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Random Penetrance of Mutations Among Individuals:A New Type of Genetic Drift in Molecular Evolution

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Phenomics 2021年第3期1卷 105-112页

作者： Xun gu Department of Genetics Development and Cell BiologyIowa State UniversityAmesIA 50011USA

The determinative view of mutation penetrance is a fundamental assumption for the building of molecular evolutionary theory:individuals in the population with the same genotype have the same fitness *** this view has been constantly challenged by experimental evidence,it is desirable to examine to what extent violation of this view could affect our under-standing of molecular *** this end,the author formulated a new theory of molecular evolution under a random model of penetrance:for any individual with the same mutational genotype,the coefficient of selection is a random *** follows that,in addition to the conventional Ne-genetic drift(Ne is the effective population size),the variance of penetrance among individuals(ε^(2))represents a new type of genetic drift,coined by theε^(2)-genetic *** has been demonstrated that these two genetic drifts together provided new insights on the nearly neutral evolution:the evolutionary rate is inversely related to the log-of-Ne when theε^(2)-genetic drift is *** log-of-Ne feature ofε^(2)-genetic drift did explain well why the dN/dS ratio(the nonsynonymous rate to the synonymous rate)in humans is only as twofold as that in mice,while the effective population size(Ne)of mice is about two-magnitude larger than that of *** was estimated that,for the first time,the variance of random penetrance in mammalian genes was approximatelyε^(2)≈5.89×10^(-3).

关键词： Random penetrance Genetic drift Nearly neutral evolution Effective population size Rate of molecular evolution

超声引导经皮与腹腔镜肝穿刺置管引流术治疗细菌性肝脓肿效果对比分析

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河南外科学杂志 2024年第2期30卷 14-16页

作者：马东明顾小晖郑州大学附属郑州中心医院肝胆胰微创外科郑州450007 郑州大学第二附属医院普通外科郑州450014

目的比较超声引导经皮与腹腔镜肝穿刺置管引流术治疗细菌性肝脓肿(PLA)的效果。方法回顾性分析2022-03-2023-03郑州大学附属郑州中心医院肝胆胰微创外科收治的68例PLA患者的临床资料,根据超声引导肝穿刺置管引流的方法分为经皮穿刺组和... 详细信息

目的比较超声引导经皮与腹腔镜肝穿刺置管引流术治疗细菌性肝脓肿(PLA)的效果。方法回顾性分析2022-03-2023-03郑州大学附属郑州中心医院肝胆胰微创外科收治的68例PLA患者的临床资料,根据超声引导肝穿刺置管引流的方法分为经皮穿刺组和腔镜穿刺组,各34例。比较2组患者的基线资料、围术期指标,统计并发症发生率,评价治疗效果。结果2组患者的体温恢复时间差异无统计学意义(P>0.05)。腔镜穿刺组患者的白细胞计数恢复正常时间、拔管时间、住院时间均短于经皮穿刺组,住院费用及切口感染等并发症发生率均高于经皮穿刺组,差异均有统计学意义(P0.05)。结论对PLA患者采取超声引导经皮与腹腔镜肝穿刺置管引流术均有良好的疗效。其中腹腔镜肝穿刺置管引流术具有患者术后恢复快的优势,经皮肝穿刺置管引流术则在并发症和住院费用方面优于腹腔镜肝穿刺置管引流术。

关键词：细菌性肝脓肿腹腔镜手术经皮肝穿刺置管疗效

基于“杂合以治”探讨新九针优势技术组合在针灸临床中的运用

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针灸临床杂志 2024年第9期40卷 92-95页

作者：顾倪瑄黄丽冀来喜山西中医药大学山西太原030024

总结冀来喜教授“杂合以治”思想在针灸临床中的运用。冀教授尊崇“融西贯中”的理念,倡导“杂合以治”的思想,提出“新九针优势技术组合”的观点,倡导临床治病“以效为宗”。冀教授“杂合以治”学术思想对规范疾病的临床治疗路径具有... 详细信息

总结冀来喜教授“杂合以治”思想在针灸临床中的运用。冀教授尊崇“融西贯中”的理念,倡导“杂合以治”的思想,提出“新九针优势技术组合”的观点,倡导临床治病“以效为宗”。冀教授“杂合以治”学术思想对规范疾病的临床治疗路径具有深远的指导意义,现初步总结冀教授的临床经验以推动针灸学更好地发展,并附医案一则进行阐述。

