han XiuFeng YU DunBo School of Physics and Electronic Science Hunan University of Science and Technology National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of Sciences Grirem Advanced Materials Co. LtdGeneral Research Institute for Nonferrous Metals

The magnetic domain structures of the 100 oriented Fe 81 Ga 19 polycrystalline alloys with rapid quenching(RQ) and post-annealing(PA) thermal treatments are investigated by using magnetic force microscopy(MFM).The surfaces of the RQ alloy rods take on the dendritic domains after undergoing a standard mechanical *** after PA processing,the distinct domain structures are observed at different *** wide stripe-like domain patterns appear in the surface of those PA rods at 550°C while the ramous domains remain at 400°C annealing.X-ray diffraction patterns indicate that a thin iron layer is formed on the surface of the specimens annealed at higher *** soft magnetic iron layer,actually acting as a shield for the stray fields emerging from the internal magnetic structures underneath,brings about the presentation of the wide internal domains.

关键词： Galfenol polycrystal magnetic force microscopy magnetic domains thermal treatment magnetostriction

膝关节骨性关节炎轻症患者膝关节三维有限元建模及力学分析

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中国医学物理学杂志 2024年第3期41卷 382-388页

作者：周陶勇杨永盛鲁宁唐浩杨延东韩谢川昆明理工大学机电工程学院云南昆明650500 昆明医科大学第二附属医院骨科云南昆明650500

目的:在缺少层厚较薄的CT和MRI数据的情况下建立膝关节骨性关节炎(KOA)轻症患者膝关节三维有限元模型,并研究胫骨平台内外侧的应力分布。方法:以一名患有轻度KOA的女性患者为研究对象,自盆骨至腓骨胫骨远端进行连续断层扫描。将得到的DI... 详细信息

目的:在缺少层厚较薄的CT和MRI数据的情况下建立膝关节骨性关节炎(KOA)轻症患者膝关节三维有限元模型,并研究胫骨平台内外侧的应力分布。方法:以一名患有轻度KOA的女性患者为研究对象,自盆骨至腓骨胫骨远端进行连续断层扫描。将得到的DICOM格式文件导入至Mimics软件中并通过阈值分割提取膝关节中的骨性结构,将提取出的骨骼进行蒙版编辑、空腔填充、区域增长等操作后导入3-matic中做光顺、包覆处理。在Geomagic Wrap将处理后的骨性结构使用网格医生检查,修复表面缺陷并拟合曲面。以轮廓延展的思路建立相关的软骨、半月板和韧带,并在SolidWorks中以原点重合的方式与骨性结构进行装配。接下来在ANSYS软件中定义材料、设置接触、划分网格、设置约束和载荷,分析在双腿站立下胫骨平台上的应力分布情况。结果:成功建立了包括骨性结构、软骨、韧带的完整膝关节模型。在双腿站立状态下,接触应力峰值约为1.21 MPa,位于胫骨平台内侧中部,胫骨平台外侧的最大应力为0.72 MPa,内外侧间室分别承担总载荷的62.7%和37.3%。结论:通过CT提取加软件绘制的方式建立了全膝关节模型,有限元分析结果符合临床预期,通过此方法建立的模型可靠,能进行后续的研究。

关键词：膝关节骨性关节炎膝关节有限元建模生物力学

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肿瘤坏死因子α诱导蛋白8样分子1在小鼠急性肝损伤中的作用及机制

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新乡医学院学报 2024年第8期41卷 712-717页

作者：常勇生田雪钦赵雨欣宋苗苗王涵娄运伟常廷民新乡医学院第一附属医院消化内科河南卫辉453100 河南省免疫与靶向药物重点实验室河南新乡453003 河南省分子诊断与医学检验技术协同创新中心河南新乡453003

目的探讨肿瘤坏死因子α诱导蛋白8样分子1(TNFAIP8L1)在小鼠急性肝损伤中的作用及机制。方法选择C57BL/6J雄性野生型(WT)小鼠和C57BL/6J雌性TNFAIP8L1^(+/-)小鼠杂交繁殖的第2代TNFAIP8L1^(+/-)小鼠和WT小鼠,进一步自交繁殖出第3代雄性T... 详细信息

