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Antidepressant-Like Activity of Tetramethylpyrazine Measured by Chronic Experimental Method in Rat Model of Depression

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Pharmacology & Pharmacy 2012年第1期3卷 52-57页

作者： Lijian Yu Xiaodan Jiang yongping zhang Mingneng Liao Rundi Ma Tingxi Yu 不详

The aim of this study was to investigate the potential antidepressive-like effect of tetramethylpyrazine (TMP), one of available blood-activating and stasis-eliminating components from traditional Chinese medicines, in chronic mild stress (CMS)-induced rat model of depression. Male Sprague-Dawley (SD) strain rats were divided into six matched groups (n = 13 or 14 in each group) based on their sucrose consumption: control, CMS, CMS + fluoxetine (FLU), and CMS + TMP groups. The rats except control were housed separately in different rooms, and the rat model of depression was established by exposing to an unpredictable sequence of stressors for 28 days;the rats in CMS + FLU were exposed to CMS and received administration of FLU (2.0 mg/kg/d, ig) for 28 days;the rats in CMS + TMP groups were exposed to CMS and received administration of TMP (10, 20, 40 mg/kg/d, ig), respectively, for 28 days. The rats in control group were given ordinary daily care, and the rats in control and CMS groups received ig administration of normal saline instead of FLU or TMP. The body weight, food intake and fluid consumption were measured, and the behaviors were examined by open field test before and after CMS, and forced-swimming test was performed 1 day after last unpredictable stressor. Chronic administration of TMP partially reversed the effects of CMS on consumption of sucrose solution and locomotion and exploration behavior, and potently shortened the immobility time during forced-swimming test following CMS in rats. The results showed that long-term administration of TMP partially reversed the effects of CMS on the body weight gain, the consumption of sucrose solution, the squares crossin gand rearing in open field test, and the immobility time during forced-swimming test in rats. The present data provide evidences that TMP possesses obvious antidepressant-like activity in CMS-induced rat model of depression.

关键词： Tetramethylpyrazine Antidepressive-Like Activity Chronic Mild Stress Rats

Ultra-homogeneous dense Ag nano layer enables long lifespan solid-state lithium metal batteries

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Journal of Energy Chemistry 2024年第9期96卷 110-119页

作者： Yaning Liu Tianqi Yang Ruyi Fang Chengwei Lu Ruojian Ma Ke Yue Zhen Xiao Xiaozheng Zhou Wenkui zhang Xinping He yongping Gan Jun zhang Xinhui Xia Hui Huang Xinyong Tao Yang Xia College of Materials Science and Engineering Zhejiang University of TechnologyHangzhou 310014ZhejiangChina Key Laboratory of Rare Earth Optoelectronic Materials and Devices of Zhejiang Province Institute of Optoelectronic Materials and DevicesChina Jiliang UniversityHangzhou 310018ZhejiangChina

The unstable electrolyte/lithium(Li)anode interface has been one of the key challenges in realizing high energy density solid-state lithium metal batteries(LMBs)***,a dense and uniform silver(Ag)nano interlayer with a thickness of∼35 nm is designed accurately by magnetron sputtering technology to optimize the electrolyte/Li anode *** Ag nano layer reacts with Li metal anode to in-situ form Li-Ag alloy,thus enhancing the physical interfacial contact,and further improving the interfacial wettability and *** particular,the Li-Ag alloy is inclined to form AgLi phase proved by cryo-TEM and DFT,effectively preventing SN from continuously“attacking”the Li metal anode due to the lower adsorption of succinonitrile(SN)molecules on AgLi than that of pure Li metal,thereby significantly reinforcing the interfacial ***,the enhanced physical and chemical stability of electrolyte/Li anode interface promotes the homogeneous deposition of Li^(+)and inhibits the dendrite *** Li-symmetric cell maintains stable operation for up to 1700 h and the cycling stability of LiFePO_(4)|SPE|Li full cell is remarkably improved at room temperature(capacity retention rate of 91.9%for 200 cycles).This work opens an effective way for accurate and controllable interface design of long lifespan solid-state LMBs.