关键词：杂合以治融西贯中新九针优势技术组合名医经验冀来喜

Effects and mechanisms of silibinin on human hepatocellular carcinoma xenografts in nude mice

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World Journal of Gastroenterology 2009年第16期15卷 1943-1950页

作者： Wei Cui Fan gu Ke-Qin Hu Division of Gastroenterology and Chao Family Comprehensive Cancer Center University of California Orange School of Medicine Orange CA 92868 United States Department of Surgery Nanfang Hospital Southern Medical University Guangzhou 510515 Guangdong Province China

AIM:To investigate the in vivo effects and mechanisms of silibinin on the growth of hepatocellular carcinoma (HCC) xenografts in nude ***: Nude mice bearing HuH7 xenografts were used to assess the anti-HCC effects and mechanisms of ***: Silibinin resulted in a potent dosedependent reduction of HuH7 xenografts in association with a significant decrease in Ki-67 and α-fetoprotein production, nuclear NF-κB content, polo-like kinase 1, Rb phosphorylation, and E2F1/DP1 complex, but increased p27/CDK4 complex and checkpoint kinase 1 expression, suggesting that the in vivo effects of silibinin are mediated by inhibiting G1-S transition of the cell cycle. Silibinin-induced apoptosis of HuH7 xenografts was associated with inhibited survivin phosphorylation. Silibinin-reduced growth of HuH7 xenografts was associated with decreased p-ERK, increased PTEN expression and the activity of silibinin was correlated with decreased p-Akt production, indicating involvement of PTEN/PI3K/Akt and ERK pathways in its in vivo anti-HCC effects. Silibinin-reduced growth of HuH7 xenografts was also associated with a significant increase in AC-H3 and AC-H4 expression and the production of superoxide dismutase (SOD)-***: Silibinin reduces HCC xenograft growth through the inhibition of cell proliferation, cell cycle progression and PTEN/P-Akt and ERK signaling, inducing cell apoptosis, and increasing histone acetylation and SOD-1 expression.

关键词： Apoptosis Cell cycle Chemoprevention Hepatocellular carcinoma Histone acetylation Silibinin

从“以补为通”理论探讨补益药治疗老年动脉粥样硬化

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中医学报 2024年第1期39卷 22-25页

作者：赵雪杜文婷顾耘上海中医药大学附属龙华医院上海200032

动脉粥样硬化好发于老年人群,衰老作为其重要的危险因素在临床治疗时不可忽视。中医认为,衰老可归因于脏腑气血阴阳亏虚,多表现为虚证,治疗宜使用补益类药物,佐以活血、祛痰、清热、化湿等药物全面施治。“以补为通”理论源于“塞因塞用... 详细信息

动脉粥样硬化好发于老年人群,衰老作为其重要的危险因素在临床治疗时不可忽视。中医认为,衰老可归因于脏腑气血阴阳亏虚,多表现为虚证,治疗宜使用补益类药物,佐以活血、祛痰、清热、化湿等药物全面施治。“以补为通”理论源于“塞因塞用,以补开塞”,指用补益的方法治疗闭塞不通的真虚假实证,此处的以补为通,还另指使用补益的方法治疗缓解期的本虚标实与虚实夹杂之证。补益药可以通过提高抗氧化物活力、促进自由基岐化、直接中和自由基来抑制自由基的产生,维持机体抗氧化系统的平衡,从而实现抗衰老。

关键词：老年动脉粥样硬化 “以补为通” 补益药氧化应激

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种植体周软组织增量材料的研究进展

中国口腔种植学杂志 2024年第3期29卷 284-288页

作者：陈佳欣顾新华浙江大学医学院附属第一医院口腔科杭州310003 浙江大学医学院口腔医学院杭州310058

随着种植牙技术日渐成熟,种植修复中种植牙的美学效果和种植体周组织的长期健康日益受到关注。牙缺失常伴随缺牙区周围软硬组织量的减少,常不能满足种植修复的要求,因此种植体周软硬组织增量是牙种植的关键步骤。本文旨在介绍常见的种... 详细信息

