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Dipeptides VL increase protein accumulation in C2C12 cells by activating the Akt-mTOR pathway and inhibiting the NF-κB pathway

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Food Bioscience 2022年第1期45卷 122-130页

作者： Mingliang Li Ying Wei Zhiyuan Feng Muyi cai Yaguang Xu Ruizeng Gu yongqing Ma Xingchang Pan Beijing Engineering Research Center of Protein&Functional Peptides China National Research Institute of Food and Fermentation IndustriesBeijing 100015PR China

The Akt-mTOR signaling pathway plays a central role in regulating intracellular protein metabolism,and the NF-κB signaling pathway plays a vital role in developing skeletal muscle *** this study,we took the three dipeptides Val-Leu(VL),Leu-Leu(LL),and Leu-Gln(LQ)identified from corn peptides as the research objects and proved that peptides could promote C2C12 cell differentiation and protein synthesis by activating the Akt-mTOR signaling *** the other hand,the dipeptides also inhibited the classical pathway of the NF-κB signaling pathway,down-regulated the expression of two E3 ubiquitin ligases MAFbx and MURF-1,attenuated apoptosis induced by TNF-α,and thus inhibited protein degradation in *** conclusion,the dipeptides isolated from corn peptides showed the effect of increasing protein accumulation in skeletal muscle,suggesting the application potential of corn peptides in promoting the growth of skeletal muscle *** addition,this experiment compared the different characteristics of the effects of the dipeptide VL and its corresponding amino acid mixture on the Akt-mTOR signaling pathway.

关键词： VL C2C12 Akt-mTOR NF-κB Skeletal muscle

Nanog、Sox2、TFF3在肠型胃癌中的表达及其与肠型胃癌预后关系的研究

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癌症进展 2018年第1期16卷 73-76页

作者：张咏梅范丽昕蔡永清朴正爱王海周易董华承李萍大连市第三人民医院肿瘤科辽宁大连1160300

目的探讨Nanog、Sox2、TFF3在肠型胃癌中的表达及其与肠型胃癌预后的关系。方法回顾性分析60例肠型胃癌患者的临床资料,应用免疫组化法检测Nanog、Sox2、TFF3在肠型胃癌患者中的表达情况,分析其表达情况与患者临床病理特征及预后的关系... 详细信息

目的探讨Nanog、Sox2、TFF3在肠型胃癌中的表达及其与肠型胃癌预后的关系。方法回顾性分析60例肠型胃癌患者的临床资料,应用免疫组化法检测Nanog、Sox2、TFF3在肠型胃癌患者中的表达情况,分析其表达情况与患者临床病理特征及预后的关系。结果 60例肠型胃癌患者中,Nanog高表达者38例(63.3%)、TFF3高表达者33例(55.0%),Sox2低表达者35例(58.3%)。单因素分析结果显示,Nanog、TFF3、Sox2的表达情况与肠型胃癌患者的肿瘤浸润深度、淋巴结转移情况及TNM分期有关(P﹤0.05),与肠型胃癌患者的年龄、性别、肿瘤部位无关(P﹥0.05)。多因素分析结果显示,Nanog、Sox2、TFF3的表达情况与肠型胃癌患者的无病生存期和总生存期有关,同时具有Nanog高表达、TFF3高表达、Sox2低表达的肠型胃癌患者预后最差。结论Nanog、Sox2、TFF3可成为评价肠型胃癌患者预后的生物标志物,联合检测更利于判断肠型胃癌患者的预后。

关键词：肠型胃癌 Nanog Sox2 TFF3

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月桂胺从盐酸介质中萃取Au(Ⅲ)

山东师范大学学报（自然科学版） 1997年第1期12卷 46-48页

作者：韩景田柴金岭鲁建军蔡永青滨州医学院基础部山东师范大学化学系

研究了月桂胺（Ｂ）的三氯甲烷溶液从盐酸介质中对ＡｕＣｌ－４的萃取，确定了萃合物的组成为ＢＨ＋·ＡｕＣｌ－４，测得ｌｇＫｅｘ＝２１８．

关键词：金萃取月桂胺盐酸介质

油纸绝缘变压器极化等效电路分析及其老化评估

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电工技术学报 2016年第15期31卷 204-212页

作者：蔡金锭刘永清蔡嘉福州大学电气工程与自动化学院福州350108 国网福建省电力有限公司物资分公司福州350103

提出一种判断油纸绝缘设备弛豫响应扩展德拜等效电路极化支路数的方法。该方法应用微分解谱法,对油纸绝缘设备测试获得的回复电压谱线进行逐次解谱,将隐含在回复电压谱线中的弛豫响应特征以子谱线的形式展现出来。然后根据回复电压微分... 详细信息

提出一种判断油纸绝缘设备弛豫响应扩展德拜等效电路极化支路数的方法。该方法应用微分解谱法,对油纸绝缘设备测试获得的回复电压谱线进行逐次解谱,将隐含在回复电压谱线中的弛豫响应特征以子谱线的形式展现出来。然后根据回复电压微分子谱线的数量,判断扩展德拜等效电路的极化支路数。研究发现,随着油纸绝缘设备老化程度的不断劣化,弛豫响应极化支路及其松弛极化强度也伴随之增大。如果油纸绝缘设备的绝缘状况良好,则松弛极化强度值较小,反之油纸设备的绝缘状况越差,弛豫极化强度越强其值就越大。该方法为应用弛豫响应等效电路判别油纸绝缘设备老化状况提供了一种有力的分析手段。

