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Physical-property cutoffs of tight reservoirs by field and laboratory experiments: a case study from Chang 6, 8–9 in Ordos Basin

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Frontiers of Earth Science 2021年第2期15卷 471-489页

作者： Bingbing SHI Xiangchun CHANG Zhongquan LIU Ye LIU Tianchen GE Pengfei ZHANG yongrui wang Yue wang Lixin MAO College of Earth Science and Engineering Shandong University of Science and TechnologyQingdao 266590China Laboratory for Marine Mineral Resources Pilot National Laboratory for Marine Science and TechnologyQingdao 266071China Petroleum Exploration and Development Research Institute Shengli Oilfield Company of SINOPECDongying 257015China Jiangsu Design Institute of Geology for Mineral Resources Xuzhou 221006China

Tight sandstone reservoirs are generally characterized by complex reservoir quality,non-Darcy flow,and strong *** utilized for evaluating physical property cutoffs of conventional reservoirs maybe ***,a comprehensive investigation on physical property cutoffs of tight sandstone reservoirs is crucial for the reserve evaluation and successful *** this study,a set of evaluation approaches take advantage of field operations(i.e.,core drilling,oil testing,and wireline well logging data),and simulation experiments(i.e.,high-pressure mercury injection-capillary pressure(MICP)experiment,oil-water relative permeability experiment,nuclear magnetic resonance(NMR)experiment,and biaxial pressure simulation experiment)were comparatively optimized to determine the physical property cutoffs of effective reservoirs in the Upper Triassic Chang 6,Chang 8 and Chang 9 oil layers of the Zhenjing *** results show that the porosity cutoffs of the Chang 6,Chang 8,and Chang 9 oil layers are 7.9%,6.4%,and 8.6%,and the corresponding permeability are 0.08 mD,0.05 mD,and 0.09 mD,*** with wireline well logging,mud logging,and oil testing,the cut-off of the thickness of single-layer effective reservoirs are approximately 3.0 m,3.0 m,and 2.0 m,*** on the cutoffs of critical properties,a superimposed map showing the planar distribution of the prospective targets can be mapped,which may delineate the effective boundary of prospective targets for petroleum exploration of tight sandstone reservoirs.

关键词： tight sandstone reservoirs cutoffs of petrophysical property field operations simulation experiments Yanchang Formation Ordos Basin

Tight sandstone reservoir sensitivity and damage mechanism analysis: A case study from Ordos Basin, China and implications for reservoir damage prevention

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Energy Geoscience 2022年第4期3卷 394-416页

作者： Zhongquan Liu Bingbing Shi Tianchen Ge Fenggui Sui Yue wang Pengfei Zhang Xiangchun Chang Ye Liu yongrui wang Zhaoyang wang Petroleum Exploration and Development Research Institute Shengli Oilfield Company of SINOPECDongying257015China College of Earth Science and Engineering Shandong University of Science and TechnologyQingdaoShandong266590China Institute of Western Frontier Area Shengli Oilfield CompanySINOPECDongying257000China Laboratory for Marine Mineral Resources Qingdao National Laboratory for Marine Science and TechnologyQingdao266071China

Analysis of reservoir sensitivity to velocity,water,salt,acid,alkali and stress is critical for reservoir *** study the tight sandstone reservoir sensitivity at different formation depths(effective stress)and formation water conditions(pH,salinity,and fluid velocity),a series of dynamic core flow tests under different pH,salinity,acid,and effective stress conditions were performed on samples from tight sandstone reservoirs of the Upper Triassic Yanchang 8(T_(3)y^(8))Member and conventional reservoirs of the Middle-Lower Jurassic Yan'an 9(J_(1-2)y^(9))Member in the Ordos *** results indicate that,compared with the conventional reservoirs,the tight sandstone reservoirs are more sensitive to velocity and stress,less sensitive to water,alkali and salinity,and respond better to acid *** addition,the critical conditions(salinity,velocity,pH,and stress)for pumping drilling,completion,and fracturing fluids into tight sandstone reservoirs were investigated.A combination of scanning electron microscopy coupled with energy-dispersive spectrometry(SEM-EDS),cathodoluminescence(CL),casting thin section(CTS)and nuclear magnetic resonance(NMR)images,high-pressure mercury injection capillary pressure(MICP)measurements as well as X-ray fluorescence spectral(XRF)analyses were employed to analyze the damage mechanisms of the conventional reservoirs(J_(1-2)y^(9))and tight sandstone reservoirs(T_(3)y^(8))caused by fluid *** results suggest that reservoir sensitivity is primarily conditioned by the composition of detrital components and interstitial fillings,petrophysical properties,pore-throat structure,and diagenetic *** these factors control the sensitivity types and extent of the *** results indicate that the poorer the reservoir physical properties,the stronger the reservoir heterogeneity and sensitivity,implying that tight sandstone reservoirs are more susceptible to changes in fluids than conventional *** study offer

