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Tumor initiation and early tumorigenesis:molecular mechanisms and interventional targets

Signal Transduction and Targeted Therapy 2024年第7期9卷 2900-2935页

作者： Shaosen Zhang Xinyi Xiao yonglin Yi Xinyu Wang Lingxuan Zhu Yanrong Shen Dongxin Lin Chen Wu Department of Etiology and Carcinogenesis National Cancer Center/National Clinical Research Center/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College100021 BeijingChina Key Laboratory of Cancer Genomic Biology Chinese Academy of Medical Sciences and Peking Union Medical College100021 BeijingChina Changping Laboratory 100021 BeijingChina Collaborative Innovation Center for Cancer Personalized Medicine Nanjing Medical UniversityNanjing 211166China Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaGuangzhou 510060China CAMS Oxford Institute Chinese Academy of Medical Sciences100006 BeijingChina

Tumorigenesis is a multistep process,with oncogenic mutations in a normal cell conferring clonal advantage as the initial ***,despite pervasive somatic mutations and clonal expansion in normal tissues,their transformation into cancer remains a rare event,indicating the presence of additional driver events for progression to an irreversible,highly heterogeneous,and invasive ***,researchers are emphasizing the mechanisms of environmental tumor risk factors and epigenetic alterations that are profoundly influencing early clonal expansion and malignant evolution,independently of inducing ***,clonal evolution in tumorigenesis reflects a multifaceted interplay between cell-intrinsic identities and various cell-extrinsic factors that exert selective pressures to either restrain uncontrolled proliferation or allow specific clones to progress into ***,the mechanisms by which driver events induce both intrinsic cellular competency and remodel environmental stress to facilitate malignant transformation are not fully *** this review,we summarize the genetic,epigenetic,and external driver events,and their effects on the co-evolution of the transformed cells and their ecosystem during tumor initiation and early malignant evolution.A deeper understanding of the earliest molecular events holds promise for translational applications,predicting individuals at high-risk of tumor and developing strategies to intercept malignant transformation.

关键词： alterations mechanisms restrain

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When Does Sora Show:The Beginning of TAO to Imaginative Intelligence and Scenarios Engineering

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IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 809-815页

作者： Fei-Yue Wang Qinghai Miao Lingxi Li Qinghua Ni Xuan Li Juanjuan Li Lili Fan yonglin Tian Qing-Long Han School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory for Management and Control of Complex Systems Chinese Academy of SciencesBeijing 100190China Faculty of Innovation Engineering Macao University of Science and TechnologyMacao 999078China Department of Electrical and Computer Engineering Indiana University-Purdue University IndianapolisIndianapolisIN 46202USA Faculty of Innovation Engineering Macao University of Science and TechnologyMacao 999078China Virtual Reality Fundamental Research Laboratory Department of Mathematics and TheoriesPeng Cheng LaboratoryShenzhen 518000China State Key Laboratory of Multimodal Artificial Intelligence Systems Institute of AutomationChinese Academy of SciencesBeijing 100190China School of Information and Electronics Beijing Institute of TechnologyBeijing 100081China School of Science Computing and Engineering TechnologiesSwinburne University of TechnologyMelbourneVIC 3122Australia

DURING our discussion at workshops for writing“What Does ChatGPT Say:The DAO from Algorithmic Intelligence to Linguistic Intelligence”[1],we had expected the next milestone for Artificial Intelligence(AI)would be in the direction of Imaginative Intelligence(II),i.e.,something similar to automatic wordsto-videos generation or intelligent digital movies/theater technology that could be used for conducting new“Artificiofactual Experiments”[2]to replace conventional“Counterfactual Experiments”in scientific research and technical development for both natural and social studies[2]-[6].Now we have OpenAI’s Sora,so soon,but this is not the final,actually far away,and it is just the beginning.

关键词： something Intelligence replace

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Machine learning ensemble model prediction of northward shift in potato cyst nematodes(Globodera rostochiensis and ***)distribution under climate change conditions

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Journal of Integrative Agriculture 2024年第10期23卷 3576-3591页

作者： Yitong He Guanjin Wang yonglin Ren Shan Gao Dong Chu Simon J.McKirdy Shandong Engineering Research Centre for Environment-friendly Agricultural Pest Management College of Plant Health andMedicineQingdao Agricultural UniversityQingdao 266109China Harry Butler Institute Murdoch UniversityMurdochWA 6150Australia School of Information Technology Murdoch UniversityPerthWA 6150Australia Hebei Dahaituo National Nature Reserve Management Centre Chicheng 075500China

