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3-Epi-betulinic acid 3-O-β-D-glucopyranoside(eBAG)induces autophagy by activation of AMP-activated protein kinase in hepatocellular carcinoma

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Food Science and Human Wellness 2024年第3期13卷 1453-1464页

作者： Mengjie Liu Xuqiang Liu Kaiyue He yongping jian Yujia Li Jinrong Guo Jingyu Yang Zhixiang Xu Wenyi Kang School of Life Sciences Henan UniversityKaifeng 475004China National R&D Center for Edible Fungus Processing Technology Henan UniversityKaifeng 475004China Joint International Research Laboratory of Food&Medicine Resource Function Kaifeng 475004China Shenzhen Research Institute of Henan University Shenzhen 518000China

3-Epi-betulinic acid 3-O-β-D-glucopyranoside(eBAG)is a pentacyclic triterpene mainly distributed in food and medicinal plants,which exhibits various pharmacological ***,whether these functions are attributed to eBAG or additional components in these plants remain ***,we report that eBAG exerted an inhibitory activity against hepatocellular carcinoma and esophageal cancer *** induced non-apoptotic cell death in hepatocellular carcinoma *** eBAG-induced cell death was inhibited by knock-down of autophagy related gene(ATG)5 and ATG7,by administration of 3-methyladenine,a selective autophagy inhibitor that suppresses phosphoinositide 3-kinase(PI3K),and by chloroquine,a classic autophagy flux *** demonstrated that eBAG induced an autophagy-mediated cell *** of eBAG mimicked cellular bioenergetics depletion leading to the reduction of intracellular ATP,activation of AMP-activated protein kinase(AMPK),and inhibition of ***-treatment with compound C,an AMPK inhibitor,abrogated cell death induced by *** further validated the anti-tumor effect of eBAG in the murine xenograft model of hepatocellular carcinoma and found that eBAG treatment promoted the induction of autophagy and reduction of tumor growth in *** a functional food ingredient,eBAG is a potential therapeutic agent for the treatment of hepatocellular carcinoma and esophageal cancer.

关键词： eBAG Autophagy ATP AMPK Hepatocellular carcinoma

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慢性牙周炎超声龈下洁治和手工龈下刮治的疗效比较

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中国临床医学 2010年第4期17卷 582-583页

作者：筒永平上海市浦东新区人民医院口腔科上海201200

目的:比较超声龈下洁治和手工龈下刮治治疗慢性牙周炎的临床疗效。方法:32例慢性牙周炎患者随机分为两组,分别使用超声龈下洁治和手工龈下刮治的方法进行龈下刮治和根面平整术,分别在术后1个月和3个月观察两组患者的菌斑指数、牙龈出血... 详细信息

目的:比较超声龈下洁治和手工龈下刮治治疗慢性牙周炎的临床疗效。方法:32例慢性牙周炎患者随机分为两组,分别使用超声龈下洁治和手工龈下刮治的方法进行龈下刮治和根面平整术,分别在术后1个月和3个月观察两组患者的菌斑指数、牙龈出血指数、牙周袋深度和牙周附着水平等牙周指数的变化。结果:在牙周治疗术后1个月和3个月时,两组患者的菌斑指数、牙龈出血指数、牙周袋深度和牙周附着水平等牙周指数较基线均显著下降(P0.05)。结论:超声龈下洁治和手工龈下刮治一样能够有效地治疗慢性牙周炎。

关键词：超声洁治慢性牙周炎龈下刮治

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平喘固本汤合补肺汤治疗COPD稳定期患者的临床观察

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中国现代医生 2016年第30期54卷 138-140页

作者：简永平福建省龙岩市妇幼保健院中医内科福建龙岩364300

目的探讨平喘固本汤合补肺汤治疗COPD稳定期患者的临床效果及其对患者免疫功能、炎性反应的影响。方法随机将选取78例COPD稳定期患者分为观察组和对照组,对照组给予常规西药治疗,观察组在常规西药治疗基础上加服平喘固本汤合补肺汤,对... 详细信息