随着种植牙技术日渐成熟,种植修复中种植牙的美学效果和种植体周组织的长期健康日益受到关注。牙缺失常伴随缺牙区周围软硬组织量的减少,常不能满足种植修复的要求,因此种植体周软硬组织增量是牙种植的关键步骤。本文旨在介绍常见的种植体周软组织增量材料,为解决种植体周软组织不足问题提供参考。

关键词：牙种植自体组织移植软组织增量材料

Synthesis,Structures,Luminescence and Catalytic Activity in the Knoevenagel Condensation Reaction of Two Cd(Ⅱ)Coordination Polymers Based on a Biphenyl-dicarboxylic Acid

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Chinese Journal of Structural Chemistry 2022年第2期41卷 34-42,I0008页

作者： WU Jiang gu Jin-Zhong Key Laboratory for Tibet Plateau Phytochemistry of Qinghai Province School of PharmacyQinghai University for NationalitiesXining 810007China College of Chemistry and Chemical Engineering Lanzhou UniversityLanzhou 730000China

Two cadmium(II)coordination polymers,namely[Cd(μ-dda)(H2 biim)]n(1)and[Cd(μ4-dda)(py)]n(2)have been constructed hydrothermally using H2 dda(H2 dda=4,4?-dihydroxybiphenyl-3,3?-dicarboxylic acid),H_(2)biim(H_(2)biim=2,2?-biimidazole),py(py=pyridine),and cadmium chloride at 160°*** products were isolated as stable crystalline solids and were characterized by IR spectra,elemental analyses,thermogravimetric analyses(TGA),and single-crystal X-ray diffraction ***-crystal X-ray diffraction analyses revealed that both compounds crystallize in the monoclinic system,space group C2/*** 1 discloses a 1 D chain *** 2 features a 3 D *** luminescent properties of compounds 1 and 2 were ***,the catalytic activities in the Knoevenagel condensation reaction of two compounds were *** 1 exhibits an excellent catalytic activity in the Knoevenagel condensation reaction at room temperature.

关键词： coordination polymer dicarboxylic acid luminescence catalytic properties Knoevenagel condensation reaction

Causal Viscosity in Global Dynamics of Advection-Dominated Accretion Flows Around Black Holes

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Chinese Physics Letters 2000年第2期17卷 151-153页

作者： gu Wei-Min LU Ju-Fu Center for Astrophysics University of Science and Technology of ChinaHefei 230026 National Astronomical Observatories Chinese Academy of Sciences

We modify the viscosity to disappear inside the sonic point in the advection-dominated accretion flows (ADAF's) around black holes, and obtain the causally connected, physically self-consistent ADAF-thin disk solutions. Such global solutions differ from previous ones in quantitative details. The results show that the range of variation for the value of the outer boundary Rout is very large, from 30Rg to 106Rg. There is a narrow region for which the rotating motion of the flow is super-Keplerian in each global solution. An example global solution with the causal viscosity is given explicitly, for which R8=2.28Rg and j=1.7564(cRg).

关键词： viscosity global details

“双碳”背景下发电行业碳排放权价值评估方法研究

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现代工业经济和信息化 2024年第9期14卷 172-175页

作者：谷慧玲欧开旺河北工程大学管理工程与商学院河北邯郸056038

发电行业作为我国首个纳入碳市场的行业,对其碳排放权进行评估将有助于加快相关企业进行绿色转型,促进碳排放权交易市场健康运行,为碳市场扩容提供一定的支撑。目前,我国碳市场还不够成熟,并没有一种完全适用的评估方法对碳排放权这一... 详细信息

发电行业作为我国首个纳入碳市场的行业,对其碳排放权进行评估将有助于加快相关企业进行绿色转型,促进碳排放权交易市场健康运行,为碳市场扩容提供一定的支撑。目前,我国碳市场还不够成熟,并没有一种完全适用的评估方法对碳排放权这一新兴资产进行估值。因此,结合发电行业的发展现状及特点,在介绍六种价值评估方法的基础上,选取了三种适合发电行业碳排放权价值评估的方法进行分析,旨在促进我国碳市场的健康有序发展,稳步推进“双碳”目标的实现进程。

关键词：价值评估碳排放权发电行业