关键词： Silvernano layer Poly(ethylene oxide) Solid polymer electrolyte Succinonitrile Lithium metal battery

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蝴蝶兰花自然衰老与活性氧代谢的关系

东北林业大学学报 2013年第3期41卷 78-81页

作者：张永平唐山师范学院唐山063000

以蝴蝶兰花的萼片、花瓣和唇瓣为试材,研究其自然衰老过程中活性氧及相关酶的生理变化,探索花朵衰老的主要因素。结果表明:萼片、花瓣和唇瓣从小蕾期至初开期的超氧化物歧化酶(SOD)和过氧化物酶(POD)活性没有表现出明显的变化,但在盛开... 详细信息

以蝴蝶兰花的萼片、花瓣和唇瓣为试材,研究其自然衰老过程中活性氧及相关酶的生理变化,探索花朵衰老的主要因素。结果表明:萼片、花瓣和唇瓣从小蕾期至初开期的超氧化物歧化酶(SOD)和过氧化物酶(POD)活性没有表现出明显的变化,但在盛开期与衰败期二者活性显著升高;过氧化氢酶(CAT)活性在开花的各个时期总体表现为先下降后上升的趋势;从小蕾期至初开期,超氧阴离子(O-2.)的产生速率一直处于较低水平,盛开期开始明显上升,衰败期急剧增加;从小蕾期至初开期,H2O2质量摩尔浓度逐渐降低,衰败期质量摩尔浓度显著增加;可溶性蛋白质量浓度从小蕾期至衰败期逐渐降低;丙二醛(MDA)质量摩尔浓度从小蕾期到盛开期逐渐降低,盛开期达到最低,此后质量摩尔浓度迅速升高。在自然衰老过程中,萼片、花瓣和唇瓣三者的生理过程变化相似,但萼片最早,花瓣次之,唇瓣最慢。O-2.是决定蝴蝶兰花衰老的主要因素。

关键词：蝴蝶兰花活性氧抗氧化酶

Improving anti-Gram-positive-bacterial performance and osteogenesis for zinc alloy via mussel mimetic polydopamine with non-antibiotic lysozyme and parathyroid hormone

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Biosurface and Biotribology 2023年第4期9卷 199-209页

作者： Deren Zhao Tianhao Chen Jinqian Chen Banglun Huang Jihua Nie Hulin Liu Yangkai Liu Zilin Chen Feng Zou Qiqi Lu Xiaodong Tan Yunjie Xiang Jing Li yongping zhang Xue Feng Xi Rao School of Materials and Energy Southwest UniversityChongqingChina Chongqing Key Laboratory of Soft-Matter Material Chemistry and Function Manufacturing Southwest UniversityChongqingChina Department of Clinical Laboratory University-Town Hospital of Chongqing Medical UniversityChongqingChina

In this work,a novel coating with a non-antibiotic agent for inhibiting Gram-positive bacteria and promoting osteogenesis was prepared on zinc-aluminium alloy(ZA6-1)via mussel mimetic polydopamine(PDA)containing lysozyme(LYS)and parathyroid hormone(PTH).The results indicate that as-deposited coatings can efficiently decrease the degradation rate of ZA6-1 from 0.52 to 0.16 mm/year,and the addition of LYS weakens the coating resistance,while the addition of PTH enhances the coating *** spite that no obvious inhibition of Escherichia coli is observed,the coated zinc alloys show good in vitro antibacterial performance against Staphylococcus *** with ZA6-1 zinc alloys,the increase of antibacterial efficacy reaches 86.9%-90.1%.Furthermore,the lower hydrophilicity(26.4°),higher osteoblast cell viability(>100%),good osteoblast cell morphology and better osteoblast cell differentiation(ALP=107.7%)for PDA-LYS/PTH coated samples support that as-prepared coating is promising for modifying biodegradable zinc implants.

关键词： antibacterial biocompatibility non-antibiotic antimicrobial strategy

In Vitro Study on Lethal Effect of Human Choroidal Melanoma OCM-1 Cell Line by Repeating -70℃ Freeze Thawing

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眼科学报 2007年第1期23卷 31-36页

作者： Bin Liu yongping Li Bo zhang Wenxin zhang National Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat-sen University Guangzhou 510060 China

Objective: To investigate the effects of repeating-70℃freeze thawing on human choroidal melanoma cell line OCM-1. Methods: OCM-1 cells were frozen by repeating -70℃ freeze thawing with various durations and frequencies. Then the inhibit rate of cells was examined by MTT essay. The cell viability was measured by monoclonal formation assay. We also used the HE staining, immunohistochemistry staining and the laser-scanning confocal microscopy (LSCM) to investigate the morphological changes of the cells. Results: The growth of OCM-1 cells was inhibited by repeating -70℃ freeze thawing in time-dependent and frequency-dependent manners (P < 0.01). Different morphous including necrosis and apoptosis of the cells could be observed after -70℃ freeze thawing by the LSCM. Conclusion: Repeating -70℃ freeze thawing can not only kill cells directly and induce considerable cells to apoptosis, but also inhibit the growth of the survivals. The kill and wound ratio of the cells disposal with different times and frequencies present variance. And the distinction when treated with different frequencies during the same time is much more significant than different times with the same frequency, which guide clinical workers to choose repeating cryotherapy with short term method instead of single cryotherapy with long term in choroidal melanoma treatment.