目的探讨肿瘤坏死因子α诱导蛋白8样分子1(TNFAIP8L1)在小鼠急性肝损伤中的作用及机制。方法选择C57BL/6J雄性野生型(WT)小鼠和C57BL/6J雌性TNFAIP8L1^(+/-)小鼠杂交繁殖的第2代TNFAIP8L1^(+/-)小鼠和WT小鼠,进一步自交繁殖出第3代雄性TNFAIP8L1^(-/-)小鼠和第3代WT雄性小鼠。分别取5只正常第3代雄性WT小鼠和5只正常第3代雄性TNFAIP8L1^(-/-)小鼠,检测比较2种正常小鼠的血清丙氨酸氨基转移酶(ALT)水平,苏木精-伊红(HE)染色观察2种正常小鼠肝组织中炎症细胞浸润及细胞坏死情况,采用流式细胞术检测2种正常小鼠肝组织髓系细胞亚群中性粒细胞(Neu)、嗜酸性粒细胞(EOS)、树突状细胞(DC)、骨髓来源的巨噬细胞(BMDMs)、骨髓来源的单核细胞(BMNCs)所占百分比。另取5只第3代雄性WT小鼠和4只第3代雄性TNFAIP8L1^(-/-)小鼠,采用脂多糖(LPS)/D-半乳糖胺(D-Gal)诱导制备急性肝损伤小鼠模型,24 h后采取上述方法检测比较2种急性肝损伤小鼠血清ALT水平,观察2种急性肝损伤小鼠肝组织中炎症细胞浸润及细胞坏死情况,并检测2种急性肝损伤小鼠肝组织髓系细胞亚群Neu、EOS、DC、BMDMs、BMNCs所占百分比。结果正常WT小鼠和TNFAIP8L1^(-/-)组小鼠肝组织中髓系细胞亚群Neu、EOS、DC、BMDMs、BMNCs百分比及血清ALT水平比较差异无统计学意义(P>0.05)。正常WT小鼠和TNFAIP8L1^(-/-)小鼠的肝组织HE染色结果均显示肝小叶结构完整清晰,肝细胞形态正常、排列整齐,无明显炎症细胞浸润及细胞坏死。急性肝损伤24 h后,TNFAIP8L1^(-/-)小鼠肝组织髓系细胞亚群中Neu、BMNCs百分比及血清ALT水平显著高于WT小鼠(P0.05)。急性肝损伤WT小鼠肝组织中肝小叶结构模糊,肝细胞肿胀、散在空泡样脂肪变性,有少量炎症细胞浸润。急性肝损伤TNFAIP8L1^(-/-)小鼠肝组织中肝小叶结构几乎不存在,肝细胞损伤严重且大量坏死,并有大量炎症细胞浸润。结论TNFAIP8L1基因缺陷不影响小鼠肝组织中髓系细胞的发育和小鼠肝脏稳态。TNFAIP8L1在急性肝损伤的发生发展过程中起抑制作用。TNFAIP8L1基因缺陷加重LPS/D-Gal诱导的急性肝损伤,有可能是通过增加Neu和BMNCs浸润而招募其他类型的免疫细胞浸润入肝组织,从而加重肝细胞的坏死。

关键词：肿瘤坏死因子α诱导蛋白8样分子1 急性肝损伤中性粒细胞单核细胞

Geochemistry and Zircon U-Pb Geochronology of Early Paleozoic S-type Granites in the Eastern Qilian Block,Northwest China

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Acta Geologica Sinica(English Edition) 2021年第2期95卷 439-458页

作者： LIU Xiuting LI Binkai han Jilong REN Erfeng GAO Donglin DU yongsheng REN Qianhui ZhanG Yan Key Laboratory of Comprehensive and Highly Efficient Utilization of Salt Lake Resources Qinghai Institute of Salt LakesChinese Academy of SciencesXining 810008China Key Laboratory of Salt Lake Geology and Environment of Qinghai Province Qinghai Institute ofSalt LakesChinese Academy of SciencesXining 810008China university ofChinese Academy of Sciences Beijing 100049China College of Chemical and Pharmaceutical Engineering(Hebei) University of Science and TechnologyShijiazhuang 050018China department of Geological Engineering Qinghai UniversityXining 810016China department of Water Conservancy and Electric Power Qinghai UniversityXining 810016China Qinghai Province Nonferrous Metals Third Geological Exploration Institute Xining 810012China

The Qilian Block(QB)is a Precambrian micro-continent located in the northeastern Qinghai–Tibet *** Lower Paleozoic granitic magmatic rocks crop out in the QB.A new integrated study of zircon U-Pb ages and systematic whole-rock geochemical data for the Xindian,Dongjiazhuang and Xiaogaoling granites in the eastern segment of the QB constrains their emplacement ages,petrogenesis,and regional evolutionary history.U-Pb dating reveals that the Xindian granite was emplaced 454 Ma,and both the Dongjiazhuang and Xiaogaoling granites were emplaced ca.440 *** study shows that all granites belong to the high-K calc-alkaline to shoshonitic series and are S-type granites formed by partial melting of continental crust,mainly *** infer that these ca.454–445 Ma granites formed in a syn-collisional setting during the continental collisional between the Qaidam and Qilian blocks.

