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Elevated serum uric acid level as a predictor for cardiovascu-lar and all-cause mortality in Chinese patients with high cardiovascular risk

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Journal of Geriatric Cardiology 2008年第1期5卷 15-20页

作者： yongquan wu meijing li jue li yingyi luo yan xing dayi hu Heart Lung and Blood Vessel CenterTongji UniversityShanghai 200092China HeartLung and Blood Vessel CenterTongji UniversityShanghai 200092China HeartLung and Blood Vessel CenterTongji UniversityShanghai 200092China HeartLung and Blood Vessel CenterTongji UniversityShanghai 200092China HeartLung and Blood Vessel CenterTongji UniversityShanghai 200092China HeartLung and Blood Vessel CenterTongji UniversityShanghai 200092China

Objective To assess the predictive value of serum uric acid levels for cardiovascular and all-cause mortality in a large prospective population based *** The study was based on 3648 participants in Shanghai and Beijing,who were inpatients with high cardiovascular(CV) risk at baseline (2004.7 to 2005.1),and blood was ***-up for death from cardiovascular disease and any cause was complete until January 1,*** The mean follow-up was 1 *** were 303 deaths during follow-up,of which 121 were *** mortality rates were 8.3 % for all patients,6.8% for female patients (116/1715),and 9.7% (187/1933) for male *** men,patients in the lower and higher uric acid groups had increased cardiac and overall mortality risks compared with patients in the normal uric acid *** relation was found in women but not statistically *** adjusting for other conventional risk factors (age,diabetes,hypertension,diuretic use and smoking),baseline uric acid level was still associated with increased risk for death from cardiovascular disease (P=0.005),or death from all causes (P=0.014) Conclusion Our data suggest that abnormal serum uric acid levels are independently and significantly associated with risk of cardiovascular and all-cause mortality.(J Geriatr Cardiol 2008;5:15-20)

关键词： epidemiology uric acid cardiovascular mortality all-cause mortality

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