关键词：冻融脉络膜黑素瘤 OCM-1细胞杀伤效果体外研究

Identification of potential immune-related mechanisms related to the development of multiple myeloma

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Chinese Medical Journal 2024年第13期137卷 1603-1613页

作者： Yaomei Wang Wenli zhang Tiandong Li Mengmeng Liu Mengya Gao Xinqing Li Yufei Chen yongping Song Wei Li Chunyan Du Fang Wang Lina Liu Department of Hematology The Affiliated Cancer Hospital of Zhengzhou University&Henan Cancer HospitalZhengzhouHenan 450008China The Academy of Medical Science College of MedicalZhengzhou UniversityZhengzhouHenan 450052China College of Public Health Zhengzhou UniversityZhengzhouHenan 450000China Department of Research and Foreign Affairs The Affiliated Cancer Hospital of Zhengzhou University&Henan Cancer HospitalZhengzhouHenan 450008China Department of Clinical Medicine Zhengzhou UniversityZhengzhouHenan 450052China Department of Hematology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450052China Laboratory Animal Center School of Medical SciencesZhengzhou UniversityZhengzhouHenan 450052China

Background:Although significant advances have been made in the treatment of multiple myeloma(MM),leading to unprecedented response and survival rates among patients,the majority eventually relapse,and a cure remains *** situation is closely related to an incomplete understanding of the immune microenvironment,especially monocytes/macrophages in patients with treatment-naïve *** aim of this study was to provide insight into the immune microenvironment,especially monocytes/macrophages,in patients with treatment-naïve ***:This study used the single-cell RNA sequencing(scRNA-seq)data of both patients with MM and heathy donors to identify immune cells,including natural killer(NK)cells,T cells,dendritic cells(DCs),and monocytes/*** data and flow cytometry analysis of monocytes/macrophages were used to further examine the effect of monocytes/macrophages in treatment-naïve MM ***:A significant difference was observed between the bone marrow(BM)immune cells of the healthy controls and treatment-naïve MM patients through *** is noteworthy that,through an scRNA-seq data analysis,this study found that interferon(IFN)-induced NK/T cells,terminally differentiated effector memory(TEMRA)cells,T-helper cells characterized by expression of IFN-stimulated genes(ISG^(+)Th cells),IFN-responding exhausted T cells,mannose receptor C-type 1(MRC1)^(+)DCs,IFN-responding DCs,MHCII^(+)DCs,and immunosuppressive monocytes/macrophages were enriched in patients with treatment-naïve ***,transcriptomic data of monocytes/macrophages demonstrated that"don’t eat me"-related genes and IFN-induced genes increase in treatment-naïve MM ***,scRNA-seq,transcriptomic data,and flow cytometry also showed an increased proportion of CD16^(+)monocytes/macrophages and expression level of ***-cell communication analysis indicated that monocytes/macrophages,whose related important signaling pathways include migration i

关键词： Multiple myeloma Monocytes/macrophages Single-cell RNA sequencing Immune cell Microenvironment Bone marrow Molecular characterization

基于微透析结合UPLC的弩药微乳经皮给药后多成分皮肤药动学研究

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南京中医药大学学报 2024年第2期40卷 167-173页

作者：谢欢宋选飞周斌刘耀杨芳芳陈迎龙朱艳张永萍贵州中医药大学药学院贵州贵阳550025 贵州省中药民族药炮制与制剂工程技术研究中心贵州贵阳550025 国家苗药工程技术研究中心贵州贵阳550025 贵州中医药大学针灸推拿学院贵州贵阳550025 贵州健康职业学院中医药系贵州铜仁554300

目的考察弩药微乳多成分在自制探针上的回收率与温度、灌流速度、浓度的关系,研究弩药微乳多成分在家兔皮肤组织中的药动学特征。方法采用UPLC测定绿原酸、苯甲酰新乌头原碱、杠柳毒苷、新乌头碱质量浓度;采用增量法与减量法探究温度、... 详细信息