关键词： geochemistry geochronology petrogenesis syn-collision Qilian Block NW China

A Novel Image Retrieval Model

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A Novel Image Retrieval Model

Engineering of a NIR-activable hydrogel-coated mesoporous bioactive glass scaffold with dual-mode parathyroid hormone derivative release property for angiogenesis and bone regeneration

2002年第6届信号处理国际会议

作者： JunWei han Lei Guo and yongsheng Bao department of Automatic Control Northwestern Polytechnical university Xi’an China

＜正＞ Image retrieval is the hot point of researchers in many domains. Traditional text-based query methods use caption and keywords to annotate and retrieval image databases, which often consumes a mass of human labor. Feature vector based retrieval methods only can provide the query by example, and can ’t provide retrieval on semantic level. In this paper, we propose a novel image retrieval model that combines good qualities of those two methods above-mentioned. It utilizes the image low-level features and the user relevance feedback mechanism to classify images and acquire high-level semantic information. Furthermore, the image classification and the semantic information arc not fixed, which can be changed by the user according to his preference. Experiments show that our scheme can achieve high efficiency.

关键词： Image retrieval image classification relevance feedback mechanism semantic information.

来源： cnki会议评论

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Bioactive Materials 2023年第8期26卷 1-13页

作者： Shi Liu Zhengzhe han Ji-Na Hao Dapeng Zhang Xianglong Li Yuanyuan Cao Jinghuan Huang yongsheng Li Lab of Low-Dimensional Materials Chemistry Key Laboratory for Ultrafine Materials of Ministry of EducationFrontier Science Center of the Materials Biology and Dynamic ChemistryShanghai Engineering Research Center of Hierarchical NanomaterialsSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai200237China department of Orthopedic Surgery and Shanghai Institute of Microsurgery on Extremities Shanghai Jiao Tong University Affiliated Sixth People’s Hospital600 Yishan RoadShanghai200233PR China Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan School of Chemistry and Chemical EngineeringShihezi UniversityShihezi832003China

Osteogenesis,osteoclastogenesis,and angiogenesis play crucial roles in bone *** hormone(PTH),an FDA-approved drug with pro-osteogenic,pro-osteoclastogenic and proangiogenic capabilities,has been employed for clinical osteoporosis treatment through systemic intermittent ***,the successful application of PTH for local bone defect repair generally requires the incorporation and delivery by appropriate *** several scaffolds have been developed to deliver PTH,they suffer from the weaknesses such as uncontrollable PTH release,insufficient porous structure and low mechanical ***,a novel kind of NIR-activable scaffold(CBP/MBGS/PTHrP-2)with dual-mode PTHrP-2(a PTH derivative)release capability is developed to synergistically promote osteogenesis and angiogenesis for high-efficacy bone regeneration,which is fabricated by integrating the PTHrP-2-loaded hierarchically mesoporous bioactive glass(MBG)into the N-hydroxymethylacrylamide-modified,photothermal agent-doped,poly(N-isopropylacrylamide)-based thermosensitive hydrogels through assembly *** on/off NIR irradiation,the thermoresponsive hydrogel gating undergoes a reversible phase transition to allow the precise control of on-demand pulsatile and long-term slow release of PTHrP-2 from MBG *** NIR-activated dual-mode delivery of PTHrP-2 by this scaffold enables a well-maintained PTHrP-2 concentration at the bone defect sites to continually stimulate vascularization and promote osteoblasts to facilitate and accelerate bone *** vivo experiments confirm the significant improvement of bone reparative effect on critical-size femoral defects of *** work paves an avenue for the development of novel dual-mode delivery systems for effective bone regeneration.

关键词： Parathyroid hormone Dual-mode release Thermosensitive hydrogel Angiogenesis Bone regeneration