检索结果-南通市图书馆

What Should Be Done to Re-evaluate Cessation of Nucleos(t)ide Analog Therapy for Chronic Hepatitis B Infection?

Infectious Diseases & Immunity 2021年第2期1卷 93-102页

作者： yongqian cheng Yingjie Ji Huijuan Duan Yuanyuan Li George Lau Fu-Sheng Wang The Fifth Medical Center of Chinese PLA General Hospital(Beijing 302 Hospital) BeijingChina Humanity and Health Clinical Trial Center Humanity and Health Medical GroupHong Kong SARChina

Anti-viral therapy with nucleos(t)ide analogs(NUCs)for chronic hepatitis B(CHB)is generally considered to be a long-term *** guidelines issued by Asian Pacific Association for the Study of the Liver,European Association for the Study of the Liver,and American Association for the Study of Liver Diseases have recently proposed requirements and standards for cessation of NUCs,but it remains unclear which proportion of CHB patients on long-term or prolonged treatment of NUCs will relapse after NUCs ***,paradoxical increase in loss of hepatitis B surface antigen(HBsAg)with or without the development of anti-hepatitis B surface antibody has been observed in NUCs’treated CHB patients with cessation of ***,it is of great clinical relevance to identify CHB who might have been over-treated with NUCs and might even benefit HBsAg loss or seroconversion with cessation of *** address these issues,our review comprehensively analyzed the data from recent clinical trials in which the antiviral efficacy in the long-term or prolonged treatment of NUCs and/or interferon-a for CHB patients were ***,the relevant problems and deficiencies existing in the study design of previous clinical studies were also *** solve the unmet issues in the field,a prospective study with a large-enough sample size would be required to understand the related virologic and immunological markers that can accurately predict the outcome and prognosis of the CHB patients who stop the NUCs *** the rapid advancement of antiviral drug development for CHB patients,the future ideal regimens should include multiple targets for antiviral drug therapy combined with efficient immune-modulatory therapy,which will help more CHB patients to obtain functional cure with NUCs cessation.

关键词： Hepatitis B,chronic Cessation of therapy Nucleoside analogs

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

白腐真菌生物膜反应器的脱色降解实验研究

引用

上海环境科学 2000年第Z1期19卷 73-76页

作者：黄民生程永前上海大学环境学院上海 200072 上海大学环境学院上海 200072

研究使用白腐真菌生物膜反应器对活性艳红X-3B染料进行脱色和降解实验,结果表明,白腐真菌生物膜对活性艳红具有迅速的脱色效果,富氮条件和初始pH值为中性或偏碱性有利于染料的脱色.从实验过程中共培养液和菌体颜色变化情况以及共培养液... 详细信息

研究使用白腐真菌生物膜反应器对活性艳红X-3B染料进行脱色和降解实验,结果表明,白腐真菌生物膜对活性艳红具有迅速的脱色效果,富氮条件和初始pH值为中性或偏碱性有利于染料的脱色.从实验过程中共培养液和菌体颜色变化情况以及共培养液的UV-VIS扫描曲线结果分析看,白腐真菌生物膜首先将染料吸附而后进行生物降解.由于共培养液属于人工配制,且含有多种成分,而处理出水内含较多的真菌孢子和菌丝,所以对脱色降解后出水进一步净化十分必要,化学混凝法对其具有很好的净化效果.

关键词：白腐真菌染料活性艳红脱色降解实验条件

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

白腐真菌对染料的脱色与降解

引用

上海环境科学 2000年第3期19卷 124-128页

作者：黄民生程永前张国莹上海大学环境学院上海200072

利用白腐真菌对染料脱色和降解的过程机理及影响因素进行了较为系统的介绍,结果认为,白腐真菌对染料的脱色及降解作用可能主要是由于其在次生代谢阶段产生的木质素过氧化酶LIPs和锰过氧化酶MnPs所致。在培养基中加入黎芦醇等能够显著提... 详细信息

