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持续质量改进措施在医院卫生管理中的应用效果分析

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中国卫生产业 2024年第2期21卷 66-69页

作者：刘斌郭威秦永梅淮安市第五人民医院医务处江苏淮安223300

在医疗服务领域,质量始终是关键。持续质量改进(Continuous Quality Improvement,CQI)是一种以数据驱动的管理方法,通过不断监测、评估和改进医疗服务流程,旨在提高医疗服务的质量和效率。在医院卫生管理中,实施持续质量改进措施对于提... 详细信息

在医疗服务领域,质量始终是关键。持续质量改进(Continuous Quality Improvement,CQI)是一种以数据驱动的管理方法,通过不断监测、评估和改进医疗服务流程,旨在提高医疗服务的质量和效率。在医院卫生管理中,实施持续质量改进措施对于提高医疗服务水平、保障患者安全具有重要意义,能够为患者提供更加安全、有效、优质的医疗服务。本文将深入分析持续质量改进措施在医院卫生管理中的应用效果,以期为医疗行业提供有益的参考和借鉴。

关键词：医院持续质量改进卫生管理

有机肥替代部分化肥对土壤养分及小麦生长的影响

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农业技术与装备 2024年第9期 171-173页

作者：何川秦永美周康才南京市浦口区现代农业发展服务中心江苏南京210000

通过试验,对比分析了不同类型有机肥替代部分化肥对小麦生长及土壤养分的影响,结果显示:不同有机肥替代方案对小麦种植土壤pH值没有显著影响但有机质和全氮的含量有所提升,部分有机肥替代方案对小麦产量和肥料利用率有一定的提升效果。

关键词：小麦肥效试验有机肥料地力提升

Cotton GhPOX1 encoding plant class Ⅲ peroxidase may be responsible for the high level of reactive oxygen species production that is related to cotton fiber elongation

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Journal of Genetics and Genomics 2009年第3期36卷 141-150页

作者： Wenqian Mei yongmei qin Wenqiang Song Jun Li Yuxian Zhu National Laboratory of Protein Engineering and Plant Genetic Engineering Department of Biochemistry and Molecular Biology College of Life Sciences Peking University Beijing 100871 China

The accumulation of reactive oxygen species （ROS） is involved in plant cell development. In plant, class III peroxidases are heme-containing enzymes encoded by a large multi-gene family participated in the release or consumption of ROS. The specific function of each member of the family is still elusive. Here, we showed that ROS was significantly generated during cotton fiber initiation and elongation, whereas, application of NADPH oxidase inhibitor diphenyleneiodonium （DPI） and peroxidase inhibitor salicylhydroxamic acid （SHAM） to the wild-type cotton ovule culture significantly suppressed fiber growth, respectively. Their inhibitory effects were caused by the reduction of superoxide radical （O2^-）. Ten GhPOX genes （cDNAs） encoding cotton class III peroxidases were isolated, among them eight GhPOX genes were reported for the first time. Microarray analyses indicated that GhPOX1 was the mostly predominantly expressed in fast-elongating cotton fiber cells. Real-time quantitative PCR analysis revealed the transcript level of GhPOX1 was over 400-fold higher in growing fiber cells than in ovules, flowers, roots, stems and leaves. To reveal the role of GhPOX1 in plant development, its Arabidopsis orthologue atpox13 mutant was demonstrated to be defective in branch root development. Taken together, the data suggest that GhPOX1 plays an important role during fiber cell elongation possibly by mediating production of reactive oxygen species.

关键词： Class III peroxidase GhPOX1 reactive oxygen species (ROS) cotton (Gossypium hirsutum)

Arabidopsis transcription factor TCP4 represses chlorophyll biosynthesis to prevent petal greening

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Plant Communications 2022年第4期3卷 124-136页

作者： Xinhui Zheng Jingqiu Lan Hao Yu Jingzhe Zhang Yi Zhang yongmei qin Xiao-Dong Su Genji qin State Key Laboratory of Protein and Plant Gene Research School of Life SciencesPeking UniversityBeijing 100871People’s Republic of China