目的探讨平喘固本汤合补肺汤治疗COPD稳定期患者的临床效果及其对患者免疫功能、炎性反应的影响。方法随机将选取78例COPD稳定期患者分为观察组和对照组,对照组给予常规西药治疗,观察组在常规西药治疗基础上加服平喘固本汤合补肺汤,对两组患者治疗后的肺功能进行测试;观察两组患者免疫球蛋白IgA、IgG、IgM的变化,淋巴亚细胞群CD3^+、CD4+、CD8^+含量及CD4+/CD8^+值,炎性相关因子IL-13、SP-D、PCT、SAA、NF-κB、sTREM-1及IP-10表达量。结果治疗后,观察组患者的FEV1、FVC均显著高于对照组(P0.05);观察组患者的免疫球蛋白IgA、IgG、IgM表达量均显著高于对照组(P<0.05),淋巴亚细胞群CD3^+、CD4+及CD4+/CD8^+值也明显高于对照组,而CD8^+显著低于对照组(P<0.05)。结论平喘固本汤合补肺汤能有效改善COPD稳定期患者的肺功能,增强患者免疫力,降低炎症反应指标,对于COPD的治疗效果显著,有较高的临床推广价值。

关键词：慢性阻塞性肺疾病平喘固本汤补肺汤肺功能炎性反应

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Eco-environment range in the source regions of the Yangtze and Yellow rivers

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Journal of Geographical Sciences 2003年第2期13卷 172-180页

作者： DING Yongjian,YANG jianping,LIU Shiyin,CHEN Rensheng,WANG Genxu,SHEN yongping,WANG jian,XIE Changwei,ZHANG Shiqing(Cold and Arid Regions Environmental and Engineering Research Institute, CAS, Lanzhou 730000, China) CAS Cold and Arid Regions Environmental and Engineering Research Institute Lanzhou China (GRID:grid.9227.e) (ISNI:***)

Based on geographical and hydrological extents delimited, four principles are identified, as the bases for delineating the ranges of the source regions of the Yangtze and Yellow rivers in the paper. According to the comprehensive analysis of topographical characteristics, climate conditions, vegetation distribution and hydrological features, the source region ranges for eco-environmental study are defined. The eastern boundary point is Dari hydrological station in the upper reach of the Yellow River. The watershed above Dari hydrological station is the source region of the Yellow River which drains an area of 4.49×10 4 km 2 . Natural environment is characterized by the major topographical types of plateau lakes and marshland, gentle landforms, alpine cold semi-arid climate, and steppe and meadow vegetation in the source region of the Yellow River. The eastern boundary point is the convergent site of the Nieqiaqu and the Tongtian River in the upstream of the Yangtze River. The watershed above the convergent site is the source region of the Yangtze River, with a watershed area of 12.24×10 4 km 2 . Hills and alpine plain topography, gentle terrain, alpine cold arid and semi-arid climate, and alpine cold grassland and meadow are natural conditions in the source region of the Yangtze River.

关键词： the source regions of the Yangtze and Yellow rivers eco-environmental range CLC number:X171.1

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辨证论治酒依赖稽延性戒断症状80例临床研究

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中国药物滥用防治杂志 2006年第5期12卷 265-267页

作者：简永平王东明聂榕春福建省龙岩市第三医院药物依赖治疗中心龙岩364000

目的:了解中医药辨证论治酒依赖稽延性戒断症状的疗效及不良反应。方法:选取符合标准的酒依赖患者,经苯二氮类替代递减治疗后,抑郁自评量表(SDS)>53分、焦虑自评量表(SAS)>50分者160例,随机分成治疗组和对照组各80例,治疗组选择以葛... 详细信息

目的:了解中医药辨证论治酒依赖稽延性戒断症状的疗效及不良反应。方法:选取符合标准的酒依赖患者,经苯二氮类替代递减治疗后,抑郁自评量表(SDS)>53分、焦虑自评量表(SAS)>50分者160例,随机分成治疗组和对照组各80例,治疗组选择以葛花解酲汤加减组成具有健脾利湿、清解湿热之功的基本方辨证施治,对照组以抗抑郁治疗为主,选用临床疗效总评量表(CGI)、SDS、SAS,睡眠状态问卷量表(SQ)及不良反应评定量表(TESS)对疗效及不良反应进行评定。结果:两组治疗2周后SDS、SAS、SQ量表分下降,与治疗前量表分差异有显著性(P0.05)。治疗4周后,治疗组SDS、SAS、SQ量表分下降明显,与对照组量表分差异有显著性(P<0.01);治疗组疗效总评分(GI),疗效指数分(EI)均优于对照组,不良反应严重程度总评分(TESS)低于对照组,其差异有显著性(P<0.01)。结论:以健脾利湿,清解湿热之药为基本方加减辨证论治酒依赖稽延性戒断症状疗效肯定,副作用小,依从性高。