利用白腐真菌对染料脱色和降解的过程机理及影响因素进行了较为系统的介绍,结果认为,白腐真菌对染料的脱色及降解作用可能主要是由于其在次生代谢阶段产生的木质素过氧化酶LIPs和锰过氧化酶MnPs所致。在培养基中加入黎芦醇等能够显著提高LIPs的产生;富氮培养基会抑制LIPs的生成;缓冲液的选择对维持适宜的pH值和菌丝的形态有一定作用,从而影响其脱色效果;富氧环境是一切白腐真菌对染料进行脱色和降解的必要条件;适度的搅拌混合有利于反应时的物质之间传递;一般地,在培养时间达到3d以后白腐真菌才能达到较高的脱色与降解活性。染料分子大小和结构及其基团的位置对脱色及降解效果有明显影响。使用特殊填料来提高处理系统中的生物量以克服真菌生长速度相对较慢,提高处理能力是该技术今后的研究重点。

关键词：白腐真菌染料脱色降解废水处理

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Three-dimensional fracture of UO2 ceramic pellets by phase field modeling

引用

Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 169-180页

作者： Wei Xiong Xuan Ye Hongzhang cheng Xiaoming Liu Institute of Nuclear and New Energy Technology Collaborative Innovation Center of Advanced Nuclear Energy Technology Key Laboratory of Advanced Reactor Engineering and Safety of Ministry of Education Tsinghua University State Key Laboratory of Nonlinear Mechanics Institute of Mechanics Chinese Academy of Sciences School of Engineering Science University of Chinese Academy of Sciences

Fracture is the primary failure type for the UO2ceramic pellets,which are operated under irradiation and thermal processes,and physically confined by the *** this work,by combining closely coupled physical processes of heat conduction,heat transfer,and mechanical deformation with the cohesive phase field framework,we proposed a high-precision modeling of quasistatic cracking of three-dimensional （3D） UO2ceramic fuel pellets under high temperature and *** simulation results agree well with the experimental results,indicating that the proposed method has the potential to capture 3D crack modes in the interested time ***,we studied the relation of the 3D fracture patterns of fuel pellets with the peak power *** was found that the power level plays a critical role in determining the competition between radial and circumferential cracks,as well as transverse penetrating cracks.

关键词： phase field method nuclear fuel pellet coupled thermo-mechanical model thermal fracture

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Tailoring Light–Matter Interactions in Overcoupled Resonator for Biomolecule Recognition and Detection

引用

Nano-Micro Letters 2025年第1期17卷 262-280页

作者： Dongxiao Li Hong Zhou Zhihao Ren cheng Xu chengkuo Lee Department of Electrical and Computer Engineering National University of SingaporeSingapore 117583Singapore Center for Intelligent Sensors and MEMS(CISM) National University of SingaporeSingapore 117608Singapore

Plasmonic nanoantennas provide unique opportunities for precise control of light–matter coupling in surface-enhanced infrared absorption(SEIRA)spectroscopy,but most of the resonant systems realized so far suffer from the obstacles of low sensitivity,narrow bandwidth,and asymmetric Fano resonance ***,we demonstrated an overcoupled resonator with a high plasmon-molecule coupling coefficient(μ)(OC-Hμresonator)by precisely controlling the radiation loss channel,the resonator-oscillator coupling channel,and the frequency detuning *** observed a strong dependence of the sensing performance on the coupling state,and demonstrated that OC-Hμresonator has excellent sensing properties of ultra-sensitive(7.25%nm^(−1)),ultra-broadband(3–10μm),and immune asymmetric Fano *** characteristics represent a breakthrough in SEIRA technology and lay the foundation for specific recognition of biomolecules,trace detection,and protein secondary structure analysis using a single array(array size is 100×100μm^(2)).In addition,with the assistance of machine learning,mixture classification,concentration prediction and spectral reconstruction were achieved with the highest accuracy of 100%.Finally,we demonstrated the potential of OC-Hμresonator for SARS-CoV-2 *** findings will promote the wider application of SEIRA technology,while providing new ideas for other enhanced spectroscopy technologies,quantum photonics and studying light–matter interactions.