Green petals pose a challenge for pollinators to distinguish flowers from leaves,but they are valuable as a specialty flower ***,little is understood about the molecular mechanisms that underlie the development of green ***,we report that CINCINNATA(CIN)-like TEOSINTE BRANCHED 1/CYCLOIDEA/PCF(TCP)proteins play key roles in the control of petal *** septuple tcp2/3/4/5/10/13/17 mutant produced flowers with green petals due to chlorophyll *** of TCP4 complemented the petal phenotype of tcp2/3/4/5/10/13/*** found that chloroplasts were converted into leucoplasts in the distal parts of wild-type petals but not in the proximal parts during flower development,whereas plastid conversion was compromised in the distal parts of tcp2/3/4/5/10/13/17 ***4 and most CIN-like TCPs were predominantly expressed in distal petal regions,consistent with the green–white pattern in wild-type petals and the petal greening observed in the distal parts of tcp2/3/4/5/10/13/17 ***-sequencing data revealed that most chlorophyll biosynthesis genes were downregulated in the white distal parts of wild-type petals,but these genes had elevated expression in the distal green parts of tcp2/3/4/5/10/13/17 petals and the green proximal parts of wild-type *** revealed that TCP4 repressed chlorophyll biosynthesis by directly binding to the promoters of PROTOCHLOROPHYLLIDE REDUCTASE(PORB),DIVINYL REDUCTASE(DVR),and SUPPRESSOR OF OVEREXPRESSION OF CO 1(SOC1),which are known to promote petal *** found that the conversion of chloroplasts to leucoplasts and the green coloration in the proximal parts of petals appeared to be conserved among plant *** findings uncover a major molecular mechanism that underpins the formation of petal color patterns and provide a foundation for the breeding of plants with green flowers.

关键词： flower development petal greening plastid conversion chlorophyll biosynthesis TCP transcription factors

松树赤枯病玫瑰拟盘多毛孢菌的鉴定及生物学特性研究

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山东农业科学 2024年第6期56卷 113-119页

作者：韩凤英亓玉昆杨慧秦永梅周丽颜李星仪李海燕刘敏王清海山东农业工程学院山东济南250100 山东省林业科学研究院山东济南250014 济南市公园发展服务中心山东济南250001

本研究对从山东威海双岛林场采集的松树枯萎样本进行分离培养、单孢纯化、致病性测定,得到一株能引起松树赤枯病的病原菌,编号为RCBHL。经形态学观察和多基因(ITS、TEF-1、TUB2)系统发育分析,将菌株鉴定为玫瑰拟盘多毛孢菌(Pestalotiops... 详细信息

本研究对从山东威海双岛林场采集的松树枯萎样本进行分离培养、单孢纯化、致病性测定,得到一株能引起松树赤枯病的病原菌,编号为RCBHL。经形态学观察和多基因(ITS、TEF-1、TUB2)系统发育分析,将菌株鉴定为玫瑰拟盘多毛孢菌(Pestalotiopsis rosea)。生物学特性测定结果表明,该菌株最适生长温度为20~25℃,最优生长培养基为PDA培养基,最适生长pH值为6.0,最适光照条件为24 h光照。该研究结果可为松树赤枯病的防治提供理论依据。

关键词：松树赤枯病分离纯化病原鉴定生物学特性

沙利度胺联合英夫利西治疗难治性炎症性肠病效果及对胰岛素样生长因子-1、转化生长因子-β1的影响

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实用临床医药杂志 2024年第1期28卷 68-72,77页

作者：孟利军郭晓鹤董戴源杨艳薛耀峰周保林秦咏梅新乡医学院第一附属医院消化内科河南新乡453100

目的探讨沙利度胺联合英夫利西(IFX)治疗难治性炎症性肠病(IBD)的效果及对胰岛素样生长因子-1(IGF-1)、转化生长因子-β1(TGF-β1)含量的影响。方法选取120例难治性IBD患者,随机分为实验组和对照组,每组60例。2组均给予常规治疗(美沙拉... 详细信息

目的探讨沙利度胺联合英夫利西(IFX)治疗难治性炎症性肠病(IBD)的效果及对胰岛素样生长因子-1(IGF-1)、转化生长因子-β1(TGF-β1)含量的影响。方法选取120例难治性IBD患者,随机分为实验组和对照组,每组60例。2组均给予常规治疗(美沙拉嗪),对照组给予IFX,实验组给予IFX联合沙利度胺,连续治疗2个月。比较2组疗效、肠道菌群紊乱率、不良反应及治疗前和治疗1、2个月后克罗恩病活动指数(CDAI)、胶囊内镜评分指数(Lewis评分)、血清IGF-1、TGF-β1水平及营养状态指标[白蛋白(ALB)、转铁蛋白(Tf)]。结果实验组治疗总有效率高于对照组,差异有统计学意义(P0.05)。结论沙利度胺联合IFX治疗难治性IBD患者,可调节其血清IGF-1、TGF-β1水平,有效缓解临床表现,抑制炎症活动,改善患者营养状态与肠道菌群紊乱,且安全性高。

关键词：沙利度胺英夫利西难治性炎症性肠病胰岛素样生长因子-1 转化生长因子-β1 营养状态

Germylene-Fe complexes caused by heterometallic coupling and investigation into the 3d-4p bonding

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Chinese Chemical Letters 2024年第3期35卷 304-307页