关键词：酒依赖稽延性戒断症状中医药

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Gas-solid flow in a high-density circulating fluidized bed riser with Geldart group B particles

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Particuology 2016年第6期14卷 103-109页

作者： jian Chang KaiZhang Wenqi Zhu yongping Yang Beijing Key Laboratory of Emission Surveillance and Control for Thermal Power Generation North China Electn'c Power University Belting 102206 China

We carried out experiments to explore and characterize the gas-solid flow dynamics of Geldart group B particles in a dense circulating fluidized bed riser. By reducing the pressure drop across the solid control valve and increasing the solid inventory in the storage tank, a high solid circulation rate and a solid holdup above 0.075 throughout the riser were simultaneously achieved. At a solid-to-gas mass flux ratio of approximately 105, flow transitioned from fast fluidization to a dense suspension upflow. In the axial direction of the riser, solid holdup had an exponential profile, increasing with increasing solid circulation rate and Jot decreasing superficial gas velocity. From the riser＇s center to its wall, the solid holdup increased markedly, exhibiting a steep parabolic profile. Increasing the solid circulation rate increased the radial non-uniformity of the solid concentration, while increasing the superficial gas velocity had the opposite effect, In our dense circulating fluidized bed riser, Geldart group B particles had similar slip characteristics to Geldart group A particles,

关键词： Circulating fluidized bed riser Dense gas-solid flow High density High flux Hydrodynamics Geldart group B particle

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Simulated and Experimental Study of Seabed Sediments Sampling Parameters Based on the VOF Method

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Chinese Journal of Mechanical Engineering 2022年第2期35卷 265-278页

作者： Shudong He Youduo Peng yongping Jin jian Yan Buyan Wan National-Local Joint Engineering Laboratory of Marine Resources Exploration Equipment and Safety Technology Hunan University of Science and TechnologyXiangtan 411201China

Sediments in the seabed hold vital clues to the study of marine geology,microbial communities and history of ocean life,and the remote operated vehicle(ROV)mounted tubular sampling is an important way to obtain ***,sampling in the seabed is a particularly difficult and complicated task due to the difficulty accessing deep water *** sampling is affected by the sampler’s structural parameters,operation parameters and the interaction between the sampling tube and sediments,which usually results in low volume and coring rate of sediments *** paper simulated the soft viscous seabed sediments as non-Newtonian Herschel-Bulkley viscoplastic fluids and established a numerical model for the tubular sampling based on the volume of fluid(VOF)*** influence rules of the sampling tube diameter,drainage area rate,penetration velocity,and sediments dynamic viscosity on coring rate and volume were *** results showed that coring volume was negatively correlated with all the parameters except the sampling tube ***,coring rate decreased with increases in penetration velocity,drainage area rate,and sediments dynamic *** coring rate first increased and then decreased with increasing of the sampling tube diameter,and the peak value was also influenced by penetration ***,based on the numerical simulation results,an experimental sampling platform was set up and real-world sampling experiments were *** simulation results tallied with the experimental results,with a maximum absolute error of only 4.6%,which verified that the numerical simulation model accurately reflected real-world *** findings in this paper can provide a theoretical basis for facilitating the optimal design of the geometric structure of the seabed sediments samplers and the parameters in the sampling process.

关键词： Seabed sediments Sampler VOF method Computational fluid dynamics Coring volume Coring rate

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The Jackson Inequality for the Best L^2-Approximation of Functions on [0,1] with the Weight x

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Numerical Mathematics(Theory,Methods and Applications) 2008年第3期1卷 340-356页

作者： jian Li yongping Liu School of Mathematical Sciences Beijing Normal University Beijing 100875China

Let L^2（[0, 1], x） be the space of the real valued, measurable, square summable functions on [0, 1] with weight x, and let n be the subspace of L2（[0, 1], x） defined by a linear combination of Jo（μkX）, where Jo is the Bessel function of order 0 and {μk} is the strictly increasing sequence of all positive zeros of Jo. For f ∈ L^2（[0, 1], x）, let E（f, n） be the error of the best L2（[0, 1], x）, i.e., approximation of f by elements of n. The shift operator off at point x ∈[0, 1] with step t ∈[0, 1] is defined by T（t）f（x）=1/π∫0^π f（√x^2 ＋t^2-2xtcosO）dθ The differences （I- T（t））^r/2f = ∑j=0^∞（-1）^j（j^r/2）T^j（t）f of order r ∈ （0, ∞） and the L^2（[0, 1],x）- modulus of continuity ωr（f,τ） = sup{｜｜（I- T（t））^r/2f｜｜：0≤ t ≤τ] of order r are defined in the standard way, where T^0（t） = I is the identity operator. In this paper, we establish the sharp Jackson inequality between E（f, n） and ωr（f, τ） for some cases of r and τ. More precisely, we will find the smallest constant n（τ, r） which depends only on n, r, and % such that the inequality E（f, n）≤ n（τ, r）ωr（f, τ） is valid.