关键词： Plasmonic nanoantennas Light-matter interaction Surface-enhanced infrared absorption Overcoupled Biosensing

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

肾移植前后丙型肝炎病毒感染的管理

引用

实用器官移植电子杂志 2021年第1期9卷 80-84页

作者：黄霞吉英杰程勇前南方医科大学第二临床医学院广东广州510515 中国人民解放军总医院第五医学中心老年医学科北京100039

丙型肝炎病毒(hepatitis C virus,HCV)除导致肝功能损伤外,约43%~85%的慢性丙型肝炎(chronic hepatitis C,CHC)患者可伴有多种肝外表现(extrahepatic manifestations,EHM)[1-4],包括多种HCV感染相关肾脏疾病[5-6]。Ferri等[2]研究表明,CHC患者出现尿蛋白的风险增高51%,慢性肾脏病(chronic kidney disease,CKD)发生率增高43%。Park等[7]通过回顾性队列纳入美国Truven Health MarketScan数据库(2008—2015年)的56448例HCV感染者和倾向评分(1:3)匹配的169344例非HCV感染患者进行多变量Cox回归模型分析,结果显示,HCV感染患者发生CKD的风险比增加27%(危险比为1.27;95%置信区间为1.18~1.37)。

关键词：慢性丙型肝炎慢性肾脏病肝功能损伤丙型肝炎病毒 HCV感染肾脏疾病置信区间肾移植

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A Multi-Objective Particle Swarm Optimization Algorithm Based on Decomposition and Multi-Selection Strategy

引用

Computers, Materials & Continua 2025年第1期82卷 997-1026页

作者： Li Ma Cai Dai Xingsi Xue cheng Peng School of Computer Science Shaanxi Normal UniversityXi’an710119China Fujian Provincial Key Laboratory of Big Data Mining and Applications Fujian University of TechnologyFuzhou350118China Information Construction and Management Center and Institute of Artificial Intelligence and Educational New Productivity Ningxia Normal UniversityGuyuan756099China

The multi-objective particle swarm optimization algorithm(MOPSO)is widely used to solve multi-objective optimization *** the article,amulti-objective particle swarm optimization algorithmbased on decomposition and multi-selection strategy is proposed to improve the search ***,two update strategies based on decomposition are used to update the evolving population and external archive,***,a multiselection strategy is *** first strategy is for the subspace without a non-dominated *** the neighbor particles,the particle with the smallest penalty-based boundary intersection value is selected as the global optimal solution and the particle far away fromthe search particle and the global optimal solution is selected as the personal optimal solution to enhance global *** second strategy is for the subspace with a non-dominated *** the neighbor particles,two particles are randomly selected,one as the global optimal solution and the other as the personal optimal solution,to enhance local *** third strategy is for Pareto optimal front(PF)discontinuity,which is identified by the cumulative number of iterations of the subspace without non-dominated *** the subsequent iteration,a new probability distribution is used to select from the remaining subspaces to ***,an adaptive inertia weight update strategy based on the dominated degree is designed to further improve the search ***,the proposed algorithmis compared with fivemulti-objective particle swarm optimization algorithms and five multi-objective evolutionary algorithms on 22 test *** results show that the proposed algorithm has better performance.

关键词： Multi-objective optimization multi-objective particle swarm optimization decomposition multi-selection strategy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Resistance of Cement-based Grouting Materials with Nano- SiO_(2) Emulsion to Chloride Ion Penetration

引用

Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 114-119页

作者： LI Shuiping cheng Jian WEI Chao YUAN Bin YU chengxiao College of Architectural Science and Engineering Yangzhou UniversityYangzhou 225127China

The chloride penetration resistance of cement-based grout materials was improved by nano-silica *** of mixtures containing different nano-silica particles or emulsions were exposed in sodium chloride solutions of specific concentrations with different test *** properties of the mixes were assessed in terms of weight loss and compressive strength.X-ray diffraction(XRD)and scanning electron microscopy(SEM)of mixes were performed to analysis the phase evolution and *** results demonstrated that the introduction of nano-SiO_(2) emulsion significantly decreased the compressive strength loss and calcium hydroxide(CH)crystal content of hydration production,and then enhanced the resistance of cement-based grouting materials to chloride ion *** improvement derives from the filling and pozzolanic effects of nano-SiO_(2) particles,which were incorporated via an emulsion and attributed to a well dispersion in grouting matrix.