关键词： Formation damage prevention Reservoir sensitivity Tight sandstone reservoir Yanchang Formation Ordos basin

输尿管软镜与经皮肾镜碎石术在肾结石治疗中的对比研究

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泌尿外科杂志（电子版） 2024年第1期16卷 25-28页

作者：向习文谭奎张旭杨春娇朱冠向凯严飞王永瑞建始县中医医院外三科湖北恩施445300 建始县中医医院麻醉科湖北恩施445300

目的对比观察输尿管软镜碎石术(retrograde intrarenal surgery,RIRS)与经皮肾镜碎石术(percutaneous nephrolithotomy,PCNL)在肾结石治疗中的应用效果。方法选取2021年1—12月建始县中医医院收治的52例肾结石患者进行研究,按照不同手... 详细信息

目的对比观察输尿管软镜碎石术(retrograde intrarenal surgery,RIRS)与经皮肾镜碎石术(percutaneous nephrolithotomy,PCNL)在肾结石治疗中的应用效果。方法选取2021年1—12月建始县中医医院收治的52例肾结石患者进行研究,按照不同手术方法分为观察组与对照组,每组26例。观察组行RIRS治疗,对照组行PCNL治疗。比较两组手术相关指标、应激反应指标、疼痛程度、舒适状况、肾功能、不良反应及清石率。结果观察组手术下床活动、住院时间短于对照组,且术中出血量少于对照组,差异有统计学意义(P0.05)。结论RIRS具有更为显著的优势,可显著改善肾功能,减轻疼痛,缩短康复时间,且安全性更高。

关键词：输尿管软镜碎石术经皮肾镜碎石术肾结石

Genomic features for adaptation and evolutionary dynamics of four major Asian domestic carps

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Science China(Life Sciences) 2024年第6期67卷 1308-1310页

作者： Cheng wang Liandong Yang yongrui Lu Chengchi Fang Xiaoni Gan Yiyu Chen Shunping He State Key Laboratory of Freshwater Ecology and Biotechnology Institute of HydrobiologyChinese Academy of SciencesWuhan 430072China University of Chinese Academy of Sciences Beijing 100049China Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunming 650223China Academy of Plateau Science and Sustainability Qinghai Normal UniversityXining 810016China National Natural Science Foundation of China Beijing 100085China

Dear Editor,The coexistence of various species in a shared natural environment often results in the differentiation of their ecological niches,as they adapt to specific ecological roles(Jani?ováet al.,2018),this process leads to the development of distinct phenotypic traits and dietary preferences(Li et al.,2021).Studying this adaptive evolution,the four major Asian domestic carps,namely Ctenopharyngodon idella(grass carp),Mylopharyngodon piceus(black carp).