目的考察弩药微乳多成分在自制探针上的回收率与温度、灌流速度、浓度的关系,研究弩药微乳多成分在家兔皮肤组织中的药动学特征。方法采用UPLC测定绿原酸、苯甲酰新乌头原碱、杠柳毒苷、新乌头碱质量浓度;采用增量法与减量法探究温度、灌流速度、质量浓度对探针回收率的影响,UPLC测定弩药微乳经皮给药后不同时间点透析液中多成分含量变化,并用DAS2.0软件处理数据。结果升高温度,各成分探针回收率逐渐提高;流速越大,药物回收率越低,且回收率与探针周围药物质量浓度关系不大。弩药微乳中绿原酸、苯甲酰新乌头原碱、杠柳毒苷、新乌头碱在皮下组织中的药动学参数C max分别为(3.24±0.36)(1.04±0.29)(4.78±2.15)(2.86±0.55)μg·mL^(-1);AUC 0-∞分别为(52.42±30.84)(7.70±3.73)(42.23±13.93)(22.68±12.51)h·μg·mL^(-1)。结论首次采用微透析在体实时取样技术,建立UPLC检测方法,对弩药微乳经皮给药后多成分皮肤药动学进行研究,为弩药微乳后续的考察及应用提供参考。

关键词：弩药微乳微透析 UPLC 皮肤药动学

Thermosphere joint observations by TM-1 constellations and Swarm-B during the April 2023 geomagnetic storm

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Earth and Planetary Physics 2024年第2期8卷 307-316页

作者： yongping Li YueQiang Sun XianGuo zhang JiangZhao Ai XiaoLiang Zheng Jia Li YuJie Wang BiBo Guo Feng Yan ShiLong Wei XinChun Tang YuanYuan Cao National Space Science Center Chinese Academy of SciencesBeijing 100190China Beijing Key Laboratory of Space Environment Exploration Beijing 100190China Key Laboratory of Science and Technology on Space Environment Situational Awareness Chinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Shenzhen Aerospace Dongfanghong Satellite LtdShenzhen 518057China

The response of thermosphere density to geomagnetic storms is a complicated physical ***-satellite joint observations at the same altitude but different local times(LTs)are important for understanding this process;however,until now such studies have hardly been *** this report,we analyze in detail the thermosphere mass density response at 510 km during the April 23−24,2023 geomagnetic storm using data derived from the TM-1(TianMu-1)satellite constellation and Swarm-B *** observations show that there were significant LT differences in the hemispheric asymmetry of the thermosphere mass density during the geomagnetic *** observed by satellite TM02 at nearly 11.3 and 23.3 LTs were larger in the northern hemisphere than in the *** TM04 dayside density observations appear to be almost symmetrical with respect to the equator,though southern hemisphere densities on the nightside were ***-B data exhibit near-symmetry between the *** addition,the mass density ratio results show that TM04 nightside observations,TM02 data,and Swarm-B data all clearly show stronger effects in the southern hemisphere,except for TM04 on the dayside,which suggest hemispheric *** South-North density enhancement differences in TM02 and TM04 on dayside can reach 130%,and Swarm-B data even achieve 180%*** the observations of all three satellites,large-scale traveling atmospheric disturbances(TADs)first appear at high latitudes and propagate to low latitudes,thereby disturbing the atmosphere above the equator and even into the opposite ***00 model simulations were also performed on this geomagnetic *** are absent in the NRLMSISE00 *** satellite data suggest that NRLMSISE00 significantly underestimates the magnitude of the density response of the thermosphere during geomagnetic storms,especially at high latitudes in both ***,use of the density simulation of NRLM

关键词： TM-1 constellation Swarm-B joint observations geomagnetic storm Local Times

Design and measurement of a piezoresistive triaxial accelerometer based on MEMS technology

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Journal of Semiconductors 2012年第10期33卷 48-52页

作者：杜春晖何常德于佳琪葛晓洋张永平张文栋 Key Laboratory of Instrumentation Science&Dynamic Measurement Ministry of EducationNorth University of China Key Laboratory of Science and Technology on Electronic Test&Measurement North University of China Key Laboratory of Science and Technology on Electronic Test&Measurement

With the springing up of the MEMS industry,research on accelerometers is focused on miniaturization, integration,high reliability,and high resolution,and shares extensive application prospects in military and civil *** with the traditional single cantilever beam structure or ＂cantilever-mass＂ structure,the proposed structure of ＂8-beams/mass＂ with its varistor completely symmetric distribution in micro-silicon piezoresistive triaxial accelerometer in this paper has a higher axial sensitivity and smaller cross-axis *** ANSYS, the process of structural analysis and the manufacturing flow of sensing unit are *** dynamic testing conditions, it can be concluded that the axial sensitivity of x,y,and z are Sx-48μV/g,Sy = 54μV/g and Sz = 217μV/g respectively,and the nonlinearities are 0.4%,0.6%and 0.4%.

关键词： cross-axis sensitivity piezoresistive symmetric distribution triaxial accelerometer