关键词： grouting materials nano-SiO_(2)emulsion chloride ion penetration,weight loss strength loss

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Preparation of FeCoNi medium entropy alloy from Fe^(3+)-Co^(2+)-Ni^(2+)solution system

引用

International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 92-101页

作者： Zongyou cheng Qing Zhao Mengjie Tao Jijun Du Xingxi Huang chengjun Liu Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education) Northeastern UniversityShenyang 110819China School of Metallurgy Northeastern UniversityShenyang 110819China Engineering Research Center of Frontier Technologies for Low-carbon Steelmaking(Ministry of Education) Shenyang 110819China

In recent years,medium entropy alloys have become a research hotspot due to their excellent physical and chemical *** controlling reasonable elemental composition and processing parameters,the medium entropy alloys can exhibit similar properties to high entropy alloys and have lower *** this paper,a FeCoNi medium entropy alloy precursor was prepared via sol-gel and coprecipitation methods,respectively,and FeCoNi medium entropy alloys were prepared by carbothermal and hydrogen *** phases and magnetic properties of FeCoNi medium entropy alloy were *** showed that FeCoNi medium entropy alloy was produced by carbothermal and hydrogen reduction at 1500℃.Some carbon was detected in the FeCoNi medium entropy alloy prepared by carbothermal *** alloy prepared by hydrogen reduction was uniform and showed a relatively high ***,the hydrogen reduction product exhibited better saturation magnetization and lower coercivity.

关键词： medium entropy alloy sol-gel co-precipitation carbothermal hydrogen reduction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Investigating Müller glia reprogramming in mice: a retrospective of the last decade, and a look to the future

引用

Neural Regeneration Research 2025年第4期20卷 946-959页

作者： Zhiyuan Yin Jiahui Kang Xuan cheng Hui Gao Shujia Huo Haiwei Xu Key Lab of Visual Damage and Regeneration&Restoration of Chongqing Southwest Eye HospitalSouthwest HospitalThird Military Medical University(Army Medical University)ChongqingChina

Müller glia,as prominent glial cells within the retina,plays a significant role in maintaining retinal homeostasis in both healthy and diseased *** lower vertebrates like zebrafish,these cells assume responsibility for spontaneous retinal regeneration,wherein endogenous Müller glia undergo proliferation,transform into Müller glia-derived progenitor cells,and subsequently regenerate the entire retina with restored ***,Müller glia in the mouse and human retina exhibit limited neural reprogramming.Müller glia reprogramming is thus a promising strategy for treating neurodegenerative ocular disorders.Müller glia reprogramming in mice has been accomplished with remarkable success,through various *** in molecular,genetic,epigenetic,morphological,and physiological evaluations have made it easier to document and investigate the Müller glia programming process in ***,there remain issues that hinder improving reprogramming efficiency and ***,understanding the reprogramming mechanism is crucial toward exploring factors that will improve Müller glia reprogramming efficiency,and for developing novel Müller glia reprogramming *** review describes recent progress in relatively successful Müller glia reprogramming *** also provides a basis for developing new Müller glia reprogramming strategies in mice,including epigenetic remodeling,metabolic modulation,immune regulation,chemical small-molecules regulation,extracellular matrix remodeling,and cell-cell fusion,to achieve Müller glia reprogramming in mice.

关键词： cell fusion chemical small-molecules epigenetic extracellular matrix immune metabolic mice Müller glia neurodegenerative diseases reprogramming retina regeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：