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Lipopolysaccharide Could Be Internalized into Human Peripheral Blood Mononuclear Cells and Elicits TNF-α Release,but not via the Pathway of Toll-Like Receptor 4 on the Cell Surface

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Cellular & Molecular Immunology 2004年第5期1卷 373-377页

作者： HongZhou GuofuDing WeiLiu LiangxiWang yonglinglu HongweiCao JiangZheng DepartmentofPharmacology CollegeofMedicineThirdMilitaryMedicalUniversityChongqing400038China. MedicalResearchCenter SouthwesternHospitalThirdMilitaryMedicalUniversityChongqing400038China.

Lipopolysaccharide(LPS),the principal component of the outer membrane of Gram-negative bacteria,stimulates various cell types to release numerous proinflammatory mediators such as TNF-α,IL-6 and IL-12,which may damage cells and lead to organ injury,even sepsis and septic ***-like receptor 4(TLR4) has been identified as the receptor involved in the recognition of LPS,but the role of LPS uptake in activating signal transduction remains *** the present study,TNF-α was used as a marker of macrophages/ monocytes activated by LPS,and CQ was used as an inhibitor of endosome mature in order to definitude what stage of the signal transduction elicited by LPS was *** found that there indeed existed internalization of LPS and internalization partially participated in LPS signaling since CQ inhibited cytokine release,and decreased accumulation of FITC-LPS in *** contrast,anti-hTLR4 antibody could decrease cytokine release,but had no inhibition on accumulation of *** result revealed that inhibition of cytokine release was related to reduction of FITC-LPS accumulation in the *** TLR4 on the cell surface couldn't participate in internalization of ***,LPS signaling and internalization couldn't be viewed as mutually independent *** & Molecular Immunology.2004;1(5):373-377.

关键词： LPS TNF-α TLR4 internalization CQ

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