Potato cyst nematodes(PCNs)are a significant threat to potato production,having caused substantial damage in many *** the future distribution of PCN species is crucial to implementing effective biosecurity strategies,especially given the impact of climate change on pest species invasion and *** learning(ML),specifically ensemble models,has emerged as a powerful tool in predicting species distributions due to its ability to learn and make predictions based on complex data ***,this research utilised advanced machine learning techniques to predict the distribution of PCN species under climate change conditions,providing the initial element for invasion risk *** first used Global Climate Models to generate homogeneous climate predictors to mitigate the variation among ***,five machine learning models were employed to build two groups of ensembles,single-algorithm ensembles(ESA)and multi-algorithm ensembles(EMA),and compared their *** this research,the EMA did not always perform better than the ESA,and the ESA of Artificial Neural Network gave the highest performance while being *** results indicated that the distribution range of PCNs would shift northward with a decrease in tropical zones and an increase in northern ***,the total area of suitable regions will not change significantly,occupying 16-20%of the total land surface(18%under current conditions).This research alerts policymakers and practitioners to the risk of PCNs’incursion into new ***,this ML process offers the capability to track changes in the distribution of various species and provides scientifically grounded evidence for formulating long-term biosecurity plans for their control.

关键词： invasive species distribution future climates homogeneous climate predictors single-algorithm ensembles multi-algorithm ensembles artificial neural network

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Perforation of Meckel's diverticulum in two neonates with single umbilical artery

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World Journal of Pediatric Surgery 2024年第2期7卷 158-160页

作者： Lifeng Zhang Shannan Wu Xuefeng Miao yonglin Li Xiaojian Yuan Zhigang Gao General Pediatric Surgery Children's HospitalZhejiang University School of MedicineHangzhouChina Department of Pediatric Surgery Yiwu Branch of Children's HospitalZhejiang University School of MedicineYiwuChina

Meckel's diverticulum(MD)is the most common congenital anomaly of the gastro-intestinal(GI)*** main clinical mani-festation of MD in childhood is GI ***,symptomatic manifestation in the neonatal period is rare.1 Single umbil-ical artery(SUA)was first reported by Hyrtl in 1870.2 In recent years,SUA has been reported to be a marker for fetal congenital malformations,chromosomal abnormali-ties,premature birth,and low birth weight,which can lead to severe adverse *** hereby report two cases of MD perfora-tion in neonates with SUA in the Yiwu Branch of Children's Hospital,Zhejiang University School of Medicine.

关键词： Meckel artery fetal

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Electroacupuncture ameliorates blood-brain barrier disruption after ischemic stroke through histone acetylation regulation at the matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 2 genes

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Journal of Traditional Chinese Medicine 2024年第4期44卷 734-744页

作者： CHEN yonglin OUyang Ling MENG Lingling WU Bufan PENG Rou LIU Sitong HOU Dan WANG Yaling JING Xinyue LU Shengfeng FU Shuping Key Laboratory of Acupuncture and Medicine Research of Ministry of Education Nanjing University of Chinese MedicineNanjing 210023China

OBJECTIVE:To explore whether the regulation of matrix metalloproteinase 9(MMP-9)/tissue inhibitors of MMPs(TIMPs)gene expression through histone acetylation is a possible mechanism by which electroacupuncture(EA)protects blood-brain barrier(BBB)integrity in a middle cerebral artery occlusion(MCAO)rat ***:Male Sprague-Dawley rats were divided into four groups:the sham group,the MCAO group,the MCAO+EA(MEA)group,and the MCAO+EA+HAT inhibitor(HATi)*** MCAO model was generated by blocking the middle cerebral *** was applied to Baihui(GV20).Samples were collected 1 or 3 d after *** function scores and Evans blue extravasation were employed to evaluate the poststroke *** effect of EA on MMP-9/TIMPs gene expression was assessed by real-time fluorescence quantitative polymerase chain reaction(RT-qPCR)and chromatin immunoprecipitation(ChIP).RESULTS:Our results showed that EA treatment prominently improved neurological function and ameliorated BBB *** RT-qPCR assay showed that EA reduced the expression of MMP-9 and promoted TIMP-2 mRNA expression,but HATi reversed these effects of *** addition,ChIP results revealed that EA decreased the enrichment of H3K9ace/H3K27ace at MMP-9 promoters and notably stimulated the recruitment of H3K9ace/H3K27ace at TIMP-2 ***:EA treatment at Baihui(GV20)regulates the transcription of MMP-9 and TIMP-2 through histone acetylation modification in the acute stage of stroke,which preserves the structural integrity of the BBB in MCAO *** findings suggested that the histone acetylation-mediated transcriptional activity of target genes may be a crucial mechanism of EA treatment in stroke.