关键词：弛豫响应回复电压微分解谱等效电路松弛极化强度

Preparation of copper nanoparticles modified with [BMIm]BF_4 ionic liquid

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Engineering Sciences 2010年第2期8卷 20-23页

作者： Su yongqing Li Cong Yang Mingdi cai Ying Ren Nianjun Faculty of Chemist-ry ＆ Chemical Engineering Yunnan Normal University Kunming 65009i China

Copper nanoparticles was prepared by ascorbic acid reducing CuC12 solution modified with [ BMIm ] BF4 ionic liquid. The size of copper nanoparticles was obviously affected by the concentration of Cu2＋ . The diameter of nanoparticles was smaller than 10 nm when the Cu2＋ concentration was smaller than 2× 10.2 moL/L. The pH and temperature of reductive reaction had no obvious effect on the size of copper nanoparticles.

关键词： copper nanoparticles [ BMIm ] BF4 ascorbic acid preparation

Carboxylic Acid as Traceless Directing Group for Pd/Cu-Catalyzed Decarboxylative ortho-halogenation of Aryl Carboxylic Acids with NaX

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Carboxylic Acid as Traceless Directing Group for Pd/Cu-Catal...

Overview of the Mars climate station for Tianwen-1 mission

中国化学会第十六届全国均相催化学术会议

作者： yongqing Jiang Shuiliang Wang 付拯江 Hu cai College of Chemistry Nanchang University 南昌大学化学学院

＜正＞Transition-metal catalyzed C-H bond halogenation of aromatics has been a state-of-the-art strategy from the standpoint of the atom- and step-economy, and considerable efforts has been put forward into transition... 详细信息

关键词： Decarboxylation C-H activation Halogenations Traceless directing group

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Earth and Planetary Physics 2020年第4期4卷 371-383页

作者： yongqing Peng LeiBo Zhang ZhiGuo cai ZhaoGang Wang HaiLong Jiao DongLi Wang XianTao Yang LianGuo Wang Xu Tan Feng Wang Jing Fang ZhouLu Sun HongLiang Feng XiaoRui Huang Yan Zhu Ming Chen LiangHai Li YanHua Li Beijing Research Institute of Telemetry Beijing 100076China National Space Science Center Chinese Academy of SciencesBeijing 100012China National Astronomical Observatories Chinese Academy of SciencesBeijing 100012China Chinese Academy of Aerospace Electronics Technology Beijing 100012China

The background and scientific objectives of the Mars Climate Station(MCS)for Tianwen-1 are introduced,accompanied by a comparative review of the status of related meteorological observation missions and of advanced sensing *** one of the China Tianwen-1 Mission’s principal scientific payloads,the MCS contains four measurement sensors and one electronic processing unit that are specially designed to measure local temperature,pressure,wind,and sound on the Martian *** MCS’s measurement principles,technical schemes,ground calibration techniques,and adaptability evaluation to the Mars surface environment of MCS are introduced in *** conclusion presents measurement performance specifications of the MCS,based on ground test results,that will provide guidance to future research based on data from the Tianwen-1 and later Mars missions.

关键词： Tianwen-1 Mars exploration Mars climate station

Integrated optoelectronic chip pair for transmitting and receiving optical signals simultaneously

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Chinese Optics Letters 2019年第4期17卷 52-56页

作者： Kai Liu Qi Wei yongqing Huang Xiaofeng Duan Qi Wang Xiaomin Ren Shiwei cai State Key Laboratory of Information Photonics and Optical Communications Beijing University of Posts and Telecommunications

An integrated optoelectronic chip pair, which can transmit and receive optical signals simultaneously, is proposed in this Letter. The design and optimization of its key structure, the vertical cavity surface emitting laser's distributed Bragg reflector, are presented. Analysis is also done for its influence on the integrated chip's performance. Moreover, the chip pair's performance under dynamic conditions is analyzed. Their 3 dB modulation bandwidths are higher than 10 GHz, and their 3 dB photo-response bandwidths are around 23 GHz. Their applications will further improve the performances of the optical interconnects.

关键词： integrated optoelectronic proposed in this Letter applications

A pair of integrated optoelectronic transceiving chips for optical interconnects

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Chinese Optics Letters 2018年第9期16卷 46-50页

作者： Kai Liu Huize Fan yongqing Huang Xiaofeng Duan Qi Wang Xiaomin Ren Qi Wei and Shiwei cai State Key Laboratory of Information Photonics and Optical Communications Beijing University of Posts and TelecommunicationsBeijing 100876China

In this Letter, a pair of integrated optoelectronic transceiving chips is proposed. They are constructed by integrating a vertical cavity surface emitting laser unit above a positive-intrinsic-negative photodetector unit. One of the transceiving chips emits light at the wavelength of 848.1 nm with a threshold current of 0.8 mA and a slope efficiency of 0.81 W/A. It receives light between 801 and 814 nm with a quantum efficiency of higher than 70%. On its counterpart, the other one of the transceiving chips emits light at the wavelength of 805.3 nm with a threshold current of 1.1 mA and a slope efficiency of 0.86 W/A. It receives light between 838 and 855 nm with a quantum efficiency of higher than 70%. The proposed pair of integrated optoelectronic transceiving chips can work full-duplex with each other, and they can be applied to single fiber bidirectional optical interconnects.

关键词： length PIN PD AC VCSEL A pair of integrated optoelectronic transceiving chips for optical interconnects