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Anti-inflammatory effects and mechanism of triterpene alcohols from camellia oil

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Food Science and Human Wellness 2024年

作者： yonglin li Shengmin Zhou Jie Qiang Yongsheng Cao Huijun Yang Yuan Gao Qi li Xiuzhu Yu Engineering Research Center of Grain and Oil Functionalized Processing Universities of Shaanxi Province， College of Food Science and Engineering， Northwest A&F University Wilmar (Shanghai) Biotechnology Research & Development Center Co.Ltd Shaanxi Guanzhongyoufang Oil Co.， Ltd

Camellia oil， which contains a high content of triterpene alcohol， is known for a series of bioactivities including anti-inflammation. Amyrins are recognized as high bioactivity of anti-inflammation. However， no comparative study on triterpene alcohols from camellia oil. In this study， four high content triterpene alcohols from camellia oil， namely β-amyrin， ψ-taraxasterol， parkeol， and butyrospermol were evaluated through lipopolysaccharide induced RAW 264.7 cell inflammation. The results showed that butyrospermol exhibited the highest anti-inflammatory activity， surpassing that of β-amyrin. Characterization of signaling pathways showed that butyrospermol inhibited TLR4， NF-κB and MAPK pathways， suppressing the transcription of Tlr4， expression of p65， IκBα， ERK， JNK， and p38， and the phosphorylation of p65， IκBα， ERK， and p38. The anti-inflammatory effect of butyrospermol was further validated by phorbol 12-myristate 13-acetate induced mouse ear edema. The results in mouse showed that butyrospermol could inhibit the increase of TNF-α， IL-1β， p-JNK， p-p38， p-IκBα， and their corresponding mRNA levels. Our study provides new perspective on the anti-inflammatory role of different triterpene alcohols and explaining the bioactivity of camellia oil.

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基于光辐射强度的日盲紫外放电检测结果一致性校准方法

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电工技术学报 2024年第13期39卷 4176-4187,4256页

作者：李泳霖黄世龙刘云鹏耿江海杨家骏新能源电力系统全国重点实验室(华北电力大学) 北京102206 华北电力大学河北省输变电设备安全防御重点实验室保定071003

随着紫外放电检测技术的广泛应用,为解决不同型号日盲紫外成像仪的检测结果缺乏一致性和可比性的问题,该文基于MODTRAN模型分析了温度、湿度、气压和检测距离等不同因素对日盲紫外波段光辐射的大气传输过程的影响特性,建立了紫外检测辐... 详细信息

随着紫外放电检测技术的广泛应用,为解决不同型号日盲紫外成像仪的检测结果缺乏一致性和可比性的问题,该文基于MODTRAN模型分析了温度、湿度、气压和检测距离等不同因素对日盲紫外波段光辐射的大气传输过程的影响特性,建立了紫外检测辐射传输模型,搭建了辐射计量一致性校准平台,提出了紫外检测结果一致性校准方法。利用该方法建立了3台不同型号紫外成像仪的检测结果一致性校准公式,可将紫外成像仪测得的光斑面积换算为检测目标产生的光辐射强度。使用3台紫外成像仪对棒-板模型电晕放电和氘灯光源进行紫外放电检测,由一致性校准公式所得检测目标的光辐射强度计算值的相对标准偏差均小于0.1,验证了一致性校准方法的普适性。

关键词：紫外放电检测辐射传输模型辐射计量一致性校准平台一致性校准方法光辐射强度

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鄂尔多斯盆地杭锦旗地区断控气藏差异

吉林大学学报（地球科学版） 2024年第3期54卷 773-783页

作者：李勇霖倪智勇李晓光韩子敬张威安川中国石油大学(北京)油气资源与勘探国家重点实验室北京102249 中国石油大学(北京)地球科学学院北京102249 中国石化华北油气分公司勘探开发研究院郑州450006

鄂尔多斯盆地杭锦旗地区泊尔江海子断裂南北地区工业气流井分布与烃源岩演化程度不匹配,且该断裂南北地区天然气成藏期次存在差异。本文在烃源岩演化史和断裂发育史的基础上,结合天然气组分碳同位素、天然气干燥系数、流体包裹体特征以... 详细信息