关键词： blood-brain barrier matrix metalloproteinase 9 tissue inhibitor of metalloproteinases electroacupuncture histone acetylation

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电磁搅拌的半固态60Si2Mn的变形特性

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材料研究学报 2000年第6期14卷 591-594页

作者：宋仁伯康永林杨雄飞毛卫民杨卯生北京科技大学

利用Ｇｌｅｅｂｌｅ－１５００材料热／力模拟机，研究了电磁搅拌的半固态６０Ｓｉ２Ｍｎ在不同的变形温度、变形速率下的变形抗力规律，并与常规铸造的６０Ｓｉ２Ｍｎ进行了比较通过对其在固液两相区变形后的外观形貌观察，分析了变形... 详细信息

利用Ｇｌｅｅｂｌｅ－１５００材料热／力模拟机，研究了电磁搅拌的半固态６０Ｓｉ２Ｍｎ在不同的变形温度、变形速率下的变形抗力规律，并与常规铸造的６０Ｓｉ２Ｍｎ进行了比较通过对其在固液两相区变形后的外观形貌观察，分析了变形过程中金属的流动规律．研究表明：半固态试样在固液两相区变形时，其变形抗力明显低于常规铸造的变形抗力，并且随着变形温度的升高，变形抗力降低；随着变形速率的降低，热软化越明显；同时发现，在固液两相区单向压缩时。

关键词：变形抗力 60SiMn 弹簧钢半固态加工

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基于光辐射强度的日盲紫外放电检测结果一致性校准方法

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电工技术学报 2024年第13期39卷 4176-4187,4256页

作者：李泳霖黄世龙刘云鹏耿江海杨家骏新能源电力系统全国重点实验室(华北电力大学) 北京102206 华北电力大学河北省输变电设备安全防御重点实验室保定071003

随着紫外放电检测技术的广泛应用,为解决不同型号日盲紫外成像仪的检测结果缺乏一致性和可比性的问题,该文基于MODTRAN模型分析了温度、湿度、气压和检测距离等不同因素对日盲紫外波段光辐射的大气传输过程的影响特性,建立了紫外检测辐... 详细信息

随着紫外放电检测技术的广泛应用,为解决不同型号日盲紫外成像仪的检测结果缺乏一致性和可比性的问题,该文基于MODTRAN模型分析了温度、湿度、气压和检测距离等不同因素对日盲紫外波段光辐射的大气传输过程的影响特性,建立了紫外检测辐射传输模型,搭建了辐射计量一致性校准平台,提出了紫外检测结果一致性校准方法。利用该方法建立了3台不同型号紫外成像仪的检测结果一致性校准公式,可将紫外成像仪测得的光斑面积换算为检测目标产生的光辐射强度。使用3台紫外成像仪对棒-板模型电晕放电和氘灯光源进行紫外放电检测,由一致性校准公式所得检测目标的光辐射强度计算值的相对标准偏差均小于0.1,验证了一致性校准方法的普适性。

关键词：紫外放电检测辐射传输模型辐射计量一致性校准平台一致性校准方法光辐射强度

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Precipitation characteristic of high strength steels microalloyed with titanium produced by compact strip production

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Journal of University of Science and Technology Beijing 2008年第4期15卷 389-395页

作者： Jian Zhou yonglin kang Xinping mao School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China CSP Institute for Technology Guangzhou Iron ＆ Steel Enterprises Group Guangzhou 510730 China

Transmission electron microscopy （TEM） and physics-chemical phase analysis were employed to investigate the precipitates in high strength steels microalloyed with Ti produced by compact strip production （CSP）. It was seen that precipitates in Ti microalloyed steels mainly included TiN, Ti4C2S2, and TiC. The size of TiN particles varied from 50 to 500 nm, and they could precipitate during or before soaking. The Ti4C2S2 with the size of 40-100 nm might precipitate before rolling, and the TiC particles with the size of 5-50 nm precipitated heterogeneously. High Ti content would lead to the presence of bigger TiC particles that precipitated in austenite, and by contrast, TiC particles that precipitated in ferrite and the transformation of austenite to ferrite was smaller. They were less than 30 nm and mainly responsible for precipitate strengthening. It should be noted that the TiC particles in higher Ti content were generally smaller than those in the steel with a lower Ti content.