关键词： Jackson inequality modulus of continuity best approximation Bessel function.

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Numerical investigation of Weber number and gravity effects on fluid flow and heat transfer of successive droplets impacting liquid film

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Science China(Technological Sciences) 2023年第2期66卷 548-559页

作者： WANG JiXiang QIAN jian CHEN Xia LI EnHui CHEN yongping College of Electrical Energy and Power EngineeringYangzhou UniversityYangzhou 225009China Department of Mechanical and Aerospace Engineering The Hong Kong University of Science and TechnologyHong Kong 999077China jiangsu Key Laboratory of Micro and Nano Heat Fluid Flow Technology and Energy Application School of Environmental Science and EngineeringSuzhou University of Science and TechnologySuzhou 215009China Key Laboratory of Energy Thermal Conversion and Control of Ministry of Education School of Energy and EnvironmentSoutheast UniversityNanjing 210096China Beijing Institute of Electronic Engineering Beijing 100854China

Droplet-based high heat flux dissipation technique under multi-gravitational environments has gained increasing research attention due to the increased requirements of heat dissipation in advanced air-/space-borne *** this paper,a threedimensional model was developed to investigate the impact of continuous droplets on liquid film under various Weber numbers and gravity *** other words,the effects of Weber number and gravity load on the flow and heat transfer characteristics were *** results demonstrated that the dissipated heat flux was positively correlated with both Weber number and gravity load.A large Weber number indicated larger kinetic energy of a droplet,leading to a greater disturbance on the impacted film *** the Weber number was doubled,the average wall heat flux could be enhanced by 36.3%.In addition,the heat flux could be boosted by 5.4%when the gravity load ranged from 0 to ***,a weightless condition suppressed the vapor escape rates on the heating wall where the volume fraction of the vapor on the wall could increase by 20%under 0g,leading to deteriorated heat transfer *** novelty in this paper lies in the accurate three-dimensional modeling of an aerospaceoriented droplet impacting two-phase heat transfer and fluid dynamics,associating macro-scale thermal performance to microscale thermophysics *** findings of this study could guide the development of aerospace-borne spray cooling facilities for advanced aerospace thermal management.

关键词： multiple droplets impact phase-change heat transfer multiphase fluid dynamics weightlessness hyper-gravity

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甲状腺切除手术中应用钳式超声刀和传统电刀的效果比较

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中国普外基础与临床杂志 2017年第10期24卷 1226-1229页

作者：简永平陈锐锋李宝龙戚甫建南方医科大学第五附属医院普外科广州510900

目的比较甲状腺切除手术中应用钳式超声刀和传统电刀的效果。方法前瞻性收集笔者所在医院于2016年2月至2017年1月期间收治的160例接受开放性甲状腺手术患者的临床资料,随机分为钳式电刀组和传统电刀组,各80例。比较2组患者的手术效果指... 详细信息

目的比较甲状腺切除手术中应用钳式超声刀和传统电刀的效果。方法前瞻性收集笔者所在医院于2016年2月至2017年1月期间收治的160例接受开放性甲状腺手术患者的临床资料,随机分为钳式电刀组和传统电刀组,各80例。比较2组患者的手术效果指标、术后并发症发生情况和术后切口数字疼痛分级法(NRS)评分。结果在手术效果指标方面,钳式超声刀组患者的手术时间、术中出血量、术后引流量、术后引流时间、手术切口长度和住院时间均短于或低于传统电刀组,差异均有统计学意义(P0.05);在术后切口NRS评分方面,重复测量资料的方差分析结果表明,各时点钳式超声刀组患者的NRS评分均低于传统电刀组(P<0.05)。结论开放性甲状腺手术中使用钳式超声刀可有效提高手术效果,减轻术后的疼痛,降低并发症的发生率。

关键词：钳式超声刀传统电刀甲状腺切除手术并发症

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