作者： Yingying qin yongmei Kang Lei Zhang Jianping Sun Zhijing Zhang Jialei Xu Fanlong Zeng Anyang Li Wenyuan Wang Weiqun Shi Key Laboratory of Synthetic and Natural Functional Molecule of Ministry of Education College of Chemistry and Materials ScienceNorthwest UniversityXi'an 710127China Laboratory of Nuclear Energy Chemistry Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Shaanxi Coal and Chemical Industry Xi'an 710054China

The interpretation of heterometallic bonding nature is a basic work of inorganic *** means of intermetallic substitution of germylene anions with iron halide complexes CpFe(CO)_(2)I andβ-diketiminato Fe^Ⅱchloride,the ferrogermylene complexes 3a,3b and 4a were synthesized and structurally *** structural and IR characterizations show the presence of the Ge←Feπbackbonding in molecules 3a,3b and *** computational works on frontier molecular orbitals and their comparison of energy states confirmed thatσdonation andπbackbonding are both weak in these molecules,despite three complexes have longer Ge-Fe bonds,whose strength decreases slightly with the degressive electron density around Fe environment in a sequence from 3a,3b to 4a.

关键词： Metallic bonding Germylene Iron Crystal structure σbond πbackbond

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测绘工程本科专业创新人才培养方案解析

测绘通报 2014年第6期 124-127页

作者：许才军秦咏梅武汉大学测绘学院湖北武汉430079

以武汉大学2013版测绘工程本科培养方案为例,探讨信息化测绘发展阶段测绘工程本科人才培养方案的构建原则,创新型、复合型课程体系的设置方法,分析测绘工程专业(卓越工程师教育培养计划)的培养特色。新版培养方案为培养"高品质、国际化... 详细信息

以武汉大学2013版测绘工程本科培养方案为例,探讨信息化测绘发展阶段测绘工程本科人才培养方案的构建原则,创新型、复合型课程体系的设置方法,分析测绘工程专业(卓越工程师教育培养计划)的培养特色。新版培养方案为培养"高品质、国际化、创新型"高级测绘工程专业人才奠定了坚实基础。

关键词：测绘工程培养方案课程体系创新人才

TFEB/LAMP2 contributes to PM0.2-induced autophagy-lysosome dysfunction and alpha-synuclein dysregulation in astrocytes

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Journal of Environmental Sciences 2024年第11期145卷 117-127页

作者： Ben Li Ting Liu yongmei Shen Jiangnan qin Xiaohan Chang Meiqiong Wu Jianquan Guo Liangpo Liu Cailing Wei Yi Lyu Fengjie Tian Jinzhu Yin Tong Wang Wenping Zhang Yulan Qiu School of Public Health Shanxi Medical UniversityTaiyuan 030000China Hainan Provincial Center for Disease Control and Prevention Haikou 570100China Department of Neurosurgery Sinopharm Tongmei General HospitalDatong 037003China Key Laboratory of Coal Environmental Pathogenicity and Prevention(Shanxi Medical University) Ministry of EducationTaiyuan 030000China

Atmospheric particulatematter(PM)exacerbates the risk factor for Alzheimer’s and Parkinson’s diseases(PD)by promoting the alpha-synuclein(α-syn)pathology in the ***,the molecular mechanisms of astrocytes involvement inα-syn pathology underlying the process remain *** study investigated PM with particle size<200 nm(PM_(0.2))exposure-inducedα-syn pathology in ICR mice and primary astrocytes,then assessed the effects of mammalian target of rapamycin inhibitor(PP242)in vitro *** observed theα-syn pathology in the brains of exposed ***,PM_(0.2)-exposed mice also exhibited the activation of glial cell and the inhibition of *** vitro study,PM_(0.2)(3,10 and 30μg/mL)induced inflammatory response and the disorders ofα-syn degradation in primary astrocytes,and lysosomal-associated membrane protein 2(LAMP2)-mediated autophagy underliesα-syn *** abnormal function of autophagy-lysosome was specifically manifested as the expression of microtubule-associated protein light chain 3(LC3II),cathepsin B(CTSB)and lysosomal abundance increased first and then decreased,which might both be a compensatory mechanism to toxicα-syn accumulation induced by PM_(0.2).Moreover,with the transcription factor EB(TFEB)subcellular localization and the increase in LC3II,LAMP2,CTSB,and cathepsin D proteins were identified,leading to the restoration of the degradation ofα-syn after the intervention of *** results identified that PM_(0.2)exposure could promote theα-syn pathological dysregulation in astrocytes,providing mechanistic insights into how PM_(0.2)increases the risk of developing PD and highlighting TFEB/LAMP2 as a promising therapeutic target for antagonizing PM_(0.2)toxicity.

关键词： PM_(0.2) Astrocytes α-Synuclein Autophagy-lysosome