关键词： Asian evolutionary ecological

Sucrose-associated SnRK1a1-mediated phosphorylation of Opaque2 modulates endosperm filling in maize

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Molecular Plant 2024年第5期17卷 788-806页

作者： Tao Yang Yunqin Huang Longyu Liao Shanshan wang Haoyu Zhang Jingying Pan Yongcai Huang Xiaoling Li Di Chen Tao Liu Xiaoduo Lu yongrui Wu State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China Sichuan Agricultural UniversityChengdu 611130SichuanChina National Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant SciencesShanghai lnstitute of Plant Physiology and EcologyChinese Academy of SciencesShanghai 200032China Institute of Molecular Breeding for Maize Qilu Normal UniversityJinanChina

During maize endosperm filling,sucrose not only serves as a source of carbon skeletons for storage-reserve synthesis but also acts as a stimulus to promote this ***,the molecular mechanisms underlying sucrose and endosperm filling are poorly *** this study,we found that sucrose promotes the expression of endosperm-filling hub gene Opaque2(O2),coordinating with storage-reserve *** showed that the protein kinase SnRK1a1 can attenuate O2-mediated transactivation,but sucrose can release this *** assays revealed that SnRK1a1 phosphorylates O2 at serine 41(S41),negatively affecting its protein stability and transactivation *** observed that mutation of SnRK1a1 results in larger seeds with increased kernel weight and storage reserves,while overexpression of SnRK1a1 causes the opposite *** of the native O2(O2-OE),phospho-dead(O2-SA),and phospho-mimetic(O2-SD)variants all increased 100-kernel *** O2-SA seeds exhibit smaller kernel size,they have higher accumulation of starch and proteins,resulting in larger vitreous endosperm and increased test weight.O2-SD seeds display larger kernel size but unchanged levels of storage reserves and test weight.O2-OE seeds show elevated kernel dimensions and nutrient storage,like a mixture of O2-SA and O2-SD ***,our study discovers a novel regulatory mechanism of maize endosperm *** of S41 as a SnRK1-mediated phosphorylation site in O2 offers a potential engineering target for enhancing storage-reserve accumulation and yield in maize.

关键词： maize Opaque2 SnRK1 endosperm phosphorylation sucrose

传统工业大锅与小锅炒制羊肉臊子挥发性风味物质差异分析

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食品科学 2021年第14期42卷 180-186页

作者：柏霜王永瑞罗瑞明宁夏大学农学院宁夏银川750021

研究羊肉臊子传统工业大锅与小锅炒制过程中挥发性化合物变化规律,测定炒制过程中不同加工阶段挥发性化合物的变化。采用电子鼻测定炒制各阶段气味强度,顶空固相微萃取气相色谱-质谱联用技术对挥发性化合物进行定量分析。结果表明:在整... 详细信息

研究羊肉臊子传统工业大锅与小锅炒制过程中挥发性化合物变化规律,测定炒制过程中不同加工阶段挥发性化合物的变化。采用电子鼻测定炒制各阶段气味强度,顶空固相微萃取气相色谱-质谱联用技术对挥发性化合物进行定量分析。结果表明:在整体气味感知上,采用电子鼻可以区分炒制各加工阶段的气味。气相色谱-质谱方法检测出炒制羊肉臊子传统工业大锅104种,小锅171种挥发性化合物,醛类、醇类、酮类是羊肉臊子的主要挥发性化合物。通过电子鼻技术和气相色谱-质谱相结合的方法,可以较好区分工业大锅与小锅炒制滩羊肉臊子,为智能风味炒制机的研发提供了理论依据。

关键词：炒制羊肉臊子气相色谱-质谱法电子鼻挥发性化合物

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C2C电子商务市场整体卖家信用分布研究

情报杂志 2012年第5期31卷 122-127页

作者：彭惠王永瑞北京邮电大学经济管理学院北京100876

随着人们对网上购物的接受程度逐步提高,C2C电子商务越来越火爆。然而由于网络的虚拟性和开放性以及买卖双方的不对称使得诚信成为制约电子商务发展的瓶颈,大部分电子商务平台都采取信用评价体系来解决这一问题,但是效果却不尽如人意。... 详细信息

随着人们对网上购物的接受程度逐步提高,C2C电子商务越来越火爆。然而由于网络的虚拟性和开放性以及买卖双方的不对称使得诚信成为制约电子商务发展的瓶颈,大部分电子商务平台都采取信用评价体系来解决这一问题,但是效果却不尽如人意。旨在调查现有信用评价体系下的市场整体卖家信分布和结构,发现卖家在各信用等级上的分布曲线呈现出凸向原点的特征,而且随着时间的演进这种趋势愈加明显。通过理论分析我们认为形成倒金字塔形总体信用度分布的根源在于基于交易量的累积信用积分的评级制度、电子商务市场规模的加速增长、市场选择下信用等级和交易量之间的正反馈效应。随着市场规模的扩大,它已不能客观反映卖家诚信,并具有鼓励卖家采取信用炒作等非诚信行为的特点。最后提出了评价体系的改进建议。