鄂尔多斯盆地杭锦旗地区泊尔江海子断裂南北地区工业气流井分布与烃源岩演化程度不匹配,且该断裂南北地区天然气成藏期次存在差异。本文在烃源岩演化史和断裂发育史的基础上,结合天然气组分碳同位素、天然气干燥系数、流体包裹体特征以及断层在不同方向上的封闭性,对断裂南北地区天然气的来源、成藏期次、成藏时间以及运移通道进行对比。结果表明:天然气组分碳同位素符合“正碳同位素序列”特征,即δ^(13)C_(1)<δ^(13)C_(2)<δ^(13)C_(3),表明研究区的天然气是单一来源;断裂南部天然气干燥系数分布在0.85~0.96,平均值为0.91,断裂北部天然气干燥系数分布在0.95~0.97;断裂南部地区下石盒子组储层中与天然气共生的盐水包裹体主频温度主要分布区间为95~115℃与125~135℃,断裂北部地区下石盒子组储层中与天然气共生的盐水包裹体均一温度主要分布在75~155℃之间;结合研究区埋藏史得出断裂南部地区天然气为两期成藏,成藏时间分别是晚侏罗世—早白垩世(155~142 Ma)和早白垩世末(116~110 Ma),北部地区天然气为一期成藏,成藏时间为早白垩世末(128~117 Ma)。泊尔江海子断裂自古生代以来发生了多期活动,其在燕山期的活动是造成断裂南北地区天然气分布、热演化程度、成藏期次差异的主要原因。

关键词：天然气成藏流体包裹体鄂尔多斯盆地泊尔江海子断裂杭锦旗地区

Experiments and model development of p-nitrochlorobenzene and naphthalene purification in a continuous tower melting crystallizer

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Chinese Journal of Chemical Engineering 2023年第12期64卷 9-17页

作者： Wenlong Xiao yonglin li Zhengming Yi Sheng Yang He’an Luo School of Chemical Engineering Xiangtan UniversityXiangtan 411105China School of Energy Science and Engineering Central South UniversityChangsha 410083China College of Materials and Chemical Engineering Hunan Institute of EngineeringXiangtan 411105China

With the increasing demand for high-purity products,the industrial application of melt crystallization technology has been highly *** this study,the purification process of nitrochlorobenzene binary eutectic system(NBES)and naphthalene–benzothiophene solid solution system(NBSSS)in tower melting crystallizer is analyzed,and a mathematical model of crystallization process is *** key parameters in terms of feed concentration,crystal bed height,reflux ratio and stirring speed effi-ciency on purification effects were discussed by the established *** results show that the concentration of p-nitrochlorobenzene was purified from 90.85%to 99.99%,when the crystal bed height is 600 mm,the reflux ratio is 2.5,and the stirring speed is 12 rmin^(-1).The naphthalene concentration is purified from 95.89%to 99.99%,when the crystal bed height is 400 mm,the reflux ratio is 1.43,and the stirring speed is 16 rmin^(-1).The quality of the model is evaluated by the ARD(average relative deviation).The minimum ARD values of the NBES and NBSSS are 2.39%and 5.22%,respectively,indicating the model satisfactorily explains the purification process.

关键词： Crystallization Separation Mathematical modeling Crystallizer Purification

Mathematical model of solidification for round CC billets

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Journal of University of Science and Technology Beijing 2005年第5期12卷 400-405页

作者： yonglin li Pei Zhao Guoguang Cheng Shengtao Qiu Jianping Zhang Metallurgical and Ecological Engineering School University of Science and Technology Beijing Beijing 100083 China National Engineering and Research Center for Continuous Casting Technology Central Iron and Steel Research Institute Beijing 100081 China Technology Center Ma＇anshan Iron ＆ Steel Co. Ltd Ma＇anshan 243000 China

A coupled mathematical model was established to simulate the whole solidification process of round billet continuous casting for wheel steel using piecewise linear functions of heat flux density in the mold, the secondary cooling zone and the with- drawing-straightening zone. The calculated results were consistent with the measured data showing that the model accords with the practice. The surface temperature and the solidified shell thickness of round billets are more strongly influenced by casting speed than by casting temperature. The holding zones have effect on surface temperature, which is more obvious for the 450 mm round billet. The relation between casting temperature/speed and solidification end is expressed as a linear function. The solidification end is located after straightening machine.