关键词： compact strip production (CSP) precipitation Ti microalloyed steels nanometer particle

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大黄糖络丸通过调控PI3K-Akt/NF-κB信号通路减轻糖尿病大鼠大血管炎症反应

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中国病理生理杂志 2024年第4期40卷 646-652页

作者：姚建莉梁永林任梦函杨丽霞甘肃中医药大学甘肃兰州730000 甘肃省中医药研究院甘肃兰州730050

目的:基于磷脂酰肌醇3-激酶(PI3K)-蛋白激酶B(PKB/Akt)/核因子κB(NF-κB)信号通路,探讨大黄糖络丸(RSP)防治Zucker糖尿病肥胖(ZDF)大鼠大血管炎症反应的作用机制。方法:15只雄性ZDF(fa/+)大鼠作为对照组;高脂饲料诱导成模的75只雄性ZDF... 详细信息

目的:基于磷脂酰肌醇3-激酶(PI3K)-蛋白激酶B(PKB/Akt)/核因子κB(NF-κB)信号通路,探讨大黄糖络丸(RSP)防治Zucker糖尿病肥胖(ZDF)大鼠大血管炎症反应的作用机制。方法:15只雄性ZDF(fa/+)大鼠作为对照组;高脂饲料诱导成模的75只雄性ZDF(fa/fa)大鼠随机分为模型组,高、中、低剂量RSP组,以及二甲双胍组,每组15只。药物干预12周后,处死大鼠,分离血清,检测高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)和总胆固醇(TC)水平;ELISA法检测大鼠血清CD4、白细胞介素6(IL-6)和肿瘤坏死因子α(TNF-α)含量;HE染色观察大鼠腹主动脉组织病理改变;免疫组化染色检测腹主动脉中单核细胞趋化蛋白1(MCP-1)蛋白表达;RT-qPCR检测大鼠腹主动脉中PI3K、Akt和NF-κB p65的mRNA表达;Western blot观察腹主动脉组织中PI3K、Akt、p-Akt、p-IκB和NF-κB p65蛋白水平。结果:与模型组相比,RSP显著降低糖尿病大鼠空腹血糖及LDL-C、TG和TC水平(P<0.05),升高HDL-C水平(P<0.05或P<0.01),显著降低血清炎症介质表达,IL-6、TNF-α和CD4水平显著下降(P<0.05或P<0.01),腹主动脉组织病理学损伤程度显著减轻,腹主动脉中PI3K、Akt和NF-κB p65的mRNA及蛋白水平,以及MCP-1、p-Akt和p-IκB蛋白水平均显著降低(P<0.05或P<0.01)。结论:RSP可降糖调脂并减轻糖尿病大鼠大血管炎症损伤,其机制可能与抑制PI3K-Akt/NF-κB信号通路活化、减轻炎症反应有关。

关键词：大黄糖络丸糖尿病大血管病变 ZDF大鼠炎症 PI3K-Akt/NF-κB信号通路

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Exosome-loaded biomaterials for tendon/ligament repair

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Biomaterials Translational 2024年第2期5卷 129-143页

作者： Haohan Wang yonglin Guo Yiwen Jiang Yingyu Ge Hanyi Wang Dingyi Shi Guoyang Zhang Jinzhong Zhao Yuhao kang Liren Wang Shanghai Jiao Tong University School of Medicine ShanghaiChina Department of Orthopaedics Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina School of Materials Science and Engineering East China University of Science and TechnologyShanghaiChina

Exosomes,a specialised type of extracellular vesicle,have attracted significant attention in the realm of tendon/ligament repair as a potential biologic therapeutic *** the competence of key substances responsible for the delivery function was gradually elucidated,series of shortcomings exemplified by the limited stability still need to be ***,how to take maximum advantage of the biological characteristics of exosomes is of great ***,the comprehensive exploration and application of biomedical engineering has improved the availability of exosomes and revealed the future direction of exosomes combined with *** review delves into the present application of biomaterials such as nanomaterials,hydrogels,and electrospun scaffolds,serving as the carriers of exosomes in tendon/ligament *** pinpointing and exploring their strengths and limitations,it offers valuable insights,paving the way the future direction of biomaterials in the application of exosomes in tendon/ligament repair in this field.

关键词： biomaterials electrospinning exosomes hydrogel microspheres hydrogels nanoparticles

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