关键词： C2C电子商务信用评级体系信用分布演进分析改进建议

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纳米分子筛在炼油和石油化工中的应用

催化学报 2013年第1期34卷 69-79页

作者：慕旭宏王殿中王永睿林民程时标舒兴田中国石化石油化工科学研究院石油化工催化材料与反应工程国家重点实验室北京100083

介绍了纳米ZSM-5分子筛的合成及其在直馏汽油非临氢改质中的应用、纳米β分子筛的合成及其在苯与乙烯液相烷基化中的应用、纳米空心钛硅分子筛(HTS)的合成及其在环己酮氨肟化过程中的应用以及纳米Silicalite-1分子筛的合成及其在环己酮... 详细信息

介绍了纳米ZSM-5分子筛的合成及其在直馏汽油非临氢改质中的应用、纳米β分子筛的合成及其在苯与乙烯液相烷基化中的应用、纳米空心钛硅分子筛(HTS)的合成及其在环己酮氨肟化过程中的应用以及纳米Silicalite-1分子筛的合成及其在环己酮肟气相贝克曼重排生产己内酰胺中的应用,并简要综述了上述纳米分子筛合成和应用方面的最新研究进展. 结果表明,对于炼油和石油化工中易结焦失活的催化反应过程,分子筛的纳米化可抑制催化剂快速失活,延长催化剂寿命.

关键词：纳米分子筛 ZSM-5 β 钛硅分子筛 Silicalite-1 汽油改质乙苯己内酰胺

Novel Pt(IV) complex OAP2 induces STING activation and pyroptosis via mitochondrial membrane remodeling for synergistic chemo-immunotherapy

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1742-1758页

作者： Renming Fan Ruizhuo Lin Shuo Zhang Aohua Deng yongrui Hai Junyan Zhuang Yang Liu Maosheng Cheng Gaofei Wei Institute of Medical Research Northwestern Polytechnical UniversityXi'an 710072China Research&Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen 518057China Key Laboratory of Structure-Based Drug Design and Discovery Ministry of EducationSchool of Pharmaceutical EngineeringShenyang Pharmaceutical UniversityShenyang 110016China

Mitochondrial membrane remodeling can trigger the release of mitochondrial DNA (mtDNA), leading to the activation of cellular oxidative stress and immune responses. While the role of mitochondrial membrane remodeling in promoting inflammation in hepatocytes is well-established, its effects on tumors have remained unclear. In this study, we designed a novel Pt(IV) complex, OAP2, which is composed of oxaliplatin (Oxa) and acetaminophen (APAP), to enhance its anti-tumor effects and amplify the immune response. Our findings demonstrate that OAP2 induces nuclear DNA damage, resulting in the production of nuclear DNA. Additionally, OAP2 downregulates the expression of mitochondrial Sam50, to promote mitochondrial membrane remodeling and trigger mtDNA secretion, leading to double-stranded DNA accumulation and ultimately synergistically activating the intracellular cGAS-STING pathway. The mitochondrial membrane remodeling induced by OAP2 overcomes the limitations of Oxa in activating the STING pathway and simultaneously promotes gasdermin-D-mediated cell pyroptosis. OAP2 also promotes dendritic cell maturation and enhances the quantity and efficacy of cytotoxic T cells, thereby inhibiting cancer cell proliferation and metastasis. Briefly, our study introduces the first novel small-molecule inhibitor that regulates mitochondrial membrane remodeling for active immunotherapy in anti-tumor research, which may provide a creative idea for targeting organelle in anti-tumor therapy.

关键词： Anti-tumor drug Prodrug Platinum Chemo-immunotherapy Mitochondrial membrane modeling STING Pyroptosis mtDNA