关键词： round billet surface temperature solidified shell thickness solidification end

Small-signal stability analysis of photovoltaic generation connected to weak AC grid

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Journal of Modern Power Systems and Clean Energy 2019年第2期7卷 254-267页

作者： Qi JIA Gangui YAN Yuru CAI yonglin li Jinhao ZHANG Northeast Electric Power University

A small-signal model of photovoltaic(PV)generation connected to weak AC grid is established based on a detailed model of the structure and connection of a PV generation system. An eigenvalue analysis is then employed to study the stability of PV generation for different grid strengths and control parameters in a phaselocked loop(PLL) controller in the voltage source converter. The transfer function of the power control loop in the dq rotation frame is developed to reveal the influence mechanism of PLL gains on the small-signal stability of PV generation. The results can be summarized as follows:(1)oscillation phenomena at a frequency of about 5 Hz may occur when the grid strength is low;(2) the tuning control parameters of the PLL have a noticeable effect on the damping characteristics of the system, and larger proportional gain can improve the system damping;(3)within a frequency range of 4-5 Hz,the PLL controller has positive feedback on the power loop of PV generation. A virtual inductance control strategy is proposed to improve the operational stability of PV generation. Finally, a simulation model of PV generation connected to weak AC grid is built in PSCAD/EMTDC and the simulation results are used to validate the analysis.

关键词： Photovoltaic generation Weak AC grid Small-signal model Eigenvalue analysis Virtual inductance control strategy

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基于智能算法的装配线平衡问题研究

南京工程学院学报（自然科学版） 2024年第1期22卷 1-8页

作者：李永林郑堃史金飞南京工程学院机械工程学院江苏南京211167

为提高汽车发动机装配线的柔性程度,提出多目标混合整数线性规划模型.该模型考虑平衡问题的三个目标,即产品的节拍时间最小、将相同的工序尽可能放到同一个工作站、不同工作站间的工作负载均衡最大;采用粒子群算法进行装配线平衡优化.... 详细信息

为提高汽车发动机装配线的柔性程度,提出多目标混合整数线性规划模型.该模型考虑平衡问题的三个目标,即产品的节拍时间最小、将相同的工序尽可能放到同一个工作站、不同工作站间的工作负载均衡最大;采用粒子群算法进行装配线平衡优化.试验结果表明本文提出的多目标混合整数线性规划模型可以帮助决策者协调装配线的布局,实现生产效率的最大化.

关键词：装配线平衡多目标优化遗传算法群体智能算法

Efficient separation of phenols from coal tar with aqueous solution of amines by liquid-liquid extraction

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Chinese Journal of Chemical Engineering 2021年第7期34卷 180-188页

作者： yonglin li He'an Luo Qiuhong Ai Kuiyi You Fei Zhao Wenlong Xiao School of Chemical Engineering Xiangtan UniversityXiangtan 411105China National&Local United Engineering Research Center for Chemical Process Simulation and Intensification Xiangtan UniversityXiangtan 411105China

In this paper,a method of extracting phenols from coal tar by amines aqueous solution was *** effects of various amines on the extraction properties of phenols in coal tar were researched from the views of molecular *** parameters such as molar ratio,concentration,extraction time and temperature for the extraction of coal tar by the monoethanolamine and ethylenediamine aqueous solution were *** results show that the organic amine with more amino groups,hydroxyl structure and strong electronegativity exhibited better extraction *** the optimal conditions,the extraction yields of phenols in coal tar by the monoethanolamine or ethylenediamine aqueous solution are above 80%,and the recovery yields of amines reach 99%.Furthermore,the probable geometries of complexes formed by the combination of phenols and organic amines were calculated by density function *** addition,several thermodynamic models were evaluated through comparing the relative deviation of simulation results by ASPEN PLUS to the experimental ones,which provide feasibility thermodynamic models for the simulation of extraction *** present work affords a mild,efficient and green approach for the extraction of phenols from coal tar by an aqueous solution of amines in industry application.

关键词： Amines Coal tar liquid-liquid equilibrium Thermodynamic model

Effects of caveolin-1 on bone marrow mesenchymal stem cells differentiating into neuron-like cells An atomic force microscopy observation

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Neural Regeneration Research 2011年第16期6卷 1227-1231页

作者： Jingjing Lu lijun Jing yonglin Jia Jinyi li liudong Wang Tao Peng Yanjie Jia Department of Neurology First Affifiated Hospital of Zhengzhou University Zhengzhou 450052 Henan Province China

Bone marrow mesenchymal stem cells （MSCs） from rats were transfected with Rn-siRNA-caveolin-1 and differentiated into neuron-like cells using fasudil hydrochloride. Membrane ultrastructural changes in MSCs were observed under atomic force microscopy. Caveolin-l-transfected rat MSCs exhibited weak nuclear refraction, dense caveolae and long finger-like cellular processes prior to fasudil hydrochloride treatment. MSCs differentiating into neuron-like cells exhibited weak nuclear refraction and large cellular processes without caveolae. We hypothesize that caveolin-1 plays an important role in the regulation of bone marrow MSC differentiating into neuron-like cells.

关键词： atomic force microscopy bone marrow mesenchymal stem cells caveolin-1 neurons differentiation neural regeneration